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Found 10 matching records:

Displaying record number 53818

HXB2 Location Gag(18-26) Gag Epitope Map
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Epitope

KIRLRPGGK

Epitope Alignment

Variants

KIRLRPGGr diminished HLA binding or increased off-rate

Species (MHC/HLA) human(A*03:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1300`
Epitope Seq.	`KIRLRPGGK`
Variant Seq.	`KIRLRPGGr`
Mutations	K/R
Epitope Location	K9R
HXB2 Location	K26R
Mutation Type	DHB: diminished HLA binding or increased off-rate
Method	CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note	This variant was seen in Donor1 and Recipient1. It was not recognized by either subject and showed diminished binding to HLA. The restricting HLA-A*0301 was only carried in the Donor.

References

Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.

Displaying record number 53817

HXB2 Location Gag(20-28) Gag Epitope Map
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Epitope

RLRPGGKKK

Epitope Alignment

Variants

`RLRPGGrKK`		observed variant
`RLRPGGrKt`		escape documented in this paper
`RLRPGGKKq`		diminished HLA binding or increased off-rate; escape documented in this paper

Species (MHC/HLA) human(A*03:01)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`1301`
Epitope Seq.	`RLRPGGKKK`
Variant Seq.	`RLRPGGrKK`
Mutations	K/R
Epitope Location	K7R
HXB2 Location	K26R
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note	This K26R variant was found in both Donor1 and Recipient1. The restricting HLA-A*0301 was only carried in the Donor.

Variant ID.	`1302`
Epitope Seq.	`RLRPGGKKK`
Variant Seq.	`RLRPGGrKt`
Mutations	K/R K/T
Epitope Location	K7R K9T
HXB2 Location	K26R K28T
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note	Donor1 who carried the restricting HLA-A*0301 generated this mutation which rose to fixation and was not recognized. It was not found in Recipient1 as the mutation arose after transmission of virus between the pair.

Variant ID.	`1303`
Epitope Seq.	`RLRPGGKKK`
Variant Seq.	`RLRPGGKKq`
Mutations	K/Q
Epitope Location	K9Q
HXB2 Location	K28Q
Mutation Type	DHB: diminished HLA binding or increased off-rate E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note	This K28Q variant was seen in Donor2 and Recipient2, where only the donor carried the restricting allele. It was not recognized and binding to HLA was abrogated in the Donor.

References

Displaying record number 53819

HXB2 Location Gag(24-31) Gag Epitope Map
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Epitope

GGKKKYKL

Epitope Alignment

Variants

`GGrKKYKL`		escape documented in this paper
`GGKKqYrL`		diminished HLA binding or increased off-rate; escape documented in this paper

Epitope Name GL8

Species (MHC/HLA) human(B*08:01)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1304`
Epitope Seq.	`GGKKKYKL`
Variant Seq.	`GGrKKYKL`
Mutations	K/R
Epitope Location	K3R
HXB2 Location	K26R
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant was seen in Donor1 and Recipient1, where only the donor carried the restricting HLA-B*0801 allele. It was not recognized by either subject.

Variant ID.	`1305`
Epitope Seq.	`GGKKKYKL`
Variant Seq.	`GGKKqYrL`
Mutations	K/Q K/R
Epitope Location	K5Q K7R
HXB2 Location	K28Q K30R
Mutation Type	DHB: diminished HLA binding or increased off-rate E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note	This anchor residue variant was seen in Donor2 and Recipient2, both of whom carried the restricting HLA-B*0801 allele. It was not recognized and binding to HLA was greatly reduced.

References

Displaying record number 53820

HXB2 Location Gag(71-79) Gag Epitope Map
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Epitope

GTEELRSLY

Epitope Alignment

Variants

GTEELRSLf diminished HLA binding or increased off-rate; escape documented in this paper

Species (MHC/HLA) human(A*01:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1307`
Epitope Seq.	`GTEELRSLY`
Variant Seq.	`GTEELRSLf`
Mutations	Y/F
Epitope Location	Y9F
HXB2 Location	Y79F
Mutation Type	DHB: diminished HLA binding or increased off-rate E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note	This Y79F variant was seen in Donor1 and Recipient1, where only the donor carried the restricting HLA-A*0101 allele. It was not recognized and showed loss of binding to HLA.

References

Displaying record number 53821

HXB2 Location Gag(71-79) Gag Epitope Map
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Epitope

GSEELRSLY

Epitope Alignment

Variants

GSEEikSLY diminished HLA binding or increased off-rate; escape documented in this paper

Species (MHC/HLA) human(A*01:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1306`
Epitope Seq.	`GSEELRSLY`
Variant Seq.	`GSEEikSLY`
Mutations	L/I R/K
Epitope Location	L5I R6K
HXB2 Location	L75I R76K
Mutation Type	DHB: diminished HLA binding or increased off-rate E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note	This variant was seen in Donor2 and Recipient2, both of whom carried the restricting HLA-A*0101 allele. It was not recognized and binding to HLA was reduced.

References

Displaying record number 53822

HXB2 Location Gag(93-101) Gag Epitope Map
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Epitope

EVKDTKEAL

Epitope Alignment

Variants

`dVKgTKEAL`		escape documented in this paper
`dVKDTKEAL`		escape documented in this paper; susceptible form

Species (MHC/HLA) human(B*08:01)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1308`
Epitope Seq.	`EVKDTKEAL`
Variant Seq.	`dVKgTKEAL`
Mutations	E/D D/G
Epitope Location	E1D D4G
HXB2 Location	E93D D96G
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant was found in Donor2 but not transmitted to Recipient2. The variant was not recognized by CTL. Both donor and recipient carried the restricting HLA-B*0801 allele

Variant ID.	`1309`
Epitope Seq.	`EVKDTKEAL`
Variant Seq.	`dVKDTKEAL`
Mutations	E/D
Epitope Location	E1D
HXB2 Location	E93D
Mutation Type	E: escape documented in this paper SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant was found in Donor2 and Recipient2 both of whom were restricting HLA-B*0801 carriers. The variant was not recognized by CTL in Donor2, but was recognized in Recipient2 from whom it was driven out de novo in time.

References

Displaying record number 53824

HXB2 Location Rev(55-63) Rev Epitope Map
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Epitope

ISERILSTY

Epitope Alignment

Variants

ISERILSTf diminished HLA binding or increased off-rate; escape documented in this paper

Species (MHC/HLA) human(A*01:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1310`
Epitope Seq.	`ISERILSTY`
Variant Seq.	`ISERILSTf`
Mutations	Y/F
Epitope Location	Y9F
HXB2 Location	Y63F
Mutation Type	DHB: diminished HLA binding or increased off-rate E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note	This anchor residue variant was seen in Donor2 and Recipient2, both of whom carried the restricting HLA-A*0101 allele. It was not recognized by either subject and binding to HLA was greatly reduced.

References

Displaying record number 53823

HXB2 Location gp160(586-593) gp160 Epitope Map
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Epitope

YLKDQQLL

Epitope Alignment

Variants

YLqDQQLL diminished HLA binding or increased off-rate; escape documented in this paper

Species (MHC/HLA) human(B*08:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1311`
Epitope Seq.	`YLKDQQLL`
Variant Seq.	`YLqDQQLL`
Mutations	K/Q
Epitope Location	K3Q
HXB2 Location	K588Q
Mutation Type	DHB: diminished HLA binding or increased off-rate E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note	This anchor residue variant was seen in Donor2 and Recipient2, both of whom carried the restricting HLA-B*0801 allele. It was not recognized by either subject and binding to HLA was greatly reduced.

References

Displaying record number 53826

HXB2 Location Nef(13-20) Nef Epitope Map
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Epitope

WPTVRERM

Epitope Alignment

Variants

`WPaVRERM`		diminished HLA binding or increased off-rate; escape documented in this paper; susceptible form
`WPaVRkRM`		diminished HLA binding or increased off-rate; escape documented in this paper; susceptible form

Species (MHC/HLA) human(B*08:01)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1312`
Epitope Seq.	`WPTVRERM`
Variant Seq.	`WPaVRERM`
Mutations	T/A
Epitope Location	T3A
HXB2 Location	T15A
Mutation Type	DHB: diminished HLA binding or increased off-rate E: escape documented in this paper SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note	This variant was found in Donor2 and Recipient2, both of whom carried the restricting HLA-B*0801 allele. The variant was not recognized by CTL in Donor2, but was recognized in Recipient2. This variant also had reduced binding to HLA.

Variant ID.	`1313`
Epitope Seq.	`WPTVRERM`
Variant Seq.	`WPaVRkRM`
Mutations	T/A E/K
Epitope Location	T3A E6K
HXB2 Location	T15A E18K
Mutation Type	DHB: diminished HLA binding or increased off-rate E: escape documented in this paper SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note	This variant was found in Donor2 and Recipient2 both of whom carried the restricting HLA-B*0801 allele. The variant was not recognized by CTL in Donor2, but was recognized in Recipient2 from whom it was driven out de novo in time. This variant also had reduced binding to HLA.

References

Displaying record number 53825

HXB2 Location Nef(90-97) Nef Epitope Map
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Epitope

FLKEKGGL

Epitope Alignment

Variants

FLKEqGGL escape documented in this paper

Species (MHC/HLA) human(B*08:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1314`
Epitope Seq.	`FLKEKGGL`
Variant Seq.	`FLKEqGGL`
Mutations	K/Q
Epitope Location	K5Q
HXB2 Location	K94Q
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note	This variant was found in Donor2 and Recipient2, both of whom carried the restricting HLA-B*0801 allele. The variant was not recognized by CTL in Donor2, but was recognized in Recipient2 from whom it was driven out de novo in time.