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Found 20 matching records:

Displaying record number 54627

HXB2 Location Gag(24-31) Gag Epitope Map
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Epitope

GGKKKYKL

Epitope Alignment

Variants

GGKKKYKf escape documented in this paper

Epitope Name GL8

Species (MHC/HLA) human(B8)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`954`
Epitope Seq.	`GGKKKYKL`
Variant Seq.	`GGKKKYKf`
Mutations	L/F
Epitope Location	L8F
HXB2 Location	L31F
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy
Note	Presumed escape variant was transmitted from a B8 positive donor to a B8 negative recipient. The variant was not recognized by CTLs.

References

Liu2006 Yi Liu, John McNevin, Jianhong Cao, Hong Zhao, Indira Genowati, Kim Wong, Sherry McLaughlin, Matthew D. McSweyn, Kurt Diem, Claire E. Stevens, Janine Maenza, Hongxia He, David C. Nickle, Daniel Shriner, Sarah E. Holte, Ann C. Collier, Lawrence Corey, M. Juliana McElrath, and James I. Mullins. Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection. J. Virol., 80(19):9519-9529, Oct 2006. PubMed ID: 16973556. Show all entries for this paper.

Displaying record number 54145

HXB2 Location Gag(145-155) Gag Epitope Map
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Epitope

QAISPRTLNAW

Epitope Alignment

Variants

QAlSPRTLNAW diminished response

Epitope Name QW11

Species (MHC/HLA) human(A*25:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`955`
Epitope Seq.	`QAISPRTLNAW`
Variant Seq.	`QAlSPRTLNAW`
Mutations	I/L
Epitope Location	I3L
HXB2 Location	I147L
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy
Note	Amino acid site in the third position potentially experienced positive selection. Wt form of the epitope was 2.4 times better recognized than the variant.

References

Displaying record number 54147

HXB2 Location Gag(203-212) Gag Epitope Map
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Epitope

ETINEEAAEW

Epitope Alignment

Variants

ETINdEAAEW diminished response

Epitope Name EW10

Species (MHC/HLA) human(A*25:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`956`
Epitope Seq.	`ETINEEAAEW`
Variant Seq.	`ETINdEAAEW`
Mutations	E/D
Epitope Location	E5D
HXB2 Location	E207D
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy
Note	Amino acid site in the 5th position potentially experienced positive selection. Wt form of the epitope was 27 times better recognized than the variant, making the variant a partial escape.

References

Displaying record number 54149

HXB2 Location Pol(24-31) Pol Epitope Map
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Epitope

NSPTRREL

Epitope Alignment

Variants

tSPTRREL escape documented in this paper

Epitope Name NL8

Species (MHC/HLA) human(C*01:02)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`957`
Epitope Seq.	`NSPTRREL`
Variant Seq.	`tSPTRREL`
Mutations	N/T
Epitope Location	N1T
HXB2 Location	N24T
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy
Note	Position 4 in the epitope had potentially experienced positive selection. The variant was full escape, as it was not recognized by CTLs.

References

Displaying record number 54151

HXB2 Location Pol(283-290) Pol Epitope Map
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Epitope

TAFTIPSI

Epitope Alignment

Variants

`TAFTIPSt`		diminished response
`TAFTIPSr`		diminished response
`TAFTIPSv`		diminished response

Epitope Name TI8

Species (MHC/HLA) human(B*51:01)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`958`
Epitope Seq.	`TAFTIPSI`
Variant Seq.	`TAFTIPSt`
Mutations	I/T
Epitope Location	I8T
HXB2 Location	I290T
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy
Note	Last position (8) of the epitope had potentially experienced positive selection. Wt form of the epitope was >100 times better recognized than the variant, making the variant a partial escape.

Variant ID.	`959`
Epitope Seq.	`TAFTIPSI`
Variant Seq.	`TAFTIPSr`
Mutations	I/R
Epitope Location	I8R
HXB2 Location	I290R
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy
Note	Last position (8) of the epitope had potentially experienced positive selection. Wt form of the epitope was >100 times better recognized than the variant, making the variant a partial escape.

Variant ID.	`960`
Epitope Seq.	`TAFTIPSI`
Variant Seq.	`TAFTIPSv`
Mutations	I/V
Epitope Location	I8V
HXB2 Location	I290V
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy
Note	Last position (8) of the epitope had potentially experienced positive selection. Wt form of the epitope was >100 times better recognized than the variant, making the variant a partial escape.

References

Displaying record number 54152

HXB2 Location Pol(291-299) Pol Epitope Map
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Epitope

NNETPGVRY

Epitope Alignment

Variants

`NNETPGiRY`		susceptible form
`NsETPGVRY`		susceptible form
`NNEiPGVRY`		susceptible form
`NNEiPGiRY`		susceptible form
`NNgTPGVRY`		diminished response
`NNEvPGiRY`		susceptible form

Epitope Name NY9

Species (MHC/HLA) human(B*18:01)

Variant Details

Showing all: 6 variant(s).

Variant ID.	`961`
Epitope Seq.	`NNETPGVRY`
Variant Seq.	`NNETPGiRY`
Mutations	V/I
Epitope Location	V7I
HXB2 Location	V297I
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy
Note	The variant was recognized by CTLs to a similar extent as the wt form of the epitope.

Variant ID.	`962`
Epitope Seq.	`NNETPGVRY`
Variant Seq.	`NsETPGVRY`
Mutations	N/S
Epitope Location	N2S
HXB2 Location	N292S
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy
Note	The variant was recognized by CTLs to a similar extent as the wt form of the epitope.

Variant ID.	`963`
Epitope Seq.	`NNETPGVRY`
Variant Seq.	`NNEiPGVRY`
Mutations	T/I
Epitope Location	T4I
HXB2 Location	T294I
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy
Note	The variant was recognized by CTLs to a similar extent as the wt form of the epitope.

Variant ID.	`964`
Epitope Seq.	`NNETPGVRY`
Variant Seq.	`NNEiPGiRY`
Mutations	T/I V/I
Epitope Location	T4I V7I
HXB2 Location	T294I V297I
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy
Note	The variant was recognized by CTLs to a similar extent as the wt form of the epitope.

Variant ID.	`965`
Epitope Seq.	`NNETPGVRY`
Variant Seq.	`NNgTPGVRY`
Mutations	E/G
Epitope Location	E3G
HXB2 Location	E293G
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy
Note	Wt form of the epitope was 22 times better recognized than the variant, making the variant a partial escape.

Variant ID.	`966`
Epitope Seq.	`NNETPGVRY`
Variant Seq.	`NNEvPGiRY`
Mutations	T/V V/I
Epitope Location	T4V V7I
HXB2 Location	T294V V297I
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy
Note	The variant was recognized by CTLs to a similar extent as the wt form of the epitope.

References

Displaying record number 54153

HXB2 Location Pol(359-367) Pol Epitope Map
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Epitope

ELRQHLLRW

Epitope Alignment

Variants

ELRQHLLkW escape documented in this paper

Epitope Name EW9

Species (MHC/HLA) human(A*25:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`967`
Epitope Seq.	`ELRQHLLRW`
Variant Seq.	`ELRQHLLkW`
Mutations	R/K
Epitope Location	R8K
HXB2 Location	R366K
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy
Note	This is a newly defined epitope. Position 8 in the epitope had potentially experienced positive selection. The variant was full escape, as it was not recognized by CTLs.

References

Displaying record number 54155

HXB2 Location Vpr(29-37) Vpr Epitope Map
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Epitope

EAVRHFPRI

Epitope Alignment

Variants

`EAVRHFPRt`		diminished response
`EAVRHFPRl`		diminished response

Epitope Name EI9

Species (MHC/HLA) human(B*51:01)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`968`
Epitope Seq.	`EAVRHFPRI`
Variant Seq.	`EAVRHFPRt`
Mutations	I/T
Epitope Location	I9T
HXB2 Location	I37T
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy
Note	Last position (9)in the epitope had potentially experienced positive selection. Wt form of the epitope was 43 times better recognized than the variant, making the variant a partial escape.

Variant ID.	`969`
Epitope Seq.	`EAVRHFPRI`
Variant Seq.	`EAVRHFPRl`
Mutations	I/L
Epitope Location	I9L
HXB2 Location	I37L
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy
Note	Last position (9)in the epitope had potentially experienced positive selection. Wt form of the epitope was 18 times better recognized than the variant, making the variant a partial escape.

References

Displaying record number 54158

HXB2 Location Tat(3-11) Tat Epitope Map
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Epitope

PVDPRLEPW

Epitope Alignment

Variants

`PVDPRLdPW`		escape documented in this paper
`PVDPsLEPW`		escape documented in this paper
`PVDPkLEPW`		escape documented in this paper

Epitope Name PW9

Species (MHC/HLA) human(A*25:01)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`970`
Epitope Seq.	`PVDPRLEPW`
Variant Seq.	`PVDPRLdPW`
Mutations	E/D
Epitope Location	E7D
HXB2 Location	E9D
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy
Note	Positions 5 and 7 in the epitope had potentially experienced positive selection. The variant was full escape, as it was not recognized by CTLs.

Variant ID.	`971`
Epitope Seq.	`PVDPRLEPW`
Variant Seq.	`PVDPsLEPW`
Mutations	R/S
Epitope Location	R5S
HXB2 Location	R7S
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy
Note	Positions 5 and 7 in the epitope had potentially experienced positive selection. The variant was full escape, as it was not recognized by CTLs.

Variant ID.	`972`
Epitope Seq.	`PVDPRLEPW`
Variant Seq.	`PVDPkLEPW`
Mutations	R/K
Epitope Location	R5K
HXB2 Location	R7K
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy
Note	Positions 5 and 7 in the epitope had potentially experienced positive selection. The variant was full escape, as it was not recognized by CTLs.

References

Displaying record number 54159

HXB2 Location Tat(30-37) Tat Epitope Map
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Epitope

CCFHCQVC

Epitope Alignment

Variants

`CClHCQVC`		escape documented in this paper
`CCFHCQsC`		escape documented in this paper

Epitope Name CC8

Species (MHC/HLA) human(C*12:03)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`973`
Epitope Seq.	`CCFHCQVC`
Variant Seq.	`CClHCQVC`
Mutations	F/L
Epitope Location	F3L
HXB2 Location	F32L
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy
Note	Position 3 in the epitope had potentially experienced positive selection. The variant was full escape, as it was not recognized by CTLs.

Variant ID.	`974`
Epitope Seq.	`CCFHCQVC`
Variant Seq.	`CCFHCQsC`
Mutations	V/S
Epitope Location	V7S
HXB2 Location	V36S
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy
Note	Position 3 in the epitope had potentially experienced positive selection. The variant was full escape, as it was not recognized by CTLs.

References

Displaying record number 54157

HXB2 Location Vpu(74-82) Vpu Epitope Map
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Epitope

HAPWDVNDL

Epitope Alignment

Variants

HAPWDVNDm susceptible form

Epitope Name HL9

Species (MHC/HLA) human(C*01:02)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`975`
Epitope Seq.	`HAPWDVNDL`
Variant Seq.	`HAPWDVNDm`
Mutations	L/M
Epitope Location	L9M
HXB2 Location	L82M
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy
Note	Last position (9) in the epitope had potentially experienced positive selection. The variant was recognized by CTLs to at a better extent than the wt form of the epitope.

References

Displaying record number 54160

HXB2 Location gp160(31-39) gp160 Epitope Map
View variants at this location

Epitope

AENLWVTVY

Epitope Alignment

Variants

`AdNLWVTVY`		susceptible form
`tdNLWVTVY`		susceptible form
`tEdLWVTVY`		escape documented in this paper
`eEdLWVTVY`		escape documented in this paper
`AEdsWVTVY`		escape documented in this paper

Epitope Name AY9

Species (MHC/HLA) human(B*18:01)

Variant Details

Showing all: 5 variant(s).

Variant ID.	`976`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`AdNLWVTVY`
Mutations	E/D
Epitope Location	E2D
HXB2 Location	E32D
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy
Note	Position 1 in the epitope had potentially experienced positive selection. The variant was recognized by CTLs to a similar extent as the wt form of the epitope.

Variant ID.	`977`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`tdNLWVTVY`
Mutations	A/T E/D
Epitope Location	A1T E2D
HXB2 Location	A31T E32D
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy
Note	Position 1 in the epitope had potentially experienced positive selection. The variant was recognized by CTLs to a similar extent as the wt form of the epitope.

Variant ID.	`978`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`tEdLWVTVY`
Mutations	A/T N/D
Epitope Location	A1T N3D
HXB2 Location	A31T N33D
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy
Note	Position 1 in the epitope had potentially experienced positive selection. The variant was full escape, as it was not recognized by CTLs.

Variant ID.	`979`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`eEdLWVTVY`
Mutations	A/E N/D
Epitope Location	A1E N3D
HXB2 Location	A31E N33D
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy
Note	Position 1 in the epitope had potentially experienced positive selection. The variant was full escape, as it was not recognized by CTLs.

Variant ID.	`980`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`AEdsWVTVY`
Mutations	N/D L/S
Epitope Location	N3D L4S
HXB2 Location	N33D L34S
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy
Note	Position 1 in the epitope had potentially experienced positive selection. The variant was full escape, as it was not recognized by CTLs.

References

Displaying record number 54161

HXB2 Location gp160(61-69) gp160 Epitope Map
View variants at this location

Epitope

YETEVHNVW

Epitope Alignment

Variants

`YgTEVHNVW`		diminished response
`YdTEVHNVW`		diminished response
`YETEaHNVW`		susceptible form
`YdTEaHNVW`		diminished response

Epitope Name YW9

Species (MHC/HLA) human(B*18:01)

Variant Details

Showing all: 4 variant(s).

Variant ID.	`981`
Epitope Seq.	`YETEVHNVW`
Variant Seq.	`YgTEVHNVW`
Mutations	E/G
Epitope Location	E2G
HXB2 Location	E62G
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy
Note	Positions 2 and 5 in the epitope had potentially experienced positive selection. Wt form of the epitope was 22 times better recognized than the variant, making the variant a partial escape.

Variant ID.	`982`
Epitope Seq.	`YETEVHNVW`
Variant Seq.	`YdTEVHNVW`
Mutations	E/D
Epitope Location	E2D
HXB2 Location	E62D
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy
Note	Positions 2 and 5 in the epitope had potentially experienced positive selection. Wt form of the epitope was 13 times better recognized than the variant, making the variant a partial escape.

Variant ID.	`983`
Epitope Seq.	`YETEVHNVW`
Variant Seq.	`YETEaHNVW`
Mutations	V/A
Epitope Location	V5A
HXB2 Location	V65A
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy
Note	Positions 2 and 5 in the epitope had potentially experienced positive selection. The variant was recognized by CTLs to a similar extent as the wt form of the epitope.

Variant ID.	`984`
Epitope Seq.	`YETEVHNVW`
Variant Seq.	`YdTEaHNVW`
Mutations	E/D V/A
Epitope Location	E2D V5A
HXB2 Location	E62D V65A
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy
Note	Positions 2 and 5 in the epitope had potentially experienced positive selection. Wt form of the epitope was >83 times better recognized than the variant, making the variant a partial escape.

References

Displaying record number 54162

HXB2 Location gp160(88-96) gp160 Epitope Map
View variants at this location

Epitope

NVTENFNMW

Epitope Alignment

Variants

`NVTEdFdMW`		escape documented in this paper
`NVTEeFdMW`		escape documented in this paper
`NVTEsFdMW`		escape documented in this paper

Epitope Name NW9

Species (MHC/HLA) human(A*25:01)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`985`
Epitope Seq.	`NVTENFNMW`
Variant Seq.	`NVTEdFdMW`
Mutations	N/D N/D
Epitope Location	N5D N7D
HXB2 Location	N92D N94D
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy
Note	Positions 5 and 7 in the epitope had potentially experienced positive selection. The variant was full escape, as it was not recognized by CTLs.

Variant ID.	`986`
Epitope Seq.	`NVTENFNMW`
Variant Seq.	`NVTEeFdMW`
Mutations	N/E N/D
Epitope Location	N5E N7D
HXB2 Location	N92E N94D
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy
Note	Positions 5 and 7 in the epitope had potentially experienced positive selection. The variant was full escape, as it was not recognized by CTLs.

Variant ID.	`987`
Epitope Seq.	`NVTENFNMW`
Variant Seq.	`NVTEsFdMW`
Mutations	N/S N/D
Epitope Location	N5S N7D
HXB2 Location	N92S N94D
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy
Note	Positions 5 and 7 in the epitope had potentially experienced positive selection. The variant was full escape, as it was not recognized by CTLs.

References

Displaying record number 54163

HXB2 Location gp160(217-226) gp160 Epitope Map
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Epitope

YCAPAGFAIL

Epitope Alignment

Variants

YCAPAGFAIi escape documented in this paper

Epitope Name YL10

Species (MHC/HLA) human(C*01:02)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`988`
Epitope Seq.	`YCAPAGFAIL`
Variant Seq.	`YCAPAGFAIi`
Mutations	L/I
Epitope Location	L10I
HXB2 Location	L226I
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy
Note	Last position (10)in the epitope had potentially experienced positive selection. The variant was full escape, as it was not recognized by CTLs.

References

Displaying record number 54164

HXB2 Location gp160(321-330) gp160 Epitope Map
View variants at this location

Epitope

EIIGDIRQAY

Epitope Alignment

Variants

`qIIGDIRQAY`		diminished response
`dIIGDIRQAh`		diminished response
`EIIGnIRQAh`		diminished response
`EIIGDIRQAh`		escape documented in this paper

Epitope Name EY10

Species (MHC/HLA) human(A*25:01)

Variant Details

Showing all: 4 variant(s).

Variant ID.	`989`
Epitope Seq.	`EIIGDIRQAY`
Variant Seq.	`qIIGDIRQAY`
Mutations	E/Q
Epitope Location	E1Q
HXB2 Location	E321Q
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy
Note	Positions 1, 5 and 10 (last)in the epitope had potentially experienced positive selection. Wt form of the epitope was >200 times better recognized than the variant, making the variant a partial escape.

Variant ID.	`990`
Epitope Seq.	`EIIGDIRQAY`
Variant Seq.	`dIIGDIRQAh`
Mutations	E/D Y/H
Epitope Location	E1D Y10H
HXB2 Location	E321D Y330H
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy
Note	Positions 1, 5 and 10 (last)in the epitope had potentially experienced positive selection. Wt form of the epitope was 34 times better recognized than the variant, making the variant a partial escape.

Variant ID.	`991`
Epitope Seq.	`EIIGDIRQAY`
Variant Seq.	`EIIGnIRQAh`
Mutations	Y/H D/N
Epitope Location	Y10H D5N
HXB2 Location	Y330H D325N
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy
Note	Positions 1, 5 and 10 (last)in the epitope had potentially experienced positive selection. Wt form of the epitope was 15.9 times better recognized than the variant, making the variant a partial escape.

Variant ID.	`992`
Epitope Seq.	`EIIGDIRQAY`
Variant Seq.	`EIIGDIRQAh`
Mutations	Y/H
Epitope Location	Y10H
HXB2 Location	Y330H
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy
Note	Positions 1, 5 and 10 (last)in the epitope had potentially experienced positive selection. The variant was full escape, as it was not recognized by CTLs.

References

Displaying record number 54165

HXB2 Location gp160(341-349) gp160 Epitope Map
View variants at this location

Epitope

TLSQIVTKL

Epitope Alignment

Variants

TLSkIVTKL escape documented in this paper

Epitope Name TL9

Species (MHC/HLA) human(A*02:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`993`
Epitope Seq.	`TLSQIVTKL`
Variant Seq.	`TLSkIVTKL`
Mutations	Q/K
Epitope Location	Q4K
HXB2 Location	Q344K
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy
Note	Position 4 in the epitope had potentially experienced positive selection. The variant was full escape, as it was not recognized by CTLs.

References

Displaying record number 54167

HXB2 Location gp160(712-720) gp160 Epitope Map
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Epitope

YSPLSLQTL

Epitope Alignment

Variants

YSPLSLQTr escape documented in this paper

Epitope Name YL9

Species (MHC/HLA) human(C*01:02)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`994`
Epitope Seq.	`YSPLSLQTL`
Variant Seq.	`YSPLSLQTr`
Mutations	L/R
Epitope Location	L9R
HXB2 Location	L720R
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy
Note	Last position (9)in the epitope had potentially experienced positive selection. The variant was full escape, as it was not recognized by CTLs.

References

Displaying record number 54168

HXB2 Location Nef(5-13) Nef Epitope Map
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Epitope

WSKSSIIGW

Epitope Alignment

Variants

`WSKtSIIGW`		escape documented in this paper
`WSKSSmIGW`		escape documented in this paper

Epitope Name WW9

Species (MHC/HLA) human(A*25:01)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`995`
Epitope Seq.	`WSKSSIIGW`
Variant Seq.	`WSKtSIIGW`
Mutations	S/T
Epitope Location	S4T
HXB2 Location	S8T
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy
Note	Positions 4 and 6 in the epitope had potentially experienced positive selection. The variant was full escape, as it was not recognized by CTLs.

Variant ID.	`996`
Epitope Seq.	`WSKSSIIGW`
Variant Seq.	`WSKSSmIGW`
Mutations	I/M
Epitope Location	I6M
HXB2 Location	I10M
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy
Note	Positions 4 and 6 in the epitope had potentially experienced positive selection. The variant was full escape, as it was not recognized by CTLs.

References

Displaying record number 54172

HXB2 Location Nef(90-97) Nef Epitope Map
View variants at this location

Epitope

FLKEKGGL

Epitope Alignment

Variants

`FLKEeGGL`		escape documented in this paper
`FLKEgGGL`		observed variant
`FLKgeGGL`		observed variant
`FLKveGGL`		observed variant
`cLKEKGGL`		observed variant
`sLKEKGGL`		observed variant
`FLKEeGGL{p}`		observed variant

Epitope Name FL8

Species (MHC/HLA) human(B8)

Variant Details

Showing all: 7 variant(s).

Variant ID.	`997`
Epitope Seq.	`FLKEKGGL`
Variant Seq.	`FLKEeGGL`
Mutations	K/E
Epitope Location	K5E
HXB2 Location	K94E
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy
Note	Presumed escape variant was transmitted from a B8 positive donor to a B8 negative recipient. The variant was not recognized by CTLs.

Variant ID.	`998`
Epitope Seq.	`FLKEKGGL`
Variant Seq.	`FLKEgGGL`
Mutations	K/G
Epitope Location	K5G
HXB2 Location	K94G
Mutation Type	OV: observed variant
Note	Variant was found in 2/26 clones in the patient at sampling times 76 and 113.

Variant ID.	`999`
Epitope Seq.	`FLKEKGGL`
Variant Seq.	`FLKgeGGL`
Mutations	E/G K/E
Epitope Location	E4G K5E
HXB2 Location	E93G K94E
Mutation Type	OV: observed variant
Note	Variant was found in 1/39 clones in the patient at sampling times 8, 22 and 50.

Variant ID.	`1001`
Epitope Seq.	`FLKEKGGL`
Variant Seq.	`FLKveGGL`
Mutations	E/V K/E
Epitope Location	E4V K5E
HXB2 Location	E93V K94E
Mutation Type	OV: observed variant
Note	Variant was found in 2/10 clones in the patient at sampling time 23.

Variant ID.	`2259`
Epitope Seq.	`FLKEKGGL`
Variant Seq.	`cLKEKGGL`
Mutations	F/C
Epitope Location	F1C
HXB2 Location	F90C
Mutation Type	OV: observed variant
Note	Variant was found in 1/68 clones in the patient at several latter sampling times.

Variant ID.	`2260`
Epitope Seq.	`FLKEKGGL`
Variant Seq.	`sLKEKGGL`
Mutations	F/S
Epitope Location	F1S
HXB2 Location	F90S
Mutation Type	OV: observed variant
Note	Variant was found in 1/68 clones in the patient at several latter sampling times.

Variant ID.	`2275`
Epitope Seq.	`FLKEKGGL{E}`
Variant Seq.	`FLKEeGGL{p}`
Mutations	E/P K/E
Epitope Location	E+1P K5E
HXB2 Location	E98P K94E
Mutation Type	OV: observed variant
Note	Reversion variant was observed in the patient at several different sampling times.