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Found 26 matching records:

Displaying record number 61193

HXB2 Location  Gag(114-122)   Gag Epitope Map
View variants at this location
Epitope KTQQAAADK   Epitope Alignment
Variants
KaQQAAADt   observed variant
Species (MHC/HLA human, mouse(B*57)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3597
Epitope Seq.  KTQQAAADK
Variant Seq.  KaQQAAADt
Mutations T/A K/T
Epitope Location T2A K9T
HXB2 Location T115A K122T
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Other
Note Vaccine-included variant KaQQAAADt is present in a highly variable region of Gag p17 and forms 11% of 4,300 database sequences.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61139

HXB2 Location  Gag(177-187)   Gag Epitope Map
View variants at this location
Epitope EGATPQDLNTM   Epitope Alignment
Variants
EGATPQDLNmM  
Species (MHC/HLA human, mouse(B*67:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3576
Epitope Seq.  EGATPQDLNTM
Variant Seq.  EGATPQDLNmM
Mutations T/M
Epitope Location T10M
HXB2 Location T206M
Mutation Type
Epitope Subtype B
Variant Subtype B
Method Other
Note Epitope variant EGATPQDLNmM was present in mosaic 2 of the second generation tHIVconsvX vaccine.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61140

HXB2 Location  Gag(177-187)   Gag Epitope Map
View variants at this location
Epitope EGATPQDLNMM   Epitope Alignment
Variants
EGATPQDLNtM  
Species (MHC/HLA human, mouse(B*67:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3578
Epitope Seq.  EGATPQDLNMM
Variant Seq.  EGATPQDLNtM
Mutations M/T
Epitope Location M10T
HXB2 Location M186T
Mutation Type
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note Protective Japanese variant epitope EGATPQDLNtM was present in mosaic 1 of the second generation tHIVconsvX vaccine.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61141

HXB2 Location  Gag(180-188)   Gag Epitope Map
View variants at this location
Epitope TPQDLNTML   Epitope Alignment
Variants
TPQDLNmML  
Species (MHC/HLA human, mouse(B*67:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3579
Epitope Seq.  TPQDLNTML
Variant Seq.  TPQDLNmML
Mutations T/M
Epitope Location T7M
HXB2 Location T186M
Mutation Type
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Other
Note Epitope variant TPQDLNmML was present in mosaic 2 of the second generation tHIVconsvX vaccine.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61142

HXB2 Location  Gag(180-188)   Gag Epitope Map
View variants at this location
Epitope TPQDLNMML   Epitope Alignment
Variants
TPQDLNtML  
Species (MHC/HLA human, mouse(B*67:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3580
Epitope Seq.  TPQDLNMML
Variant Seq.  TPQDLNtML
Mutations M/T
Epitope Location M7T
HXB2 Location M186T
Mutation Type
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Other
Note Protective Japanese variant epitope TPQDLNtML was present in mosaic 1 of the second generation tHIVconsvX vaccine.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61138

HXB2 Location  Gag(197-205)   Gag Epitope Map
View variants at this location
Epitope AMQMLKDTI   Epitope Alignment
Variants
AMQMLKeTI  
Species (MHC/HLA human, mouse

Variant Details

Showing all: 1 variant(s).


Variant ID.  3575
Epitope Seq.  AMQMLKDTI
Variant Seq.  AMQMLKeTI
Mutations D/E
Epitope Location D7E
HXB2 Location D203E
Mutation Type
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note AMQMLKeTI was a stronger variant of AMQMLKDTI in Mosaic 2 of the tHIVconsvX vaccine, generation 2.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61137

HXB2 Location  Gag(197-205)   Gag Epitope Map
View variants at this location
Epitope AMQMLKETI   Epitope Alignment
Variants
AMQMLKdTI   diminished response
Species (MHC/HLA human, mouse

Variant Details

Showing all: 1 variant(s).


Variant ID.  3574
Epitope Seq.  AMQMLKETI
Variant Seq.  AMQMLKdTI
Mutations E/D
Epitope Location E7D
HXB2 Location E203D
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note AMQMLKdTI was a weaker variant of AMQMLKETI in Mosaic 1 of the tHIVconsvX vaccine, generation 2.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61143

HXB2 Location  Gag(198-205)   Gag Epitope Map
View variants at this location
Epitope MQMLKDTI   Epitope Alignment
Variants
MQMLKeTI  
Species (MHC/HLA human, mouse(B*52:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3581
Epitope Seq.  MQMLKDTI
Variant Seq.  MQMLKeTI
Mutations D/E
Epitope Location D6E
HXB2 Location D203E
Mutation Type
Epitope Subtype B
Variant Subtype B
Method Other
Note Protective Japanese variant epitope MQMLKeTI was present in mosaic 1 of the second generation tHIVconsvX vaccine.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61144

HXB2 Location  Gag(198-205)   Gag Epitope Map
View variants at this location
Epitope MQMLKETI   Epitope Alignment
Variants
MQMLKdTI  
Species (MHC/HLA human, mouse(B*52:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3582
Epitope Seq.  MQMLKETI
Variant Seq.  MQMLKdTI
Mutations E/D
Epitope Location E6D
HXB2 Location E203D
Mutation Type
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Other
Note Epitope variant MQMLKdTI was present in Mosaic 1 of the tHIVconsvX vaccine.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61146

HXB2 Location  Gag(199-209)   Gag Epitope Map
View variants at this location
Epitope QMLKETINEEA   Epitope Alignment
Variants
QMLKdTINEEA  
Species (MHC/HLA human, mouse(B*52:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3584
Epitope Seq.  QMLKETINEEA
Variant Seq.  QMLKdTINEEA
Mutations E/D
Epitope Location E5D
HXB2 Location E203D
Mutation Type
Epitope Subtype B
Variant Subtype B
Method Other
Note Epitope variant QMLKdTINEEA is present in Mosaic 1 of generation 2 tHIVconsvX vaccine.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61145

HXB2 Location  Gag(199-209)   Gag Epitope Map
View variants at this location
Epitope QMLKDTINEEA   Epitope Alignment
Variants
QMLKeTINEEA  
Species (MHC/HLA human, mouse(B*52:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3583
Epitope Seq.  QMLKDTINEEA
Variant Seq.  QMLKeTINEEA
Mutations D/E
Epitope Location D5E
HXB2 Location D203E
Mutation Type
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Other
Note Protective Japanese variant epitope QMLKeTINEEA is present in Mosaic 2 of the second generation vaccine tHIVconsvX.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61195

HXB2 Location  Gag(202-210)   Gag Epitope Map
View variants at this location
Epitope KDTINEEAA   Epitope Alignment
Variants
KeTINEEAA   observed variant; susceptible form
Species (MHC/HLA human, mouse(B*40)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3600
Epitope Seq.  KDTINEEAA
Variant Seq.  KeTINEEAA
Mutations D/E
Epitope Location D2E
HXB2 Location D203E
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Other
Note Highly conserved variant KdTINEEAA was present in the vaccine, recognized and conserved in 50% of 4,300 database sequences.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61194

HXB2 Location  Gag(202-210)   Gag Epitope Map
View variants at this location
Epitope KETINEEAA   Epitope Alignment
Variants
KdTINEEAA   observed variant; susceptible form
Species (MHC/HLA human, mouse(B*40)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3599
Epitope Seq.  KETINEEAA
Variant Seq.  KdTINEEAA
Mutations E/D
Epitope Location E2D
HXB2 Location E203D
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Other
Note Highly conserved variant KdTINEEAA was present in the vaccine, recognized and conserved in 41% of 4,300 database sequences.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61196

HXB2 Location  Gag(240-249)   Gag Epitope Map
View variants at this location
Epitope TSTLQEQIGW   Epitope Alignment
Variants
TSTLQEQIaW   observed variant
Epitope Name TW10
Species (MHC/HLA human, mouse(B*57)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3598
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSTLQEQIaW
Mutations G/A
Epitope Location G9A
HXB2 Location G248A
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Other
Note Vaccine-included variant TSTLQEQIaW is present in a moderately variable region of Gag p17 and forms 23% of 4,300 database sequences.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61149

HXB2 Location  Gag(275-282)   Gag Epitope Map
View variants at this location
Epitope RMYSPVSI   Epitope Alignment
Variants
RMYSPtSI  
Species (MHC/HLA human, mouse(B*52:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3586
Epitope Seq.  RMYSPVSI
Variant Seq.  RMYSPtSI
Mutations V/T
Epitope Location V6T
HXB2 Location V280T
Mutation Type
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Other
Note Protective Japanese variant epitope RMYSPtSI was present in Mosaic 2 of the 2nd generation vaccine, tHIVconsvX.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61147

HXB2 Location  Gag(275-282)   Gag Epitope Map
View variants at this location
Epitope RMYSPTSI   Epitope Alignment
Variants
RMYSPvSI  
Species (MHC/HLA human, mouse(B*52:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3585
Epitope Seq.  RMYSPTSI
Variant Seq.  RMYSPvSI
Mutations T/V
Epitope Location T6V
HXB2 Location T280V
Mutation Type
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Other
Note Epitope variant RMYSPvSI is present in Mosaic 1 of generation 2 vaccine, tHIVconsvX.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61150

HXB2 Location  Gag(316-323)   Gag Epitope Map
View variants at this location
Epitope WMTDTLLV   Epitope Alignment
Variants
WMTeTLLV  
Species (MHC/HLA human, mouse(B*52:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3588
Epitope Seq.  WMTDTLLV
Variant Seq.  WMTeTLLV
Mutations D/E
Epitope Location D4E
HXB2 Location D319E
Mutation Type
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Other
Note Protective Japanese variant epitope WMTeTLLV is present in Mosaic 2 of second generation vaccine, tHIVconsvX.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61148

HXB2 Location  Gag(316-323)   Gag Epitope Map
View variants at this location
Epitope WMTETLLV   Epitope Alignment
Variants
WMTdTLLV  
Species (MHC/HLA human, mouse(B*52:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3587
Epitope Seq.  WMTETLLV
Variant Seq.  WMTdTLLV
Mutations E/D
Epitope Location E4D
HXB2 Location E319D
Mutation Type
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Other
Note Epitope variant WMTdTLLV is present in Mosaic 1 of second generation vaccine, tHIVconsvX.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61151

HXB2 Location  Gag(327-337)   Gag Epitope Map
View variants at this location
Epitope NPDCKTILRAL   Epitope Alignment
Variants
NPDCKTILkAL  
Species (MHC/HLA human, mouse(B*67:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3589
Epitope Seq.  NPDCKTILRAL
Variant Seq.  NPDCKTILkAL
Mutations R/K
Epitope Location R9K
HXB2 Location R335K
Mutation Type
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Other
Note Japanese Protective variant epitope NPDCKTILkAL was present in Mosaic 2 of second generation vaccine, tHIVconsvX.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61152

HXB2 Location  Gag(327-337)   Gag Epitope Map
View variants at this location
Epitope NPDCKTILKAL   Epitope Alignment
Variants
NPDCKTILrAL  
Species (MHC/HLA human, mouse(B*67:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3590
Epitope Seq.  NPDCKTILKAL
Variant Seq.  NPDCKTILrAL
Mutations K/R
Epitope Location K9R
HXB2 Location K335R
Mutation Type
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Other
Note Variant epitope NPDCKTILKAL was present in Mosaic 1 of second generation vaccine, tHIVconsvX.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61158

HXB2 Location  Pol(132-140)   Pol Epitope Map
View variants at this location
Epitope LVGPTPVNI   Epitope Alignment
Variants
LiGPTPVNI   diminished response
Species (MHC/HLA human, mouse

Variant Details

Showing all: 1 variant(s).


Variant ID.  3595
Epitope Seq.  LVGPTPVNI
Variant Seq.  LiGPTPVNI
Mutations V/I
Epitope Location V2I
HXB2 Location V133I
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Other
Note Variant epitope LiGPTPVNI had a weaker response than LVGPTPVNI and was present in Mosaic 1 of second generation vaccine, tHIVconsvX.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61159

HXB2 Location  Pol(132-140)   Pol Epitope Map
View variants at this location
Epitope LIGPTPVNI   Epitope Alignment
Variants
LvGPTPVNI  
Species (MHC/HLA human, mouse

Variant Details

Showing all: 1 variant(s).


Variant ID.  3596
Epitope Seq.  LIGPTPVNI
Variant Seq.  LvGPTPVNI
Mutations I/V
Epitope Location I2V
HXB2 Location I133V
Mutation Type
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Other
Note Epitope variant LvGPTPVNI has a stronger response than the epitope LIGPTPVNI. It is present in mosaic 1 of the second generation vaccine, tHIVconsvX.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61155

HXB2 Location  Pol(783-791)   Pol Epitope Map
View variants at this location
Epitope LEGKVILVA   Epitope Alignment
Variants
LEGKiILVA  
Species (MHC/HLA human, mouse(B*40:06)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3592
Epitope Seq.  LEGKVILVA
Variant Seq.  LEGKiILVA
Mutations V/I
Epitope Location V5I
HXB2 Location V787I
Mutation Type
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Other
Note Protective Japanese variant eptiope LEGKiILVA is present in Mosaic 2 of second generation vaccine, tHIVconsvX.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61154

HXB2 Location  Pol(783-791)   Pol Epitope Map
View variants at this location
Epitope LEGKIILVA   Epitope Alignment
Variants
LEGKvILVA  
Species (MHC/HLA human, mouse(B*40:06)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3591
Epitope Seq.  LEGKIILVA
Variant Seq.  LEGKvILVA
Mutations I/V
Epitope Location I5V
HXB2 Location I787V
Mutation Type
Epitope Subtype B
Variant Subtype B
Method Other
Note Epitope variant LEGKvILVA is present in Mosaic 1 of the second generation vaccine, tHIVconsvX.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61157

HXB2 Location  Pol(912-919)   Pol Epitope Map
View variants at this location
Epitope GERIVDII   Epitope Alignment
Variants
GERIiDII  
Species (MHC/HLA human, mouse(B*40:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3593
Epitope Seq.  GERIVDII
Variant Seq.  GERIiDII
Mutations V/I
Epitope Location V5I
HXB2 Location V916I
Mutation Type
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Other
Note Variant epitope GERIiDII was present in Mosaic 1 of second generation vaccine, tHIVconsvX.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61156

HXB2 Location  Pol(912-919)   Pol Epitope Map
View variants at this location
Epitope GERIIDII   Epitope Alignment
Variants
GERIvDII  
Species (MHC/HLA human, mouse(B*40:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3594
Epitope Seq.  GERIIDII
Variant Seq.  GERIvDII
Mutations I/V
Epitope Location I5V
HXB2 Location I916V
Mutation Type
Epitope Subtype B
Variant Subtype B
Method Other
Note Protective Japanese variant epitope GERIvDII was present in Mosaic 2 of the second generation vaccine, tHIVconsvX.

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


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