HIV molecular immunology database

Databases
Sequence DB Immunology DB Neutralization DB Ab contacts DB HCV Databases HFV Databases
Search
CTL/CD8+ Search T Helper/CD4+ Search Antibody Search CTL Variant Search T Helper Variant Search Patient Search JSON API Search Search Help
Tools
All Immunology Tools CATNAP CombiNAber HIV Genome Browser Quickalign Analyze Align Algnment Slicer PeptGen PepMap Motif Scan Hepitope HLA Freq Analysis ELF Sequence Locator SeqPublish Heatmap Epigraph Vaccine Suite Mosaic Vaccine Suite N-Glycosite Highlighter Protein Feature Accent Variable Region Neutralization Index
Products
Epitope Maps Epitope & Antibody Tables Epitope Alignments Epitope Density Plots T-Cell Epitope Variants Neutralizing Ab Resources
& CATNAP Data Sets: HLA Typing and
Epitope Mapping Tools & Links
Info
Compendia Reviews About the Database FAQ How to Cite this Database Sequence Alignments Database Tutorials

 

Search the Epitope Variant and Escape Mutation Database

Help

Found 2 matching records:

Displaying record number 53745

HXB2 Location  Gag(167-175)   Gag Epitope Map
View variants at this location
Epitope EVIPMFSAL   Epitope Alignment
Variants
EVIPMFaAL   escape documented in this paper; TCR related mutation
EVIPMFtAL   escape documented in this paper; TCR related mutation
kVIPMFSAL   diminished HLA binding or increased off-rate
EiIPMFSAL   observed variant
EVIPvFSAL   observed variant
gVIPMFSAL   observed variant
EgIPMFSAL   observed variant
EVIPMFpAL   observed variant
EiIPMFaAL   observed variant
EmIPMFaAL   observed variant
EVIPMFttL   observed variant
EiIPMFtAL   observed variant
EeIPMFtAL   observed variant
EVIPiFtAL   observed variant
EVIPvFtAL   observed variant
EiIPiFtAL   observed variant
Species (MHC/HLA)  human(A*26:01, A*26:03)

Variant Details

Showing all: 16 variant(s).

Variant ID.  683
Epitope Seq.  EVIPMFSAL
Variant Seq.  EVIPMFaAL
Mutations S/A
Epitope Location S7A
HXB2 Location S173A
Mutation Type E: escape documented in this paper
TCR: TCR related mutation
Method CD8 T-cell Elispot - IFNy
Note Variant bound to A*2603 with equal affinity as the consensus form but could not be recognized by an EVIPMFSAL-specific T-cell clone, so it may mediate TCR escape

Variant ID.  684
Epitope Seq.  EVIPMFSAL
Variant Seq.  EVIPMFtAL
Mutations S/T
Epitope Location S7T
HXB2 Location S173T
Mutation Type E: escape documented in this paper
TCR: TCR related mutation
Epitope Subtype A, B, CRF01_AE, D
Variant Subtype C
Method CD8 T-cell Elispot - IFNy
Note Variant bound to A*2603 with equal affinity as the consensus form but could not be recognized by an EVIPMFSAL-specific T-cell clone, so it may mediate TCR escape

Variant ID.  685
Epitope Seq.  EVIPMFSAL
Variant Seq.  kVIPMFSAL
Mutations E/K
Epitope Location E1K
HXB2 Location E167K
Mutation Type DHB: diminished HLA binding or increased off-rate
Method CD8 T-cell Elispot - IFNy
Note Variant did not bind to A*2603.

Variant ID.  686
Epitope Seq.  EVIPMFSAL
Variant Seq.  EiIPMFSAL
Mutations V/I
Epitope Location V2I
HXB2 Location V168I
Mutation Type OV: observed variant
Variant Subtype A
Note Variant found in clade A from HIV sequence database.

Variant ID.  687
Epitope Seq.  EVIPMFSAL
Variant Seq.  EVIPvFSAL
Mutations M/V
Epitope Location M5V
HXB2 Location M171V
Mutation Type OV: observed variant
Variant Subtype A
Note Variant found in clade A from HIV sequence database.

Variant ID.  688
Epitope Seq.  EVIPMFSAL
Variant Seq.  gVIPMFSAL
Mutations E/G
Epitope Location E1G
HXB2 Location E167G
Mutation Type OV: observed variant
Variant Subtype A
Note Variant found in clade A from HIV sequence database.

Variant ID.  689
Epitope Seq.  EVIPMFSAL
Variant Seq.  EgIPMFSAL
Mutations V/G
Epitope Location V2G
HXB2 Location V168G
Mutation Type OV: observed variant
Variant Subtype B
Note Variant found in clade B from HIV sequence database.

Variant ID.  690
Epitope Seq.  EVIPMFSAL
Variant Seq.  EVIPMFpAL
Mutations S/P
Epitope Location S7P
HXB2 Location S173P
Mutation Type OV: observed variant
Variant Subtype CRF01_AE
Note Variant found in clade E from HIV sequence database.

Variant ID.  691
Epitope Seq.  EVIPMFSAL
Variant Seq.  EiIPMFaAL
Mutations V/I S/A
Epitope Location V2I S7A
HXB2 Location V168I S173A
Mutation Type OV: observed variant
Variant Subtype B
Note Variant found in clade B from HIV sequence database.

Variant ID.  692
Epitope Seq.  EVIPMFSAL
Variant Seq.  EmIPMFaAL
Mutations V/M S/A
Epitope Location V2M S7A
HXB2 Location V168M S173A
Mutation Type OV: observed variant
Variant Subtype B
Note Variant found in clade B from HIV sequence database.

Variant ID.  693
Epitope Seq.  EVIPMFSAL
Variant Seq.  EVIPMFttL
Mutations S/T A/T
Epitope Location S7T A8T
HXB2 Location S173T A174T
Mutation Type OV: observed variant
Variant Subtype B
Note Variant found in clade B from HIV sequence database.

Variant ID.  694
Epitope Seq.  EVIPMFSAL
Variant Seq.  EiIPMFtAL
Mutations V/I S/T
Epitope Location V2I S7T
HXB2 Location V168I S173T
Mutation Type OV: observed variant
Variant Subtype C
Note Variant found in clade C from HIV sequence database.

Variant ID.  695
Epitope Seq.  EVIPMFSAL
Variant Seq.  EeIPMFtAL
Mutations V/E S/T
Epitope Location V2E S7T
HXB2 Location V168E S173T
Mutation Type OV: observed variant
Variant Subtype C
Note Variant found in clade C from HIV sequence database.

Variant ID.  696
Epitope Seq.  EVIPMFSAL
Variant Seq.  EVIPiFtAL
Mutations M/I S/T
Epitope Location M5I S7T
HXB2 Location M171I S173T
Mutation Type OV: observed variant
Variant Subtype C
Note Variant found in clade C from HIV sequence database.

Variant ID.  697
Epitope Seq.  EVIPMFSAL
Variant Seq.  EVIPvFtAL
Mutations M/V S/T
Epitope Location M5V S7T
HXB2 Location M171V S173T
Mutation Type OV: observed variant
Variant Subtype A
Note Variant found in clade A from HIV sequence database.

Variant ID.  698
Epitope Seq.  EVIPMFSAL
Variant Seq.  EiIPiFtAL
Mutations V/I M/I S/T
Epitope Location V2I M5I S7T
HXB2 Location V168I M171I S173T
Mutation Type OV: observed variant
Variant Subtype C
Note Variant found in clade C from HIV sequence database.

References

Kawashima2005 Yuka Kawashima, Manami Satoh, Shinichi Oka, and Masafumi Takiguchi. Identification and Characterization of HIV-1 Epitopes Presented by HLA-A*2603: Comparison Between HIV-1 Epitopes Presented by A*2601 and A*2603. Hum. Immunol., 66(11):1155-1166, Nov 2005. PubMed ID: 16571416. Show all entries for this paper.

Displaying record number 53746

HXB2 Location  gp160(64-73)   gp160 Epitope Map
View variants at this location
Epitope EVHNVWATHA   Epitope Alignment
Variants
EVHNiWATHA   susceptible form
EiHNVWATHA   diminished HLA binding or increased off-rate; susceptible form
EaHNVWATHA   diminished HLA binding or increased off-rate; susceptible form
EmHNVWATHA   diminished HLA binding or increased off-rate; inferred escape
EaHNiWATHA   observed variant
EkHNVWATHA   diminished HLA binding or increased off-rate
gVHNVWATHA   observed variant
EVHNmWATHA   observed variant
EVHNVsATHA   observed variant
EkHNiWATHA   observed variant
EkHNVsATHA   observed variant
EVHNVWAiHA   observed variant
EVHNVWATyA   observed variant
EVHNVWAkHA   observed variant
EVHNVWATqA   observed variant
ErHNVWATHA   observed variant
EVyNiWATHA   observed variant
EqHNVWATHA   observed variant
EqHiVWATHA   observed variant
EaHNVsATHA   observed variant
EgHNVWATHA   observed variant
EVHNaWATHA   observed variant
EVHNtWATHA   observed variant
EVHNVWgTfA   observed variant
gaHNiWATHA   observed variant
EaHNiWAsHA   observed variant
EaHdiWATHA   observed variant
EVHNVWATHv   observed variant
EVHNVWtTHA   observed variant
EmrsiWATHA   observed variant
Species (MHC/HLA)  human(A*26:03)

Variant Details

Showing all: 30 variant(s).

Variant ID.  699
Epitope Seq.  EVHNVWATHA
Variant Seq.  EVHNiWATHA
Mutations V/I
Epitope Location V5I
HXB2 Location V68I
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note Variant bound to A*2603 with equal affinity as the wt and was efficiently recognized by CTLs.

Variant ID.  700
Epitope Seq.  EVHNVWATHA
Variant Seq.  EiHNVWATHA
Mutations V/I
Epitope Location V2I
HXB2 Location V65I
Mutation Type DHB: diminished HLA binding or increased off-rate
SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note Variant bound to A*2603 with reduced affinity compared to the wt but was efficiently recognized by CTLs.

Variant ID.  701
Epitope Seq.  EVHNVWATHA
Variant Seq.  EaHNVWATHA
Mutations V/A
Epitope Location V2A
HXB2 Location V65A
Mutation Type DHB: diminished HLA binding or increased off-rate
SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note Variant bound to A*2603 with reduced affinity compared to the wt but was efficiently recognized by CTLs.

Variant ID.  702
Epitope Seq.  EVHNVWATHA
Variant Seq.  EmHNVWATHA
Mutations V/M
Epitope Location V2M
HXB2 Location V65M
Mutation Type DHB: diminished HLA binding or increased off-rate
IE: inferred escape
Method CD8 T-cell Elispot - IFNy
Note Variant did not bind to A*2603.

Variant ID.  703
Epitope Seq.  EVHNVWATHA
Variant Seq.  EaHNiWATHA
Mutations V/A V/I
Epitope Location V2A V5I
HXB2 Location V65A V68I
Mutation Type OV: observed variant
Epitope Subtype A, B, C, CRF01_AE
Variant Subtype D
Note Variant most common in clade D but present in all subtypes in HIV sequence database.

Variant ID.  704
Epitope Seq.  EVHNVWATHA
Variant Seq.  EkHNVWATHA
Mutations V/K
Epitope Location V2K
HXB2 Location V65K
Mutation Type DHB: diminished HLA binding or increased off-rate
Method CD8 T-cell Elispot - IFNy
Note Variant did not bind to A*2603.

Variant ID.  705
Epitope Seq.  EVHNVWATHA
Variant Seq.  gVHNVWATHA
Mutations E/G
Epitope Location E1G
HXB2 Location E64G
Mutation Type OV: observed variant
Variant Subtype B
Note Variant found in clade B from HIV sequence database.

Variant ID.  706
Epitope Seq.  EVHNVWATHA
Variant Seq.  EVHNmWATHA
Mutations V/M
Epitope Location V5M
HXB2 Location V68M
Mutation Type OV: observed variant
Variant Subtype B
Note Variant found in clade B from HIV sequence database.

Variant ID.  707
Epitope Seq.  EVHNVWATHA
Variant Seq.  EVHNVsATHA
Mutations W/S
Epitope Location W6S
HXB2 Location W69S
Mutation Type OV: observed variant
Variant Subtype A, B
Note Variant found in clades A and B from HIV sequence database.

Variant ID.  708
Epitope Seq.  EVHNVWATHA
Variant Seq.  EkHNiWATHA
Mutations V/K V/I
Epitope Location V2K V5I
HXB2 Location V65K V68I
Mutation Type OV: observed variant
Variant Subtype A, B, D
Note Variant found in clades A, B and D from HIV sequence database.

Variant ID.  709
Epitope Seq.  EVHNVWATHA
Variant Seq.  EkHNVsATHA
Mutations V/K W/S
Epitope Location V2K W6S
HXB2 Location V65K W69S
Mutation Type OV: observed variant
Variant Subtype A
Note Variant found in clade A from HIV sequence database.

Variant ID.  710
Epitope Seq.  EVHNVWATHA
Variant Seq.  EVHNVWAiHA
Mutations T/I
Epitope Location T8I
HXB2 Location T71I
Mutation Type OV: observed variant
Variant Subtype B
Note Variant found in clade B from HIV sequence database.

Variant ID.  711
Epitope Seq.  EVHNVWATHA
Variant Seq.  EVHNVWATyA
Mutations H/Y
Epitope Location H9Y
HXB2 Location H72Y
Mutation Type OV: observed variant
Variant Subtype B
Note Variant found in clade B from HIV sequence database.

Variant ID.  712
Epitope Seq.  EVHNVWATHA
Variant Seq.  EVHNVWAkHA
Mutations T/K
Epitope Location T8K
HXB2 Location T71K
Mutation Type OV: observed variant
Variant Subtype B
Note Variant found in clade B from HIV sequence database.

Variant ID.  713
Epitope Seq.  EVHNVWATHA
Variant Seq.  EVHNVWATqA
Mutations H/Q
Epitope Location H9Q
HXB2 Location H72Q
Mutation Type OV: observed variant
Variant Subtype B
Note Variant found in clade B from HIV sequence database.

Variant ID.  714
Epitope Seq.  EVHNVWATHA
Variant Seq.  ErHNVWATHA
Mutations V/R
Epitope Location V2R
HXB2 Location V65R
Mutation Type OV: observed variant
Variant Subtype A, B
Note Variant found in clades A and B from HIV sequence database.

Variant ID.  715
Epitope Seq.  EVHNVWATHA
Variant Seq.  EVyNiWATHA
Mutations H/Y V/I
Epitope Location H3Y V5I
HXB2 Location H66Y V68I
Mutation Type OV: observed variant
Note Variant not found by authors in HIV sequence database.

Variant ID.  716
Epitope Seq.  EVHNVWATHA
Variant Seq.  EqHNVWATHA
Mutations V/Q
Epitope Location V2Q
HXB2 Location V65Q
Mutation Type OV: observed variant
Variant Subtype A
Note Variant found in clade A from HIV sequence database.

Variant ID.  717
Epitope Seq.  EVHNVWATHA
Variant Seq.  EqHiVWATHA
Mutations V/Q N/I
Epitope Location V2Q N4I
HXB2 Location V65Q N67I
Mutation Type OV: observed variant
Variant Subtype A
Note Variant found in clade A from HIV sequence database.

Variant ID.  718
Epitope Seq.  EVHNVWATHA
Variant Seq.  EaHNVsATHA
Mutations V/A W/S
Epitope Location V2A W6S
HXB2 Location V65A W69S
Mutation Type OV: observed variant
Variant Subtype A
Note Variant found in clade A from HIV sequence database.

Variant ID.  719
Epitope Seq.  EVHNVWATHA
Variant Seq.  EgHNVWATHA
Mutations V/G
Epitope Location V2G
HXB2 Location V65G
Mutation Type OV: observed variant
Variant Subtype C
Note Variant found in clade C from HIV sequence database.

Variant ID.  720
Epitope Seq.  EVHNVWATHA
Variant Seq.  EVHNaWATHA
Mutations V/A
Epitope Location V5A
HXB2 Location V68A
Mutation Type OV: observed variant
Variant Subtype C
Note Variant found in clade C from HIV sequence database.

Variant ID.  721
Epitope Seq.  EVHNVWATHA
Variant Seq.  EVHNtWATHA
Mutations V/T
Epitope Location V5T
HXB2 Location V68T
Mutation Type OV: observed variant
Variant Subtype C
Note Variant found in clade C from HIV sequence database.

Variant ID.  722
Epitope Seq.  EVHNVWATHA
Variant Seq.  EVHNVWgTfA
Mutations A/G H/F
Epitope Location A7G H9F
HXB2 Location A70G H72F
Mutation Type OV: observed variant
Variant Subtype C
Note Variant found in clade C from HIV sequence database.

Variant ID.  723
Epitope Seq.  EVHNVWATHA
Variant Seq.  gaHNiWATHA
Mutations E/G V/A V/I
Epitope Location E1G V2A V5I
HXB2 Location E64G V65A V68I
Mutation Type OV: observed variant
Variant Subtype D
Note Variant found in clade D from HIV sequence database.

Variant ID.  724
Epitope Seq.  EVHNVWATHA
Variant Seq.  EaHNiWAsHA
Mutations V/A V/I T/S
Epitope Location V2A V5I T8S
HXB2 Location V65A V68I T71S
Mutation Type OV: observed variant
Variant Subtype D
Note Variant found in clade D from HIV sequence database.

Variant ID.  725
Epitope Seq.  EVHNVWATHA
Variant Seq.  EaHdiWATHA
Mutations V/A N/D V/I
Epitope Location V2A N4D V5I
HXB2 Location V65A N67D V68I
Mutation Type OV: observed variant
Variant Subtype D
Note Variant found in clade D from HIV sequence database.

Variant ID.  726
Epitope Seq.  EVHNVWATHA
Variant Seq.  EVHNVWATHv
Mutations A/V
Epitope Location A10V
HXB2 Location A73V
Mutation Type OV: observed variant
Variant Subtype B, CRF01_AE
Note Variant found in clades B and E from HIV sequence database.

Variant ID.  727
Epitope Seq.  EVHNVWATHA
Variant Seq.  EVHNVWtTHA
Mutations A/T
Epitope Location A7T
HXB2 Location A70T
Mutation Type OV: observed variant
Variant Subtype CRF01_AE
Note Variant found in clade E from HIV sequence database.

Variant ID.  728
Epitope Seq.  EVHNVWATHA
Variant Seq.  EmrsiWATHA
Mutations V/M H/R N/S V/I
Epitope Location V2M H3R N4S V5I
HXB2 Location V65M H66R N67S V68I
Mutation Type OV: observed variant
Variant Subtype CRF01_AE
Note Variant found in clade E from HIV sequence database.

References

Kawashima2005 Yuka Kawashima, Manami Satoh, Shinichi Oka, and Masafumi Takiguchi. Identification and Characterization of HIV-1 Epitopes Presented by HLA-A*2603: Comparison Between HIV-1 Epitopes Presented by A*2601 and A*2603. Hum. Immunol., 66(11):1155-1166, Nov 2005. PubMed ID: 16571416. Show all entries for this paper.

Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy
Dept of Health & Human Services Los Alamos National Institutes of Health