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Found 9 matching records:

Displaying record number 55736

HXB2 Location Gag(180-188) Gag Epitope Map
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TPQDLNTML

`TPQDmNTML`		calculated escape
`TPQDsNTML`		calculated escape
`TPQDyNTML`		calculated escape

Species (MHC/HLA) human(B*81)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`1523`
Epitope Seq.	`TPQDLNTML`
Variant Seq.	`TPQDmNTML`
Mutations	L/M
Epitope Location	L5M
HXB2 Location	L184M
Mutation Type	CE: calculated escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Variants TPQDmNTML, TPQDyNTML, TPQDsNTML were resistant to CTL response, but associated with lower viral loads, suggesting a fitness cost to the mutation.

Variant ID.	`1524`
Epitope Seq.	`TPQDLNTML`
Variant Seq.	`TPQDsNTML`
Mutations	L/S
Epitope Location	L5S
HXB2 Location	L184S
Mutation Type	CE: calculated escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Variants TPQDmNTML, TPQDyNTML, TPQDsNTML were resistant to CTL response, but associated with lower viral loads, suggesting a fitness cost to the mutation.

Variant ID.	`1525`
Epitope Seq.	`TPQDLNTML`
Variant Seq.	`TPQDyNTML`
Mutations	L/Y
Epitope Location	L5Y
HXB2 Location	L184Y
Mutation Type	CE: calculated escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Variants TPQDmNTML, TPQDyNTML, TPQDsNTML were resistant to CTL response, but associated with lower viral loads, suggesting a fitness cost to the mutation.

References

Rousseau2008 Christine M. Rousseau, Marcus G. Daniels, Jonathan M. Carlson, Carl Kadie, Hayley Crawford, Andrew Prendergast, Philippa Matthews, Rebecca Payne, Morgane Rolland, Dana N. Raugi, Brandon S. Maust, Gerald H. Learn, David C. Nickle, Hoosen Coovadia, Thumbi Ndung'u, Nicole Frahm, Christian Brander, Bruce D. Walker, Philip J. R. Goulder, Tanmoy Bhattacharya, David E. Heckerman, Bette T. Korber, and James I. Mullins. HLA Class I-Driven Evolution of Human Immunodeficiency Virus Type 1 Subtype C Proteome: Immune Escape and Viral Load. J. Virol., 82(13):6434-6446, Jul 2008. PubMed ID: 18434400. Show all entries for this paper.

Displaying record number 56143

HXB2 Location Gag(240-249) Gag Epitope Map
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Epitope

TSTLQEQIGW

Epitope Alignment

Variants

`TSnLQEQIGW`		calculated escape
`TSsLQEQIGW`		calculated escape

Species (MHC/HLA) human(B*58:01, B57)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1526`
Epitope Seq.	`TSTLQEQIGW`
Variant Seq.	`TSnLQEQIGW`
Mutations	T/N
Epitope Location	T3N
HXB2 Location	T242N
Mutation Type	CE: calculated escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

Variant ID.	`1527`
Epitope Seq.	`TSTLQEQIGW`
Variant Seq.	`TSsLQEQIGW`
Mutations	T/S
Epitope Location	T3S
HXB2 Location	T242S
Mutation Type	CE: calculated escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

References

Displaying record number 58681

HXB2 Location Gag(335-343) Gag Epitope Map
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Epitope

RALGPGATM

Epitope Alignment

Variants

`RALGtGATM`		calculated escape
`RALGvGATM`		calculated escape
`RALGsGATM`		calculated escape
`RALGqGATM`		calculated escape
`RALGaGATM`		calculated escape

Species (MHC/HLA) human

Variant Details

Showing all: 5 variant(s).

Variant ID.	`3083`
Epitope Seq.	`RALGPGATM`
Variant Seq.	`RALGtGATM`
Mutations	P/T
Epitope Location	P5T
HXB2 Location	P339T
Mutation Type	CE: calculated escape
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

Variant ID.	`3084`
Epitope Seq.	`RALGPGATM`
Variant Seq.	`RALGvGATM`
Mutations	P/V
Epitope Location	P5V
HXB2 Location	P339V
Mutation Type	CE: calculated escape
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

Variant ID.	`3085`
Epitope Seq.	`RALGPGATM`
Variant Seq.	`RALGsGATM`
Mutations	P/S
Epitope Location	P5S
HXB2 Location	P339S
Mutation Type	CE: calculated escape
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

Variant ID.	`3086`
Epitope Seq.	`RALGPGATM`
Variant Seq.	`RALGqGATM`
Mutations	P/Q
Epitope Location	P5Q
HXB2 Location	P339Q
Mutation Type	CE: calculated escape
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

Variant ID.	`3087`
Epitope Seq.	`RALGPGATM`
Variant Seq.	`RALGaGATM`
Mutations	P/A
Epitope Location	P5A
HXB2 Location	P339A
Mutation Type	CE: calculated escape
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

References

Displaying record number 56144

HXB2 Location Gag(335-343) Gag Epitope Map
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Epitope

RALGPGATL

Epitope Alignment

Variants

`RALGaGATL`		calculated escape
`RALGqGATL`		calculated escape
`RALGsGATL`		calculated escape
`RALGtGATL`		calculated escape
`RALGvGATL`		calculated escape

Species (MHC/HLA) human

Variant Details

Showing all: 5 variant(s).

Variant ID.	`1528`
Epitope Seq.	`RALGPGATL`
Variant Seq.	`RALGaGATL`
Mutations	P/A
Epitope Location	P5A
HXB2 Location	P339A
Mutation Type	CE: calculated escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

Variant ID.	`1529`
Epitope Seq.	`RALGPGATL`
Variant Seq.	`RALGqGATL`
Mutations	P/Q
Epitope Location	P5Q
HXB2 Location	P339Q
Mutation Type	CE: calculated escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

Variant ID.	`1530`
Epitope Seq.	`RALGPGATL`
Variant Seq.	`RALGsGATL`
Mutations	P/S
Epitope Location	P5S
HXB2 Location	P339S
Mutation Type	CE: calculated escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

Variant ID.	`1531`
Epitope Seq.	`RALGPGATL`
Variant Seq.	`RALGtGATL`
Mutations	P/T
Epitope Location	P5T
HXB2 Location	P339T
Mutation Type	CE: calculated escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

Variant ID.	`1532`
Epitope Seq.	`RALGPGATL`
Variant Seq.	`RALGvGATL`
Mutations	P/V
Epitope Location	P5V
HXB2 Location	P339V
Mutation Type	CE: calculated escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

References

Displaying record number 56145

HXB2 Location Pol(724-734) Pol Epitope Map
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Epitope

QEEHEKYHSNW

Epitope Alignment

Variants

`QaEHEKYHSNW`		calculated escape
`QdEHEKYHSNW`		calculated escape
`QgEHEKYHSNW`		calculated escape
`QvEHEKYHSNW`		calculated escape

Species (MHC/HLA) human(B*44:03)

Variant Details

Showing all: 4 variant(s).

Variant ID.	`1533`
Epitope Seq.	`QEEHEKYHSNW`
Variant Seq.	`QaEHEKYHSNW`
Mutations	E/A
Epitope Location	E2A
HXB2 Location	E725A
Mutation Type	CE: calculated escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

Variant ID.	`1534`
Epitope Seq.	`QEEHEKYHSNW`
Variant Seq.	`QdEHEKYHSNW`
Mutations	E/D
Epitope Location	E2D
HXB2 Location	E725D
Mutation Type	CE: calculated escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

Variant ID.	`1535`
Epitope Seq.	`QEEHEKYHSNW`
Variant Seq.	`QgEHEKYHSNW`
Mutations	E/G
Epitope Location	E2G
HXB2 Location	E725G
Mutation Type	CE: calculated escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

Variant ID.	`1536`
Epitope Seq.	`QEEHEKYHSNW`
Variant Seq.	`QvEHEKYHSNW`
Mutations	E/V
Epitope Location	E2V
HXB2 Location	E725V
Mutation Type	CE: calculated escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

References

Displaying record number 58683

HXB2 Location Vif(32-40) Vif Epitope Map
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Epitope

SKRASGWFF

Epitope Alignment

Variants

`SqRASGWFF`		calculated escape
`SrRASGWFF`		calculated escape
`SgRASGWFF`		calculated escape

Species (MHC/HLA) human(B*15:03)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`3090`
Epitope Seq.	`SKRASGWFF`
Variant Seq.	`SqRASGWFF`
Mutations	K/Q
Epitope Location	K2Q
HXB2 Location	K33Q
Mutation Type	CE: calculated escape
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

Variant ID.	`3091`
Epitope Seq.	`SKRASGWFF`
Variant Seq.	`SrRASGWFF`
Mutations	K/R
Epitope Location	K2R
HXB2 Location	K33R
Mutation Type	CE: calculated escape
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

Variant ID.	`3092`
Epitope Seq.	`SKRASGWFF`
Variant Seq.	`SgRASGWFF`
Mutations	K/G
Epitope Location	K2G
HXB2 Location	K33G
Mutation Type	CE: calculated escape
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

References

Displaying record number 56146

HXB2 Location Vif(32-40) Vif Epitope Map
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Epitope

SKRASGWFY

Epitope Alignment

Variants

`SgRASGWFY`		calculated escape
`SqRASGWFY`		calculated escape
`SrRASGWFY`		calculated escape

Species (MHC/HLA) human(B*15:03)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`2276`
Epitope Seq.	`SKRASGWFY`
Variant Seq.	`SgRASGWFY`
Mutations	K/G
Epitope Location	K2G
HXB2 Location	K33G
Mutation Type	CE: calculated escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

Variant ID.	`2277`
Epitope Seq.	`SKRASGWFY`
Variant Seq.	`SqRASGWFY`
Mutations	K/Q
Epitope Location	K2Q
HXB2 Location	K33Q
Mutation Type	CE: calculated escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

Variant ID.	`2278`
Epitope Seq.	`SKRASGWFY`
Variant Seq.	`SrRASGWFY`
Mutations	K/R
Epitope Location	K2R
HXB2 Location	K33R
Mutation Type	CE: calculated escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

References

Displaying record number 58682

HXB2 Location Rev(15-22) Rev Epitope Map
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Epitope

AVRIIKIM

Epitope Alignment

Variants

`AVqIIKIM`		calculated escape
`AVkIIKIM`		calculated escape

Species (MHC/HLA) human

Variant Details

Showing all: 2 variant(s).

Variant ID.	`3088`
Epitope Seq.	`AVRIIKIM`
Variant Seq.	`AVqIIKIM`
Mutations	R/Q
Epitope Location	R3Q
HXB2 Location	R17Q
Mutation Type	CE: calculated escape
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

Variant ID.	`3089`
Epitope Seq.	`AVRIIKIM`
Variant Seq.	`AVkIIKIM`
Mutations	R/K
Epitope Location	R3K
HXB2 Location	R17K
Mutation Type	CE: calculated escape
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

References

Displaying record number 56147

HXB2 Location Rev(15-22) Rev Epitope Map
View variants at this location

Epitope

AVRIIKIL

Epitope Alignment

Variants

`AVkIIKIL`		calculated escape
`AVqIIKIL`		calculated escape

Species (MHC/HLA) human

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1540`
Epitope Seq.	`AVRIIKIL`
Variant Seq.	`AVkIIKIL`
Mutations	R/K
Epitope Location	R3K
HXB2 Location	R17K
Mutation Type	CE: calculated escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

Variant ID.	`1541`
Epitope Seq.	`AVRIIKIL`
Variant Seq.	`AVqIIKIL`
Mutations	R/Q
Epitope Location	R3Q
HXB2 Location	R17Q
Mutation Type	CE: calculated escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.