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Found 9 matching records:

Displaying record number 57959

HXB2 Location Gag(77-85) Gag Epitope Map
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Epitope

SLYNTVVTL

Epitope Alignment

Variants

SLYNTVaTL susceptible form

Epitope Name SL9

Species (MHC/HLA) human(A*02:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`2690`
Epitope Seq.	`SLYNTVVTL`
Variant Seq.	`SLYNTVaTL`
Mutations	V/A
Epitope Location	V7A
HXB2 Location	V83A
Mutation Type	SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	SLYNTVVTL underwent adaptation to neo-epitope SLYNTVaTL. 4 subjects had higher EliSpot responses to the neo-epitope than to the non-adapted form.

References

Keane2012 Niamh M. Keane, Steven G. Roberts, Coral-Ann M. Almeida, Tanya Krishnan, Abha Chopra, Emma Demaine, Rebecca Laird, Monika Tschochner, Jonathan M. Carlson, Simon Mallal, David Heckerman, Ian James, and Mina John. High-Avidity, High-IFN-gamma-Producing CD8 T-Cell Responses following Immune Selection during HIV-1 Infection. Immunol. Cell Biol., 90(2):224-234, Feb 2012. PubMed ID: 21577229. Show all entries for this paper.

Displaying record number 57960

HXB2 Location Gag(355-363) Gag Epitope Map
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Epitope

GPSHKARVL

Epitope Alignment

Variants

GPgHKARVL susceptible form

Epitope Name GL9

Species (MHC/HLA) human(B*07:02)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`2691`
Epitope Seq.	`GPSHKARVL`
Variant Seq.	`GPgHKARVL`
Mutations	S/G
Epitope Location	S3G
HXB2 Location	S357G
Mutation Type	SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	GPSHKARVL underwent adaptation to neo-epitope GPgHKARVL. 5 subjects had higher EliSpot responses to the neo-epitope than to the non-adapted form.

References

Displaying record number 57957

HXB2 Location Pol(724-734) Pol Epitope Map
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Epitope

QEEHERYHSNW

Epitope Alignment

Variants

QEEHEkYHSNW susceptible form

Epitope Name QW11

Species (MHC/HLA) human(B*44:02)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`2688`
Epitope Seq.	`QEEHERYHSNW`
Variant Seq.	`QEEHEkYHSNW`
Mutations	R/K
Epitope Location	R6K
HXB2 Location	R729K
Mutation Type	SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	QEEHERYHSNW underwent adaptation to neo-epitope QEEHEkYHSNW. 2 subjects had higher EliSpot responses to the neo-epitope than to the non-adapted form.

References

Displaying record number 57955

HXB2 Location Pol(838-847) Pol Epitope Map
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Epitope

STTVKAACWW

Epitope Alignment

Variants

`STaVKAACWW`		escape documented in this paper; literature escape
`SnTVKAACWW`		escape documented in this paper; literature escape

Epitope Name SW10

Species (MHC/HLA) human(B*57:01)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`2685`
Epitope Seq.	`STTVKAACWW`
Variant Seq.	`STaVKAACWW`
Mutations	T/A
Epitope Location	T3A
HXB2 Location	T840A
Mutation Type	E: escape documented in this paper LE: literature escape
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	STTVKAACWW underwent classical escape, with adapted forms STaVKAACWW and SnTVKAACWW having abrogated EliSpot responses.

Variant ID.	`2686`
Epitope Seq.	`STTVKAACWW`
Variant Seq.	`SnTVKAACWW`
Mutations	T/N
Epitope Location	T2N
HXB2 Location	T839N
Mutation Type	E: escape documented in this paper LE: literature escape
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	STTVKAACWW underwent classical escape, with adapted forms STaVKAACWW and SnTVKAACWW having abrogated EliSpot responses.

References

Displaying record number 57962

HXB2 Location Vpr(59-67) Vpr Epitope Map
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Epitope

ALIRILQQL

Epitope Alignment

Variants

AiIRILQQL susceptible form

Epitope Name AL9

Species (MHC/HLA) human(A*02:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`2693`
Epitope Seq.	`ALIRILQQL`
Variant Seq.	`AiIRILQQL`
Mutations	L/I
Epitope Location	L2I
HXB2 Location	L60I
Mutation Type	SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	ALIRILQQL underwent adaptation to neo-epitope AiIRILQQL. 1 subject had higher EliSpot responses to the neo-epitope than to the non-adapted form.

References

Displaying record number 57954

HXB2 Location Nef(90-97) Nef Epitope Map
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Epitope

FLKEKGGL

Epitope Alignment

Variants

`FLKEqGGL`		escape documented in this paper; literature escape; non-susceptible form
`FLKEeGGL`		escape documented in this paper; literature escape; non-susceptible form
`FLKEnGGL`		escape documented in this paper; literature escape; non-susceptible form; susceptible form

Epitope Name FL8

Species (MHC/HLA) human(B*08:01)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`2682`
Epitope Seq.	`FLKEKGGL`
Variant Seq.	`FLKEqGGL`
Mutations	K/Q
Epitope Location	K5Q
HXB2 Location	K94Q
Mutation Type	E: escape documented in this paper LE: literature escape NSF: non-susceptible form
Method	CD8 T-cell Elispot - IFNy
Note	FLKEKGGL underwent classical escape, with adapted forms FLKEqGGL, FLKEeGGL, and FLKEnGGL having abrogated EliSpot responses.

Variant ID.	`2683`
Epitope Seq.	`FLKEKGGL`
Variant Seq.	`FLKEeGGL`
Mutations	K/E
Epitope Location	K5E
HXB2 Location	K94E
Mutation Type	E: escape documented in this paper LE: literature escape NSF: non-susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	FLKEKGGL underwent classical escape, with adapted forms FLKEqGGL, FLKEeGGL, and FLKEnGGL having abrogated EliSpot responses.

Variant ID.	`2684`
Epitope Seq.	`FLKEKGGL`
Variant Seq.	`FLKEnGGL`
Mutations	K/N
Epitope Location	K5N
HXB2 Location	K94N
Mutation Type	E: escape documented in this paper LE: literature escape NSF: non-susceptible form SF: susceptible form
Method	CD8 T-cell Elispot - IFNy
Note	FLKEKGGL underwent classical escape, with adapted forms FLKEqGGL, FLKEeGGL, and FLKEnGGL having abrogated EliSpot responses. Longitudinal study of an acute subtype A infection in a B*08-positive patient revealed early responses to FLKEKGGL and its variant, FLKEnGGL. The patient's sequences were the non-adapted form and remained invariant despite high-magnitude responses.

References

Displaying record number 57956

HXB2 Location Nef(105-115) Nef Epitope Map
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Epitope

KRQDILDWVY

Epitope Alignment

Variants

KRQeILDWVY susceptible form

Epitope Name KY11

Species (MHC/HLA) human(C*07:02)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`2687`
Epitope Seq.	`KRQDILDWVY`
Variant Seq.	`KRQeILDWVY`
Mutations	D/E
Epitope Location	D4E
HXB2 Location	D108E
Mutation Type	SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	KRQDILDWVY underwent adaptation to neo-epitope KRQeILDWVY. 8 subjects had higher EliSpot responses to the neo-epitope than to the non-adapted form.

References

Displaying record number 57958

HXB2 Location Nef(128-137) Nef Epitope Map
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Epitope

TPGPGIRYPL

Epitope Alignment

Variants

TPGPGvRYPL susceptible form

Epitope Name TL10

Species (MHC/HLA) human(B*07:02)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`2689`
Epitope Seq.	`TPGPGIRYPL`
Variant Seq.	`TPGPGvRYPL`
Mutations	I/V
Epitope Location	I6V
HXB2 Location	I133V
Mutation Type	SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	TPGPGIRYPL underwent adaptation to neo-epitope TPGPGvRYPL. 6 subjects had higher EliSpot responses to the neo-epitope than to the non-adapted form.

References

Displaying record number 57961

HXB2 Location Nef(183-191) Nef Epitope Map
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Epitope

WKFDSRLAF

Epitope Alignment

Variants

WrFDSRLAF susceptible form

Epitope Name WF9

Species (MHC/HLA) human(B*15:03)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`2692`
Epitope Seq.	`WKFDSRLAF`
Variant Seq.	`WrFDSRLAF`
Mutations	K/R
Epitope Location	K2R
HXB2 Location	K184R
Mutation Type	SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	WKFDSRLAF underwent adaptation to neo-epitope WrFDSRLAF. 1 subject had higher EliSpot responses to the neo-epitope than to the non-adapted form.