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Found 11 matching records:

Displaying record number 53748

HXB2 Location Gag(20-29) Gag Epitope Map
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Epitope

RLRPGGKKKY

Epitope Alignment

Variants

RLRPGGrKKY susceptible form

Epitope Name RY10

Species (MHC/HLA) human(B62)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`752`
Epitope Seq.	`RLRPGGKKKY`
Variant Seq.	`RLRPGGrKKY`
Mutations	K/R
Epitope Location	K7R
HXB2 Location	K26R
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Chromium-release assay
Note	Variant was detected over a 5 year time period in a patient. The variant was better recognized than the wt epitope by patient CTLs.

References

Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.

Displaying record number 53755

HXB2 Location Gag(77-85) Gag Epitope Map
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Epitope

SLYNTVATL

Epitope Alignment

Variants

`SLfNTiATL`		escape documented in this paper
`SLfNTiAaL`		observed variant
`SLfNTVAvL`		escape documented in this paper
`SLfsTVAvL`		observed variant
`SLfNTVAvp`		observed variant
`SLfNTiAvL`		observed variant

Epitope Name SL9

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 6 variant(s).

Variant ID.	`753`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTiATL`
Mutations	Y/F V/I
Epitope Location	Y3F V6I
HXB2 Location	Y79F V82I
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, Chromium-release assay
Note	Variant was found in the beginning and at the end of a 7 year period in a patient. It was not recognized by patient CTLs.

Variant ID.	`754`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTiAaL`
Mutations	Y/F V/I T/A
Epitope Location	Y3F V6I T8A
HXB2 Location	Y79F V82I T84A
Mutation Type	OV: observed variant
Note	Variant was found in 1/22 clones at the beginning of a 7 year period in a patient.

Variant ID.	`755`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTVAvL`
Mutations	Y/F T/V
Epitope Location	Y3F T8V
HXB2 Location	Y79F T84V
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, Chromium-release assay
Note	Variant dominated in the middle of a 7 year period in a patient. It was not recognized by patient CTLs.

Variant ID.	`756`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfsTVAvL`
Mutations	Y/F N/S T/V
Epitope Location	Y3F N4S T8V
HXB2 Location	Y79F N80S T84V
Mutation Type	OV: observed variant
Note	Variant was found in 1/28 clones at the middle of a 7 year period in a patient.

Variant ID.	`757`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTVAvp`
Mutations	Y/F T/V L/P
Epitope Location	Y3F T8V L9P
HXB2 Location	Y79F T84V L85P
Mutation Type	OV: observed variant
Note	Variant was found in 1/28 clones at the middle of a 7 year period in a patient.

Variant ID.	`758`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTiAvL`
Mutations	Y/F V/I T/V
Epitope Location	Y3F V6I T8V
HXB2 Location	Y79F V82I T84V
Mutation Type	OV: observed variant
Note	Variant was found at the end of a 7 year period in a patient.

References

Displaying record number 53749

HXB2 Location Gag(260-267) Gag Epitope Map
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Epitope

EIYKRWII

Epitope Alignment

Variants

dIYKRWII susceptible form

Epitope Name EI8

Species (MHC/HLA) human(B8)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`759`
Epitope Seq.	`EIYKRWII`
Variant Seq.	`dIYKRWII`
Mutations	E/D
Epitope Location	E1D
HXB2 Location	E260D
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Chromium-release assay
Note	This variant was the only form of the epitope detected over a 5 year time period in a patient. The variant was equally well recognized by patient CTLs as the wt consensus B epitope.

References

Displaying record number 53758

HXB2 Location Gag(275-282) Gag Epitope Map
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Epitope

RMYSPTSI

Epitope Alignment

Variants

`RMYSPvSI`		diminished response
`RMYSPvgI`		observed variant
`RMYSPvSt`		observed variant
`RMYSPsSI`		observed variant
`RvYSPTSI`		observed variant

Epitope Name RI8

Species (MHC/HLA) human(B52)

Variant Details

Showing all: 5 variant(s).

Variant ID.	`760`
Epitope Seq.	`RMYSPTSI`
Variant Seq.	`RMYSPvSI`
Mutations	T/V
Epitope Location	T6V
HXB2 Location	T280V
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy, Chromium-release assay
Note	Variant dominated in the beginning of a 7 year period in a patient and reverted to wt later on. The variant was less well recognized by patient CTLs compared to the wt form.

Variant ID.	`761`
Epitope Seq.	`RMYSPTSI`
Variant Seq.	`RMYSPvgI`
Mutations	T/V S/G
Epitope Location	T6V S7G
HXB2 Location	T280V S281G
Mutation Type	OV: observed variant
Note	Variant was found in 1/8 clones at the beginning of a 7 year period in a patient.

Variant ID.	`762`
Epitope Seq.	`RMYSPTSI`
Variant Seq.	`RMYSPvSt`
Mutations	T/V I/T
Epitope Location	T6V I8T
HXB2 Location	T280V I282T
Mutation Type	OV: observed variant
Note	Variant was found in 1/15 clones at the middle of a 7 year period in a patient.

Variant ID.	`763`
Epitope Seq.	`RMYSPTSI`
Variant Seq.	`RMYSPsSI`
Mutations	T/S
Epitope Location	T6S
HXB2 Location	T280S
Mutation Type	OV: observed variant
Note	Variant was found in 3/15 clones at the middle of a 7 year period in a patient.

Variant ID.	`764`
Epitope Seq.	`RMYSPTSI`
Variant Seq.	`RvYSPTSI`
Mutations	M/V
Epitope Location	M2V
HXB2 Location	M276V
Mutation Type	OV: observed variant
Note	Variant was found in 1/13 clones at the middle of a 7 year period in a patient.

References

Displaying record number 53759

HXB2 Location Gag(298-306) Gag Epitope Map
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Epitope

DRFYKTLRA

Epitope Alignment

Variants

`DRFYrTLRA`		diminished response
`DRFYrTpRA`		observed variant
`kRFYKTLRA`		observed variant
`DRFcKTLRA`		observed variant
`DRFYKTLgA`		observed variant

Epitope Name DA9

Species (MHC/HLA) human(B14)

Variant Details

Showing all: 5 variant(s).

Variant ID.	`765`
Epitope Seq.	`DRFYKTLRA`
Variant Seq.	`DRFYrTLRA`
Mutations	K/R
Epitope Location	K5R
HXB2 Location	K302R
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy, Chromium-release assay
Note	Variant dominated in the beginning of a 7 year period in a patient and reverted to wt later on. The variant was less well recognized by patient CTLs compared to the wt form.

Variant ID.	`766`
Epitope Seq.	`DRFYKTLRA`
Variant Seq.	`DRFYrTpRA`
Mutations	K/R L/P
Epitope Location	K5R L7P
HXB2 Location	K302R L304P
Mutation Type	OV: observed variant
Note	Variant was found in 2/8 clones at the beginning of a 7 year period in a patient.

Variant ID.	`767`
Epitope Seq.	`DRFYKTLRA`
Variant Seq.	`kRFYKTLRA`
Mutations	D/K
Epitope Location	D1K
HXB2 Location	D298K
Mutation Type	OV: observed variant
Note	Variant was found in 1/13 clones at the middle of a 7 year period in a patient.

Variant ID.	`768`
Epitope Seq.	`DRFYKTLRA`
Variant Seq.	`DRFcKTLRA`
Mutations	Y/C
Epitope Location	Y4C
HXB2 Location	Y301C
Mutation Type	OV: observed variant
Note	Variant was found in 5/13 clones at the middle of a 7 year period in a patient.

Variant ID.	`769`
Epitope Seq.	`DRFYKTLRA`
Variant Seq.	`DRFYKTLgA`
Mutations	R/G
Epitope Location	R8G
HXB2 Location	R305G
Mutation Type	OV: observed variant
Note	Variant was found in 1/13 clones at the middle of a 7 year period in a patient.

References

Displaying record number 53756

HXB2 Location Gag(305-313) Gag Epitope Map
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Epitope

RAEQASQEV

Epitope Alignment

Variants

`RAEQAtQEV`		diminished response
`RAEQASQdV`		escape documented in this paper
`RAEQAtQdV`		observed variant
`RAEQAShdV`		observed variant
`RAErAtQEV`		observed variant
`gAEQASQdV`		observed variant
`RAEhASQdV`		observed variant
`RAEQAlQdV`		observed variant

Epitope Name RV9

Species (MHC/HLA) human(Cw8)

Variant Details

Showing all: 8 variant(s).

Variant ID.	`770`
Epitope Seq.	`RAEQASQEV`
Variant Seq.	`RAEQAtQEV`
Mutations	S/T
Epitope Location	S6T
HXB2 Location	S310T
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy, Chromium-release assay
Note	Variant dominated in the middle of a 7 year period in a patient. The variant was less well recognized by patient CTLs compared to the wt form.

Variant ID.	`771`
Epitope Seq.	`RAEQASQEV`
Variant Seq.	`RAEQASQdV`
Mutations	E/D
Epitope Location	E8D
HXB2 Location	E312D
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, Chromium-release assay
Note	Variant dominated in the beginning of a 7 year period in a patient. The variant was not recognized by patient CTLs.

Variant ID.	`772`
Epitope Seq.	`RAEQASQEV`
Variant Seq.	`RAEQAtQdV`
Mutations	S/T E/D
Epitope Location	S6T E8D
HXB2 Location	S310T E312D
Mutation Type	OV: observed variant
Note	Variant was found at the middle of a 7 year period in a patient.

Variant ID.	`773`
Epitope Seq.	`RAEQASQEV`
Variant Seq.	`RAEQAShdV`
Mutations	Q/H E/D
Epitope Location	Q7H E8D
HXB2 Location	Q311H E312D
Mutation Type	OV: observed variant
Note	Variant was found in 1/15 clones at the middle of a 7 year period in a patient.

Variant ID.	`774`
Epitope Seq.	`RAEQASQEV`
Variant Seq.	`RAErAtQEV`
Mutations	Q/R S/T
Epitope Location	Q4R S6T
HXB2 Location	Q308R S310T
Mutation Type	OV: observed variant
Note	Variant was found in 2/16 clones at the middle of a 7 year period in a patient.

Variant ID.	`775`
Epitope Seq.	`RAEQASQEV`
Variant Seq.	`gAEQASQdV`
Mutations	R/G E/D
Epitope Location	R1G E8D
HXB2 Location	R305G E312D
Mutation Type	OV: observed variant
Note	Variant was found in 1/13 clones at the middle of a 7 year period in a patient.

Variant ID.	`776`
Epitope Seq.	`RAEQASQEV`
Variant Seq.	`RAEhASQdV`
Mutations	Q/H E/D
Epitope Location	Q4H E8D
HXB2 Location	Q308H E312D
Mutation Type	OV: observed variant
Note	Variant was found in 1/13 clones at the middle of a 7 year period in a patient.

Variant ID.	`777`
Epitope Seq.	`RAEQASQEV`
Variant Seq.	`RAEQAlQdV`
Mutations	S/L E/D
Epitope Location	S6L E8D
HXB2 Location	S310L E312D
Mutation Type	OV: observed variant
Note	Variant was found in 1/13 clones at the end of a 7 year period in a patient.

References

Displaying record number 53751

HXB2 Location Pol(173-181) Pol Epitope Map
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Epitope

GPKVKQWPL

Epitope Alignment

Variants

`GPrVKQWPL`		susceptible form
`GPrVKQgPL`		observed variant

Epitope Name GL9

Species (MHC/HLA) human(B8)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`778`
Epitope Seq.	`GPKVKQWPL`
Variant Seq.	`GPrVKQWPL`
Mutations	K/R
Epitope Location	K3R
HXB2 Location	K175R
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Chromium-release assay
Note	Variant persisted throughout a 5-year period in a patient. The variant was equally well recognized by patient CTLs as the wt form.

Variant ID.	`779`
Epitope Seq.	`GPKVKQWPL`
Variant Seq.	`GPrVKQgPL`
Mutations	K/R W/G
Epitope Location	K3R W7G
HXB2 Location	K175R W179G
Mutation Type	OV: observed variant
Note	Variant was found in 1/8 clones at the end of a 5 year period in a patient.

References

Displaying record number 53752

HXB2 Location Pol(313-321) Pol Epitope Map
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Epitope

AIFQSSMTK

Epitope Alignment

Variants

`AIFQSSMTr`		escape documented in this paper
`tIFQSSMTr`		observed variant
`AIFQSSMar`		observed variant

Epitope Name AK9

Species (MHC/HLA) human(A11)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`780`
Epitope Seq.	`AIFQSSMTK`
Variant Seq.	`AIFQSSMTr`
Mutations	K/R
Epitope Location	K9R
HXB2 Location	K321R
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, Chromium-release assay
Note	Variant persisted throughout a 5-year period in a patient. The variant was not recognized by patient CTLs.

Variant ID.	`781`
Epitope Seq.	`AIFQSSMTK`
Variant Seq.	`tIFQSSMTr`
Mutations	A/T K/R
Epitope Location	A1T K9R
HXB2 Location	A313T K321R
Mutation Type	OV: observed variant
Note	Variant was found in 1/15 clones at the end of a 5 year period in a patient.

Variant ID.	`782`
Epitope Seq.	`AIFQSSMTK`
Variant Seq.	`AIFQSSMar`
Mutations	T/A K/R
Epitope Location	T8A K9R
HXB2 Location	T320A K321R
Mutation Type	OV: observed variant
Note	Variant was found in 1/15 clones at the end of a 5 year period in a patient.

References

Displaying record number 53753

HXB2 Location Pol(415-426) Pol Epitope Map
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Epitope

LVGKLNWASQIY

Epitope Alignment

Variants

LVGKLNWASQIh observed variant

Epitope Name LY12

Species (MHC/HLA) human(B62)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`783`
Epitope Seq.	`LVGKLNWASQIY`
Variant Seq.	`LVGKLNWASQIh`
Mutations	Y/H
Epitope Location	Y12H
HXB2 Location	Y426H
Mutation Type	OV: observed variant
Note	Variant was found in 1/6 clones at the beginning of a 5 year period in a patient.

References

Displaying record number 53761

HXB2 Location gp160(584-592) gp160 Epitope Map
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Epitope

ERYLKDQQL

Epitope Alignment

Variants

ERYLqDQQL diminished response

Epitope Name EL9

Species (MHC/HLA) human(B14)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`784`
Epitope Seq.	`ERYLKDQQL`
Variant Seq.	`ERYLqDQQL`
Mutations	K/Q
Epitope Location	K5Q
HXB2 Location	K588Q
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy, Chromium-release assay
Note	This variant was the only form of the epitope detected over a 6-year period in a patient. The variant was much less well recognized by patient CTLs compared to the wt form.

References

Displaying record number 53754

HXB2 Location gp160(586-593) gp160 Epitope Map
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Epitope

YLKDQQLL

Epitope Alignment

Variants

`YLrDQQLL`		observed variant
`YLKgQQLL`		observed variant

Epitope Name YL8

Species (MHC/HLA) human(B8)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`785`
Epitope Seq.	`YLKDQQLL`
Variant Seq.	`YLrDQQLL`
Mutations	K/R
Epitope Location	K3R
HXB2 Location	K588R
Mutation Type	OV: observed variant
Note	Variant was found in 1/9 clones at the beginning of a 5 year period in a patient.

Variant ID.	`786`
Epitope Seq.	`YLKDQQLL`
Variant Seq.	`YLKgQQLL`
Mutations	D/G
Epitope Location	D4G
HXB2 Location	D589G
Mutation Type	OV: observed variant
Note	Variant was found in 1/8 clones at the end of a 5 year period in a patient.