Found 7 matching records:
HXB2 Location | Nef(77-85) | Nef Epitope Map
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Epitope |
RPMTYKGAL
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Epitope Alignment | ||||
Variants |
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Epitope Name | RL9 | |||||
Species (MHC/HLA) | human(B7 supertype) |
Showing all: 1 variant(s).
Variant ID. | 1029 |
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Epitope Seq. | RPMTYKGAL |
Variant Seq. | RPMTYraAr |
Mutations | K/R G/A L/R |
Epitope Location | K6R G7A L9R |
HXB2 Location | K82R G83A L85R |
Mutation Type | SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This variant was found by challenge of 23 subjects with a novel Nef potential T-cell epitope panel in Subtype B. |
Malhotra2007a Uma Malhotra, Fusheng Li, Jessica Nolin, Megan Allison, Hong Zhao, James I. Mullins, Steve Self, and M. Juliana McElrath. Enhanced Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Nef-Specific T Cells Recognizing Multiple Variants in Early HIV-1 Infection. J. Virol., 81(10):5225-5237, May 2007. PubMed ID: 17329342. Show all entries for this paper.
HXB2 Location | Nef(83-91) | Nef Epitope Map
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Epitope |
AAVDLSHFL
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Epitope Alignment | ||||||||||||||||
Variants |
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Epitope Name | AL9 | |||||||||||||||||
Species (MHC/HLA) | human(B62, Cw8) |
Showing all: 5 variant(s).
Variant ID. | 1030 |
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Epitope Seq. | AAVDLSHFL |
Variant Seq. | gAVDLSHFL |
Mutations | A/G |
Epitope Location | A1G |
HXB2 Location | A83G |
Mutation Type | SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This variant was found by challenge of 23 subjects with a novel Nef potential T-cell epitope panel in Subtype B. It was recognized by an HLA-B62- (Subject 1212) and an HLA-Cw08-restricted (Subject 1238) response. |
Variant ID. | 1031 |
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Epitope Seq. | AAVDLSHFL |
Variant Seq. | AAiDLSHFL |
Mutations | V/I |
Epitope Location | V3I |
HXB2 Location | V85I |
Mutation Type | SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This variant was found by challenge of 23 subjects with a novel Nef potential T-cell epitope panel in Subtype B. It was recognized by an HLA-B62- (Subject 1212) and an HLA-Cw08-restricted (Subject 1238) response. |
Variant ID. | 1032 |
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Epitope Seq. | AAVDLSHFL |
Variant Seq. | AAlDLSHFL |
Mutations | V/L |
Epitope Location | V3L |
HXB2 Location | V85L |
Mutation Type | DR: diminished response SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This variant was found by challenge of 23 subjects with a novel Nef potential T-cell epitope panel in Subtype B. It was recognized by an HLA-B62- (Subject 1212) response. HLA-Cw08-restricted CTL response (Subject 1238) was detected, but at 114-fold lower avidity. |
Variant ID. | 1033 |
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Epitope Seq. | AAVDLSHFL |
Variant Seq. | gAlDLSHFL |
Mutations | A/G V/L |
Epitope Location | A1G V3L |
HXB2 Location | A83G V85L |
Mutation Type | DR: diminished response |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This variant was found by challenge of 23 subjects with a novel Nef potential T-cell epitope panel in Subtype B. HLA-B62-restricted CTL response (Subject 1212) was detected but at 92-fold lower avidity. HLA-Cw08-restricted CTL response (Subject 1238) was detected by at 25-fold lower avidity. |
Variant ID. | 1034 |
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Epitope Seq. | AAVDLSHFL |
Variant Seq. | gAfDLSHFL |
Mutations | A/G V/F |
Epitope Location | A1G V3F |
HXB2 Location | A83G V85F |
Mutation Type | DR: diminished response NSF: non-susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This variant was found by challenge of 23 subjects with a novel Nef potential T-cell epitope panel in Subtype B. HLA-B62-restricted CTL response (Subject 1212) was detected but at 166-fold lower avidity. HLA-Cw08-restricted CTL response (Subject 1238) was not detected. |
Malhotra2007a Uma Malhotra, Fusheng Li, Jessica Nolin, Megan Allison, Hong Zhao, James I. Mullins, Steve Self, and M. Juliana McElrath. Enhanced Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Nef-Specific T Cells Recognizing Multiple Variants in Early HIV-1 Infection. J. Virol., 81(10):5225-5237, May 2007. PubMed ID: 17329342. Show all entries for this paper.
HXB2 Location | Nef(83-92) | Nef Epitope Map
View variants at this location |
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Epitope |
AAVDLSHFLK
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Epitope Alignment | ||||
Variants |
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Epitope Name | AK10 | |||||
Species (MHC/HLA) | human(A11) |
Showing all: 1 variant(s).
Variant ID. | 1035 |
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Epitope Seq. | AAVDLSHFLK |
Variant Seq. | vAlDLSHFLK |
Mutations | A/V V/L |
Epitope Location | A1V V3L |
HXB2 Location | A83V V85L |
Mutation Type | SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This variant was found by challenge of 23 subjects with a novel Nef potential T-cell epitope panel in Subtype B. |
Malhotra2007a Uma Malhotra, Fusheng Li, Jessica Nolin, Megan Allison, Hong Zhao, James I. Mullins, Steve Self, and M. Juliana McElrath. Enhanced Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Nef-Specific T Cells Recognizing Multiple Variants in Early HIV-1 Infection. J. Virol., 81(10):5225-5237, May 2007. PubMed ID: 17329342. Show all entries for this paper.
HXB2 Location | Nef(105-115) | Nef Epitope Map
View variants at this location |
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Epitope |
KRQDILDLWVY
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Epitope Alignment | |||||||||||||
Variants |
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Epitope Name | KY11 | ||||||||||||||
Species (MHC/HLA) | human(Cw7) |
Showing all: 4 variant(s).
Variant ID. | 1036 |
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Epitope Seq. | KRQDILDLWVY |
Variant Seq. | rRQDILDLWVY |
Mutations | K/R |
Epitope Location | K1R |
HXB2 Location | K105R |
Mutation Type | SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This variant was found by challenge of 23 subjects with a novel Nef potential T-cell epitope panel in Subtype B. |
Variant ID. | 1037 |
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Epitope Seq. | KRQDILDLWVY |
Variant Seq. | KRQeILDLWVY |
Mutations | D/E |
Epitope Location | D4E |
HXB2 Location | D108E |
Mutation Type | SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This variant was found by challenge of 23 subjects with a novel Nef potential T-cell epitope panel in Subtype B. |
Variant ID. | 1038 |
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Epitope Seq. | KRQDILDLWVY |
Variant Seq. | rRQeILDLWVY |
Mutations | K/R D/E |
Epitope Location | K1R D4E |
HXB2 Location | K105R D108E |
Mutation Type | SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This variant was found by challenge of 23 subjects with a novel Nef potential T-cell epitope panel in Subtype B. |
Variant ID. | 1039 |
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Epitope Seq. | KRQDILDLWVY |
Variant Seq. | KRQDILDLWiY |
Mutations | V/I |
Epitope Location | V10I |
HXB2 Location | V114I |
Mutation Type | SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This variant was found by challenge of 23 subjects with a novel Nef potential T-cell epitope panel in Subtype B. It was found as an autologous sequence in HLA-Cw07-restricted Subject 1188. |
Malhotra2007a Uma Malhotra, Fusheng Li, Jessica Nolin, Megan Allison, Hong Zhao, James I. Mullins, Steve Self, and M. Juliana McElrath. Enhanced Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Nef-Specific T Cells Recognizing Multiple Variants in Early HIV-1 Infection. J. Virol., 81(10):5225-5237, May 2007. PubMed ID: 17329342. Show all entries for this paper.
HXB2 Location | Nef(128-137) | Nef Epitope Map
View variants at this location |
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Epitope |
TPGPGTRYPL
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Epitope Alignment | ||||
Variants |
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Epitope Name | TL10 | |||||
Species (MHC/HLA) | human(B35) |
Showing all: 1 variant(s).
Variant ID. | 1040 |
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Epitope Seq. | TPGPGTRYPL |
Variant Seq. | TPGPGvRYPL |
Mutations | T/V |
Epitope Location | T6V |
HXB2 Location | T133V |
Mutation Type | SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This variant was found by challenge of 23 subjects with a novel Nef potential T-cell epitope panel in Subtype B. |
Malhotra2007a Uma Malhotra, Fusheng Li, Jessica Nolin, Megan Allison, Hong Zhao, James I. Mullins, Steve Self, and M. Juliana McElrath. Enhanced Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Nef-Specific T Cells Recognizing Multiple Variants in Early HIV-1 Infection. J. Virol., 81(10):5225-5237, May 2007. PubMed ID: 17329342. Show all entries for this paper.
HXB2 Location | Nef(135-143) | Nef Epitope Map
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Epitope |
YPLTFGWCF
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Epitope Alignment | ||||||||||||||||
Variants |
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Epitope Name | YF9 | |||||||||||||||||
Species (MHC/HLA) | human(B18, B35) |
Showing all: 5 variant(s).
Variant ID. | 1041 |
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Epitope Seq. | YPLTFGWCF |
Variant Seq. | fPLTFGWCF |
Mutations | Y/F |
Epitope Location | Y1F |
HXB2 Location | Y135F |
Mutation Type | SF: susceptible form SSF: subtype-specific susceptible form |
Epitope Subtype | A, B, C |
Variant Subtype | A, B, C |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This variant was found by challenge of 23 subjects with a novel Nef potential T-cell epitope panel in Subtype B. It was the only HLA-B35-restricted autologous variant sequence found. fPLTFGWCF was recognized by CTL restricted by either HLA-B35 or -B18. |
Variant ID. | 1042 |
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Epitope Seq. | YPLTFGWCF |
Variant Seq. | YPLcFGWCF |
Mutations | T/C |
Epitope Location | T4C |
HXB2 Location | T138C |
Mutation Type | SF: susceptible form SSF: subtype-specific susceptible form |
Epitope Subtype | A, B, C |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This variant was found by challenge of 23 subjects with a novel Nef potential T-cell epitope panel in Subtype B. It was not found as an autologous sequence but was recognized by HLA-B35-restricted CTL. |
Variant ID. | 1043 |
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Epitope Seq. | YPLTFGWCF |
Variant Seq. | fPLcFGWCF |
Mutations | Y/F T/C |
Epitope Location | Y1F T4C |
HXB2 Location | Y135F T138C |
Mutation Type | SF: susceptible form SSF: subtype-specific susceptible form |
Epitope Subtype | A, B, C |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This variant was found by challenge of 23 subjects with a novel Nef potential T-cell epitope panel in Subtype B. It was not found as an autologous sequence but was recognized by HLA-B35-restricted CTL. |
Variant ID. | 1044 |
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Epitope Seq. | YPLTFGWCF |
Variant Seq. | YPLTFGWCy |
Mutations | F/Y |
Epitope Location | F9Y |
HXB2 Location | F143Y |
Mutation Type | SF: susceptible form SSF: subtype-specific susceptible form |
Epitope Subtype | A, B, C |
Variant Subtype | A, C |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This variant was found by challenge of 23 subjects with a novel Nef potential T-cell epitope panel in Subtype B. It was not found as an autologous sequence but was recognized by HLA-B35- or HLA-B18-restricted CTL. |
Variant ID. | 1045 |
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Epitope Seq. | YPLTFGWCF |
Variant Seq. | YPLTlGWCF |
Mutations | F/L |
Epitope Location | F5L |
HXB2 Location | F139L |
Mutation Type | NSF: non-susceptible form SF: susceptible form SNSF: subtype-specific non-susceptible form |
Epitope Subtype | A, B, C |
Variant Subtype | F |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This variant was found by challenge of 23 subjects with a novel Nef potential T-cell epitope panel in Subtype B. It was not found as an autologous sequence and was not recognized by HLA-B35- or HLA-B18- (Subject 1362) restricted CTL. |
Malhotra2007a Uma Malhotra, Fusheng Li, Jessica Nolin, Megan Allison, Hong Zhao, James I. Mullins, Steve Self, and M. Juliana McElrath. Enhanced Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Nef-Specific T Cells Recognizing Multiple Variants in Early HIV-1 Infection. J. Virol., 81(10):5225-5237, May 2007. PubMed ID: 17329342. Show all entries for this paper.
HXB2 Location | Nef(183-191) | Nef Epitope Map
View variants at this location |
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Epitope |
WKFDSRLAF
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Epitope Alignment | |||||||||||||||||||
Variants |
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Epitope Name | WF9 | ||||||||||||||||||||
Species (MHC/HLA) | human(B*15:03) |
Showing all: 6 variant(s).
Variant ID. | 1046 |
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Epitope Seq. | WKFDSRLAF |
Variant Seq. | WKFDSRLAl |
Mutations | F/L |
Epitope Location | F9L |
HXB2 Location | F191L |
Mutation Type | SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This variant was found by challenge of 23 subjects with a novel Nef potential T-cell epitope panel in Subtype B. It was recognized by HLA-B1503-restricted CTL (Subject 1188). |
Variant ID. | 1047 |
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Epitope Seq. | WKFDSRLAF |
Variant Seq. | WrFDSRLAF |
Mutations | K/R |
Epitope Location | K2R |
HXB2 Location | K184R |
Mutation Type | SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This variant was found by challenge of 23 subjects with a novel Nef potential T-cell epitope panel in Subtype B. It was recognized by HLA-B1503-restricted CTL (Subject 1188). |
Variant ID. | 1048 |
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Epitope Seq. | WKFDSRLAF |
Variant Seq. | WKrDShLAF |
Mutations | F/R R/H |
Epitope Location | F3R R6H |
HXB2 Location | F185R R188H |
Mutation Type | SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This variant was found by challenge of 23 subjects with a novel Nef potential T-cell epitope panel in Subtype B. It was recognized by HLA-B1503-restricted CTL (Subject 1188). |
Variant ID. | 1049 |
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Epitope Seq. | WKFDSRLAF |
Variant Seq. | WKFDSsLAF |
Mutations | R/S |
Epitope Location | R6S |
HXB2 Location | R188S |
Mutation Type | DR: diminished response |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This variant was found by challenge of 23 subjects with a novel Nef potential T-cell epitope panel in Subtype B. It was recognized by HLA-B1503-restricted CTL (Subject 1188), though at a 5-fold reduction. |
Variant ID. | 1050 |
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Epitope Seq. | WKFDSRLAF |
Variant Seq. | WKFDShLAF |
Mutations | R/H |
Epitope Location | R6H |
HXB2 Location | R188H |
Mutation Type | DR: diminished response |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This variant was found by challenge of 23 subjects with a novel Nef potential T-cell epitope panel in Subtype B. It was recognized by HLA-B1503-restricted CTL (Subject 1188), though at a 10-fold reduction. |
Variant ID. | 1051 |
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Epitope Seq. | WKFDSRLAF |
Variant Seq. | WKFaSRLAF |
Mutations | D/A |
Epitope Location | D4A |
HXB2 Location | D186A |
Mutation Type | OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | Sequence |
Note | This variant was the only WF9 autologous variant found in 1/12 clones from HLA-B1503-restricted Subject 1188. It was not tested. |
Malhotra2007a Uma Malhotra, Fusheng Li, Jessica Nolin, Megan Allison, Hong Zhao, James I. Mullins, Steve Self, and M. Juliana McElrath. Enhanced Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Nef-Specific T Cells Recognizing Multiple Variants in Early HIV-1 Infection. J. Virol., 81(10):5225-5237, May 2007. PubMed ID: 17329342. Show all entries for this paper.
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