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Found 3 matching records:

Displaying record number 38

HXB2 Location  Gag(24-31)   Gag Epitope Map
View variants at this location
Epitope GGKKKYKL   Epitope Alignment
Variants
GGKKKYrL   subtype-specific non-susceptible form
GGnKrYrL   subtype-specific non-susceptible form
GGKKKYqL   subtype-specific non-susceptible form
GGKKKYrm   subtype-specific non-susceptible form
GGsKKYKL   subtype-specific non-susceptible form
GGKKtYqL   subtype-specific non-susceptible form
Species (MHC/HLA human(B8)

Variant Details

Showing all: 6 variant(s).


Variant ID.  1104
Epitope Seq.  GGKKKYKL
Variant Seq.  GGKKKYrL
Mutations K/R
Epitope Location K7R
HXB2 Location K30R
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype B
Method Chromium-release assay
Note This circulating Ugandan variant was not recognized by a CTL clone from a patient infected with Clade B virus.


Variant ID.  1105
Epitope Seq.  GGKKKYKL
Variant Seq.  GGnKrYrL
Mutations K/N K/R K/R
Epitope Location K3N K5R K7R
HXB2 Location K26N K28R K30R
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype B
Method Chromium-release assay
Note A peptide containing this circulating Ugandan variant was not recognized by a CTL clone from a Clade B-infected patient.


Variant ID.  1106
Epitope Seq.  GGKKKYKL
Variant Seq.  GGKKKYqL
Mutations K/Q
Epitope Location K7Q
HXB2 Location K30Q
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype B
Method Chromium-release assay
Note A peptide containing this circulating Ugandan variant was not recognized by a CTL clone from a Clade B-infected patient.


Variant ID.  1107
Epitope Seq.  GGKKKYKL
Variant Seq.  GGKKKYrm
Mutations K/R L/M
Epitope Location K7R L8M
HXB2 Location K30R L31M
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype B
Method Chromium-release assay
Note A peptide containing this circulating Ugandan variant was not recognized by a CTL clone from a Clade B-infected patient.


Variant ID.  1108
Epitope Seq.  GGKKKYKL
Variant Seq.  GGsKKYKL
Mutations K/S
Epitope Location K3S
HXB2 Location K26S
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype B
Method Chromium-release assay
Note A peptide containing this circulating Ugandan variant was not recognized by a CTL clone from a Clade B-infected patient.


Variant ID.  1109
Epitope Seq.  GGKKKYKL
Variant Seq.  GGKKtYqL
Mutations K/T K/Q
Epitope Location K5T K7Q
HXB2 Location K28T K30Q
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype B
Method Chromium-release assay
Note A peptide containing this circulating Ugandan variant was not recognized by a CTL clone from a Clade B-infected patient.

References

McAdam1998 S. McAdam, P. Kaleebu, P. Krausa, P. Goulder, N. French, B. Collin, T. Blanchard, J. Whitworth, A. McMichael, and F. Gotch. Cross-Clade Recognition of p55 by Cytotoxic T Lymphocytes in HIV-1 Infection. AIDS, 12:571-579, 1998. PubMed ID: 9583596. Show all entries for this paper.


Displaying record number 74

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLfNaiAvL   subtype-specific non-susceptible form
SLfNTVATL   subtype-specific non-susceptible form
SLYNTiATL   subtype-specific susceptible form
Epitope Name SL9
Species (MHC/HLA human(A*02:01)

Variant Details

Showing all: 3 variant(s).


Variant ID.  1111
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNaiAvL
Mutations Y/F T/A V/I T/V
Epitope Location Y3F T5A V6I T8V
HXB2 Location Y79F T81A V82I T84V
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype B
Variant Subtype A
Method Chromium-release assay
Note Recombinant vaccinia virus containing this Clade A circulating Ugandan variant was not recognized by a CTL clone from a Clade B-infected patient.


Variant ID.  1112
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVATL
Mutations Y/F
Epitope Location Y3F
HXB2 Location Y79F
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype B
Variant Subtype A
Method Chromium-release assay
Note Recombinant vaccinia virus containing this Clade A circulating Ugandan variant was not recognized by a CTL clone from a Clade B-infected patient.


Variant ID.  1113
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTiATL
Mutations V/I
Epitope Location V6I
HXB2 Location V82I
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype D
Method Chromium-release assay
Note Recombinant vaccinia virus containing this Clade D circulating Ugandan variant was well recognized by a CTL clone from a Clade B-infected patient. A natural variant with the same substitution was found in the same Clade B carrying patient.

References

McAdam1998 S. McAdam, P. Kaleebu, P. Krausa, P. Goulder, N. French, B. Collin, T. Blanchard, J. Whitworth, A. McMichael, and F. Gotch. Cross-Clade Recognition of p55 by Cytotoxic T Lymphocytes in HIV-1 Infection. AIDS, 12:571-579, 1998. PubMed ID: 9583596. Show all entries for this paper.


Displaying record number 254

HXB2 Location  Gag(259-267)   Gag Epitope Map
View variants at this location
Epitope GDIYKRWII   Epitope Alignment
Variants
GeIYKRWII   subtype-specific susceptible form
Species (MHC/HLA human(B*08:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1110
Epitope Seq.  GDIYKRWII
Variant Seq.  GeIYKRWII
Mutations D/E
Epitope Location D2E
HXB2 Location D260E
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Method Chromium-release assay
Note A peptide containing this circulating Ugandan variant was recognized as well by a CTL clone from a Clade B-infected patient.

References

McAdam1998 S. McAdam, P. Kaleebu, P. Krausa, P. Goulder, N. French, B. Collin, T. Blanchard, J. Whitworth, A. McMichael, and F. Gotch. Cross-Clade Recognition of p55 by Cytotoxic T Lymphocytes in HIV-1 Infection. AIDS, 12:571-579, 1998. PubMed ID: 9583596. Show all entries for this paper.


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