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Found 28 matching records:

Displaying record number 61685

HXB2 Location Gag(6-15) Gag Epitope Map
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SILRGGKLDK

`SILRGeKLDK`		observed variant
`SvLRGGKLDK`		observed variant
`SILRGGnLDK`		literature escape

Epitope Name Gag-SK10

Species (MHC/HLA) human(A*74:01)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`4230`
Epitope Seq.	`SILRGGKLDK`
Variant Seq.	`SILRGeKLDK`
Mutations	G/E
Epitope Location	G6E
HXB2 Location	G11E
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	Variant SILRGeKLDK was found in maternal subject 133-M but not in her child, 133-C, as 100% of the circulating virus at 1.1 years post

Variant ID.	`4231`
Epitope Seq.	`SILRGGKLDK`
Variant Seq.	`SvLRGGKLDK`
Mutations	I/V
Epitope Location	I2V
HXB2 Location	I7V
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	Variant SvLRGGKLDK was first observed, and recorded as fixed at 100%, in maternal subject 133-M when her child 133-C was at 7yr of age. 133-M is A74^- (which is the restricting HLA for SK10) and this I7V mutation was always observed as a co-variant with G11E. While the I7V mutation does not appear to have been transmitted to 133-C from the mother, it arose in the child before 2.7yr. In 133-C, A74⁺, the I7V mutation was always observed as co-variant with G11E and K12N.

Variant ID.	`4232`
Epitope Seq.	`SILRGGKLDK`
Variant Seq.	`SILRGGnLDK`
Mutations	K/N
Epitope Location	K7N
HXB2 Location	K12N
Mutation Type	LE: literature escape
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	SILRGGnLDK is a known escape variant. While SILRGGnLDK does not appear to have been transmitted to 133-C from the A74^- (which is the restricting HLA for SK10) mother, it arose in the child and was observed to be at a frequency of 100% at 0.3yr. In 133-C, A74⁺, the K12N mutation was always observed as a co-variant with G11E and sometimes covariant with I7V.

References

Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.

Displaying record number 62248

HXB2 Location Gag(76-86) Gag Epitope Map
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Epitope

RSLYNTVATLY

Epitope Alignment

Variants

`RSLfNTVATLY`		observed variant
`kSLYNTVATLY`		literature escape
`RSLYNTVAvLY`		observed variant
`RSLYNTiATLY`		observed variant
`RSLYNTVvTLY`		observed variant

Epitope Name Gag-RY11

Species (MHC/HLA) human(A*30)

Variant Details

Showing all: 5 variant(s).

Variant ID.	`4289`
Epitope Seq.	`RSLYNTVATLY`
Variant Seq.	`RSLfNTVATLY`
Mutations	Y/F
Epitope Location	Y4F
HXB2 Location	Y79F
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RSLfNTVATLY (Y79F) was observed in A30⁺ (which is a restricting HLA for RY11) subject 517-M and her A30⁺ child, 517-C. It was present at all sampling time points and was always observed as a covariant with T84V and R76K. Sometimes it was also observed with A83V or V82I.

Variant ID.	`4290`
Epitope Seq.	`RSLYNTVATLY`
Variant Seq.	`kSLYNTVATLY`
Mutations	R/K
Epitope Location	R1K
HXB2 Location	R76K
Mutation Type	LE: literature escape
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	kSLYNTVATLY (R76K) is a documented escape variant. It was observed in A30⁺ (which is a restricting HLA for RY11) subject 517-M and her A30⁺ child, 517-C. It was present at all sampling time points and was always observed as a covariant with T84V. Sometimes it was also observed with A83V, Y79F, or V82I.

Variant ID.	`4291`
Epitope Seq.	`RSLYNTVATLY`
Variant Seq.	`RSLYNTVAvLY`
Mutations	T/V
Epitope Location	T9V
HXB2 Location	T84V
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RSLYNTVAvLY (T84V) was observed in A30⁺ (which is a restricting HLA for RY11) subject 517-M and her A30⁺ child, 517-C. It was present at all sampling time points and was always observed as a covariant with Y79F and R76K. Sometimes it was also observed with A83V or V82I.

Variant ID.	`4292`
Epitope Seq.	`RSLYNTVATLY`
Variant Seq.	`RSLYNTiATLY`
Mutations	V/I
Epitope Location	V7I
HXB2 Location	V82I
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RSLYNTiATLY (V82I) was observed to arise in A*30⁺ (which is a restricting HLA for RY11) subject 517-C between 2.5 and 5 years. It was always observed as a covariant with Y79F, T84V, and R76K. Sometimes it was also observed with A83V.

Variant ID.	`4293`
Epitope Seq.	`RSLYNTVATLY`
Variant Seq.	`RSLYNTVvTLY`
Mutations	A/V
Epitope Location	A8V
HXB2 Location	A83V
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RSLYNTVvTLY (A83V) was observed to arise in A*30⁺ (which is a restricting HLA for RY11) subject 517-C between 2.5 and 5 years. It was always observed as a covariant with Y79F, T84V, and R76K. Sometimes it was also observed with V82I.

References

Displaying record number 62220

HXB2 Location Gag(180-188) Gag Epitope Map
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Epitope

TPQDLNTML

Epitope Alignment

Variants

`TPtDLNTML`		literature escape
`TPaDLNTML`		observed variant
`TPsDLNTML`		observed variant

Epitope Name Gag-TL9

Species (MHC/HLA) human(B*42:01)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`4252`
Epitope Seq.	`TPQDLNTML`
Variant Seq.	`TPtDLNTML`
Mutations	Q/T
Epitope Location	Q3T
HXB2 Location	Q182T
Mutation Type	LE: literature escape
Epitope Subtype	C
Variant Subtype	C
Method	Other
Note	TPtDLNTML (Q182T) is documented escape variant. It was observed to arise in B42⁺ (which is a restricting HLA for TL9) subject 133-M when her B42^- child, 133-C, was at age 7. Q182T was also observed in B42⁺ subject 517-M when her B42⁺ child, 517-C, was 0.25yrs old. However, it was not observed in 517-C. In B42⁺ subject 021-M, the Q182T variant was observed starting at 0.1yr before the birth of her child, 021-C. However it was not observed 021-C, who is B42⁺, until 4.9yrs.

Variant ID.	`4253`
Epitope Seq.	`TPQDLNTML`
Variant Seq.	`TPaDLNTML`
Mutations	Q/A
Epitope Location	Q3A
HXB2 Location	Q182A
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Other
Note	TPaDLNTML (Q182A) was observed in B42⁺ (which is a restricting HLA for TL9) subject 517-M when her B42⁺ child, 517-C, was 0.25yrs old. However, it was not observed in 517-C.

Variant ID.	`4349`
Epitope Seq.	`TPQDLNTML`
Variant Seq.	`TPsDLNTML`
Mutations	Q/S
Epitope Location	Q3S
HXB2 Location	Q182S
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Other
Note	TPsDLNTML (Q182S) was observed in B*8101⁺ (which is a restricting HLA for TL9) subject K-3046-C at age 7.8. K-3046-C was a subject in the Pediatric Early HAART and Strategic Treatment Interruption Study.

References

Displaying record number 61683

HXB2 Location Gag(180-188) Gag Epitope Map
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Epitope

TPQDLNTML

Epitope Alignment

Variants

`TPQDLNmML`		literature escape
`TPgDLNTML`		observed variant
`TPQDLNsML`		observed variant
`TPsDLNTML`		observed variant

Epitope Name Gag-TL9

Species (MHC/HLA) human(B*81:01)

Variant Details

Showing all: 4 variant(s).

Variant ID.	`4251`
Epitope Seq.	`TPQDLNTML`
Variant Seq.	`TPQDLNmML`
Mutations	T/M
Epitope Location	T7M
HXB2 Location	T186M
Mutation Type	LE: literature escape
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	TPQDLNmML (T186X) is a documented escape variant. It was observed to arise between 0.7 and 1.3yrs in B*81⁺ (which is a restricting HLA for TL9) subject 133-C.

Variant ID.	`4346`
Epitope Seq.	`TPQDLNTML`
Variant Seq.	`TPgDLNTML`
Mutations	Q/G
Epitope Location	Q3G
HXB2 Location	Q182G
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	TPgDLNTML (Q182G) was observed in B8101⁺ (which is a restricting HLA for TL9) subject K-004-C at 12.8 years and in B8101⁺ subject K-044-C at 8 years. All were subjects in the Pediatric Early HAART and Strategic Treatment Interruption Study.

Variant ID.	`4347`
Epitope Seq.	`TPQDLNTML`
Variant Seq.	`TPQDLNsML`
Mutations	T/S
Epitope Location	T7S
HXB2 Location	T186S
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	TPQDLNsML (T186S) was observed in B*8101⁺ (which is a restricting HLA for TL9) subjects K-047-C (6.3 years), K-073-C (10.1 years), K-075-C (7.5 years), K-136-C (9.1 years), and K-146-C (3 years). All were subjects in the Pediatric Early HAART and Strategic Treatment Interruption Study.

Variant ID.	`4348`
Epitope Seq.	`TPQDLNTML`
Variant Seq.	`TPsDLNTML`
Mutations	Q/S
Epitope Location	Q3S
HXB2 Location	Q182S
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	TPsDLNTML (Q182S) was observed in B*8101⁺ (which is a restricting HLA for TL9) subject K-158-C at age 1.7. K-158-C was a subject in the Pediatric Early HAART and Strategic Treatment Interruption Study.

References

Displaying record number 62219

HXB2 Location Gag(296-304) Gag Epitope Map
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Epitope

YVDRFFKTL

Epitope Alignment

Variants

`YVDRFFrTL`		observed variant
`YVDRFFKvL`		literature escape
`YVDRFFKaL`		literature escape

Epitope Name Gag-YL9

Species (MHC/HLA) human(C*03)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`4248`
Epitope Seq.	`YVDRFFKTL`
Variant Seq.	`YVDRFFrTL`
Mutations	K/R
Epitope Location	K7R
HXB2 Location	K302R
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	YVDRFFrTL was observed in the Cw*03⁺ (which is the restricting HLA for RM9) child, 517-C. It arose between 0.2 and 2.5yrs.

Variant ID.	`4249`
Epitope Seq.	`YVDRFFKTL`
Variant Seq.	`YVDRFFKvL`
Mutations	T/V
Epitope Location	T8V
HXB2 Location	T303V
Mutation Type	LE: literature escape
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	YVDRFFKvL (T303X) is a known escape variant. It arose in the Cw*03⁺ (which is the restricting HLA for RM9) child, 517-C, between 2.5 and 5yrs.

Variant ID.	`4250`
Epitope Seq.	`YVDRFFKTL`
Variant Seq.	`YVDRFFKaL`
Mutations	T/A
Epitope Location	T8A
HXB2 Location	T303A
Mutation Type	LE: literature escape
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	YVDRFFKaL (T303X) is a known escape variant. It arose in the Cw*03⁺ (which is the restricting HLA for RM9) child, 517-C, between 5 and 8.5yrs.

References

Displaying record number 61686

HXB2 Location Pol(158-167) Pol Epitope Map
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Epitope

SPIETVPVKL

Epitope Alignment

Variants

`SPIdTVPVKL`		literature escape
`SPIEpVPVKL`		observed variant
`SPIkTVPVKL`		literature escape
`SsIETVPVKL`		literature escape
`StIETVPVKL`		observed variant

Epitope Name Pol-SL10

Species (MHC/HLA) human(B*81:01)

Variant Details

Showing all: 5 variant(s).

Variant ID.	`4233`
Epitope Seq.	`SPIETVPVKL`
Variant Seq.	`SPIdTVPVKL`
Mutations	E/D
Epitope Location	E4D
HXB2 Location	E161D
Mutation Type	LE: literature escape
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	SPIdTVPVKL (E161X) is a known escape variant. SPIdTVPVKL does not appear to have been transmitted to child 133-C from the B81^- (which is the restricting HLA for SL10) mother, 133-M. The E161D mutation arose in the B81⁺ child 133-C by 0.3yr.

Variant ID.	`4234`
Epitope Seq.	`SPIETVPVKL`
Variant Seq.	`SPIEpVPVKL`
Mutations	T/P
Epitope Location	T5P
HXB2 Location	T162P
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	SPIEpVPVKL does not appear to have been transmitted to child 133-C from the B81^- (which is the restricting HLA for SL10) mother, 133-M. The T162P mutation arose in the B81⁺ child 133-C and was only observed at the 0.3yr sampling time point at a frequency of 2%.

Variant ID.	`4235`
Epitope Seq.	`SPIETVPVKL`
Variant Seq.	`SPIkTVPVKL`
Mutations	E/K
Epitope Location	E4K
HXB2 Location	E161K
Mutation Type	LE: literature escape
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	SPIkTVPVKL (E161X) is a known escape variant. SPIkTVPVKL does not appear to have been transmitted to child 133-C from the B81^- (which is the restricting HLA for SL10) mother, 133-M. The E161K mutation arose in the B81⁺ child 133-C by 0.3yr.

Variant ID.	`4236`
Epitope Seq.	`SPIETVPVKL`
Variant Seq.	`SsIETVPVKL`
Mutations	P/S
Epitope Location	P2S
HXB2 Location	P159S
Mutation Type	LE: literature escape
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	SsIETVPVKL (P159S) is a known escape variant. SsIETVPVKL does not appear to have been transmitted to child 133-C from the B81^- (which is the restricting HLA for SL10) mother, 133-M. The P159S mutation arose in the B81⁺ child 133-C between 0.3 and 2.7yr.

Variant ID.	`4237`
Epitope Seq.	`SPIETVPVKL`
Variant Seq.	`StIETVPVKL`
Mutations	P/T
Epitope Location	P2T
HXB2 Location	P159T
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	StIETVPVKL does not appear to have been transmitted to child 133-C from the B81^- (which is the restricting HLA for SL10) mother, 133-M. The P159T mutation arose in the B81⁺ child 133-C between 4.9 and 7.7yr.

References

Displaying record number 62241

HXB2 Location Pol(282-290) Pol Epitope Map
View variants at this location

Epitope

YTAFTIPSI

Epitope Alignment

Variants

YTAFTIPSv observed variant

Epitope Name Pol-YI9

Species (MHC/HLA) human(A*02)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`4335`
Epitope Seq.	`YTAFTIPSI`
Variant Seq.	`YTAFTIPSv`
Mutations	I/V
Epitope Location	I9V
HXB2 Location	I290V
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	YTAFTIPSv (I290V) was observed in A*02⁺ (which is a restricting HLA for YI9) subject 021-M five years after the birth of her child, 021-C.

References

Displaying record number 62222

HXB2 Location Pol(328-336) Pol Epitope Map
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Epitope

AQNPEIVIY

Epitope Alignment

Variants

`ArNPEIVIY`		observed variant
`AkNPEIVIY`		observed variant
`AQNPEIVIc`		observed variant
`AQNPElVIY`		observed variant
`tQNPEIVIY`		observed variant

Epitope Name Pol-AY9

Species (MHC/HLA) human(A*30)

Variant Details

Showing all: 5 variant(s).

Variant ID.	`4254`
Epitope Seq.	`AQNPEIVIY`
Variant Seq.	`ArNPEIVIY`
Mutations	Q/R
Epitope Location	Q2R
HXB2 Location	Q329R
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	ArNPEIVIY (Q329R) was observed in A30⁺ (which is a restricting HLA for AY9) subject 517-M when her A30⁺ child, 517-C, was 6 yrs old. It was not observed in 517-C.

Variant ID.	`4255`
Epitope Seq.	`AQNPEIVIY`
Variant Seq.	`AkNPEIVIY`
Mutations	Q/K
Epitope Location	Q2K
HXB2 Location	Q329K
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	AkNPEIVIY (Q329K) was observed in A30⁺ (which is a restricting HLA for AY9) subject 517-M when her A30⁺ child, 517-C, was 6 yrs old. It was not observed in 517-C.

Variant ID.	`4256`
Epitope Seq.	`AQNPEIVIY`
Variant Seq.	`AQNPEIVIc`
Mutations	Y/C
Epitope Location	Y9C
HXB2 Location	Y336C
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	AQNPEIVIc (Y336C) was observed in A30⁺ (which is a restricting HLA for AY9) subject 517-C at 0.2yrs. However, it was not observed in the A30⁺ mother, 517-M.

Variant ID.	`4257`
Epitope Seq.	`AQNPEIVIY`
Variant Seq.	`AQNPElVIY`
Mutations	I/L
Epitope Location	I6L
HXB2 Location	I333L
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	AQNPElVIY (I333L) was observed to arise in A*30⁺ (which is a restricting HLA for AY9) subject 517-C between 0.2yrs and 2.5yrs. It was sometimes observed as a covariant with A328T.

Variant ID.	`4258`
Epitope Seq.	`AQNPEIVIY`
Variant Seq.	`tQNPEIVIY`
Mutations	A/T
Epitope Location	A1T
HXB2 Location	A328T
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	tQNPEIVIY (A328T) was observed to arise in A*30⁺ (which is a restricting HLA for AY9) subject 517-C between 2.5 and 5yrs. It was always observed as a covariant with I333L.

References

Displaying record number 62245

HXB2 Location Pol(334-342) Pol Epitope Map
View variants at this location

Epitope

VIYQYMDDL

Epitope Alignment

Variants

`iIYQYMDDL`		observed variant
`VIcQYMDDL`		observed variant

Epitope Name Pol-VL9

Species (MHC/HLA) human(A*02)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`4344`
Epitope Seq.	`VIYQYMDDL`
Variant Seq.	`iIYQYMDDL`
Mutations	V/I
Epitope Location	V1I
HXB2 Location	V334I
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	iIYQYMDDL (V334I) was observed in A02⁺ (which is a restricting HLA for VL9) subject 021-M beginning at 0.1 years before the birth of her A02⁺ child, 021-C. However, it did not appear in samples from 021-C.

Variant ID.	`4345`
Epitope Seq.	`VIYQYMDDL`
Variant Seq.	`VIcQYMDDL`
Mutations	Y/C
Epitope Location	Y3C
HXB2 Location	Y336C
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	VIcQYMDDL (Y336C) was observed in A*02⁺ (which is a restricting HLA for VL9) subject 021-C at 0.1 years.

References

Displaying record number 62216

HXB2 Location Pol(423-432) Pol Epitope Map
View variants at this location

Epitope

SQIYPGIKVR

Epitope Alignment

Variants

`SQIYPGIrVR`		observed variant
`SQIYPGvKVR`		observed variant
`SQIYPrIKVR`		observed variant
`SQIYPGIKiR`		observed variant
`SQIYPGIKVk`		literature escape

Epitope Name Pol-SR10

Species (MHC/HLA) human(A*74:01)

Variant Details

Showing all: 5 variant(s).

Variant ID.	`4238`
Epitope Seq.	`SQIYPGIKVR`
Variant Seq.	`SQIYPGIrVR`
Mutations	K/R
Epitope Location	K8R
HXB2 Location	K430R
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	SQIYPGIrVR was observed at all sampling time points in both the A74^- (which is the restricting HLA for SR10) mother, 133-M, and the A74⁺ child, 133-C. As the K430R mutation was at 100% frequency at all sampling time points, it was observed alongside all other mutations listed as variants associated with the CTL Record for Epitope Pol-SR10 (Rec #62216).

Variant ID.	`4239`
Epitope Seq.	`SQIYPGIKVR`
Variant Seq.	`SQIYPGvKVR`
Mutations	I/V
Epitope Location	I7V
HXB2 Location	I429V
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	SQIYPGvKVR was observed in the A74^- (which is the restricting HLA for SR10) mother, 133-M, but not in the A74⁺ child, 133-C. The I429V mutation was always observed as a co-variant with the K430R mutation.

Variant ID.	`4240`
Epitope Seq.	`SQIYPGIKVR`
Variant Seq.	`SQIYPrIKVR`
Mutations	G/R
Epitope Location	G6R
HXB2 Location	G428R
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	SQIYPrIKVR was observed in the A74^- (which is the restricting HLA for SR10) mother, 133-M, and in the A74⁺ child, 133-C. The G428R mutation was always observed as a co-variant with the K430R mutation and sometimes also with the R432K mutation.

Variant ID.	`4241`
Epitope Seq.	`SQIYPGIKVR`
Variant Seq.	`SQIYPGIKiR`
Mutations	V/I
Epitope Location	V9I
HXB2 Location	V431I
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	SQIYPGIKiR was observed to arise in the A*74⁺ (which is the restricting HLA for SR10) child, 133-C, between 0.3 and 2.7yr. The V431I mutation was always observed as a co-variant with both the K430R and R432K mutations.

Variant ID.	`4242`
Epitope Seq.	`SQIYPGIKVR`
Variant Seq.	`SQIYPGIKVk`
Mutations	R/K
Epitope Location	R10K
HXB2 Location	R432K
Mutation Type	LE: literature escape
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	SQIYPGIKVk is a known escape variant. It was observed to arise in the A*74⁺ (which is the restricting HLA for SR10) child, 133-C, between 0.3 and 2.7yr. The R432K mutation was always observed as a co-variant with the K430R mutation and sometimes with the V431I mutation as well.

References

Displaying record number 62244

HXB2 Location Pol(464-472) Pol Epitope Map
View variants at this location

Epitope

ILKEPVHGV

Epitope Alignment

Variants

`ILqEPVHGV`		observed variant
`ILKEPVHGa`		observed variant

Epitope Name Pol-IV9

Species (MHC/HLA) human(A*02)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`4342`
Epitope Seq.	`ILKEPVHGV`
Variant Seq.	`ILqEPVHGV`
Mutations	K/Q
Epitope Location	K3Q
HXB2 Location	K466Q
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	ILqEPVHGV (K466Q) was observed in A02⁺ (which is a restricting HLA for IV9) subject 021-M beginning at 5 years after the birth of her A02⁺ child, 021-C. However, it did not appear in samples from 021-C. K466Q was sometimes observed as a covariant with V472A.

Variant ID.	`4343`
Epitope Seq.	`ILKEPVHGV`
Variant Seq.	`ILKEPVHGa`
Mutations	V/A
Epitope Location	V9A
HXB2 Location	V472A
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	ILKEPVHGa (V472A) was observed in A02⁺ (which is a restricting HLA for IV9) subject 021-M beginning at 0.1 years before the birth of her A02⁺ child, 021-C. However, it did not appear in samples from 021-C until they were 4.9 years old. V472A was sometimes observed as a covariant with K466Q.

References

Displaying record number 62231

HXB2 Location Pol(743-751) Pol Epitope Map
View variants at this location

Epitope

LPPIVAKEI

Epitope Alignment

Variants

`LPPvVAKEI`		literature escape
`LPPIVArEI`		literature escape

Epitope Name Pol-LI9

Species (MHC/HLA) human(B*42)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`4296`
Epitope Seq.	`LPPIVAKEI`
Variant Seq.	`LPPvVAKEI`
Mutations	I/V
Epitope Location	I4V
HXB2 Location	I746V
Mutation Type	LE: literature escape
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	LPPvVAKEI (I746V) is a documented escape variant. It was observed at all sampling time points in B42⁺ (which is a restricting HLA for LI9) subject 517-M and her B42⁺ child, 517-C. It was sometimes observed as a covariant with K749R.

Variant ID.	`4297`
Epitope Seq.	`LPPIVAKEI`
Variant Seq.	`LPPIVArEI`
Mutations	K/R
Epitope Location	K7R
HXB2 Location	K749R
Mutation Type	LE: literature escape
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	LPPIVArEI (K749) is a documented escape variant. It was observed at all sampling time points in B42⁺ (which is a restricting HLA for LI9) subject 517-M and her B42⁺ child, 517-C. It was sometimes observed as a covariant with I746V.

References

Displaying record number 62232

HXB2 Location Vif(48-57) Vif Epitope Map
View variants at this location

Epitope

HPKVSSEVHI

Epitope Alignment

Variants

`HPKVSSEVHv`		observed variant
`HPKVSSEiHI`		observed variant
`HPKVSSEVHt`		observed variant
`nPKVSSEVHI`		observed variant
`HPKiSSEVHI`		observed variant
`HPrVSSEVHI`		observed variant

Epitope Name Vif-HI10

Species (MHC/HLA) human(B*42)

Variant Details

Showing all: 6 variant(s).

Variant ID.	`4298`
Epitope Seq.	`HPKVSSEVHI`
Variant Seq.	`HPKVSSEVHv`
Mutations	I/V
Epitope Location	I10V
HXB2 Location	I57V
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	HPKVSSEVHv (I57V) was observed in B42⁺ (which is a restricting HLA for HI10) subject 517-M when her B42⁺ child, 517-C, was 0.25 years old. However, it was not observed in 517-C. It was observed as a covariant with V55I.

Variant ID.	`4299`
Epitope Seq.	`HPKVSSEVHI`
Variant Seq.	`HPKVSSEiHI`
Mutations	V/I
Epitope Location	V8I
HXB2 Location	V55I
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	HPKVSSEiHI (V55I) was observed in B42⁺ (which is a restricting HLA for HI10) subject 517-M when her B42⁺ child, 517-C, was 0.25 years old. However, it was not observed in 517-C. It was sometimes seen as a covariant with I57V.

Variant ID.	`4300`
Epitope Seq.	`HPKVSSEVHI`
Variant Seq.	`HPKVSSEVHt`
Mutations	I/T
Epitope Location	I10T
HXB2 Location	I57T
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	HPKVSSEVHt (I57T) was observed in B42⁺ (which is a restricting HLA for HI10) subject 517-M when her B42⁺ child, 517-C, was 6 years old.

Variant ID.	`4301`
Epitope Seq.	`HPKVSSEVHI`
Variant Seq.	`nPKVSSEVHI`
Mutations	H/N
Epitope Location	H1N
HXB2 Location	H48N
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	nPKVSSEVHI (H48N) arose in B*42⁺ (which is a restricting HLA for HI10) subject 517-C between 0.2 and 2.5 years. It was sometimes observed as a covariant with V51I.

Variant ID.	`4302`
Epitope Seq.	`HPKVSSEVHI`
Variant Seq.	`HPKiSSEVHI`
Mutations	V/I
Epitope Location	V4I
HXB2 Location	V51I
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	HPKiSSEVHI (V51I) arose in B*42⁺ (which is a restricting HLA for HI10) subject 517-C between 0.2 and 2.5 years. It was sometimes observed as a covariant with H48N or K50R.

Variant ID.	`4303`
Epitope Seq.	`HPKVSSEVHI`
Variant Seq.	`HPrVSSEVHI`
Mutations	K/R
Epitope Location	K3R
HXB2 Location	K50R
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	HPrVSSEVHI (K50R) arose in B*42⁺ (which is a restricting HLA for HI10) subject 517-C between 2.5 and 5 years. It was sometimes observed as a covariant with V51I.

References

Displaying record number 62234

HXB2 Location Vif(54-63) Vif Epitope Map
View variants at this location

Epitope

EVHIPLGDAR

Epitope Alignment

Variants

`EVHIPLGeAR`		observed variant
`EVHIPLGDAk`		observed variant
`EVHIPvGDAR`		observed variant
`EVHIPLGDgR`		observed variant

Epitope Name Vif-ER10

Species (MHC/HLA) human(A*68:01)

Variant Details

Showing all: 4 variant(s).

Variant ID.	`4311`
Epitope Seq.	`EVHIPLGDAR`
Variant Seq.	`EVHIPLGeAR`
Mutations	D/E
Epitope Location	D8E
HXB2 Location	D61E
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	EVHIPLGeAR (D61E) was observed at all sampling time points in A6801⁺ (which is a restricting HLA for ER10) subject 133-M and her A6801⁺ child 133-C. It was sometimes observed as a covariant with L59V, R63K, or A62G.

Variant ID.	`4312`
Epitope Seq.	`EVHIPLGDAR`
Variant Seq.	`EVHIPLGDAk`
Mutations	R/K
Epitope Location	R10K
HXB2 Location	R63K
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	EVHIPLGDAk (R63K) was observed in A6801⁺ (which is a restricting HLA for ER10) subject 133-M 7 years after the birth of her child,133-C. It was also observed in 133-C, who is A6801⁺ beginning at age 4.9. It always seen as a covariant with D61E and sometimes also observed with A62G.

Variant ID.	`4313`
Epitope Seq.	`EVHIPLGDAR`
Variant Seq.	`EVHIPvGDAR`
Mutations	L/V
Epitope Location	L6V
HXB2 Location	L59V
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	EVHIPvGDAR (L59V) was observed in A6801⁺ (which is a restricting HLA for ER10) subject 133-M 7 years after the birth of her child,133-C. It was also observed in 133-C, who is A6801⁺ at age 4.9. It always seen as a covariant with D61E.

Variant ID.	`4314`
Epitope Seq.	`EVHIPLGDAR`
Variant Seq.	`EVHIPLGDgR`
Mutations	A/G
Epitope Location	A9G
HXB2 Location	A62G
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	EVHIPLGDgR (A62G) arose in A*6801⁺ (which is a restricting HLA for ER10) subject 133-C between 4.9 and 7.7yr. It was observed as a covariant with both R63K and D61E.

References

Displaying record number 62228

HXB2 Location Vif(78-87) Vif Epitope Map
View variants at this location

Epitope

DWHLGHGVSI

Epitope Alignment

Variants

`DWHLGHGaSI`		observed variant
`eWHLGHGVSI`		observed variant
`DWHLGHGiSI`		observed variant
`DWlLGHGVSI`		observed variant
`DWqLGHGVSI`		observed variant

Epitope Name Vif-WI9

Species (MHC/HLA) human(B*15:10)

Variant Details

Showing all: 5 variant(s).

Variant ID.	`4284`
Epitope Seq.	`DWHLGHGVSI`
Variant Seq.	`DWHLGHGaSI`
Mutations	V/A
Epitope Location	V8A
HXB2 Location	V85A
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	DWHLGHGaSI (V85A) was observed in B15⁺ (which is a restricting HLA for WI9) subject 517-C starting at 0.2 years. However it does not appear to have been transmitted from the B15^- mother, 517-M. It was sometimes observed as a covariant with D78E.

Variant ID.	`4285`
Epitope Seq.	`DWHLGHGVSI`
Variant Seq.	`eWHLGHGVSI`
Mutations	D/E
Epitope Location	D1E
HXB2 Location	D78E
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	eWHLGHGVSI (D78E) was observed in B15⁺ (which is a restricting HLA for WI9) subject 517-C starting at 0.2 years. However it does not appear to have been transmitted from the B15^- mother, 517-M. It was sometimes observed as a covariant with V85A.

Variant ID.	`4286`
Epitope Seq.	`DWHLGHGVSI`
Variant Seq.	`DWHLGHGiSI`
Mutations	V/I
Epitope Location	V8I
HXB2 Location	V85I
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	DWHLGHGiSI (V85I) was observed in B15⁺ (which is a restricting HLA for WI9) subject 517-C at 0.2 years. However it does not appear to have been transmitted from the B15^- mother, 517-M.

Variant ID.	`4287`
Epitope Seq.	`DWHLGHGVSI`
Variant Seq.	`DWlLGHGVSI`
Mutations	H/L
Epitope Location	H3L
HXB2 Location	H80L
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	DWlLGHGVSI (H80L) was observed in B15⁺ (which is a restricting HLA for WI9) subject 517-C at 0.2 years. However it does not appear to have been transmitted from the B15^- mother, 517-M.

Variant ID.	`4288`
Epitope Seq.	`DWHLGHGVSI`
Variant Seq.	`DWqLGHGVSI`
Mutations	H/Q
Epitope Location	H3Q
HXB2 Location	H80Q
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	DWqLGHGVSI (H80Q) was observed in B15⁺ (which is a restricting HLA for WI9) subject 517-C at 0.2 years. However it does not appear to have been transmitted from the B15^- mother, 517-M.

References

Displaying record number 62235

HXB2 Location Vif(113-121) Vif Epitope Map
View variants at this location

Epitope

DCFADSAIR

Epitope Alignment

Variants

`DCFtDSAIR`		observed variant
`DCFADSAIg`		observed variant
`DCFAeSAIR`		observed variant

Epitope Name Vif-DR10

Species (MHC/HLA) human(A*68:01)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`4315`
Epitope Seq.	`DCFADSAIR`
Variant Seq.	`DCFtDSAIR`
Mutations	A/T
Epitope Location	A4T
HXB2 Location	A116T
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	DCFtDSAIR (A116T) was observed in A6801⁺ (which is a restricting HLA for DR9) subject 133-M 7 years after the birth of her A6801⁺ child, 133-C. While it was not observed in 133-C at 0.3yr, it did emerge beginning at 2.7yr.

Variant ID.	`4316`
Epitope Seq.	`DCFADSAIR`
Variant Seq.	`DCFADSAIg`
Mutations	R/G
Epitope Location	R9G
HXB2 Location	R121G
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	DCFADSAIg (A116G) was observed in A*6801⁺ (which is a restricting HLA for DR9) subject 133-C at 2.7yr.

Variant ID.	`4317`
Epitope Seq.	`DCFADSAIR`
Variant Seq.	`DCFAeSAIR`
Mutations	D/E
Epitope Location	D5E
HXB2 Location	D117E
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	DCFAeSAIR (D117E) arose in A*6801⁺ (which is a restricting HLA for DR9) subject 133-C between 2.7 and 4.9 years.

References

Displaying record number 62243

HXB2 Location Vpr(34-42) Vpr Epitope Map
View variants at this location

Epitope

FPRPWLHGL

Epitope Alignment

Variants

`FPRvWLHGL`		observed variant
`FPRmWLHGL`		observed variant
`FPRPWLHGs`		observed variant
`FPRtWLHGL`		observed variant
`FPRaWLHGL`		observed variant
`FPRPWLHqL`		observed variant

Epitope Name Vpr-FL9

Species (MHC/HLA) human(B*42)

Variant Details

Showing all: 6 variant(s).

Variant ID.	`4336`
Epitope Seq.	`FPRPWLHGL`
Variant Seq.	`FPRvWLHGL`
Mutations	P/V
Epitope Location	P4V
HXB2 Location	P37V
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	FPRvWLHGL (P37V) was observed at various sampling time points in B42⁺ (which is a restricting HLA for FL9) subject 021-M and her B42⁺ child 021-C. It was sometimes observed as a covariant with L42S or G41Q.

Variant ID.	`4337`
Epitope Seq.	`FPRPWLHGL`
Variant Seq.	`FPRmWLHGL`
Mutations	P/M
Epitope Location	P4M
HXB2 Location	P37M
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	FPRmWLHGL (P37M) was observed at various sampling time points in B42⁺ (which is a restricting HLA for FL9) subject 021-M and her B42⁺ child 021-C.

Variant ID.	`4338`
Epitope Seq.	`FPRPWLHGL`
Variant Seq.	`FPRPWLHGs`
Mutations	L/S
Epitope Location	L9S
HXB2 Location	L42S
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	FPRPWLHGs (L42S) was observed in B42⁺ (which is a restricting HLA for FL9) subject 021-M 0.1 years before the birth of her B42⁺ child, 021-C. It was also seen in 021-C at 7.6 years. It was always observed as a covariant with P37V.

Variant ID.	`4339`
Epitope Seq.	`FPRPWLHGL`
Variant Seq.	`FPRtWLHGL`
Mutations	P/T
Epitope Location	P4T
HXB2 Location	P37T
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	FPRtWLHGL (P37T) arose in B*42⁺ (which is a restricting HLA for FL9) subject 021-C between 0.1 and 2.6 years.

Variant ID.	`4340`
Epitope Seq.	`FPRPWLHGL`
Variant Seq.	`FPRaWLHGL`
Mutations	P/A
Epitope Location	P4A
HXB2 Location	P37A
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	FPRaWLHGL (P37A) arose in B*42⁺ (which is a restricting HLA for FL9) subject 021-C between 2.6 and 4.9 years.

Variant ID.	`4341`
Epitope Seq.	`FPRPWLHGL`
Variant Seq.	`FPRPWLHqL`
Mutations	G/Q
Epitope Location	G8Q
HXB2 Location	G41Q
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	FPRPWLHqL (G41Q) observed in B*42⁺ (which is a restricting HLA for FL9) subject 021-C at 4.9 years. It was observed as a covariant with P37V.

References

Displaying record number 62230

HXB2 Location Vpr(48-57) Vpr Epitope Map
View variants at this location

Epitope

ETYGDTWTGV

Epitope Alignment

Variants

`aTYGDTWTGV`		observed variant
`ETYGDTWaGV`		observed variant

Epitope Name Vpr-EV10

Species (MHC/HLA) human(A*68)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`4294`
Epitope Seq.	`ETYGDTWTGV`
Variant Seq.	`aTYGDTWTGV`
Mutations	E/A
Epitope Location	E1A
HXB2 Location	E48A
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	aTYGDTWTGV (E48A) was observed to be fixed at 100% frequency at all sampling time points in A68^- (which is a restricting HLA for EV10) subject 517-M and her A68⁺ child, 517-C. It was always observed as a covariant with T55A.

Variant ID.	`4295`
Epitope Seq.	`ETYGDTWTGV`
Variant Seq.	`ETYGDTWaGV`
Mutations	T/A
Epitope Location	T8A
HXB2 Location	T55A
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	ETYGDTWaGV (T55A) was observed at all sampling time points in A68^- (which is a restricting HLA for EV10) subject 517-M and her A68⁺ child, 517-C. It was always observed as a covariant with E48A.

References

Displaying record number 62227

HXB2 Location Rev(52-60) Rev Epitope Map
View variants at this location

Epitope

IHSISERIL

Epitope Alignment

Variants

`IrSISERIL`		observed variant
`IHaISERIL`		observed variant
`IHSISERIi`		observed variant
`InSISERIL`		observed variant
`lHSISERIL`		observed variant
`IHSlSERIL`		observed variant
`vHSISERIL`		observed variant

Epitope Name Rev-IL9

Species (MHC/HLA) human(B*15:10)

Variant Details

Showing all: 7 variant(s).

Variant ID.	`4277`
Epitope Seq.	`IHSISERIL`
Variant Seq.	`IrSISERIL`
Mutations	H/R
Epitope Location	H2R
HXB2 Location	H53R
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	IrSISERIL (H53R) was observed in B15⁺ (which is a restricting HLA for IL9) subject 517-C at 0.2 years. However, it does not appear to have been transmitted from the B15^- mother, 517-C. This variant was always observed as a covariant with S54A. It was sometimes also observed alongside L60I.

Variant ID.	`4278`
Epitope Seq.	`IHSISERIL`
Variant Seq.	`IHaISERIL`
Mutations	S/A
Epitope Location	S3A
HXB2 Location	S54A
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	IHaISERIL (S54A) was observed in B15⁺ (which is a restricting HLA for IL9) subject 517-C at 0.2 years. However, it does not appear to have been transmitted from the B15^- mother, 517-C. This variant was always observed as a covariant with H53R. It was sometimes also observed alongside L60I.

Variant ID.	`4279`
Epitope Seq.	`IHSISERIL`
Variant Seq.	`IHSISERIi`
Mutations	L/I
Epitope Location	L9I
HXB2 Location	L60I
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	IHSISERIi (L60I) was observed in B15⁺ (which is a restricting HLA for IL9) subject 517-C at 0.2 years. However, it does not appear to have been transmitted from the B15^- mother, 517-C. This variant was always observed as a covariant with both H53R and S54A.

Variant ID.	`4280`
Epitope Seq.	`IHSISERIL`
Variant Seq.	`InSISERIL`
Mutations	H/N
Epitope Location	H2N
HXB2 Location	H53N
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	InSISERIL (H53N) was observed to arise in B*15⁺ (which is a restricting HLA for IL9) subject 517-C between 0.2 and 2.5 years. This variant was sometimes observed as a covariant with I52L, I52V, or I55L.

Variant ID.	`4281`
Epitope Seq.	`IHSISERIL`
Variant Seq.	`lHSISERIL`
Mutations	I/L
Epitope Location	I1L
HXB2 Location	I52L
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	lHSISERIL (I52L) was observed to arise in B*15⁺ (which is a restricting HLA for IL9) subject 517-C between 0.2 and 2.5 years. It was always observed as a covariant with H53N.

Variant ID.	`4282`
Epitope Seq.	`IHSISERIL`
Variant Seq.	`IHSlSERIL`
Mutations	I/L
Epitope Location	I4L
HXB2 Location	I55L
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	IHSlSERIL (I55L) was observed to arise in B*15⁺ (which is a restricting HLA for IL9) subject 517-C between 2.5 and 5 years. It was always observed as a covariant with H53N.

Variant ID.	`4283`
Epitope Seq.	`IHSISERIL`
Variant Seq.	`vHSISERIL`
Mutations	I/V
Epitope Location	I1V
HXB2 Location	I52V
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	vHSISERIL (I52V) was observed to arise in B*15⁺ (which is a restricting HLA for IL9) subject 517-C between 2.5 and 5 years. It was always observed as a covariant with H53N.

References

Displaying record number 62233

HXB2 Location Rev(65-75) Rev Epitope Map
View variants at this location

Epitope

GRPAEPVPLQL

Epitope Alignment

Variants

`GRPtEPVPLQL`		observed variant
`GRPAEPVPfQL`		observed variant
`GRPAEPVhLQL`		observed variant
`GRPAEPVsLQL`		observed variant
`GRlAEPVPLQL`		observed variant
`GRPAEPVaLQL`		observed variant
`GRPAEPVdLQL`		observed variant

Epitope Name Rev-GL11

Species (MHC/HLA) human(B*15:10)

Variant Details

Showing all: 7 variant(s).

Variant ID.	`4304`
Epitope Seq.	`GRPAEPVPLQL`
Variant Seq.	`GRPtEPVPLQL`
Mutations	A/T
Epitope Location	A4T
HXB2 Location	A68T
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	GRPtEPVPLQL (A68T) was observed at almost all sampling time points (the exception being the sample of 517-C at 0.2yr) in B1510^- (which is a restricting HLA for GL11) subject 517-M and her B1510⁺ child, 517-C. It was sometimes observed as a covariant with L73F, P72H, P72S, P67L, P72A, or P72D.

Variant ID.	`4305`
Epitope Seq.	`GRPAEPVPLQL`
Variant Seq.	`GRPAEPVPfQL`
Mutations	L/F
Epitope Location	L9F
HXB2 Location	L73F
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	GRPAEPVPfQL (L73F) was observed at all sampling time points in B1510^- (which is a restricting HLA for GL11) subject 517-M and her B1510⁺ child, 517-C. It was always seen as a covariant with A86T, and was sometimes observed also with P72H, P72S, P67L, P72A, or P72D.

Variant ID.	`4306`
Epitope Seq.	`GRPAEPVPLQL`
Variant Seq.	`GRPAEPVhLQL`
Mutations	P/H
Epitope Location	P8H
HXB2 Location	P72H
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	GRPAEPVhLQL (P72H) was observed in B1510^- (which is a restricting HLA for GL11) subject 517-M 0.25 years after the birth of her B1510⁺ child, 517-C. However, it was never observed in 517-C. It was always seen as a covariant with A86T and L73H.

Variant ID.	`4307`
Epitope Seq.	`GRPAEPVPLQL`
Variant Seq.	`GRPAEPVsLQL`
Mutations	P/S
Epitope Location	P8S
HXB2 Location	P72S
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	GRPAEPVsLQL (P72S) was observed in B1510^- (which is a restricting HLA for GL11) subject 517-M 6 years after the birth of her B1510⁺ child, 517-C. It was also observed in 517-C at age 5. It always appeared alongside A68T and was sometimes also observed as a covariant with L73F.

Variant ID.	`4308`
Epitope Seq.	`GRPAEPVPLQL`
Variant Seq.	`GRlAEPVPLQL`
Mutations	P/L
Epitope Location	P3L
HXB2 Location	P67L
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	GRlAEPVPLQL (P67L) was observed in B1510^- (which is a restricting HLA for GL11) subject 517-M 6 years after the birth of her B1510⁺ child, 517-C. It was also observed in 517-C at age 2.5. It always appeared alongside both A68T and L73F.

Variant ID.	`4309`
Epitope Seq.	`GRPAEPVPLQL`
Variant Seq.	`GRPAEPVaLQL`
Mutations	P/A
Epitope Location	P8A
HXB2 Location	P72A
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	GRPAEPVaLQL (P72A) arose in B*1510⁺ (which is a restricting HLA for GL11) subject 517-C between 2.5 and 5 years. It appeared alongside both A68T and L73F.

Variant ID.	`4310`
Epitope Seq.	`GRPAEPVPLQL`
Variant Seq.	`GRPAEPVdLQL`
Mutations	P/D
Epitope Location	P8D
HXB2 Location	P72D
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	GRPAEPVdLQL (P72D) arose in B*1510⁺ (which is a restricting HLA for GL11) subject 517-C between 2.5 and 5 years. It was observed as a covariant with both A68T and L73F.

References

Displaying record number 62240

HXB2 Location gp160(209-217) gp160 Epitope Map
View variants at this location

Epitope

SFDPIPIHY

Epitope Alignment

Variants

`SFnPIPIHY`		observed variant
`tFDPIPIHY`		literature escape
`SFDPlPIHY`		observed variant

Epitope Name Env-SY9

Species (MHC/HLA) human(A*29)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`4332`
Epitope Seq.	`SFDPIPIHY`
Variant Seq.	`SFnPIPIHY`
Mutations	D/N
Epitope Location	D3N
HXB2 Location	D211N
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	SFnPIPIHY (D211N) was observed in A*29⁺ (which is a restricting HLA for SY9) subject 021-C when they were 0.1 years old.

Variant ID.	`4333`
Epitope Seq.	`SFDPIPIHY`
Variant Seq.	`tFDPIPIHY`
Mutations	S/T
Epitope Location	S1T
HXB2 Location	S209T
Mutation Type	LE: literature escape
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	tFDPIPIHY (S206T) is a documented escape variant. It arose in A*29⁺ (which is a restricting HLA for SY9) subject 021-C between 0.1 and 2.6 years. S206T was fixed to 100% frequency in 021-C before 4.9 years. It was sometimes observed as a covariant with I210L.

Variant ID.	`4334`
Epitope Seq.	`SFDPIPIHY`
Variant Seq.	`SFDPlPIHY`
Mutations	I/L
Epitope Location	I5L
HXB2 Location	I213L
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	SFDPlPIHY (I213L) was observed in A*29⁺ (which is a restricting HLA for SY9) subject 021-C when they were 7.6 years old. It was observed as a covariant with S206T.

References

Displaying record number 62238

HXB2 Location gp160(272-288) gp160 Epitope Map
View variants at this location

Epitope

IRSENLTNNAKTIIVHL

Epitope Alignment

Variants

`IRSENLTdNAKTIIVHL`		observed variant
`IRSENLTNNvKTIIVHL`		observed variant
`IRSENLTNNiKTIIVHL`		observed variant
`IRtENLTNNAKTIIVHL`		observed variant
`IRSENLTNNtKTIIVHL`		observed variant
`IRSENLTNNArTIIVHL`		observed variant

Epitope Name Env-OLP325

Species (MHC/HLA) human(C*06:02)

Variant Details

Showing all: 6 variant(s).

Variant ID.	`4326`
Epitope Seq.	`IRSENLTNNAKTIIVHL`
Variant Seq.	`IRSENLTdNAKTIIVHL`
Mutations	N/D
Epitope Location	N8D
HXB2 Location	N279D
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	IRSENLTdNAKTIIVHL(N279D) was observed at all sampling time points in Cw0602⁺ (which is a restricting HLA for OLP325) subject 133-M and her Cw0602⁺ child, 133-C. It was sometimes observed as a covariant with A281V, A281I, A281T, or K282R.

Variant ID.	`4327`
Epitope Seq.	`IRSENLTNNAKTIIVHL`
Variant Seq.	`IRSENLTNNvKTIIVHL`
Mutations	A/V
Epitope Location	A10V
HXB2 Location	A281V
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	IRSENLTNNvKTIIVHL(A281V) was observed in Cw*0602⁺ (which is a restricting HLA for OLP325) subject 133-M 7 years after the birth of her child. It was observed as a covariant with N279D.

Variant ID.	`4328`
Epitope Seq.	`IRSENLTNNAKTIIVHL`
Variant Seq.	`IRSENLTNNiKTIIVHL`
Mutations	A/I
Epitope Location	A10I
HXB2 Location	A281I
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	IRSENLTNNiKTIIVHL (A281I) was observed at all sampling time points in Cw0602⁺ (which is a restricting HLA for OLP325) subject 133-M and her Cw0602⁺ child, 133-C. It was often observed as a covariant with N279D.

Variant ID.	`4329`
Epitope Seq.	`IRSENLTNNAKTIIVHL`
Variant Seq.	`IRtENLTNNAKTIIVHL`
Mutations	S/T
Epitope Location	S3T
HXB2 Location	S274T
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	IRtENLTNNAKTIIVHL (S274T) was observed in Cw*0602⁺ (which is a restricting HLA for OLP325) subject 133-M 7 years after the birth of her child, 133-C. It was observed as a covariant with A281I.

Variant ID.	`4330`
Epitope Seq.	`IRSENLTNNAKTIIVHL`
Variant Seq.	`IRSENLTNNtKTIIVHL`
Mutations	A/T
Epitope Location	A10T
HXB2 Location	A281T
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	IRSENLTNNtKTIIVHL (A281T) was observed in Cw*0602⁺ (which is a restricting HLA for OLP325) subject 133-C beginning when they were 0.3 years old. It was always observed as a covariant with N279D and sometimes also observed with K282R.

Variant ID.	`4331`
Epitope Seq.	`IRSENLTNNAKTIIVHL`
Variant Seq.	`IRSENLTNNArTIIVHL`
Mutations	K/R
Epitope Location	K11R
HXB2 Location	K282R
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	IRSENLTNNtKTIIVHL (K282R) was observed in Cw*0602⁺ (which is a restricting HLA for OLP325) subject 133-C when they were 2.7 years old. It was observed as a covariant with both N279D and A281T.

References

Displaying record number 62225

HXB2 Location gp160(298-307) gp160 Epitope Map
View variants at this location

Epitope

RPNNNTRKSI

Epitope Alignment

Variants

`RPNNNTRrSI`		observed variant
`RPNNNTRKSt`		observed variant
`RPNNNTRKSv`		observed variant
`RPsNNTRKSI`		observed variant
`RPgNNTRKSI`		observed variant
`RtNNNTRKSI`		observed variant
`RPNNNTRKSm`		observed variant

Epitope Name Env-RI10

Species (MHC/HLA) human(B*42)

Variant Details

Showing all: 7 variant(s).

Variant ID.	`4265`
Epitope Seq.	`RPNNNTRKSI`
Variant Seq.	`RPNNNTRrSI`
Mutations	K/R
Epitope Location	K8R
HXB2 Location	K305R
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RPNNNTRrSI (K305R) was observed in B42⁺ (which is a restricting HLA for RI10) subject 517-M and her B42⁺ child, 517-C. In both subjects, this variant was present at the first sampling time point. It was sometimes seen as a covariant with P299T, N300G, I307T, or I307M.

Variant ID.	`4266`
Epitope Seq.	`RPNNNTRKSI`
Variant Seq.	`RPNNNTRKSt`
Mutations	I/T
Epitope Location	I10T
HXB2 Location	I307T
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RPNNNTRKSt (I307T) was observed to arise in both B42⁺ (which is a restricting HLA for RI10) subject 517-M and her B42⁺ child, 517-C. In 517-M, it was first observed when her child was 6 years old. In 517-C, it arose between 5 and 8.5yrs and was seen as a covariant with K305R and N300G.

Variant ID.	`4267`
Epitope Seq.	`RPNNNTRKSI`
Variant Seq.	`RPNNNTRKSv`
Mutations	I/V
Epitope Location	I10V
HXB2 Location	I307V
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RPNNNTRKSv (I307V) was observed to arise in B*42⁺ (which is a restricting HLA for RI10) subject 517-M between 0.25 and 6 years after the birth of her child. It was sometimes seen as a covariant with N300S.

Variant ID.	`4268`
Epitope Seq.	`RPNNNTRKSI`
Variant Seq.	`RPsNNTRKSI`
Mutations	N/S
Epitope Location	N3S
HXB2 Location	N300S
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RPsNNTRKSI (N300S) was observed in B42⁺ (which is a restricting HLA for RI10) subject 517-M and her B42⁺ child, 517-C. It was first observed in 517-M when her child was aged 6 and in 517-C at age 2.5. It was sometimes seen as a covariant with I307T or K305R.

Variant ID.	`4269`
Epitope Seq.	`RPNNNTRKSI`
Variant Seq.	`RPgNNTRKSI`
Mutations	N/G
Epitope Location	N3G
HXB2 Location	N300G
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RPgNNTRKSI (N300G) was observed in B42⁺ (which is a restricting HLA for RI10) subject 517-C. While it was observed at the first sampling time point (0.2yr) in subject 517-C, it was never observed in the B42⁺ mother, 517-M. It was sometimes seen as a covariant with P299T, I307M, I307T, or K305R.

Variant ID.	`4270`
Epitope Seq.	`RPNNNTRKSI`
Variant Seq.	`RtNNNTRKSI`
Mutations	P/T
Epitope Location	P2T
HXB2 Location	P299T
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RtNNNTRKSI (P299T) was observed in B42⁺ (which is a restricting HLA for RI10) subject 517-C. While it was observed at the first sampling time point (0.2yr) in subject 517-C, it was never observed in the B42⁺ mother, 517-M. It was observed as a covariant with both N300G and K305R.

Variant ID.	`4271`
Epitope Seq.	`RPNNNTRKSI`
Variant Seq.	`RPNNNTRKSm`
Mutations	I/M
Epitope Location	I10M
HXB2 Location	I307M
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RPNNNTRKSm (I307M) was observed to arise in B*42⁺ (which is a restricting HLA for RI10) subject 517-C between 2.5 and 5 years. It was observed as a covariant with both N300G and K305R.

References

Displaying record number 62237

HXB2 Location gp160(614-631) gp160 Epitope Map
View variants at this location

Epitope

WSNKSQEDIWDNMTWMQW

Epitope Alignment

Variants

`WnNKSQEDIWDNMTWMQW`		observed variant
`WSNKSQtDIWDNMTWMQW`		observed variant
`WSNKSQEDIWnNMTWMQW`		observed variant
`WSNKSQEeIWDNMTWMQW`		observed variant
`WSNKShEDIWDNMTWMQW`		observed variant
`WSNKSQsDIWDNMTWMQW`		observed variant
`WSNKSkEDIWDNMTWMQW`		observed variant
`WSNKSyEDIWDNMTWMQW`		observed variant

Epitope Name Env-OLP371

Species (MHC/HLA) human(C*04)

Variant Details

Showing all: 8 variant(s).

Variant ID.	`4318`
Epitope Seq.	`WSNKSQEDIWDNMTWMQW`
Variant Seq.	`WnNKSQEDIWDNMTWMQW`
Mutations	S/N
Epitope Location	S2N
HXB2 Location	S615N
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	WnNKSQEDIWDNMTWMQW (S615N) was observed in Cw*04^- (which is a restricting HLA for OLP371) subject 133-M 7 years after the birth of her child, 133-C. It was observed as a covariant with E620T and D624N.

Variant ID.	`4319`
Epitope Seq.	`WSNKSQEDIWDNMTWMQW`
Variant Seq.	`WSNKSQtDIWDNMTWMQW`
Mutations	E/T
Epitope Location	E7T
HXB2 Location	E620T
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	WSNKSQtDIWDNMTWMQW (E620T) was observed in Cw04^- (which is a restricting HLA for OLP371) subject 133-M 7 years after the birth of her child. It was also seen in her Cw04⁺ child, 133-C, at all sampling time points. It was sometimes observed as a covariant with S615N, Q619H, Q619Y, D621E, or D624N.

Variant ID.	`4320`
Epitope Seq.	`WSNKSQEDIWDNMTWMQW`
Variant Seq.	`WSNKSQEDIWnNMTWMQW`
Mutations	D/N
Epitope Location	D11N
HXB2 Location	D624N
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	WSNKSQEDIWnNMTWMQW(D624N) was observed in Cw*04^- (which is a restricting HLA for OLP371) subject 133-M 7 years after the birth of her child. It was observed as a covariant with S615N and E620T.

Variant ID.	`4321`
Epitope Seq.	`WSNKSQEDIWDNMTWMQW`
Variant Seq.	`WSNKSQEeIWDNMTWMQW`
Mutations	D/E
Epitope Location	D8E
HXB2 Location	D621E
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	WSNKSQEeIWDNMTWMQW(D621E) arose in Cw*04⁺ (which is a restricting HLA for OLP371) subject 133-C between 0.3 and 2.7 years. It was observed as a covariant with E620T.

Variant ID.	`4322`
Epitope Seq.	`WSNKSQEDIWDNMTWMQW`
Variant Seq.	`WSNKShEDIWDNMTWMQW`
Mutations	Q/H
Epitope Location	Q6H
HXB2 Location	Q619H
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	WSNKShEDIWDNMTWMQW(Q619H) was observed in Cw*04⁺ (which is a restricting HLA for OLP371) subject 133-C at 4.9 years. It was observed as a covariant with E620T.

Variant ID.	`4323`
Epitope Seq.	`WSNKSQEDIWDNMTWMQW`
Variant Seq.	`WSNKSQsDIWDNMTWMQW`
Mutations	E/S
Epitope Location	E7S
HXB2 Location	E620S
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	WSNKShEDIWDNMTWMQW(E620S) was observed in Cw*04⁺ (which is a restricting HLA for OLP371) subject 133-C at 4.9 years. It was observed as a covariant with Q619K.

Variant ID.	`4324`
Epitope Seq.	`WSNKSQEDIWDNMTWMQW`
Variant Seq.	`WSNKSkEDIWDNMTWMQW`
Mutations	Q/K
Epitope Location	Q6K
HXB2 Location	Q619K
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	WSNKSkEDIWDNMTWMQW(Q619K) was observed in Cw*04⁺ (which is a restricting HLA for OLP371) subject 133-C at 4.9 years. It was observed as a covariant with E620S.

Variant ID.	`4325`
Epitope Seq.	`WSNKSQEDIWDNMTWMQW`
Variant Seq.	`WSNKSyEDIWDNMTWMQW`
Mutations	Q/Y
Epitope Location	Q6Y
HXB2 Location	Q619Y
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	WSNKSyEDIWDNMTWMQW(Q619Y) was observed in Cw*04⁺ (which is a restricting HLA for OLP371) subject 133-C at 7.7 years. It was observed as a covariant with E620T.

References

Displaying record number 62223

HXB2 Location gp160(704-712) gp160 Epitope Map
View variants at this location

Epitope

IVNRVRQGY

Epitope Alignment

Variants

`vVNRVRQGY`		observed variant
`IVrRVRQGY`		observed variant
`IVsRVRQGY`		observed variant
`IVNkVRQGY`		observed variant

Epitope Name Env-IY9

Species (MHC/HLA) human(A*30)

Variant Details

Showing all: 4 variant(s).

Variant ID.	`4259`
Epitope Seq.	`IVNRVRQGY`
Variant Seq.	`vVNRVRQGY`
Mutations	I/V
Epitope Location	I1V
HXB2 Location	I704V
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	vVNRVRQGY (I704V) was observed in A30⁺ (which is a restricting HLA for IY9) subject 517-M 0.24 years after the birth of her A30⁺ child, 517-C. While it was not initially observed in 517-C, it was seen in later samples from 2.5 yrs on. It was often observed as a covariant with N706R and sometimes with N706S or R707K.

Variant ID.	`4260`
Epitope Seq.	`IVNRVRQGY`
Variant Seq.	`IVrRVRQGY`
Mutations	N/R
Epitope Location	N3R
HXB2 Location	N706R
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	IVrRVRQGY (N706R) was observed in A30⁺ (which is a restricting HLA for IY9) subject 517-M 0.24 years after the birth of her A30⁺ child, 517-C. While it was not initially observed in 517-C, it was seen in later samples from 2.5 yrs on. It was often observed as a covariant with I704V and sometimes also with R707K.

Variant ID.	`4261`
Epitope Seq.	`IVNRVRQGY`
Variant Seq.	`IVsRVRQGY`
Mutations	N/S
Epitope Location	N3S
HXB2 Location	N706S
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	IVsRVRQGY (N706S) was observed in A30⁺ (which is a restricting HLA for IY9) subject 517-M 0.25 years after the birth of her A30⁺ child, 517-C. It was sometimes observed as a covariant with I704V.

Variant ID.	`4262`
Epitope Seq.	`IVNRVRQGY`
Variant Seq.	`IVNkVRQGY`
Mutations	R/K
Epitope Location	R4K
HXB2 Location	R707K
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	IVNkVRQGY (R707K) was observed in A30⁺ (which is a restricting HLA for IY9) subject 517-M 6 years after the birth of her A30⁺ child, 517-C. Some samples from 517-C also contained this variant. It was observed as a covariant with both I704V and N706R.

References

Displaying record number 62224

HXB2 Location gp160(794-802) gp160 Epitope Map
View variants at this location

Epitope

KYLGSLVQY

Epitope Alignment

Variants

`KYLGnLVQY`		observed variant
`KYLGSLVlY`		observed variant

Epitope Name Env-KY9

Species (MHC/HLA) human(A*30)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`4263`
Epitope Seq.	`KYLGSLVQY`
Variant Seq.	`KYLGnLVQY`
Mutations	S/N
Epitope Location	S5N
HXB2 Location	S798N
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	KYLGnLVQY (S798N) was observed in A30⁺ (which is a restricting HLA for KY9) subject 517-C beginning at the first sampling time point (age 0.2yrs). However it was not observed in 517-C’s A30⁺ mother, 517-M.

Variant ID.	`4264`
Epitope Seq.	`KYLGSLVQY`
Variant Seq.	`KYLGSLVlY`
Mutations	Q/L
Epitope Location	Q8L
HXB2 Location	Q801L
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	KYLGSLVlY (Q801L) was observed in A30⁺ (which is a restricting HLA for KY9) subject 517-C at the first sampling time point (age 0.2yrs). However it was not observed in 517-C’s A30⁺ mother, 517-M.

References

Displaying record number 62226

HXB2 Location gp160(843-851) gp160 Epitope Map
View variants at this location

Epitope

IPRRIRQGF

Epitope Alignment

Variants

`lPRRIRQGF`		observed variant
`IPRRvRQGF`		observed variant
`IPRRlRQGF`		observed variant
`IPRRfRQGF`		observed variant
`IPtRIRQGF`		observed variant

Epitope Name Env-IF9

Species (MHC/HLA) human(B*42)

Variant Details

Showing all: 5 variant(s).

Variant ID.	`4272`
Epitope Seq.	`IPRRIRQGF`
Variant Seq.	`lPRRIRQGF`
Mutations	I/L
Epitope Location	I1L
HXB2 Location	I843L
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	lPRRIRQGF (I843L) was observed in B42⁺ (which is a restricting HLA for IF9) subject 517-M and her B42⁺ child, 517-C. It was sometimes observed as a covariant with I847V, I847L, I847F, or R845T.

Variant ID.	`4273`
Epitope Seq.	`IPRRIRQGF`
Variant Seq.	`IPRRvRQGF`
Mutations	I/V
Epitope Location	I5V
HXB2 Location	I847V
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	IPRRvRQGF (I847V) was observed in B42⁺ (which is a restricting HLA for IF9) subject 517-M and her B42⁺ child, 517-C. While it was not observed in 517-C at the first sampling time point, it appeared in later samples. This variant was always observed as a covariant with I843L.

Variant ID.	`4274`
Epitope Seq.	`IPRRIRQGF`
Variant Seq.	`IPRRlRQGF`
Mutations	I/L
Epitope Location	I5L
HXB2 Location	I847L
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	IPRRlRQGF (I847L) was observed in B42⁺ (which is a restricting HLA for IF9) subject 517-M when her child was 6. While it was not observed in her B42⁺ child, 517-C, at the first sampling time point, it appeared in later samples. This variant was always observed as a covariant with I843L.

Variant ID.	`4275`
Epitope Seq.	`IPRRIRQGF`
Variant Seq.	`IPRRfRQGF`
Mutations	I/F
Epitope Location	I5F
HXB2 Location	I847F
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	IPRRfRQGF (I847F) was observed in B42⁺ (which is a restricting HLA for IF9) subject 517-M when her child was 6. While it was not observed in her B42⁺ child, 517-C, at the first sampling time point, it appeared in later samples. This variant was always observed as a covariant with I843L.

Variant ID.	`4276`
Epitope Seq.	`IPRRIRQGF`
Variant Seq.	`IPtRIRQGF`
Mutations	R/T
Epitope Location	R3T
HXB2 Location	R845T
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	IPtRIRQGF (R845T) arose in B*42⁺ (which is a restricting HLA for IF9) subject 517-C between 5 and 8.5 years. This variant was always observed as a covariant with I843L.

References

Displaying record number 62218

HXB2 Location Nef(71-79) Nef Epitope Map
View variants at this location

Epitope

RPQVPLRPM

Epitope Alignment

Variants

`RPQVPvRPM`		literature escape
`RPQaPLRPM`		observed variant
`kPQVPLRPM`		observed variant
`RPQVPiRPM`		literature escape
`RPQVPtRPM`		literature escape

Epitope Name Nef-RM9

Species (MHC/HLA) human(B*81:01)

Variant Details

Showing all: 5 variant(s).

Variant ID.	`4243`
Epitope Seq.	`RPQVPLRPM`
Variant Seq.	`RPQVPvRPM`
Mutations	L/V
Epitope Location	L6V
HXB2 Location	L76V
Mutation Type	LE: literature escape
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RPQVPvRPM (L76X) is a known escape variant. It was observed in the B81⁺ (which is the restricting HLA for RM9) child, 133-C, at 0.3yr. The only available data from the B81^- mother, 133-M, shows no L76X variant present in 133-M when her child was of age 7yr. In 133-C, the L76V mutation was sometimes observed as a co-variant with the R71K mutation.

Variant ID.	`4244`
Epitope Seq.	`RPQVPLRPM`
Variant Seq.	`RPQaPLRPM`
Mutations	V/A
Epitope Location	V4A
HXB2 Location	V74A
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RPQaPLRPM was observed in the B*81⁺ (which is the restricting HLA for RM9) child, 133-C, at 0.3yr.

Variant ID.	`4245`
Epitope Seq.	`RPQVPLRPM`
Variant Seq.	`kPQVPLRPM`
Mutations	R/K
Epitope Location	R1K
HXB2 Location	R71K
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	kPQVPLRPM was observed in the B*81⁺ (which is the restricting HLA for RM9) child, 133-C, at 0.3yr. The R71K mutation was sometimes observed as a co-variant with the L76V mutation.

Variant ID.	`4246`
Epitope Seq.	`RPQVPLRPM`
Variant Seq.	`RPQVPiRPM`
Mutations	L/I
Epitope Location	L6I
HXB2 Location	L76I
Mutation Type	LE: literature escape
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RPQVPiRPM (L76X) is a known escape variant. It arose in the B*81⁺ (which is the restricting HLA for RM9) child, 133-C, between 0.3 and 2.7yr.

Variant ID.	`4247`
Epitope Seq.	`RPQVPLRPM`
Variant Seq.	`RPQVPtRPM`
Mutations	L/T
Epitope Location	L6T
HXB2 Location	L76T
Mutation Type	LE: literature escape
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RPQVPtRPM (L76X) is a known escape variant. It arose in the B*81⁺ (which is the restricting HLA for RM9) child, 133-C, between 2.7 and 4.9yr.