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Found 10 matching records:

Displaying record number 61881

HXB2 Location  Gag(180-188)   Gag Epitope Map
View variants at this location
Epitope TPQDLNTML   Epitope Alignment
Variants
TPsDLNlML   non-susceptible form; observed variant
TPaDLNlML   non-susceptible form; observed variant
Epitope Name Gag TL9
Species (MHC/HLA human(B*6701)

Variant Details

Showing all: 2 variant(s).


Variant ID.  4091
Epitope Seq.  TPQDLNTML
Variant Seq.  TPsDLNlML
Mutations Q/S T/L
Epitope Location Q3S T7L
HXB2 Location Q182S T186L
Mutation Type NSF: non-susceptible form
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note TPsDLNlML, TL9-3S7L is a variant of B*6701-restricted WT epitope TPQDLNTML. It is not recognized by TL9-specific CTL, but is found in 2.3% chronically HIV-1-infected Japanese patients and in none who are B*6701+.


Variant ID.  4092
Epitope Seq.  TPQDLNTML
Variant Seq.  TPaDLNlML
Mutations Q/A T/L
Epitope Location Q3A T7L
HXB2 Location Q182A T186L
Mutation Type NSF: non-susceptible form
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note TPaDLNlML, TL9-3A7L is a variant of B*6701-restricted WT epitope TPQDLNTML. It is not recognized by TL9-specific CTL, but is found in 0.6% chronically HIV-1-infected Japanese patients and in none who are B*6701+.

References

Murakoshi2019 Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Yu Zhang, Takayuki Chikata, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, Keiko Sakai, and Masafumi Takiguchi. Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30333175. Show all entries for this paper.


Displaying record number 61878

HXB2 Location  Gag(198-205)   Gag Epitope Map
View variants at this location
Epitope MQMLKETI   Epitope Alignment
Variants
MQMLKdTI   non-susceptible form; observed variant
MQiLKETI   observed variant; susceptible form
Epitope Name Gag MI8
Species (MHC/HLA human(B*5201)

Variant Details

Showing all: 2 variant(s).


Variant ID.  4086
Epitope Seq.  MQMLKETI
Variant Seq.  MQMLKdTI
Mutations E/D
Epitope Location E6D
HXB2 Location E203D
Mutation Type NSF: non-susceptible form
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note MQMLKdTI, MI8-6D is a variant of B*5201-restricted WT epitope MQMLKETI. It is not recognized by MI8-specific CTL, but is found in 4.3% chronically HIV-1-infected Japanese patients and 3.6% of those who were B*5201+.


Variant ID.  4087
Epitope Seq.  MQMLKETI
Variant Seq.  MQiLKETI
Mutations M/I
Epitope Location M3I
HXB2 Location M200I
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note MQiLKETI, MI8-3I is a variant of B*5201-restricted WT epitope MQMLKETI. It was cross-recognized by MI8-specific CTL, and is found in 0.6% chronically HIV-1-infected Japanese patients and 1.2% of those who were B*5201+.

References

Murakoshi2019 Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Yu Zhang, Takayuki Chikata, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, Keiko Sakai, and Masafumi Takiguchi. Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30333175. Show all entries for this paper.


Displaying record number 61879

HXB2 Location  Gag(316-323)   Gag Epitope Map
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Epitope WMTETLLV   Epitope Alignment
Variants
WMTdTLLV   non-susceptible form; observed variant
Epitope Name Gag WV8
Species (MHC/HLA human(B*5201)

Variant Details

Showing all: 1 variant(s).


Variant ID.  4088
Epitope Seq.  WMTETLLV
Variant Seq.  WMTdTLLV
Mutations E/D
Epitope Location E4D
HXB2 Location E319D
Mutation Type NSF: non-susceptible form
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note WMTdTLLV, WV8-4D is a variant of B*5201-restricted WT epitope MQMLKETI. It is not recognized by MI8-specific CTL, but is found in 2.2% chronically HIV-1-infected B*5201+ Japanese patients.

References

Murakoshi2019 Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Yu Zhang, Takayuki Chikata, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, Keiko Sakai, and Masafumi Takiguchi. Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30333175. Show all entries for this paper.


Displaying record number 61882

HXB2 Location  Gag(327-337)   Gag Epitope Map
View variants at this location
Epitope NPDCKTILKAL   Epitope Alignment
Variants
NPDCKiILKsL   observed variant; susceptible form
NPDCKlILKsL   observed variant; susceptible form
Epitope Name Gag NL11
Species (MHC/HLA human(B*6701)

Variant Details

Showing all: 2 variant(s).


Variant ID.  4093
Epitope Seq.  NPDCKTILKAL
Variant Seq.  NPDCKiILKsL
Mutations A/S T/I
Epitope Location A10S T6I
HXB2 Location A336S T332I
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note NPDCKiILKsL, NL11-6I10S is a variant of B*6701-restricted WT epitope NPDCKTILKAL. It is cross-recognized by NL11-specific CTL, and is found in 0.9% chronically HIV-1-infected Japanese patients but none of those that are B*6701+.


Variant ID.  4094
Epitope Seq.  NPDCKTILKAL
Variant Seq.  NPDCKlILKsL
Mutations A/S T/L
Epitope Location A10S T6L
HXB2 Location A336S T332L
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note NPDCKlILKsL, NL11-6L10S is a variant of B*6701-restricted WT epitope NPDCKTILKAL. It is cross-recognized by NL11-specific CTL, and is found in 0.6% chronically HIV-1-infected Japanese patients but none of those that are B*6701+.

References

Murakoshi2019 Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Yu Zhang, Takayuki Chikata, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, Keiko Sakai, and Masafumi Takiguchi. Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30333175. Show all entries for this paper.


Displaying record number 61883

HXB2 Location  Gag(341-349)   Gag Epitope Map
View variants at this location
Epitope ATLEEMMTA   Epitope Alignment
Variants
AsLEEMMTA   observed variant; susceptible form
ATLEEMMaA   observed variant; susceptible form
ATLEEMMsA   observed variant; susceptible form
pTLEEMMTA   observed variant; susceptible form
Epitope Name Gag AA9
Species (MHC/HLA human(A*0206)

Variant Details

Showing all: 4 variant(s).


Variant ID.  4095
Epitope Seq.  ATLEEMMTA
Variant Seq.  AsLEEMMTA
Mutations T/S
Epitope Location T2S
HXB2 Location T342S
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note AsLEEMMTA, AA9-2S is a variant of A*0206-restricted WT epitope ATLEEMMTA. It is cross-recognized by AA9-specific CTL, and is found in 3.7% chronically HIV-1-infected Japanese patients and 4.1% of those that are A*0206+.


Variant ID.  4096
Epitope Seq.  ATLEEMMTA
Variant Seq.  ATLEEMMaA
Mutations T/A
Epitope Location T8A
HXB2 Location T348A
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note ATLEEMMaA, AA9-8A is a variant of A*0206-restricted WT epitope ATLEEMMTA. It is cross-recognized by AA9-specific CTL, and is found in 3.4% chronically HIV-1-infected Japanese patients and 2.7% of those that are A*0206+.


Variant ID.  4098
Epitope Seq.  ATLEEMMTA
Variant Seq.  ATLEEMMsA
Mutations T/S
Epitope Location T8S
HXB2 Location T348S
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note ATLEEMMsA, AA9-8S is a variant of A*0206-restricted WT epitope ATLEEMMTA. It is cross-recognized by AA9-specific CTL, and is found in 1.7% chronically HIV-1-infected Japanese patients and 4.1% of those that are A*0206+.


Variant ID.  4099
Epitope Seq.  ATLEEMMTA
Variant Seq.  pTLEEMMTA
Mutations A/P
Epitope Location A1P
HXB2 Location A341P
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note pTLEEMMTA, AA9-1P is a variant of A*0206-restricted WT epitope ATLEEMMTA. It is cross-recognized by AA9-specific CTL, and is found in 0.6% chronically HIV-1-infected Japanese patients and 1.4% of those that are A*0206+.

References

Murakoshi2019 Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Yu Zhang, Takayuki Chikata, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, Keiko Sakai, and Masafumi Takiguchi. Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30333175. Show all entries for this paper.


Displaying record number 61884

HXB2 Location  Pol(423-431)   Pol Epitope Map
View variants at this location
Epitope SQIYAGIKV   Epitope Alignment
Variants
SQIYpGIKV   observed variant; susceptible form
SQIYpGIKi   observed variant; susceptible form
SQIYsGIKV   observed variant; susceptible form
SQIYpGvKV   observed variant; susceptible form
SQIYpGIrV   observed variant; susceptible form
SQIYpGIri   observed variant; susceptible form
SQIYtGIKV   observed variant; susceptible form
Epitope Name Pol SV9
Species (MHC/HLA human(A*0206)

Variant Details

Showing all: 7 variant(s).


Variant ID.  4100
Epitope Seq.  SQIYAGIKV
Variant Seq.  SQIYpGIKV
Mutations A/P
Epitope Location A5P
HXB2 Location A427P
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note SQIYpGIKV, SV9-5P is a variant of A*0206-restricted WT epitope SQIYAGIKV. It is cross-recognized by SV9-specific CTL, and is found in 48.1% chronically HIV-1-infected Japanese patients and 14% of those that are A*0206+; which is a greater percentage than WT SV9.


Variant ID.  4101
Epitope Seq.  SQIYAGIKV
Variant Seq.  SQIYpGIKi
Mutations A/P V/I
Epitope Location A5P V9I
HXB2 Location A427P V431I
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note SQIYpGIKi, SV9-5P9I is a variant of A*0206-restricted WT epitope SQIYAGIKV. It is cross-recognized by SV9-specific CTL, and is found in 14.9% chronically HIV-1-infected Japanese patients and 43.9% of those that are A*0206+.


Variant ID.  4102
Epitope Seq.  SQIYAGIKV
Variant Seq.  SQIYsGIKV
Mutations A/S
Epitope Location A5S
HXB2 Location A427S
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note SQIYsGIKV, SV9-5S is a variant of A*0206-restricted WT epitope SQIYAGIKV. It is cross-recognized by SV9-specific CTL, and is found in 9.4% chronically HIV-1-infected Japanese patients and 21.1% of those that are A*0206+.


Variant ID.  4103
Epitope Seq.  SQIYAGIKV
Variant Seq.  SQIYpGvKV
Mutations A/P I/V
Epitope Location A5P I7V
HXB2 Location A427P I429V
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note SQIYpGvKV, SV9-5P7V is a variant of A*0206-restricted WT epitope SQIYAGIKV. It is cross-recognized by SV9-specific CTL, and is found in 2.3% chronically HIV-1-infected Japanese patients and 5.3% of those that are A*0206+.


Variant ID.  4104
Epitope Seq.  SQIYAGIKV
Variant Seq.  SQIYpGIrV
Mutations A/P K/R
Epitope Location A5P K8R
HXB2 Location A427P K430R
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note SQIYpGIrV, SV9-5P8R is a variant of A*0206-restricted WT epitope SQIYAGIKV. It is cross-recognized by SV9-specific CTL, and is found in 1.3% chronically HIV-1-infected Japanese patients and 5.3% of those that are A*0206+.


Variant ID.  4105
Epitope Seq.  SQIYAGIKV
Variant Seq.  SQIYpGIri
Mutations A/P K/R V/I
Epitope Location A5P K8R V9I
HXB2 Location A427P K430R V431I
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note SQIYpGIri, SV9-5P8R9I is a variant of A*0206-restricted WT epitope SQIYAGIKV. It is cross-recognized by SV9-specific CTL, and is found in 1% chronically HIV-1-infected Japanese patients and 1.8% of those that are A*0206+.


Variant ID.  4106
Epitope Seq.  SQIYAGIKV
Variant Seq.  SQIYtGIKV
Mutations A/T
Epitope Location A5T
HXB2 Location A427T
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note SQIYtGIKV, SV9-5T is a variant of A*0206-restricted WT epitope SQIYAGIKV. It is cross-recognized by SV9-specific CTL, and is found in 0.6% chronically HIV-1-infected Japanese patients and in none of the subjects that are A*0206+.

References

Murakoshi2019 Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Yu Zhang, Takayuki Chikata, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, Keiko Sakai, and Masafumi Takiguchi. Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30333175. Show all entries for this paper.


Displaying record number 61880

HXB2 Location  Pol(654-661)   Pol Epitope Map
View variants at this location
Epitope SQYALGII   Epitope Alignment
Variants
SQYALGIl   observed variant; susceptible form
SQYAiGII   observed variant; susceptible form
Epitope Name Gag SI8
Species (MHC/HLA human(B*5201)

Variant Details

Showing all: 2 variant(s).


Variant ID.  4089
Epitope Seq.  SQYALGII
Variant Seq.  SQYALGIl
Mutations I/L
Epitope Location I8L
HXB2 Location I661L
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note SQYALGIl, SI8-8L is a variant of B*5201-restricted WT epitope SQYALGII. It is cross-recognized by SI8-specific CTL, and is found in 7.5% chronically HIV-1-infected B*5201+ Japanese patients.


Variant ID.  4090
Epitope Seq.  SQYALGII
Variant Seq.  SQYAiGII
Mutations L/I
Epitope Location L5I
HXB2 Location L658I
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note SQYAiGII, SI8-5I is a variant of B*5201-restricted WT epitope SQYALGII. It is cross-recognized by SI8-specific CTL, and is found in 0.9% chronically HIV-1-infected Japanese patients but none of those that are B*5201+.

References

Murakoshi2019 Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Yu Zhang, Takayuki Chikata, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, Keiko Sakai, and Masafumi Takiguchi. Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30333175. Show all entries for this paper.


Displaying record number 61885

HXB2 Location  Pol(783-791)   Pol Epitope Map
View variants at this location
Epitope LEGKIILVA   Epitope Alignment
Variants
LEGKvILVA   observed variant; susceptible form
LEGKIIiVA   observed variant; susceptible form
LEGKvImVA   observed variant; susceptible form
LEGqIILVA   non-susceptible form; observed variant
Epitope Name Pol LA9
Species (MHC/HLA human(B*4006)

Variant Details

Showing all: 4 variant(s).


Variant ID.  4107
Epitope Seq.  LEGKIILVA
Variant Seq.  LEGKvILVA
Mutations I/V
Epitope Location I5V
HXB2 Location I787V
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note LEGKvILVA, LA9-5V is a variant of B*4006-restricted WT epitope LEGKIILVA. It is cross-recognized by LA9-specific CTL, and is found in 15.3% chronically HIV-1-infected Japanese patients and 10% of those that are B*4006+.


Variant ID.  4108
Epitope Seq.  LEGKIILVA
Variant Seq.  LEGKIIiVA
Mutations L/I
Epitope Location L7I
HXB2 Location L789I
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note LEGKIIiVA, LA9-7I is a variant of B*4006-restricted WT epitope LEGKIILVA. It is cross-recognized by LA9-specific CTL, and is found in 6.1% chronically HIV-1-infected Japanese patients but none of those that are B*4006+.


Variant ID.  4109
Epitope Seq.  LEGKIILVA
Variant Seq.  LEGKvImVA
Mutations I/V L/M
Epitope Location I5V L7M
HXB2 Location I787V L789M
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note LEGKvImVA, LA9-5V7M is a variant of B*4006-restricted WT epitope LEGKIILVA. It is cross-recognized by LA9-specific CTL, and is found in 0.7% chronically HIV-1-infected Japanese patients but none of those that are B*4006+.


Variant ID.  4110
Epitope Seq.  LEGKIILVA
Variant Seq.  LEGqIILVA
Mutations K/Q
Epitope Location K4Q
HXB2 Location K786Q
Mutation Type NSF: non-susceptible form
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note LEGqIILVA, LA9-4Q is a variant of B*4006-restricted WT epitope LEGKIILVA. It is not recognized by LA9-specific CTL, and is found in 1% chronically HIV-1-infected Japanese patients but none of those that are B*4006+.

References

Murakoshi2019 Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Yu Zhang, Takayuki Chikata, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, Keiko Sakai, and Masafumi Takiguchi. Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30333175. Show all entries for this paper.


Displaying record number 61886

HXB2 Location  Pol(799-808)   Pol Epitope Map
View variants at this location
Epitope IEAEVIPAET   Epitope Alignment
Variants
mEAEVIPAET   observed variant; susceptible form
lEAEVIPAET   observed variant; susceptible form
IEAEVIsAET   non-susceptible form; observed variant
Epitope Name Pol IT10
Species (MHC/HLA human(B*4006)

Variant Details

Showing all: 3 variant(s).


Variant ID.  4111
Epitope Seq.  IEAEVIPAET
Variant Seq.  mEAEVIPAET
Mutations I/M
Epitope Location I1M
HXB2 Location I799M
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note mEAEVIPAET, IT10-1M is a variant of B*4006-restricted WT epitope IEAEVIPAET. It is cross-recognized by IT10-specific CTL, and is found in 10.5% chronically HIV-1-infected Japanese patients and 10.3% of those patients that are B*4006+.


Variant ID.  4112
Epitope Seq.  IEAEVIPAET
Variant Seq.  lEAEVIPAET
Mutations I/L
Epitope Location I1L
HXB2 Location I799L
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note lEAEVIPAET, IT10-1L is a variant of B*4006-restricted WT epitope IEAEVIPAET. It is cross-recognized by IT10-specific CTL, and is found in 2% chronically HIV-1-infected Japanese patients and 10.3% of those patients that are B*4006+.


Variant ID.  4113
Epitope Seq.  IEAEVIPAET
Variant Seq.  IEAEVIsAET
Mutations P/S
Epitope Location P7S
HXB2 Location P805S
Mutation Type NSF: non-susceptible form
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note IEAEVIsAET, IT10-7S is a variant of B*4006-restricted WT epitope IEAEVIPAET. It is not recognized by IT10-specific CTL, and is found in 0.7% chronically HIV-1-infected Japanese patients and 3.4% of those patients that are B*4006+.

References

Murakoshi2019 Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Yu Zhang, Takayuki Chikata, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, Keiko Sakai, and Masafumi Takiguchi. Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30333175. Show all entries for this paper.


Displaying record number 61887

HXB2 Location  Pol(912-919)   Pol Epitope Map
View variants at this location
Epitope GERIVDII   Epitope Alignment
Variants
GERIiDII   observed variant; susceptible form
GERIiDmI   non-susceptible form; observed variant
GERIVDmI   non-susceptible form; observed variant
GERIiDlI   non-susceptible form; observed variant
GERliDII   non-susceptible form; observed variant
Epitope Name Pol GI8
Species (MHC/HLA human(B*4002)

Variant Details

Showing all: 5 variant(s).


Variant ID.  4114
Epitope Seq.  GERIVDII
Variant Seq.  GERIiDII
Mutations V/I
Epitope Location V5I
HXB2 Location V916I
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note GERIiDII, GI8-5I is a variant of B*4002-restricted WT epitope GERIVDII. It is cross-recognized by GI8-specific CTL, and is found in 44.7% chronically HIV-1-infected Japanese patients and 42.6% of those that are B*4002+; which is a greater percentage than WT GI8.


Variant ID.  4115
Epitope Seq.  GERIVDII
Variant Seq.  GERIiDmI
Mutations V/I I/M
Epitope Location V5I I7M
HXB2 Location V916I I918M
Mutation Type NSF: non-susceptible form
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note GERIiDmI, GI8-5I7M is a variant of B*4002-restricted WT epitope GERIVDII. It is not recognized by GI8-specific CTL, and is found in 4.1% chronically HIV-1-infected Japanese patients and 4.3% of those that are B*4002+.


Variant ID.  4116
Epitope Seq.  GERIVDII
Variant Seq.  GERIVDmI
Mutations I/M
Epitope Location I7M
HXB2 Location I918M
Mutation Type NSF: non-susceptible form
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note GERIVDmI, GI8-7M is a variant of B*4002-restricted WT epitope GERIVDII. It is not recognized by GI8-specific CTL, and is found in 8.4% chronically HIV-1-infected Japanese patients and 8.5% of those that are B*4002+.


Variant ID.  4117
Epitope Seq.  GERIVDII
Variant Seq.  GERIiDlI
Mutations V/I I/L
Epitope Location V5I I7L
HXB2 Location V916I I918L
Mutation Type NSF: non-susceptible form
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note GERIiDlI, GI8-5I7L is a variant of B*4002-restricted WT epitope GERIVDII. It is not recognized by GI8-specific CTL, and is found in 1.3% chronically HIV-1-infected Japanese patients and none of those that are B*4002+.


Variant ID.  4118
Epitope Seq.  GERIVDII
Variant Seq.  GERliDII
Mutations I/L V/I
Epitope Location I4L V5I
HXB2 Location I915L V916I
Mutation Type NSF: non-susceptible form
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note GERliDII, GI8-4L5I is a variant of B*4002-restricted WT epitope GERIVDII. It is not recognized by GI8-specific CTL, and is found in 0.7% chronically HIV-1-infected Japanese patients and 2.1% of those that are B*4002+.

References

Murakoshi2019 Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Yu Zhang, Takayuki Chikata, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, Keiko Sakai, and Masafumi Takiguchi. Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30333175. Show all entries for this paper.


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