Found 2 matching records:
HXB2 Location | Gag(147-155) | Gag Epitope Map
View variants at this location |
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Epitope |
ISPRTLNAW
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Epitope Alignment | ||||
Variants |
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Epitope Name | IW9 | |||||
Species (MHC/HLA) | human(B*57) |
Showing all: 1 variant(s).
Variant ID. | 2552 |
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Epitope Seq. | ISPRTLNAW |
Variant Seq. | lSPRTLNAW |
Mutations | I/L |
Epitope Location | I1L |
HXB2 Location | I147L |
Mutation Type | SF: susceptible form |
Epitope Subtype | A1 |
Variant Subtype | D |
Method | CD8 T-cell Elispot - IFNy |
Note | Previously-documented Clade D ISPRTLNAW escape variant I147L was not selected against among B*57+ clade A1 subjects. These subjects responded similarly to 147I and 147L. |
McKinnon2009 Lyle R. McKinnon, Rupert Capina, Harold Peters, Mark Mendoza, Joshua Kimani, Charles Wachihi, Anthony Kariri, Makobu Kimani, Meika Richmond, Sandy Koesters Kiazyk, Keith R. Fowke, Walter Jaoko, Ma Luo, T Blake Ball, and Francis A. Plummer. Clade-Specific Evolution Mediated by HLA-B*57/5801 in Human Immunodeficiency Virus Type 1 Clade A1 p24. J Virol, 83(23):12636-12642, Dec 2009. PubMed ID: 19759140. Show all entries for this paper.
HXB2 Location | Gag(240-249) | Gag Epitope Map
View variants at this location |
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Epitope |
TSTPQEQIGW
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Epitope Alignment | |||||||||||||
Variants |
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Epitope Name | TW10 | ||||||||||||||
Species (MHC/HLA) | human(B*57) |
Showing all: 4 variant(s).
Variant ID. | 2548 |
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Epitope Seq. | TSTPQEQIGW |
Variant Seq. | TSTPtEQIGW |
Mutations | Q/T |
Epitope Location | Q5T |
HXB2 Location | Q244T |
Mutation Type | NSF: non-susceptible form |
Epitope Subtype | A1 |
Variant Subtype | A1 |
Method | CD8 T-cell Elispot - IFNy |
Note | The majority of A1-infected B*57+ subjects who responded to TW10 did not respond to P243T TSTPtEQIGW or I247L TSTPQEQlGW variants, supporting previous findings that these represent escape mutations in clade A1. |
Variant ID. | 2549 |
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Epitope Seq. | TSTPQEQIGW |
Variant Seq. | TSTPQEQlGW |
Mutations | I/L |
Epitope Location | I8L |
HXB2 Location | I247L |
Mutation Type | NSF: non-susceptible form |
Epitope Subtype | A1 |
Variant Subtype | A1 |
Method | CD8 T-cell Elispot - IFNy |
Note | The majority of A1-infected B*57+ subjects who responded to TW10 did not respond to P243T TSTPtEQIGW or I247L TSTPQEQlGW variants, supporting previous findings that these represent escape mutations in clade A1. |
Variant ID. | 2550 |
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Epitope Seq. | TSTPQEQIGW |
Variant Seq. | TSTlQEQIGW |
Mutations | P/L |
Epitope Location | P4L |
HXB2 Location | P243L |
Mutation Type | DR: diminished response |
Epitope Subtype | A1 |
Variant Subtype | B, D |
Method | CD8 T-cell Elispot - IFNy |
Note | In clade A1-infected patients the recognition of the B/D consensus TSTlQEQIGW was diminished compared to that of clade A1 TSTPQEQIGW. The mutant T242N TSnlQEQIGW was previously documented for clades B and D as escape. However, despite the presumed absence of this variant in these subjects' autologous sequences, the clade B/D escape variant TSnlQEQIGW was recognized at a magnitude similar to that of consensus clade A1 TSTPQEQIGW. |
Variant ID. | 2551 |
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Epitope Seq. | TSTPQEQIGW |
Variant Seq. | TSnlQEQIGW |
Mutations | T/N P/L |
Epitope Location | T3N P4L |
HXB2 Location | T242N P243L |
Mutation Type | SF: susceptible form |
Epitope Subtype | A1 |
Variant Subtype | B, D |
Method | CD8 T-cell Elispot - IFNy |
Note | In clade A1-infected patients the recognition of the B/D consensus TSTlQEQIGW was diminished compared to that of clade A1 TSTPQEQIGW. The mutant T242N TSnlQEQIGW was previously documented for clades B and D as escape. However, despite the presumed absence of this variant in these subjects' autologous sequences, the clade B/D escape variant TSnlQEQIGW was recognized at a magnitude similar to that of consensus clade A1 TSTPQEQIGW. |
McKinnon2009 Lyle R. McKinnon, Rupert Capina, Harold Peters, Mark Mendoza, Joshua Kimani, Charles Wachihi, Anthony Kariri, Makobu Kimani, Meika Richmond, Sandy Koesters Kiazyk, Keith R. Fowke, Walter Jaoko, Ma Luo, T Blake Ball, and Francis A. Plummer. Clade-Specific Evolution Mediated by HLA-B*57/5801 in Human Immunodeficiency Virus Type 1 Clade A1 p24. J Virol, 83(23):12636-12642, Dec 2009. PubMed ID: 19759140. Show all entries for this paper.
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