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Found 10 matching records:

Displaying record number 53818

HXB2 Location  Gag(18-26)   Gag Epitope Map
View variants at this location
Epitope KIRLRPGGK   Epitope Alignment
Variants
KIRLRPGGr   diminished HLA binding or increased off-rate
Species (MHC/HLA human(A*03:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1300
Epitope Seq.  KIRLRPGGK
Variant Seq.  KIRLRPGGr
Mutations K/R
Epitope Location K9R
HXB2 Location K26R
Mutation Type DHB: diminished HLA binding or increased off-rate
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note This variant was seen in Donor1 and Recipient1. It was not recognized by either subject and showed diminished binding to HLA. The restricting HLA-A*0301 was only carried in the Donor.

References

Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.


Displaying record number 53817

HXB2 Location  Gag(20-28)   Gag Epitope Map
View variants at this location
Epitope RLRPGGKKK   Epitope Alignment
Variants
RLRPGGrKK   observed variant
RLRPGGrKt   escape documented in this paper
RLRPGGKKq   diminished HLA binding or increased off-rate; escape documented in this paper
Species (MHC/HLA human(A*03:01)

Variant Details

Showing all: 3 variant(s).


Variant ID.  1301
Epitope Seq.  RLRPGGKKK
Variant Seq.  RLRPGGrKK
Mutations K/R
Epitope Location K7R
HXB2 Location K26R
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note This K26R variant was found in both Donor1 and Recipient1. The restricting HLA-A*0301 was only carried in the Donor.


Variant ID.  1302
Epitope Seq.  RLRPGGKKK
Variant Seq.  RLRPGGrKt
Mutations K/R K/T
Epitope Location K7R K9T
HXB2 Location K26R K28T
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note Donor1 who carried the restricting HLA-A*0301 generated this mutation which rose to fixation and was not recognized. It was not found in Recipient1 as the mutation arose after transmission of virus between the pair.


Variant ID.  1303
Epitope Seq.  RLRPGGKKK
Variant Seq.  RLRPGGKKq
Mutations K/Q
Epitope Location K9Q
HXB2 Location K28Q
Mutation Type DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note This K28Q variant was seen in Donor2 and Recipient2, where only the donor carried the restricting allele. It was not recognized and binding to HLA was abrogated in the Donor.

References

Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.


Displaying record number 53819

HXB2 Location  Gag(24-31)   Gag Epitope Map
View variants at this location
Epitope GGKKKYKL   Epitope Alignment
Variants
GGrKKYKL   escape documented in this paper
GGKKqYrL   diminished HLA binding or increased off-rate; escape documented in this paper
Epitope Name GL8
Species (MHC/HLA human(B*08:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1304
Epitope Seq.  GGKKKYKL
Variant Seq.  GGrKKYKL
Mutations K/R
Epitope Location K3R
HXB2 Location K26R
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant was seen in Donor1 and Recipient1, where only the donor carried the restricting HLA-B*0801 allele. It was not recognized by either subject.


Variant ID.  1305
Epitope Seq.  GGKKKYKL
Variant Seq.  GGKKqYrL
Mutations K/Q K/R
Epitope Location K5Q K7R
HXB2 Location K28Q K30R
Mutation Type DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note This anchor residue variant was seen in Donor2 and Recipient2, both of whom carried the restricting HLA-B*0801 allele. It was not recognized and binding to HLA was greatly reduced.

References

Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.


Displaying record number 53820

HXB2 Location  Gag(71-79)   Gag Epitope Map
View variants at this location
Epitope GTEELRSLY   Epitope Alignment
Variants
GTEELRSLf   diminished HLA binding or increased off-rate; escape documented in this paper
Species (MHC/HLA human(A*01:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1307
Epitope Seq.  GTEELRSLY
Variant Seq.  GTEELRSLf
Mutations Y/F
Epitope Location Y9F
HXB2 Location Y79F
Mutation Type DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note This Y79F variant was seen in Donor1 and Recipient1, where only the donor carried the restricting HLA-A*0101 allele. It was not recognized and showed loss of binding to HLA.

References

Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.


Displaying record number 53821

HXB2 Location  Gag(71-79)   Gag Epitope Map
View variants at this location
Epitope GSEELRSLY   Epitope Alignment
Variants
GSEEikSLY   diminished HLA binding or increased off-rate; escape documented in this paper
Species (MHC/HLA human(A*01:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1306
Epitope Seq.  GSEELRSLY
Variant Seq.  GSEEikSLY
Mutations L/I R/K
Epitope Location L5I R6K
HXB2 Location L75I R76K
Mutation Type DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note This variant was seen in Donor2 and Recipient2, both of whom carried the restricting HLA-A*0101 allele. It was not recognized and binding to HLA was reduced.

References

Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.


Displaying record number 53822

HXB2 Location  Gag(93-101)   Gag Epitope Map
View variants at this location
Epitope EVKDTKEAL   Epitope Alignment
Variants
dVKgTKEAL   escape documented in this paper
dVKDTKEAL   escape documented in this paper; susceptible form
Species (MHC/HLA human(B*08:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1308
Epitope Seq.  EVKDTKEAL
Variant Seq.  dVKgTKEAL
Mutations E/D D/G
Epitope Location E1D D4G
HXB2 Location E93D D96G
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant was found in Donor2 but not transmitted to Recipient2. The variant was not recognized by CTL. Both donor and recipient carried the restricting HLA-B*0801 allele


Variant ID.  1309
Epitope Seq.  EVKDTKEAL
Variant Seq.  dVKDTKEAL
Mutations E/D
Epitope Location E1D
HXB2 Location E93D
Mutation Type E: escape documented in this paper
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant was found in Donor2 and Recipient2 both of whom were restricting HLA-B*0801 carriers. The variant was not recognized by CTL in Donor2, but was recognized in Recipient2 from whom it was driven out de novo in time.

References

Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.


Displaying record number 53824

HXB2 Location  Rev(55-63)   Rev Epitope Map
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Epitope ISERILSTY   Epitope Alignment
Variants
ISERILSTf   diminished HLA binding or increased off-rate; escape documented in this paper
Species (MHC/HLA human(A*01:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1310
Epitope Seq.  ISERILSTY
Variant Seq.  ISERILSTf
Mutations Y/F
Epitope Location Y9F
HXB2 Location Y63F
Mutation Type DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note This anchor residue variant was seen in Donor2 and Recipient2, both of whom carried the restricting HLA-A*0101 allele. It was not recognized by either subject and binding to HLA was greatly reduced.

References

Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.


Displaying record number 53823

HXB2 Location  gp160(586-593)   gp160 Epitope Map
View variants at this location
Epitope YLKDQQLL   Epitope Alignment
Variants
YLqDQQLL   diminished HLA binding or increased off-rate; escape documented in this paper
Species (MHC/HLA human(B*08:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1311
Epitope Seq.  YLKDQQLL
Variant Seq.  YLqDQQLL
Mutations K/Q
Epitope Location K3Q
HXB2 Location K588Q
Mutation Type DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note This anchor residue variant was seen in Donor2 and Recipient2, both of whom carried the restricting HLA-B*0801 allele. It was not recognized by either subject and binding to HLA was greatly reduced.

References

Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.


Displaying record number 53826

HXB2 Location  Nef(13-20)   Nef Epitope Map
View variants at this location
Epitope WPTVRERM   Epitope Alignment
Variants
WPaVRERM   diminished HLA binding or increased off-rate; escape documented in this paper; susceptible form
WPaVRkRM   diminished HLA binding or increased off-rate; escape documented in this paper; susceptible form
Species (MHC/HLA human(B*08:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1312
Epitope Seq.  WPTVRERM
Variant Seq.  WPaVRERM
Mutations T/A
Epitope Location T3A
HXB2 Location T15A
Mutation Type DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note This variant was found in Donor2 and Recipient2, both of whom carried the restricting HLA-B*0801 allele. The variant was not recognized by CTL in Donor2, but was recognized in Recipient2. This variant also had reduced binding to HLA.


Variant ID.  1313
Epitope Seq.  WPTVRERM
Variant Seq.  WPaVRkRM
Mutations T/A E/K
Epitope Location T3A E6K
HXB2 Location T15A E18K
Mutation Type DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note This variant was found in Donor2 and Recipient2 both of whom carried the restricting HLA-B*0801 allele. The variant was not recognized by CTL in Donor2, but was recognized in Recipient2 from whom it was driven out de novo in time. This variant also had reduced binding to HLA.

References

Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.


Displaying record number 53825

HXB2 Location  Nef(90-97)   Nef Epitope Map
View variants at this location
Epitope FLKEKGGL   Epitope Alignment
Variants
FLKEqGGL   escape documented in this paper
Species (MHC/HLA human(B*08:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1314
Epitope Seq.  FLKEKGGL
Variant Seq.  FLKEqGGL
Mutations K/Q
Epitope Location K5Q
HXB2 Location K94Q
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note This variant was found in Donor2 and Recipient2, both of whom carried the restricting HLA-B*0801 allele. The variant was not recognized by CTL in Donor2, but was recognized in Recipient2 from whom it was driven out de novo in time.

References

Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.


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