HIV molecular immunology database
Found 26 matching records:
| HXB2 Location | Gag(114-122) | Gag Epitope Map
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|---|---|---|---|---|---|---|
| Epitope |
KTQQAAADK
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse(B*57) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3597 |
|---|---|
| Epitope Seq. | KTQQAAADK |
| Variant Seq. | KaQQAAADt |
| Mutations | T/A K/T |
| Epitope Location | T2A K9T |
| HXB2 Location | T115A K122T |
| Mutation Type | OV: observed variant |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Other |
| Note | Vaccine-included variant KaQQAAADt is present in a highly variable region of Gag p17 and forms 11% of 4,300 database sequences. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Gag(177-187) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
EGATPQDLNTM
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse(B*67:01) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3576 |
|---|---|
| Epitope Seq. | EGATPQDLNTM |
| Variant Seq. | EGATPQDLNmM |
| Mutations | T/M |
| Epitope Location | T10M |
| HXB2 Location | T206M |
| Mutation Type | |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Other |
| Note | Epitope variant EGATPQDLNmM was present in mosaic 2 of the second generation tHIVconsvX vaccine. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Gag(177-187) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
EGATPQDLNMM
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse(B*67:01) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3578 |
|---|---|
| Epitope Seq. | EGATPQDLNMM |
| Variant Seq. | EGATPQDLNtM |
| Mutations | M/T |
| Epitope Location | M10T |
| HXB2 Location | M186T |
| Mutation Type | |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Protective Japanese variant epitope EGATPQDLNtM was present in mosaic 1 of the second generation tHIVconsvX vaccine. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Gag(180-188) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
TPQDLNTML
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse(B*67:01) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3579 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TPQDLNmML |
| Mutations | T/M |
| Epitope Location | T7M |
| HXB2 Location | T186M |
| Mutation Type | |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Other |
| Note | Epitope variant TPQDLNmML was present in mosaic 2 of the second generation tHIVconsvX vaccine. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Gag(180-188) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
TPQDLNMML
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse(B*67:01) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3580 |
|---|---|
| Epitope Seq. | TPQDLNMML |
| Variant Seq. | TPQDLNtML |
| Mutations | M/T |
| Epitope Location | M7T |
| HXB2 Location | M186T |
| Mutation Type | |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Other |
| Note | Protective Japanese variant epitope TPQDLNtML was present in mosaic 1 of the second generation tHIVconsvX vaccine. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Gag(197-205) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
AMQMLKDTI
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse | |||||
Showing all: 1 variant(s).
| Variant ID. | 3575 |
|---|---|
| Epitope Seq. | AMQMLKDTI |
| Variant Seq. | AMQMLKeTI |
| Mutations | D/E |
| Epitope Location | D7E |
| HXB2 Location | D203E |
| Mutation Type | |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy |
| Note | AMQMLKeTI was a stronger variant of AMQMLKDTI in Mosaic 2 of the tHIVconsvX vaccine, generation 2. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Gag(197-205) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
AMQMLKETI
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse | |||||
Showing all: 1 variant(s).
| Variant ID. | 3574 |
|---|---|
| Epitope Seq. | AMQMLKETI |
| Variant Seq. | AMQMLKdTI |
| Mutations | E/D |
| Epitope Location | E7D |
| HXB2 Location | E203D |
| Mutation Type | DR: diminished response |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy |
| Note | AMQMLKdTI was a weaker variant of AMQMLKETI in Mosaic 1 of the tHIVconsvX vaccine, generation 2. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Gag(198-205) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
MQMLKDTI
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse(B*52:01) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3581 |
|---|---|
| Epitope Seq. | MQMLKDTI |
| Variant Seq. | MQMLKeTI |
| Mutations | D/E |
| Epitope Location | D6E |
| HXB2 Location | D203E |
| Mutation Type | |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Other |
| Note | Protective Japanese variant epitope MQMLKeTI was present in mosaic 1 of the second generation tHIVconsvX vaccine. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Gag(198-205) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
MQMLKETI
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse(B*52:01) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3582 |
|---|---|
| Epitope Seq. | MQMLKETI |
| Variant Seq. | MQMLKdTI |
| Mutations | E/D |
| Epitope Location | E6D |
| HXB2 Location | E203D |
| Mutation Type | |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Other |
| Note | Epitope variant MQMLKdTI was present in Mosaic 1 of the tHIVconsvX vaccine. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Gag(199-209) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
QMLKETINEEA
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse(B*52:01) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3584 |
|---|---|
| Epitope Seq. | QMLKETINEEA |
| Variant Seq. | QMLKdTINEEA |
| Mutations | E/D |
| Epitope Location | E5D |
| HXB2 Location | E203D |
| Mutation Type | |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Other |
| Note | Epitope variant QMLKdTINEEA is present in Mosaic 1 of generation 2 tHIVconsvX vaccine. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Gag(199-209) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
QMLKDTINEEA
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse(B*52:01) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3583 |
|---|---|
| Epitope Seq. | QMLKDTINEEA |
| Variant Seq. | QMLKeTINEEA |
| Mutations | D/E |
| Epitope Location | D5E |
| HXB2 Location | D203E |
| Mutation Type | |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Other |
| Note | Protective Japanese variant epitope QMLKeTINEEA is present in Mosaic 2 of the second generation vaccine tHIVconsvX. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Gag(202-210) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
KDTINEEAA
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse(B*40) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3600 |
|---|---|
| Epitope Seq. | KDTINEEAA |
| Variant Seq. | KeTINEEAA |
| Mutations | D/E |
| Epitope Location | D2E |
| HXB2 Location | D203E |
| Mutation Type | OV: observed variant SF: susceptible form |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Other |
| Note | Highly conserved variant KdTINEEAA was present in the vaccine, recognized and conserved in 50% of 4,300 database sequences. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Gag(202-210) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
KETINEEAA
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse(B*40) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3599 |
|---|---|
| Epitope Seq. | KETINEEAA |
| Variant Seq. | KdTINEEAA |
| Mutations | E/D |
| Epitope Location | E2D |
| HXB2 Location | E203D |
| Mutation Type | OV: observed variant SF: susceptible form |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Other |
| Note | Highly conserved variant KdTINEEAA was present in the vaccine, recognized and conserved in 41% of 4,300 database sequences. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Gag(240-249) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
TSTLQEQIGW
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | TW10 | |||||
| Species (MHC/HLA) | human, mouse(B*57) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3598 |
|---|---|
| Epitope Seq. | TSTLQEQIGW |
| Variant Seq. | TSTLQEQIaW |
| Mutations | G/A |
| Epitope Location | G9A |
| HXB2 Location | G248A |
| Mutation Type | OV: observed variant |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Other |
| Note | Vaccine-included variant TSTLQEQIaW is present in a moderately variable region of Gag p17 and forms 23% of 4,300 database sequences. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Gag(275-282) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
RMYSPVSI
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse(B*52:01) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3586 |
|---|---|
| Epitope Seq. | RMYSPVSI |
| Variant Seq. | RMYSPtSI |
| Mutations | V/T |
| Epitope Location | V6T |
| HXB2 Location | V280T |
| Mutation Type | |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Other |
| Note | Protective Japanese variant epitope RMYSPtSI was present in Mosaic 2 of the 2nd generation vaccine, tHIVconsvX. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Gag(275-282) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
RMYSPTSI
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse(B*52:01) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3585 |
|---|---|
| Epitope Seq. | RMYSPTSI |
| Variant Seq. | RMYSPvSI |
| Mutations | T/V |
| Epitope Location | T6V |
| HXB2 Location | T280V |
| Mutation Type | |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Other |
| Note | Epitope variant RMYSPvSI is present in Mosaic 1 of generation 2 vaccine, tHIVconsvX. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Gag(316-323) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
WMTDTLLV
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse(B*52:01) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3588 |
|---|---|
| Epitope Seq. | WMTDTLLV |
| Variant Seq. | WMTeTLLV |
| Mutations | D/E |
| Epitope Location | D4E |
| HXB2 Location | D319E |
| Mutation Type | |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Other |
| Note | Protective Japanese variant epitope WMTeTLLV is present in Mosaic 2 of second generation vaccine, tHIVconsvX. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Gag(316-323) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
WMTETLLV
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse(B*52:01) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3587 |
|---|---|
| Epitope Seq. | WMTETLLV |
| Variant Seq. | WMTdTLLV |
| Mutations | E/D |
| Epitope Location | E4D |
| HXB2 Location | E319D |
| Mutation Type | |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Other |
| Note | Epitope variant WMTdTLLV is present in Mosaic 1 of second generation vaccine, tHIVconsvX. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Gag(327-337) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
NPDCKTILRAL
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse(B*67:01) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3589 |
|---|---|
| Epitope Seq. | NPDCKTILRAL |
| Variant Seq. | NPDCKTILkAL |
| Mutations | R/K |
| Epitope Location | R9K |
| HXB2 Location | R335K |
| Mutation Type | |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Other |
| Note | Japanese Protective variant epitope NPDCKTILkAL was present in Mosaic 2 of second generation vaccine, tHIVconsvX. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Gag(327-337) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
NPDCKTILKAL
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse(B*67:01) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3590 |
|---|---|
| Epitope Seq. | NPDCKTILKAL |
| Variant Seq. | NPDCKTILrAL |
| Mutations | K/R |
| Epitope Location | K9R |
| HXB2 Location | K335R |
| Mutation Type | |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Other |
| Note | Variant epitope NPDCKTILKAL was present in Mosaic 1 of second generation vaccine, tHIVconsvX. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Pol(132-140) | Pol Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
LVGPTPVNI
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse | |||||
Showing all: 1 variant(s).
| Variant ID. | 3595 |
|---|---|
| Epitope Seq. | LVGPTPVNI |
| Variant Seq. | LiGPTPVNI |
| Mutations | V/I |
| Epitope Location | V2I |
| HXB2 Location | V133I |
| Mutation Type | DR: diminished response |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Other |
| Note | Variant epitope LiGPTPVNI had a weaker response than LVGPTPVNI and was present in Mosaic 1 of second generation vaccine, tHIVconsvX. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Pol(132-140) | Pol Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
LIGPTPVNI
|
Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse | |||||
Showing all: 1 variant(s).
| Variant ID. | 3596 |
|---|---|
| Epitope Seq. | LIGPTPVNI |
| Variant Seq. | LvGPTPVNI |
| Mutations | I/V |
| Epitope Location | I2V |
| HXB2 Location | I133V |
| Mutation Type | |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Other |
| Note | Epitope variant LvGPTPVNI has a stronger response than the epitope LIGPTPVNI. It is present in mosaic 1 of the second generation vaccine, tHIVconsvX. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Pol(783-791) | Pol Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
LEGKVILVA
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse(B*40:06) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3592 |
|---|---|
| Epitope Seq. | LEGKVILVA |
| Variant Seq. | LEGKiILVA |
| Mutations | V/I |
| Epitope Location | V5I |
| HXB2 Location | V787I |
| Mutation Type | |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Other |
| Note | Protective Japanese variant eptiope LEGKiILVA is present in Mosaic 2 of second generation vaccine, tHIVconsvX. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Pol(783-791) | Pol Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
LEGKIILVA
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse(B*40:06) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3591 |
|---|---|
| Epitope Seq. | LEGKIILVA |
| Variant Seq. | LEGKvILVA |
| Mutations | I/V |
| Epitope Location | I5V |
| HXB2 Location | I787V |
| Mutation Type | |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Other |
| Note | Epitope variant LEGKvILVA is present in Mosaic 1 of the second generation vaccine, tHIVconsvX. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Pol(912-919) | Pol Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
GERIVDII
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human, mouse(B*40:02) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3593 |
|---|---|
| Epitope Seq. | GERIVDII |
| Variant Seq. | GERIiDII |
| Mutations | V/I |
| Epitope Location | V5I |
| HXB2 Location | V916I |
| Mutation Type | |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Other |
| Note | Variant epitope GERIiDII was present in Mosaic 1 of second generation vaccine, tHIVconsvX. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.
| HXB2 Location | Pol(912-919) | Pol Epitope Map
View variants at this location |
||||
|---|---|---|---|---|---|---|
| Epitope |
GERIIDII
|
Epitope Alignment | ||||
| Variants |
|
|||||
| Species (MHC/HLA) | human, mouse(B*40:02) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3594 |
|---|---|
| Epitope Seq. | GERIIDII |
| Variant Seq. | GERIvDII |
| Mutations | I/V |
| Epitope Location | I5V |
| HXB2 Location | I916V |
| Mutation Type | |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Other |
| Note | Protective Japanese variant epitope GERIvDII was present in Mosaic 2 of the second generation vaccine, tHIVconsvX. |
Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.