HIV molecular immunology database
Found 2 matching records:
| HXB2 Location | Gag(197-205) | Gag Epitope Map
View variants at this location |
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| Epitope |
AMQMLKDTI
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | G1 | |||||
| Species (MHC/HLA) | mouse(H-2Kd) | |||||
Showing all: 1 variant(s).
| Variant ID. | 2665 |
|---|---|
| Epitope Seq. | AMQMLKDTI |
| Variant Seq. | AMefLKDTa |
| Mutations | Q/E M/F I/A |
| Epitope Location | Q3E M4F I9A |
| HXB2 Location | Q199E M200F I205A |
| Mutation Type | DHB: diminished HLA binding or increased off-rate |
| Epitope Subtype | A |
| Variant Subtype | A |
| Method | HLA binding |
| Note | Artificially-produced mutant AMefLKDTa was created to abrogate the anchor residues of epitope AMQMLKDTI. Loss of HLA binding was confirmed. |
Im2011 Eung-Jun Im, Jessie P. Hong, Yaowaluck Roshorm, Anne Bridgeman, Sven Létourneau, Peter Liljeström, Mary Jane Potash, David J. Volsky, Andrew J. McMichael, and Tomáš Hanke. Protective Efficacy of Serially Up-Ranked Subdominant CD8+ T Cell Epitopes against Virus Challenges. PLoS Pathog., 7(5):e1002041, May 2011. PubMed ID: 21625575. Show all entries for this paper.
| HXB2 Location | Pol(314-322) | Pol Epitope Map
View variants at this location |
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| Epitope |
IFQSSMTKI
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | P | |||||
| Species (MHC/HLA) | mouse(H-2Kd) | |||||
Showing all: 1 variant(s).
| Variant ID. | 2663 |
|---|---|
| Epitope Seq. | IFQSSMTKI |
| Variant Seq. | IFgSSMTKa |
| Mutations | Q/G I/A |
| Epitope Location | Q3G I9A |
| HXB2 Location | Q316G I322A |
| Mutation Type | DHB: diminished HLA binding or increased off-rate |
| Epitope Subtype | A |
| Variant Subtype | A |
| Method | HLA binding |
| Note | Artificially-produced mutant IFgSSMTKa was created to abrogate the anchor residues of epitope IFQSSMTKI. Loss of HLA binding was confirmed. |
Im2011 Eung-Jun Im, Jessie P. Hong, Yaowaluck Roshorm, Anne Bridgeman, Sven Létourneau, Peter Liljeström, Mary Jane Potash, David J. Volsky, Andrew J. McMichael, and Tomáš Hanke. Protective Efficacy of Serially Up-Ranked Subdominant CD8+ T Cell Epitopes against Virus Challenges. PLoS Pathog., 7(5):e1002041, May 2011. PubMed ID: 21625575. Show all entries for this paper.