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Found 13 matching records:

Displaying record number 53223

HXB2 Location Gag(119-127) Gag Epitope Map
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AADTGNSSQ

`AADTGNgSQ`		escape documented in this paper
`eADTGNSSQ`		escape documented in this paper
`AADTkNSSQ`		escape documented in this paper
`AADTrNSSQ`		escape documented in this paper
`eADTGkSSQ`		escape documented in this paper
`AADTGNSSk`		escape documented in this paper
`AADTGsSSQ`		escape documented in this paper
`tADTGNSns`		escape documented in this paper
`AADTGNnnQ`		escape documented in this paper
`A-DTGNSSQ`		observed variant
`AAgTGNSSQ`		observed variant
`AADTeNSSQ`		observed variant
`AADTGN-S-(ss)`		escape documented in this paper
`tADTGN-Sn(s)`		escape documented in this paper
`AADTGNnS(ns)Q`		observed variant
`AADTGN-S(ss)Q`		escape documented in this paper

Epitope Name Gag AQ9

Species (MHC/HLA) human

Variant Details

Showing all: 16 variant(s).

Variant ID.	`507`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`AADTGNgSQ`
Mutations	S/G
Epitope Location	S7G
HXB2 Location	S125G
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

Variant ID.	`508`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`eADTGNSSQ`
Mutations	A/E
Epitope Location	A1E
HXB2 Location	A119E
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

Variant ID.	`509`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`AADTkNSSQ`
Mutations	G/K
Epitope Location	G5K
HXB2 Location	G123K
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

Variant ID.	`510`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`AADTrNSSQ`
Mutations	G/R
Epitope Location	G5R
HXB2 Location	G123R
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

Variant ID.	`511`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`eADTGkSSQ`
Mutations	A/E N/K
Epitope Location	A1E N6K
HXB2 Location	A119E N124K
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

Variant ID.	`512`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`AADTGNSSk`
Mutations	Q/K
Epitope Location	Q9K
HXB2 Location	Q127K
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

Variant ID.	`513`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`AADTGsSSQ`
Mutations	N/S
Epitope Location	N6S
HXB2 Location	N124S
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

Variant ID.	`514`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`tADTGNSns`
Mutations	A/T S/N Q/S
Epitope Location	A1T S8N Q9S
HXB2 Location	A119T S126N Q127S
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

Variant ID.	`515`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`AADTGNnnQ`
Mutations	S/N S/N
Epitope Location	S7N S8N
HXB2 Location	S125N S126N
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

Variant ID.	`516`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`A-DTGNSSQ`
Mutations	A/-
Epitope Location	A2-
HXB2 Location	A120-
Mutation Type	OV: observed variant
Note	1/15 clones at time point 35.

Variant ID.	`517`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`AAgTGNSSQ`
Mutations	D/G
Epitope Location	D3G
HXB2 Location	D121G
Mutation Type	OV: observed variant
Note	1/15 clones at time point 55.

Variant ID.	`518`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`AADTeNSSQ`
Mutations	G/E
Epitope Location	G5E
HXB2 Location	G123E
Mutation Type	OV: observed variant
Note	2/15 clones at time point 55 and 1/15 clones at time point 65.

Variant ID.	`2285`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`AADTGN-S-(ss)`
Mutations	S/- Q/- -/S -/S
Epitope Location	S7- Q9- -(9.1)S -(9.2)S
HXB2 Location	S125- Q127- -(127.1)S -(127.2)S
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

Variant ID.	`2287`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`tADTGN-Sn(s)`
Mutations	A/T S/- Q/N -/S
Epitope Location	A1T S7- Q9N -(9.1)S
HXB2 Location	A119T S125- Q127N -(127.1)S
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

Variant ID.	`2288`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`AADTGNnS(ns)Q`
Mutations	S/N -/N -/S
Epitope Location	S7N -(8.1)N -(8.2)S
HXB2 Location	S125N -(126.1)N -(126.2)S
Mutation Type	OV: observed variant
Note	1/15 clones at time point 556.

Variant ID.	`2299`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`AADTGN-S(ss)Q`
Mutations	S/- -/S -/S
Epitope Location	S7- -(8.1)S -(8.2)S
HXB2 Location	S125- -(126.1)S -(126.2)S
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

References

Jones2004 Nicola A. Jones, Xiping Wei, Darren R. Flower, MaiLee Wong, Franziska Michor, Michael S. Saag, Beatrice H. Hahn, Martin A. Nowak, George M. Shaw, and Persephone Borrow. Determinants of Human Immunodeficiency Virus Type 1 Escape from the Primary CD8+ Cytotoxic T Lymphocyte Response. J. Exp. Med., 200(10):1243-1256, 15 Nov 2004. PubMed ID: 15545352. Show all entries for this paper.

Yang2019 Yiding Yang, and Vitaly V. Ganusov. Defining Kinetic Properties of HIV-Specific CD8(+) T-Cell Responses in Acute Infection. Microorganisms, 7(3):microorganisms7030069 doi, Mar 2019. PubMed ID: 30836625 Show all entries for this paper.

Displaying record number 53224

HXB2 Location Gag(124-133) Gag Epitope Map
View variants at this location

Epitope

NSSQVSQNYP

Epitope Alignment

Variants

`NgSQVSQNYP`		diminished response
`NSSQaSQNYP`		diminished response
`sSSQVSQNYP`		diminished response
`NSSQdSQNYP`		diminished response
`NSSQgSQNYP`		diminished response
`kSSQVSQNYP`		diminished response
`NSSkVSQNYP`		diminished response
`NmnQVSQNYP`		diminished response
`NSS(s)QVSQNYP`		diminished response
`NS(n)SQVSQNYP`		diminished response
`NnS(ns)QVSQNYP`		diminished response

Epitope Name Gag NP10

Species (MHC/HLA) human

Variant Details

Showing all: 11 variant(s).

Variant ID.	`519`
Epitope Seq.	`NSSQVSQNYP`
Variant Seq.	`NgSQVSQNYP`
Mutations	S/G
Epitope Location	S2G
HXB2 Location	S125G
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by diminishing CTL response.

Variant ID.	`520`
Epitope Seq.	`NSSQVSQNYP`
Variant Seq.	`NSSQaSQNYP`
Mutations	V/A
Epitope Location	V5A
HXB2 Location	V128A
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by diminishing CTL response.

Variant ID.	`521`
Epitope Seq.	`NSSQVSQNYP`
Variant Seq.	`sSSQVSQNYP`
Mutations	N/S
Epitope Location	N1S
HXB2 Location	N124S
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by diminishing CTL response.

Variant ID.	`522`
Epitope Seq.	`NSSQVSQNYP`
Variant Seq.	`NSSQdSQNYP`
Mutations	V/D
Epitope Location	V5D
HXB2 Location	V128D
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by diminishing CTL response.

Variant ID.	`523`
Epitope Seq.	`NSSQVSQNYP`
Variant Seq.	`NSSQgSQNYP`
Mutations	V/G
Epitope Location	V5G
HXB2 Location	V128G
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by diminishing CTL response.

Variant ID.	`524`
Epitope Seq.	`NSSQVSQNYP`
Variant Seq.	`kSSQVSQNYP`
Mutations	N/K
Epitope Location	N1K
HXB2 Location	N124K
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by diminishing CTL response.

Variant ID.	`525`
Epitope Seq.	`NSSQVSQNYP`
Variant Seq.	`NSSkVSQNYP`
Mutations	Q/K
Epitope Location	Q4K
HXB2 Location	Q127K
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by diminishing CTL response.

Variant ID.	`526`
Epitope Seq.	`NSSQVSQNYP`
Variant Seq.	`NmnQVSQNYP`
Mutations	S/M S/N
Epitope Location	S2M S3N
HXB2 Location	S125M S126N
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by diminishing CTL response.

Variant ID.	`2289`
Epitope Seq.	`NSSQVSQNYP`
Variant Seq.	`NSS(s)QVSQNYP`
Mutations	-/S
Epitope Location	-(3.1)S
HXB2 Location	-(126.1)S
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by diminishing CTL response.

Variant ID.	`2290`
Epitope Seq.	`NSSQVSQNYP`
Variant Seq.	`NS(n)SQVSQNYP`
Mutations	-/N
Epitope Location	-(2.1)N
HXB2 Location	-(125.1)N
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by diminishing CTL response.

Variant ID.	`2291`
Epitope Seq.	`NSSQVSQNYP`
Variant Seq.	`NnS(ns)QVSQNYP`
Mutations	S/N -/N -/S
Epitope Location	S2N -(3.1)N -(3.2)S
HXB2 Location	S125N -(126.1)N -(126.2)S
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by diminishing CTL response.

References

Displaying record number 62978

HXB2 Location Gag(138-156) Gag Epitope Map
View variants at this location

Epitope

LQGQMVHQALSPRTLNAWV

Epitope Alignment

Variants

`LQGQMVHQAiSPRTLNAWV`		susceptible form
`LQGQMVHQAipPRTLNAWV`		observed variant
`LQGQMVHrAiSPRTLNAWV`		observed variant
`LQGQMVHQAiSlRTLNAWV`		observed variant
`LQGQMiHQAiSPRTLNAWV`		observed variant

Epitope Name Gag 138-156

Species (MHC/HLA) human

Variant Details

Showing all: 5 variant(s).

Variant ID.	`5089`
Epitope Seq.	`LQGQMVHQALSPRTLNAWV`
Variant Seq.	`LQGQMVHQAiSPRTLNAWV`
Mutations	L/I
Epitope Location	L10I
HXB2 Location	L147I
Mutation Type	SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Chromium-release assay, Longitudinal study
Note	Autologous susceptible form LQGQMVHQAiSPRTLNAWV was first observed in 9/15 clones at 17 days from the onset of symptoms (DFOSx) and persisted at frequencies of 13-15 per 15 clones through 556 DFOSx.

Variant ID.	`5090`
Epitope Seq.	`LQGQMVHQALSPRTLNAWV`
Variant Seq.	`LQGQMVHQAipPRTLNAWV`
Mutations	L/I S/P
Epitope Location	L10I S11P
HXB2 Location	L147I S148P
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Autologous variant LQGQMVHQAipPRTLNAWV was observed in 1/15 clones on 17 & 556 days from the onset of symptoms but was not observed in 5 intervening timepoints.

Variant ID.	`5091`
Epitope Seq.	`LQGQMVHQALSPRTLNAWV`
Variant Seq.	`LQGQMVHrAiSPRTLNAWV`
Mutations	L/I Q/R
Epitope Location	L10I Q8R
HXB2 Location	L147I Q145R
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Autologous variant LQGQMVHrAiSPRTLNAWV was observed in 1/15 clones in 1/6 sampled timepoints (35 days from the onset of symptoms).

Variant ID.	`5092`
Epitope Seq.	`LQGQMVHQALSPRTLNAWV`
Variant Seq.	`LQGQMVHQAiSlRTLNAWV`
Mutations	L/I P/L
Epitope Location	L10I P12L
HXB2 Location	L147I P149L
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Autologous variant LQGQMVHQAiSlRTLNAWV was observed in 1/15 clones in 1/6 sampled timepoints (65 days from the onset of symptoms).

Variant ID.	`5093`
Epitope Seq.	`LQGQMVHQALSPRTLNAWV`
Variant Seq.	`LQGQMiHQAiSPRTLNAWV`
Mutations	L/I V/I
Epitope Location	L10I V6I
HXB2 Location	L147I V143I
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Autologous variant LQGQMiHQAiSPRTLNAWV was observed in 1/15 clones on the last of 6 sampled timepoints (556 days from the onset of symptoms).

References

Displaying record number 53233

HXB2 Location Tat(24-32) Tat Epitope Map
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Epitope

NCYCKRCCF

Epitope Alignment

Variants

`kCYCKRCCF`		escape documented in this paper
`NCYCKkCCF`		observed variant
`tCYCKRCCF`		observed variant
`kCYCKsCCF`		observed variant
`kCYCKkCCF`		observed variant
`NCYCKkCCy`		susceptible form

Epitope Name Tat NF9

Species (MHC/HLA) human(A*29:02)

Variant Details

Showing all: 6 variant(s).

Variant ID.	`532`
Epitope Seq.	`NCYCKRCCF`
Variant Seq.	`kCYCKRCCF`
Mutations	N/K
Epitope Location	N1K
HXB2 Location	N24K
Mutation Type	E: escape documented in this paper
Note	The CTL response diminished in vivo as this variant appeared. The variant was evident by day 72.

Variant ID.	`533`
Epitope Seq.	`NCYCKRCCF`
Variant Seq.	`NCYCKkCCF`
Mutations	R/K
Epitope Location	R6K
HXB2 Location	R29K
Mutation Type	OV: observed variant
Note	1/7 clones, variant evident in samples taken at day 391.

Variant ID.	`534`
Epitope Seq.	`NCYCKRCCF`
Variant Seq.	`tCYCKRCCF`
Mutations	N/T
Epitope Location	N1T
HXB2 Location	N24T
Mutation Type	OV: observed variant
Note	5/7 clones, variant evident in samples taken at day 772.

Variant ID.	`535`
Epitope Seq.	`NCYCKRCCF`
Variant Seq.	`kCYCKsCCF`
Mutations	N/K R/S
Epitope Location	N1K R6S
HXB2 Location	N24K R29S
Mutation Type	OV: observed variant
Note	1/9 clones, variant evident in samples taken at day 772.

Variant ID.	`536`
Epitope Seq.	`NCYCKRCCF`
Variant Seq.	`kCYCKkCCF`
Mutations	N/K R/K
Epitope Location	N1K R6K
HXB2 Location	N24K R29K
Mutation Type	OV: observed variant
Note	1/9 clones, variant evident in samples taken at day 772.

Variant ID.	`5095`
Epitope Seq.	`NCYCKRCCF`
Variant Seq.	`NCYCKkCCy`
Mutations	R/K F/Y
Epitope Location	R6K F9Y
HXB2 Location	R29K F32Y
Mutation Type	SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	Please see CTL record #53225 for mutations in corresponding autologous variant NCYCKkCCy observed in subtype B-infected patient BORI.

References

Displaying record number 53225

HXB2 Location Tat(24-32) Tat Epitope Map
View variants at this location

Epitope

NCYCKKCCY

Epitope Alignment

Variants

`kCYCKKCCY`		escape documented in this paper
`kCYCKrCCY`		escape documented in this paper
`kCYCKqCCY`		escape documented in this paper
`NCYCKKyCY`		observed variant
`NCYCKKCCc`		observed variant
`NCYCKrCCf`		susceptible form

Epitope Name Tat NY9

Species (MHC/HLA) human(A*29:02)

Variant Details

Showing all: 6 variant(s).

Variant ID.	`527`
Epitope Seq.	`NCYCKKCCY`
Variant Seq.	`kCYCKKCCY`
Mutations	N/K
Epitope Location	N1K
HXB2 Location	N24K
Mutation Type	E: escape documented in this paper
Note	Variant appeared by day 31, dramatically reduced CTL recognition.

Variant ID.	`528`
Epitope Seq.	`NCYCKKCCY`
Variant Seq.	`kCYCKrCCY`
Mutations	N/K K/R
Epitope Location	N1K K6R
HXB2 Location	N24K K29R
Mutation Type	E: escape documented in this paper
Note	Variant appeared by day 218, dramatically reduced CTL recognition.

Variant ID.	`529`
Epitope Seq.	`NCYCKKCCY`
Variant Seq.	`kCYCKqCCY`
Mutations	N/K K/Q
Epitope Location	N1K K6Q
HXB2 Location	N24K K29Q
Mutation Type	E: escape documented in this paper
Note	Variant appeared by day 556, dramatically reduced CTL recognition.

Variant ID.	`530`
Epitope Seq.	`NCYCKKCCY`
Variant Seq.	`NCYCKKyCY`
Mutations	C/Y
Epitope Location	C7Y
HXB2 Location	C30Y
Mutation Type	OV: observed variant
Note	1/23 clones, transiently present at day 55.

Variant ID.	`531`
Epitope Seq.	`NCYCKKCCY`
Variant Seq.	`NCYCKKCCc`
Mutations	Y/C
Epitope Location	Y9C
HXB2 Location	Y32C
Mutation Type	OV: observed variant
Note	2/23 clones, transiently present at day 55.

Variant ID.	`5094`
Epitope Seq.	`NCYCKKCCY`
Variant Seq.	`NCYCKrCCf`
Mutations	K/R Y/F
Epitope Location	K6R Y9F
HXB2 Location	K29R Y32F
Mutation Type	SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Chromium-release assay
Note	Please see CTL record #53233 for mutations in corresponding autologous variant NCYCKrCCf observed in subtype B-infected patient WEAU.

References

Displaying record number 53235

HXB2 Location Tat(32-41) Tat Epitope Map
View variants at this location

Epitope

FHCQVCFMTK

Epitope Alignment

Variants

`FHCQVCFtTK`		escape documented in this paper
`FHCQVCFtTe`		observed variant
`lHCQVCFMkK`		escape documented in this paper

Epitope Name Tat FK10

Species (MHC/HLA) human

Variant Details

Showing all: 3 variant(s).

Variant ID.	`537`
Epitope Seq.	`FHCQVCFMTK`
Variant Seq.	`FHCQVCFtTK`
Mutations	M/T
Epitope Location	M8T
HXB2 Location	M39T
Mutation Type	E: escape documented in this paper
Note	The variant was evident during acute phase of infection. The substitution abrogated responses to the epitope.

Variant ID.	`538`
Epitope Seq.	`FHCQVCFMTK`
Variant Seq.	`FHCQVCFtTe`
Mutations	K/E M/T
Epitope Location	K10E M8T
HXB2 Location	K41E M39T
Mutation Type	OV: observed variant
Note	1/20 clones, variant found at time point 20.

Variant ID.	`539`
Epitope Seq.	`FHCQVCFMTK`
Variant Seq.	`lHCQVCFMkK`
Mutations	F/L T/K
Epitope Location	F1L T9K
HXB2 Location	F32L T40K
Mutation Type	E: escape documented in this paper
Note	The double mutation was evident at day 69 and the variant was not recognized.

References

Displaying record number 53236

HXB2 Location Tat(36-45) Tat Epitope Map
View variants at this location

Epitope

VCFMTKGLGI

Epitope Alignment

Variants

`VCFtTKGLGI`		escape documented in this paper
`VCFtTeGLGI`		observed variant
`VCFMkKGLGI`		escape documented in this paper

Epitope Name Tat VI10

Species (MHC/HLA) human(B*15:01)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`540`
Epitope Seq.	`VCFMTKGLGI`
Variant Seq.	`VCFtTKGLGI`
Mutations	M/T
Epitope Location	M4T
HXB2 Location	M39T
Mutation Type	E: escape documented in this paper
Note	The variant was evident during acute phase of infection. The substitution abrogated responses to the epitope.

Variant ID.	`541`
Epitope Seq.	`VCFMTKGLGI`
Variant Seq.	`VCFtTeGLGI`
Mutations	M/T K/E
Epitope Location	M4T K6E
HXB2 Location	M39T K41E
Mutation Type	OV: observed variant
Note	1/20 clones, variant found at time point 20.

Variant ID.	`542`
Epitope Seq.	`VCFMTKGLGI`
Variant Seq.	`VCFMkKGLGI`
Mutations	T/K
Epitope Location	T5K
HXB2 Location	T40K
Mutation Type	E: escape documented in this paper
Note	The mutation was evident at day 69 and the variant was not recognized.

References

Displaying record number 53237

HXB2 Location Tat(39-47) Tat Epitope Map
View variants at this location

Epitope

MTKGLGISY

Epitope Alignment

Variants

`tTKGLGISY`		susceptible form
`tTeGLGISY`		observed variant
`MkKGLGISY`		inferred escape; processing

Epitope Name Tat MY9

Species (MHC/HLA) human(B*15:01)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`543`
Epitope Seq.	`MTKGLGISY`
Variant Seq.	`tTKGLGISY`
Mutations	M/T
Epitope Location	M1T
HXB2 Location	M39T
Mutation Type	SF: susceptible form
Note	The variant was evident during acute phase of infection. The substitution did not abrogate responses to the epitope.

Variant ID.	`544`
Epitope Seq.	`MTKGLGISY`
Variant Seq.	`tTeGLGISY`
Mutations	M/T K/E
Epitope Location	M1T K3E
HXB2 Location	M39T K41E
Mutation Type	OV: observed variant
Note	1/20 clones, variant found at time point 20.

Variant ID.	`545`
Epitope Seq.	`MTKGLGISY`
Variant Seq.	`MkKGLGISY`
Mutations	T/K
Epitope Location	T2K
HXB2 Location	T40K
Mutation Type	IE: inferred escape P: processing
Note	This mutation was evident at day 69. CTL response was strong to the variant, but the substitution seemed to impact processing of the epitope.

References

Displaying record number 53226

HXB2 Location gp160(31-39) gp160 Epitope Map
View variants at this location

Epitope

AENLWVTVY

Epitope Alignment

Variants

`AaNLWVTaY`		diminished response
`AEkLWVTVY`		diminished response
`AENLgVTVY`		diminished response
`tENLWVTVY`		susceptible form
`vENsWVTVY`		diminished response
`tEkLWVTVY`		diminished response
`AgNLWVTVY`		diminished response
`AaNLWVTVY`		escape documented in this paper
`AkNLWVTVY`		escape documented in this paper
`tENLWVTiY`		susceptible form

Epitope Name gp160 AY9

Species (MHC/HLA) human(B*44:03)

Variant Details

Showing all: 10 variant(s).

Variant ID.	`546`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`AaNLWVTaY`
Mutations	E/A V/A
Epitope Location	E2A V8A
HXB2 Location	E32A V38A
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by reduction of CTL response.

Variant ID.	`547`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`AEkLWVTVY`
Mutations	N/K
Epitope Location	N3K
HXB2 Location	N33K
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by reduction of CTL response.

Variant ID.	`548`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`AENLgVTVY`
Mutations	W/G
Epitope Location	W5G
HXB2 Location	W35G
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by reduction of CTL response.

Variant ID.	`549`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`tENLWVTVY`
Mutations	A/T
Epitope Location	A1T
HXB2 Location	A31T
Mutation Type	SF: susceptible form
Note	Variant did not diminish CTL response.

Variant ID.	`550`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`vENsWVTVY`
Mutations	A/V L/S
Epitope Location	A1V L4S
HXB2 Location	A31V L34S
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by reduction of CTL response.

Variant ID.	`551`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`tEkLWVTVY`
Mutations	A/T N/K
Epitope Location	A1T N3K
HXB2 Location	A31T N33K
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by reduction of CTL response.

Variant ID.	`552`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`AgNLWVTVY`
Mutations	E/G
Epitope Location	E2G
HXB2 Location	E32G
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by reduction of CTL response.

Variant ID.	`553`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`AaNLWVTVY`
Mutations	E/A
Epitope Location	E2A
HXB2 Location	E32A
Mutation Type	E: escape documented in this paper
Note	Confirmed escape by dramatic decrease in CTL response.

Variant ID.	`554`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`AkNLWVTVY`
Mutations	E/K
Epitope Location	E2K
HXB2 Location	E32K
Mutation Type	E: escape documented in this paper
Note	Confirmed escape by dramatic decrease in CTL response.

Variant ID.	`555`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`tENLWVTiY`
Mutations	A/T V/I
Epitope Location	A1T V8I
HXB2 Location	A31T V38I
Mutation Type	SF: susceptible form
Note	Elicited strong CTL response

References

Displaying record number 53219

HXB2 Location gp160(209-217) gp160 Epitope Map
View variants at this location

Epitope

SFEPIPIHY

Epitope Alignment

Variants

`SFdPIPIHY`		diminished response
`SFEPIPIHf`		diminished response
`SiEPIPIHf`		diminished response
`tFEPIPIHY`		diminished response
`SsEPIPIHY`		observed variant
`SFEPIPInY`		observed variant
`SFEPIPIdf`		observed variant

Epitope Name gp160 SY9

Species (MHC/HLA) human(A*29:02)

Variant Details

Showing all: 7 variant(s).

Variant ID.	`556`
Epitope Seq.	`SFEPIPIHY`
Variant Seq.	`SFdPIPIHY`
Mutations	E/D
Epitope Location	E3D
HXB2 Location	E211D
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by reduction of CTL response.

Variant ID.	`557`
Epitope Seq.	`SFEPIPIHY`
Variant Seq.	`SFEPIPIHf`
Mutations	Y/F
Epitope Location	Y9F
HXB2 Location	Y217F
Mutation Type	DR: diminished response
Note	Variant found in two patients, somewhat reduced CTL response.

Variant ID.	`558`
Epitope Seq.	`SFEPIPIHY`
Variant Seq.	`SiEPIPIHf`
Mutations	F/I Y/F
Epitope Location	F2I Y9F
HXB2 Location	F210I Y217F
Mutation Type	DR: diminished response
Note	Rare form found at day 218. Weakest CTL response.

Variant ID.	`559`
Epitope Seq.	`SFEPIPIHY`
Variant Seq.	`tFEPIPIHY`
Mutations	S/T
Epitope Location	S1T
HXB2 Location	S209T
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by reduction of CTL response.

Variant ID.	`560`
Epitope Seq.	`SFEPIPIHY`
Variant Seq.	`SsEPIPIHY`
Mutations	F/S
Epitope Location	F2S
HXB2 Location	F210S
Mutation Type	OV: observed variant
Note	1/10 clones present at time point 41.

Variant ID.	`561`
Epitope Seq.	`SFEPIPIHY`
Variant Seq.	`SFEPIPInY`
Mutations	H/N
Epitope Location	H8N
HXB2 Location	H216N
Mutation Type	OV: observed variant
Note	7/34 clones present at time point 212 and 4/14 clones at time point 295.

Variant ID.	`562`
Epitope Seq.	`SFEPIPIHY`
Variant Seq.	`SFEPIPIdf`
Mutations	H/D Y/F
Epitope Location	H8D Y9F
HXB2 Location	H216D Y217F
Mutation Type	OV: observed variant
Note	1/11 clones present at time point 136.

References

Displaying record number 53220

HXB2 Location gp160(239-247) gp160 Epitope Map
View variants at this location

Epitope

CKNVSTVQC

Epitope Alignment

Variants

`CeNVSTVQC`		inferred escape
`CeNVSTVhC`		inferred escape
`CgNVSTVQC`		observed variant

Epitope Name gp160 CC9

Species (MHC/HLA) human(C*08:02)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`563`
Epitope Seq.	`CKNVSTVQC`
Variant Seq.	`CeNVSTVQC`
Mutations	K/E
Epitope Location	K2E
HXB2 Location	K240E
Mutation Type	IE: inferred escape
Note	4 variants found in the patient. This one and cCeNVSTVhC came up first, at day 6. This variant persisted. Not tested for impact on escape.

Variant ID.	`564`
Epitope Seq.	`CKNVSTVQC`
Variant Seq.	`CeNVSTVhC`
Mutations	K/E Q/H
Epitope Location	K2E Q8H
HXB2 Location	K240E Q246H
Mutation Type	IE: inferred escape
Note	4 variants found in the patient. This one and CeNVSTVQC came up first, at day 6. Not tested for impact on escape.

Variant ID.	`565`
Epitope Seq.	`CKNVSTVQC`
Variant Seq.	`CgNVSTVQC`
Mutations	K/G
Epitope Location	K2G
HXB2 Location	K240G
Mutation Type	OV: observed variant
Note	Rare variant present at day 35. Not tested for impact on escape.

References

Displaying record number 53234

HXB2 Location gp160(344-361) gp160 Epitope Map
View variants at this location

Epitope

QIVEKLREIKQFKNKTIVF

Epitope Alignment

Variants

`QIaEKLREIKQFKNKTIVF`		observed variant
`QIVEKLREIeQFKNKTIVF`		observed variant
`QIVkKLREIKQFKNKTIVF`		observed variant
`QIVgKLREIKQFKNKTIVF`		observed variant
`QIVgKLREIeQFKNKTIVF`		observed variant
`QIVEKLREIeQFKNKTIaF`		observed variant
`QIVEKLREIeQFKNrTIVF`		observed variant
`QIVkKLREIeQFKNKTIVF`		observed variant
`QIVEKLREIqQFKNKTIVF`		observed variant
`QIVkKLREmeQFKNKTIVF`		observed variant
`QIVEKLREIekFKNKTIVF`		observed variant
`QIVEKLREIKQFKNKkIVF`		observed variant

Epitope Name gp160 348-366

Species (MHC/HLA) human

Variant Details

Showing all: 12 variant(s).

Variant ID.	`566`
Epitope Seq.	`QIVEKLREIKQFKNKTIVF`
Variant Seq.	`QIaEKLREIKQFKNKTIVF`
Mutations	V/A
Epitope Location	V3A
HXB2 Location	V346A
Mutation Type	OV: observed variant
Note	2/7 clones present at day 16. Not tested for impact on escape.

Variant ID.	`567`
Epitope Seq.	`QIVEKLREIKQFKNKTIVF`
Variant Seq.	`QIVEKLREIeQFKNKTIVF`
Mutations	K/E
Epitope Location	K10E
HXB2 Location	K353E
Mutation Type	OV: observed variant
Note	Variant present at every time point. Not tested for impact on escape.

Variant ID.	`568`
Epitope Seq.	`QIVEKLREIKQFKNKTIVF`
Variant Seq.	`QIVkKLREIKQFKNKTIVF`
Mutations	E/K
Epitope Location	E4K
HXB2 Location	E347K
Mutation Type	OV: observed variant
Note	Variant present at 4 different time points. Not tested for impact on escape.

Variant ID.	`569`
Epitope Seq.	`QIVEKLREIKQFKNKTIVF`
Variant Seq.	`QIVgKLREIKQFKNKTIVF`
Mutations	E/G
Epitope Location	E4G
HXB2 Location	E347G
Mutation Type	OV: observed variant
Note	1/10 clones present at day 72. Not tested for impact on escape.

Variant ID.	`570`
Epitope Seq.	`QIVEKLREIKQFKNKTIVF`
Variant Seq.	`QIVgKLREIeQFKNKTIVF`
Mutations	K/E E/G
Epitope Location	K10E E4G
HXB2 Location	K353E E347G
Mutation Type	OV: observed variant
Note	Variant present at time points 136, 212. Not tested for impact on escape.

Variant ID.	`571`
Epitope Seq.	`QIVEKLREIKQFKNKTIVF`
Variant Seq.	`QIVEKLREIeQFKNKTIaF`
Mutations	K/E V/A
Epitope Location	K10E V18A
HXB2 Location	K353E V361A
Mutation Type	OV: observed variant
Note	Variant present at 3 different time points. Not tested for impact on escape.

Variant ID.	`572`
Epitope Seq.	`QIVEKLREIKQFKNKTIVF`
Variant Seq.	`QIVEKLREIeQFKNrTIVF`
Mutations	K/E K/R
Epitope Location	K10E K15R
HXB2 Location	K353E K358R
Mutation Type	OV: observed variant
Note	1/35 clones present at day 212. Not tested for impact on escape.

Variant ID.	`573`
Epitope Seq.	`QIVEKLREIKQFKNKTIVF`
Variant Seq.	`QIVkKLREIeQFKNKTIVF`
Mutations	K/E E/K
Epitope Location	K10E E4K
HXB2 Location	K353E E347K
Mutation Type	OV: observed variant
Note	Variant present at 3 different time points. Not tested for impact on escape.

Variant ID.	`574`
Epitope Seq.	`QIVEKLREIKQFKNKTIVF`
Variant Seq.	`QIVEKLREIqQFKNKTIVF`
Mutations	K/Q
Epitope Location	K10Q
HXB2 Location	K353Q
Mutation Type	OV: observed variant
Note	Variant present at time points 246, 295. Not tested for impact on escape.

Variant ID.	`575`
Epitope Seq.	`QIVEKLREIKQFKNKTIVF`
Variant Seq.	`QIVkKLREmeQFKNKTIVF`
Mutations	K/E E/K I/M
Epitope Location	K10E E4K I9M
HXB2 Location	K353E E347K I352M
Mutation Type	OV: observed variant
Note	1/11 clones present at day 391. Not tested for impact on escape.

Variant ID.	`576`
Epitope Seq.	`QIVEKLREIKQFKNKTIVF`
Variant Seq.	`QIVEKLREIekFKNKTIVF`
Mutations	K/E Q/K
Epitope Location	K10E Q11K
HXB2 Location	K353E Q354K
Mutation Type	OV: observed variant
Note	1/11 clones present at day 391. Not tested for impact on escape.

Variant ID.	`577`
Epitope Seq.	`QIVEKLREIKQFKNKTIVF`
Variant Seq.	`QIVEKLREIKQFKNKkIVF`
Mutations	T/K
Epitope Location	T16K
HXB2 Location	T359K
Mutation Type	OV: observed variant
Note	1/11 clones present at day 391. Not tested for impact on escape.

References

Displaying record number 53221

HXB2 Location gp160(584-592) gp160 Epitope Map
View variants at this location

Epitope

ERYLKDQQL

Epitope Alignment

Variants

`ERYLKeQQp`		observed variant
`ERYLrDQQL`		susceptible form
`ERYLtDQQL`		diminished response
`ERYLqDQQL`		diminished response
`ERYLsDQQL`		diminished response
`ERYLmDQQL`		diminished response
`ERYLmDQrL`		observed variant
`ERYLmDrQL`		observed variant
`ERYLmDQlL`		observed variant
`ERYLtDQrL`		observed variant
`ERYrtDQrL`		observed variant

Epitope Name gp160 EL9

Species (MHC/HLA) human

Variant Details

Showing all: 11 variant(s).

Variant ID.	`578`
Epitope Seq.	`ERYLKDQQL`
Variant Seq.	`ERYLKeQQp`
Mutations	D/E L/P
Epitope Location	D6E L9P
HXB2 Location	D589E L592P
Mutation Type	OV: observed variant
Note	Came up at day 17. Not tested for escape.

Variant ID.	`579`
Epitope Seq.	`ERYLKDQQL`
Variant Seq.	`ERYLrDQQL`
Mutations	K/R
Epitope Location	K5R
HXB2 Location	K588R
Mutation Type	SF: susceptible form
Note	Came up at day 31, did not confer escape.

Variant ID.	`580`
Epitope Seq.	`ERYLKDQQL`
Variant Seq.	`ERYLtDQQL`
Mutations	K/T
Epitope Location	K5T
HXB2 Location	K588T
Mutation Type	DR: diminished response
Note	One of the three variants found at day 218, gave diminished CTL response.

Variant ID.	`581`
Epitope Seq.	`ERYLKDQQL`
Variant Seq.	`ERYLqDQQL`
Mutations	K/Q
Epitope Location	K5Q
HXB2 Location	K588Q
Mutation Type	DR: diminished response
Note	One of the three variants found at day 218, gave diminished CTL response. Also found in another patient.

Variant ID.	`582`
Epitope Seq.	`ERYLKDQQL`
Variant Seq.	`ERYLsDQQL`
Mutations	K/S
Epitope Location	K5S
HXB2 Location	K588S
Mutation Type	DR: diminished response
Note	One of the three variants found at day 218, gave diminished CTL response.

Variant ID.	`583`
Epitope Seq.	`ERYLKDQQL`
Variant Seq.	`ERYLmDQQL`
Mutations	K/M
Epitope Location	K5M
HXB2 Location	K588M
Mutation Type	DR: diminished response
Note	Found at day 556, gave a further reduction of CTL response.

Variant ID.	`584`
Epitope Seq.	`ERYLKDQQL`
Variant Seq.	`ERYLmDQrL`
Mutations	K/M Q/R
Epitope Location	K5M Q8R
HXB2 Location	K588M Q591R
Mutation Type	OV: observed variant
Note	Double mutant found at day 556. Not tested for escape.

Variant ID.	`585`
Epitope Seq.	`ERYLKDQQL`
Variant Seq.	`ERYLmDrQL`
Mutations	K/M Q/R
Epitope Location	K5M Q7R
HXB2 Location	K588M Q590R
Mutation Type	OV: observed variant
Note	Double mutant found at day 556. Not tested for escape.

Variant ID.	`586`
Epitope Seq.	`ERYLKDQQL`
Variant Seq.	`ERYLmDQlL`
Mutations	K/M Q/L
Epitope Location	K5M Q8L
HXB2 Location	K588M Q591L
Mutation Type	OV: observed variant
Note	Double mutant found at day 556. Not tested for escape.

Variant ID.	`587`
Epitope Seq.	`ERYLKDQQL`
Variant Seq.	`ERYLtDQrL`
Mutations	K/T Q/R
Epitope Location	K5T Q8R
HXB2 Location	K588T Q591R
Mutation Type	OV: observed variant
Note	Double mutant found at day 556. Not tested for escape.

Variant ID.	`588`
Epitope Seq.	`ERYLKDQQL`
Variant Seq.	`ERYrtDQrL`
Mutations	L/R K/T Q/R
Epitope Location	L4R K5T Q8R
HXB2 Location	L587R K588T Q591R
Mutation Type	OV: observed variant
Note	Double mutant found at day 556. Not tested for escape.