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Found 7 matching records:

Displaying record number 53832

HXB2 Location  Gag(147-155)   Gag Epitope Map
View variants at this location
Epitope ISPRTLNAW   Epitope Alignment
Variants
mSPRTLNAW   escape documented in this paper
lSPRTLNAW   diminished response
{p}lSPRTLNAW   observed variant
Species (MHC/HLA human(B57)

Variant Details

Showing all: 3 variant(s).


Variant ID.  1413
Epitope Seq.  ISPRTLNAW
Variant Seq.  mSPRTLNAW
Mutations I/M
Epitope Location I1M
HXB2 Location I147M
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Sequence
Note This is de novo variant seen in infant by week 33 of age. The index peptide was recognized, but not the variant.


Variant ID.  1414
Epitope Seq.  ISPRTLNAW
Variant Seq.  lSPRTLNAW
Mutations I/L
Epitope Location I1L
HXB2 Location I147L
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Sequence
Note This is de novo variant seen in infant by week 33 of age. Both index peptide and the variant were recognized, but response to the variant was diminished.


Variant ID.  2304
Epitope Seq.  {A}ISPRTLNAW
Variant Seq.  {p}lSPRTLNAW
Mutations -/P I/L
Epitope Location --1P I1L
HXB2 Location -146P I147L
Mutation Type OV: observed variant
Method Sequence
Note A substitution proximal to the epitope and variant within the epitope was seen in infant I5 by week 33.

References

Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.


Displaying record number 53833

HXB2 Location  Gag(240-249)   Gag Epitope Map
View variants at this location
Epitope TSTLQEQIAW   Epitope Alignment
Variants
TSTLQEQItW   observed variant
TSnLQEQIAW   escape documented in this paper
Species (MHC/HLA human(B57)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1415
Epitope Seq.  TSTLQEQIAW
Variant Seq.  TSTLQEQItW
Mutations A/T
Epitope Location A9T
HXB2 Location A248T
Mutation Type OV: observed variant
Method Sequence
Note This variant was the autologous form seen in this non-HLA-B57 carrying mother, M5. The variant was transmitted to her infant, I5.


Variant ID.  1416
Epitope Seq.  TSTLQEQIAW
Variant Seq.  TSnLQEQIAW
Mutations T/N
Epitope Location T3N
HXB2 Location T242N
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant was a dominant, escape form (complete abrogation of response) that arose by week 33 in infant I5 who carried the restricting HLA allele, B57.

References

Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.


Displaying record number 53834

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KqWIIiGLNK   literature escape
KqWvImGLNK   observed variant
Species (MHC/HLA human(B27)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1417
Epitope Seq.  KRWIILGLNK
Variant Seq.  KqWIIiGLNK
Mutations R/Q L/I
Epitope Location R2Q L6I
HXB2 Location R264Q L268I
Mutation Type LE: literature escape
Method Sequence
Note This variant was seen in an HLA-B27 carrying father, and it was passed on to the non-B27-mother.


Variant ID.  1418
Epitope Seq.  KRWIILGLNK
Variant Seq.  KqWvImGLNK
Mutations R/Q I/V L/M
Epitope Location R2Q I4V L6M
HXB2 Location R264Q I266V L268M
Mutation Type OV: observed variant
Method Sequence
Note This variant arose in a non-B27 mother and it was transmitted to the infant who did carry the restricting HLA allele, B27.

References

Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.


Displaying record number 53828

HXB2 Location  Nef(73-82)   Nef Epitope Map
View variants at this location
Epitope QVPLRPMTYK   Epitope Alignment
Variants
QVPLRPMTfK   susceptible form
QVPLkPMTfK   diminished response
QVPLRPMnYK   diminished response
QVPvRPMTfK   escape documented in this paper
QVPLRPMsYr   escape documented in this paper
QVPLRPMsYK   susceptible form
Species (MHC/HLA human(A3)

Variant Details

Showing all: 6 variant(s).


Variant ID.  1419
Epitope Seq.  QVPLRPMTYK
Variant Seq.  QVPLRPMTfK
Mutations Y/F
Epitope Location Y9F
HXB2 Location Y81F
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant was the autologous, index sequence carried by an HIV-positive, transmitting mother, M3. Her infant, I3, carried the variant as its dominant form and it elicited a CTL response.


Variant ID.  1420
Epitope Seq.  QVPLRPMTYK
Variant Seq.  QVPLkPMTfK
Mutations R/K Y/F
Epitope Location R5K Y9F
HXB2 Location R77K Y81F
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Sequence
Note This early variant arose in infant I3 and elicited a diminished CTL response.


Variant ID.  1421
Epitope Seq.  QVPLRPMTYK
Variant Seq.  QVPLRPMnYK
Mutations T/N
Epitope Location T8N
HXB2 Location T80N
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Sequence
Note This early variant arose in infant I3 and elicited a diminished CTL response.


Variant ID.  1422
Epitope Seq.  QVPLRPMTYK
Variant Seq.  QVPvRPMTfK
Mutations L/V Y/F
Epitope Location L4V Y9F
HXB2 Location L76V Y81F
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant arose by week 80 in infant I3 and no CTL response was detected to it.


Variant ID.  1423
Epitope Seq.  QVPLRPMTYK
Variant Seq.  QVPLRPMsYr
Mutations K/R T/S
Epitope Location K10R T8S
HXB2 Location K82R T80S
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant arose by week 80 in infant I3 and no CTL response was detected to it.


Variant ID.  1424
Epitope Seq.  QVPLRPMTYK
Variant Seq.  QVPLRPMsYK
Mutations T/S
Epitope Location T8S
HXB2 Location T80S
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant arose by week 80 in infant I3 and it elicited a CTL response.

References

Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.


Displaying record number 53831

HXB2 Location  Nef(82-90)   Nef Epitope Map
View variants at this location
Epitope KAAFDLSFF   Epitope Alignment
Variants
KAAFDLgFF   diminished response
KgAFDLgFF   susceptible form
Species (MHC/HLA human(B57)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1425
Epitope Seq.  KAAFDLSFF
Variant Seq.  KAAFDLgFF
Mutations S/G
Epitope Location S7G
HXB2 Location S88G
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant was found in mother M5. In the infant, I5, it elicited a diminished CTL response


Variant ID.  1426
Epitope Seq.  KAAFDLSFF
Variant Seq.  KgAFDLgFF
Mutations A/G S/G
Epitope Location A2G S7G
HXB2 Location A83G S88G
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant was the dominant (only) circulating form by week 33 in infant I5 and elicited CTL response.

References

Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.


Displaying record number 53830

HXB2 Location  Nef(116-124)   Nef Epitope Map
View variants at this location
Epitope HTQGYFPDW   Epitope Alignment
Variants
HTQGfFPDW   susceptible form
nTQGfFPDW   diminished response
Species (MHC/HLA human(B57)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1427
Epitope Seq.  HTQGYFPDW
Variant Seq.  HTQGfFPDW
Mutations Y/F
Epitope Location Y5F
HXB2 Location Y120F
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note This index epitope in mother M5 generated the Y/F variant which was transmitted to infant I5 where it was recognized.


Variant ID.  1428
Epitope Seq.  HTQGYFPDW
Variant Seq.  nTQGfFPDW
Mutations H/N Y/F
Epitope Location H1N Y5F
HXB2 Location H116N Y120F
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant arose in infant I5 by week 33 and elicited a diminished CTL response.

References

Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.


Displaying record number 53829

HXB2 Location  Nef(128-137)   Nef Epitope Map
View variants at this location
Epitope TPGPGVRYPL   Epitope Alignment
Variants
TsGPGVRYPL   diminished HLA binding or increased off-rate; escape documented in this paper
TqGPGVRYPL   diminished HLA binding or increased off-rate; escape documented in this paper
Species (MHC/HLA human(B*4201)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1429
Epitope Seq.  TPGPGVRYPL
Variant Seq.  TsGPGVRYPL
Mutations P/S
Epitope Location P2S
HXB2 Location P129S
Mutation Type DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note This index epitope from mother, M4 was transmitted to infant, I4 in whom the variant form which had reduced binding to HLA-B*4201 was seen by week 26. The variant was unable to elicit a CTL response.


Variant ID.  1430
Epitope Seq.  TPGPGVRYPL
Variant Seq.  TqGPGVRYPL
Mutations P/Q
Epitope Location P2Q
HXB2 Location P129Q
Mutation Type DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note This index epitope from mother, M4 was transmitted to infant, I4 in whom the variant form which had reduced binding to HLA-B*4201 was seen by week 26. The variant was unable to elicit a CTL response.

References

Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.


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