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Found 9 matching records:

Displaying record number 55736

HXB2 Location  Gag(180-188)   Gag Epitope Map
View variants at this location
Epitope TPQDLNTML   Epitope Alignment
Variants
TPQDmNTML   calculated escape
TPQDsNTML   calculated escape
TPQDyNTML   calculated escape
Species (MHC/HLA human(B*81)

Variant Details

Showing all: 3 variant(s).


Variant ID.  1523
Epitope Seq.  TPQDLNTML
Variant Seq.  TPQDmNTML
Mutations L/M
Epitope Location L5M
HXB2 Location L184M
Mutation Type CE: calculated escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note Variants TPQDmNTML, TPQDyNTML, TPQDsNTML were resistant to CTL response, but associated with lower viral loads, suggesting a fitness cost to the mutation.


Variant ID.  1524
Epitope Seq.  TPQDLNTML
Variant Seq.  TPQDsNTML
Mutations L/S
Epitope Location L5S
HXB2 Location L184S
Mutation Type CE: calculated escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note Variants TPQDmNTML, TPQDyNTML, TPQDsNTML were resistant to CTL response, but associated with lower viral loads, suggesting a fitness cost to the mutation.


Variant ID.  1525
Epitope Seq.  TPQDLNTML
Variant Seq.  TPQDyNTML
Mutations L/Y
Epitope Location L5Y
HXB2 Location L184Y
Mutation Type CE: calculated escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note Variants TPQDmNTML, TPQDyNTML, TPQDsNTML were resistant to CTL response, but associated with lower viral loads, suggesting a fitness cost to the mutation.

References

Rousseau2008 Christine M. Rousseau, Marcus G. Daniels, Jonathan M. Carlson, Carl Kadie, Hayley Crawford, Andrew Prendergast, Philippa Matthews, Rebecca Payne, Morgane Rolland, Dana N. Raugi, Brandon S. Maust, Gerald H. Learn, David C. Nickle, Hoosen Coovadia, Thumbi Ndung'u, Nicole Frahm, Christian Brander, Bruce D. Walker, Philip J. R. Goulder, Tanmoy Bhattacharya, David E. Heckerman, Bette T. Korber, and James I. Mullins. HLA Class I-Driven Evolution of Human Immunodeficiency Virus Type 1 Subtype C Proteome: Immune Escape and Viral Load. J. Virol., 82(13):6434-6446, Jul 2008. PubMed ID: 18434400. Show all entries for this paper.


Displaying record number 56143

HXB2 Location  Gag(240-249)   Gag Epitope Map
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Epitope TSTLQEQIGW   Epitope Alignment
Variants
TSnLQEQIGW   calculated escape
TSsLQEQIGW   calculated escape
Species (MHC/HLA human(B*58:01, B57)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1526
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQIGW
Mutations T/N
Epitope Location T3N
HXB2 Location T242N
Mutation Type CE: calculated escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.


Variant ID.  1527
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSsLQEQIGW
Mutations T/S
Epitope Location T3S
HXB2 Location T242S
Mutation Type CE: calculated escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

References

Rousseau2008 Christine M. Rousseau, Marcus G. Daniels, Jonathan M. Carlson, Carl Kadie, Hayley Crawford, Andrew Prendergast, Philippa Matthews, Rebecca Payne, Morgane Rolland, Dana N. Raugi, Brandon S. Maust, Gerald H. Learn, David C. Nickle, Hoosen Coovadia, Thumbi Ndung'u, Nicole Frahm, Christian Brander, Bruce D. Walker, Philip J. R. Goulder, Tanmoy Bhattacharya, David E. Heckerman, Bette T. Korber, and James I. Mullins. HLA Class I-Driven Evolution of Human Immunodeficiency Virus Type 1 Subtype C Proteome: Immune Escape and Viral Load. J. Virol., 82(13):6434-6446, Jul 2008. PubMed ID: 18434400. Show all entries for this paper.


Displaying record number 58681

HXB2 Location  Gag(335-343)   Gag Epitope Map
View variants at this location
Epitope RALGPGATM   Epitope Alignment
Variants
RALGtGATM   calculated escape
RALGvGATM   calculated escape
RALGsGATM   calculated escape
RALGqGATM   calculated escape
RALGaGATM   calculated escape
Species (MHC/HLA human

Variant Details

Showing all: 5 variant(s).


Variant ID.  3083
Epitope Seq.  RALGPGATM
Variant Seq.  RALGtGATM
Mutations P/T
Epitope Location P5T
HXB2 Location P339T
Mutation Type CE: calculated escape
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.


Variant ID.  3084
Epitope Seq.  RALGPGATM
Variant Seq.  RALGvGATM
Mutations P/V
Epitope Location P5V
HXB2 Location P339V
Mutation Type CE: calculated escape
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.


Variant ID.  3085
Epitope Seq.  RALGPGATM
Variant Seq.  RALGsGATM
Mutations P/S
Epitope Location P5S
HXB2 Location P339S
Mutation Type CE: calculated escape
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.


Variant ID.  3086
Epitope Seq.  RALGPGATM
Variant Seq.  RALGqGATM
Mutations P/Q
Epitope Location P5Q
HXB2 Location P339Q
Mutation Type CE: calculated escape
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.


Variant ID.  3087
Epitope Seq.  RALGPGATM
Variant Seq.  RALGaGATM
Mutations P/A
Epitope Location P5A
HXB2 Location P339A
Mutation Type CE: calculated escape
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

References

Rousseau2008 Christine M. Rousseau, Marcus G. Daniels, Jonathan M. Carlson, Carl Kadie, Hayley Crawford, Andrew Prendergast, Philippa Matthews, Rebecca Payne, Morgane Rolland, Dana N. Raugi, Brandon S. Maust, Gerald H. Learn, David C. Nickle, Hoosen Coovadia, Thumbi Ndung'u, Nicole Frahm, Christian Brander, Bruce D. Walker, Philip J. R. Goulder, Tanmoy Bhattacharya, David E. Heckerman, Bette T. Korber, and James I. Mullins. HLA Class I-Driven Evolution of Human Immunodeficiency Virus Type 1 Subtype C Proteome: Immune Escape and Viral Load. J. Virol., 82(13):6434-6446, Jul 2008. PubMed ID: 18434400. Show all entries for this paper.


Displaying record number 56144

HXB2 Location  Gag(335-343)   Gag Epitope Map
View variants at this location
Epitope RALGPGATL   Epitope Alignment
Variants
RALGaGATL   calculated escape
RALGqGATL   calculated escape
RALGsGATL   calculated escape
RALGtGATL   calculated escape
RALGvGATL   calculated escape
Species (MHC/HLA human

Variant Details

Showing all: 5 variant(s).


Variant ID.  1528
Epitope Seq.  RALGPGATL
Variant Seq.  RALGaGATL
Mutations P/A
Epitope Location P5A
HXB2 Location P339A
Mutation Type CE: calculated escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.


Variant ID.  1529
Epitope Seq.  RALGPGATL
Variant Seq.  RALGqGATL
Mutations P/Q
Epitope Location P5Q
HXB2 Location P339Q
Mutation Type CE: calculated escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.


Variant ID.  1530
Epitope Seq.  RALGPGATL
Variant Seq.  RALGsGATL
Mutations P/S
Epitope Location P5S
HXB2 Location P339S
Mutation Type CE: calculated escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.


Variant ID.  1531
Epitope Seq.  RALGPGATL
Variant Seq.  RALGtGATL
Mutations P/T
Epitope Location P5T
HXB2 Location P339T
Mutation Type CE: calculated escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.


Variant ID.  1532
Epitope Seq.  RALGPGATL
Variant Seq.  RALGvGATL
Mutations P/V
Epitope Location P5V
HXB2 Location P339V
Mutation Type CE: calculated escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

References

Rousseau2008 Christine M. Rousseau, Marcus G. Daniels, Jonathan M. Carlson, Carl Kadie, Hayley Crawford, Andrew Prendergast, Philippa Matthews, Rebecca Payne, Morgane Rolland, Dana N. Raugi, Brandon S. Maust, Gerald H. Learn, David C. Nickle, Hoosen Coovadia, Thumbi Ndung'u, Nicole Frahm, Christian Brander, Bruce D. Walker, Philip J. R. Goulder, Tanmoy Bhattacharya, David E. Heckerman, Bette T. Korber, and James I. Mullins. HLA Class I-Driven Evolution of Human Immunodeficiency Virus Type 1 Subtype C Proteome: Immune Escape and Viral Load. J. Virol., 82(13):6434-6446, Jul 2008. PubMed ID: 18434400. Show all entries for this paper.


Displaying record number 56145

HXB2 Location  Pol(724-734)   Pol Epitope Map
View variants at this location
Epitope QEEHEKYHSNW   Epitope Alignment
Variants
QaEHEKYHSNW   calculated escape
QdEHEKYHSNW   calculated escape
QgEHEKYHSNW   calculated escape
QvEHEKYHSNW   calculated escape
Species (MHC/HLA human(B*44:03)

Variant Details

Showing all: 4 variant(s).


Variant ID.  1533
Epitope Seq.  QEEHEKYHSNW
Variant Seq.  QaEHEKYHSNW
Mutations E/A
Epitope Location E2A
HXB2 Location E725A
Mutation Type CE: calculated escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.


Variant ID.  1534
Epitope Seq.  QEEHEKYHSNW
Variant Seq.  QdEHEKYHSNW
Mutations E/D
Epitope Location E2D
HXB2 Location E725D
Mutation Type CE: calculated escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.


Variant ID.  1535
Epitope Seq.  QEEHEKYHSNW
Variant Seq.  QgEHEKYHSNW
Mutations E/G
Epitope Location E2G
HXB2 Location E725G
Mutation Type CE: calculated escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.


Variant ID.  1536
Epitope Seq.  QEEHEKYHSNW
Variant Seq.  QvEHEKYHSNW
Mutations E/V
Epitope Location E2V
HXB2 Location E725V
Mutation Type CE: calculated escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

References

Rousseau2008 Christine M. Rousseau, Marcus G. Daniels, Jonathan M. Carlson, Carl Kadie, Hayley Crawford, Andrew Prendergast, Philippa Matthews, Rebecca Payne, Morgane Rolland, Dana N. Raugi, Brandon S. Maust, Gerald H. Learn, David C. Nickle, Hoosen Coovadia, Thumbi Ndung'u, Nicole Frahm, Christian Brander, Bruce D. Walker, Philip J. R. Goulder, Tanmoy Bhattacharya, David E. Heckerman, Bette T. Korber, and James I. Mullins. HLA Class I-Driven Evolution of Human Immunodeficiency Virus Type 1 Subtype C Proteome: Immune Escape and Viral Load. J. Virol., 82(13):6434-6446, Jul 2008. PubMed ID: 18434400. Show all entries for this paper.


Displaying record number 58683

HXB2 Location  Vif(32-40)   Vif Epitope Map
View variants at this location
Epitope SKRASGWFF   Epitope Alignment
Variants
SqRASGWFF   calculated escape
SrRASGWFF   calculated escape
SgRASGWFF   calculated escape
Species (MHC/HLA human(B*15:03)

Variant Details

Showing all: 3 variant(s).


Variant ID.  3090
Epitope Seq.  SKRASGWFF
Variant Seq.  SqRASGWFF
Mutations K/Q
Epitope Location K2Q
HXB2 Location K33Q
Mutation Type CE: calculated escape
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.


Variant ID.  3091
Epitope Seq.  SKRASGWFF
Variant Seq.  SrRASGWFF
Mutations K/R
Epitope Location K2R
HXB2 Location K33R
Mutation Type CE: calculated escape
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.


Variant ID.  3092
Epitope Seq.  SKRASGWFF
Variant Seq.  SgRASGWFF
Mutations K/G
Epitope Location K2G
HXB2 Location K33G
Mutation Type CE: calculated escape
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

References

Rousseau2008 Christine M. Rousseau, Marcus G. Daniels, Jonathan M. Carlson, Carl Kadie, Hayley Crawford, Andrew Prendergast, Philippa Matthews, Rebecca Payne, Morgane Rolland, Dana N. Raugi, Brandon S. Maust, Gerald H. Learn, David C. Nickle, Hoosen Coovadia, Thumbi Ndung'u, Nicole Frahm, Christian Brander, Bruce D. Walker, Philip J. R. Goulder, Tanmoy Bhattacharya, David E. Heckerman, Bette T. Korber, and James I. Mullins. HLA Class I-Driven Evolution of Human Immunodeficiency Virus Type 1 Subtype C Proteome: Immune Escape and Viral Load. J. Virol., 82(13):6434-6446, Jul 2008. PubMed ID: 18434400. Show all entries for this paper.


Displaying record number 56146

HXB2 Location  Vif(32-40)   Vif Epitope Map
View variants at this location
Epitope SKRASGWFY   Epitope Alignment
Variants
SgRASGWFY   calculated escape
SqRASGWFY   calculated escape
SrRASGWFY   calculated escape
Species (MHC/HLA human(B*15:03)

Variant Details

Showing all: 3 variant(s).


Variant ID.  2276
Epitope Seq.  SKRASGWFY
Variant Seq.  SgRASGWFY
Mutations K/G
Epitope Location K2G
HXB2 Location K33G
Mutation Type CE: calculated escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.


Variant ID.  2277
Epitope Seq.  SKRASGWFY
Variant Seq.  SqRASGWFY
Mutations K/Q
Epitope Location K2Q
HXB2 Location K33Q
Mutation Type CE: calculated escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.


Variant ID.  2278
Epitope Seq.  SKRASGWFY
Variant Seq.  SrRASGWFY
Mutations K/R
Epitope Location K2R
HXB2 Location K33R
Mutation Type CE: calculated escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

References

Rousseau2008 Christine M. Rousseau, Marcus G. Daniels, Jonathan M. Carlson, Carl Kadie, Hayley Crawford, Andrew Prendergast, Philippa Matthews, Rebecca Payne, Morgane Rolland, Dana N. Raugi, Brandon S. Maust, Gerald H. Learn, David C. Nickle, Hoosen Coovadia, Thumbi Ndung'u, Nicole Frahm, Christian Brander, Bruce D. Walker, Philip J. R. Goulder, Tanmoy Bhattacharya, David E. Heckerman, Bette T. Korber, and James I. Mullins. HLA Class I-Driven Evolution of Human Immunodeficiency Virus Type 1 Subtype C Proteome: Immune Escape and Viral Load. J. Virol., 82(13):6434-6446, Jul 2008. PubMed ID: 18434400. Show all entries for this paper.


Displaying record number 58682

HXB2 Location  Rev(15-22)   Rev Epitope Map
View variants at this location
Epitope AVRIIKIM   Epitope Alignment
Variants
AVqIIKIM   calculated escape
AVkIIKIM   calculated escape
Species (MHC/HLA human

Variant Details

Showing all: 2 variant(s).


Variant ID.  3088
Epitope Seq.  AVRIIKIM
Variant Seq.  AVqIIKIM
Mutations R/Q
Epitope Location R3Q
HXB2 Location R17Q
Mutation Type CE: calculated escape
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.


Variant ID.  3089
Epitope Seq.  AVRIIKIM
Variant Seq.  AVkIIKIM
Mutations R/K
Epitope Location R3K
HXB2 Location R17K
Mutation Type CE: calculated escape
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

References

Rousseau2008 Christine M. Rousseau, Marcus G. Daniels, Jonathan M. Carlson, Carl Kadie, Hayley Crawford, Andrew Prendergast, Philippa Matthews, Rebecca Payne, Morgane Rolland, Dana N. Raugi, Brandon S. Maust, Gerald H. Learn, David C. Nickle, Hoosen Coovadia, Thumbi Ndung'u, Nicole Frahm, Christian Brander, Bruce D. Walker, Philip J. R. Goulder, Tanmoy Bhattacharya, David E. Heckerman, Bette T. Korber, and James I. Mullins. HLA Class I-Driven Evolution of Human Immunodeficiency Virus Type 1 Subtype C Proteome: Immune Escape and Viral Load. J. Virol., 82(13):6434-6446, Jul 2008. PubMed ID: 18434400. Show all entries for this paper.


Displaying record number 56147

HXB2 Location  Rev(15-22)   Rev Epitope Map
View variants at this location
Epitope AVRIIKIL   Epitope Alignment
Variants
AVkIIKIL   calculated escape
AVqIIKIL   calculated escape
Species (MHC/HLA human

Variant Details

Showing all: 2 variant(s).


Variant ID.  1540
Epitope Seq.  AVRIIKIL
Variant Seq.  AVkIIKIL
Mutations R/K
Epitope Location R3K
HXB2 Location R17K
Mutation Type CE: calculated escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.


Variant ID.  1541
Epitope Seq.  AVRIIKIL
Variant Seq.  AVqIIKIL
Mutations R/Q
Epitope Location R3Q
HXB2 Location R17Q
Mutation Type CE: calculated escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant is associated with lower viral loads, suggesting a fitness cost to the mutation.

References

Rousseau2008 Christine M. Rousseau, Marcus G. Daniels, Jonathan M. Carlson, Carl Kadie, Hayley Crawford, Andrew Prendergast, Philippa Matthews, Rebecca Payne, Morgane Rolland, Dana N. Raugi, Brandon S. Maust, Gerald H. Learn, David C. Nickle, Hoosen Coovadia, Thumbi Ndung'u, Nicole Frahm, Christian Brander, Bruce D. Walker, Philip J. R. Goulder, Tanmoy Bhattacharya, David E. Heckerman, Bette T. Korber, and James I. Mullins. HLA Class I-Driven Evolution of Human Immunodeficiency Virus Type 1 Subtype C Proteome: Immune Escape and Viral Load. J. Virol., 82(13):6434-6446, Jul 2008. PubMed ID: 18434400. Show all entries for this paper.


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