Found 12 matching records:
HXB2 Location | Gag(20-28) | Gag Epitope Map
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Epitope |
RLRPGGKKK
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Epitope Alignment | ||||
Variants |
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Species (MHC/HLA) | human(A3) |
Showing all: 1 variant(s).
Variant ID. | 305 |
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Epitope Seq. | RLRPGGKKK |
Variant Seq. | RLRPGGKKr |
Mutations | K/R |
Epitope Location | K9R |
HXB2 Location | K28R |
Mutation Type | SF: susceptible form |
Note | The variant became fixed in the viral population at 20 months post-seroconversion. CTL responses to both wild type and variant peptides were detectable and decreased over time, then increased after mutation fixation. |
Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.
HXB2 Location | Pol(283-290) | Pol Epitope Map
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Epitope |
TAFTIPSI
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Epitope Alignment | ||||
Variants |
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Species (MHC/HLA) | human(B51) |
Showing all: 1 variant(s).
Variant ID. | 306 |
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Epitope Seq. | TAFTIPSI |
Variant Seq. | TAFTIPSt |
Mutations | I/T |
Epitope Location | I8T |
HXB2 Location | I290T |
Mutation Type | E: escape documented in this paper |
Note | A dramatic decrease in CTL activity against the epitope occurred as the mutation became fixed. The variant was found at 47 months post-seroconversion. |
Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.
HXB2 Location | Pol(347-356) | Pol Epitope Map
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Epitope |
DLEIGQHRTK
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Epitope Alignment | ||||
Variants |
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Species (MHC/HLA) | human(A3) |
Showing all: 1 variant(s).
Variant ID. | 307 |
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Epitope Seq. | DLEIGQHRTK |
Variant Seq. | DLEmGQHRTK |
Mutations | I/M |
Epitope Location | I4M |
HXB2 Location | I350M |
Mutation Type | OV: observed variant |
Note | The epitope varied over time but the mutations did not become fixed. The variant arose at late timepoints. |
Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.
HXB2 Location | Pol(415-426) | Pol Epitope Map
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Epitope |
LVGKLNWASQIY
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Epitope Alignment | ||||
Variants |
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Species (MHC/HLA) | human(B15) |
Showing all: 1 variant(s).
Variant ID. | 308 |
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Epitope Seq. | LVGKLNWASQIY |
Variant Seq. | LVGKxNWASQIY |
Mutations | L/X |
Epitope Location | L5X |
HXB2 Location | L419X |
Mutation Type | OV: observed variant |
Note | The epitope varied over time but the mutations did not become fixed. The variant arose at late timepoints. |
Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.
HXB2 Location | Pol(743-751) | Pol Epitope Map
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Epitope |
LPPVVAKEI
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Epitope Alignment | ||||
Variants |
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Species (MHC/HLA) | human(B51) |
Showing all: 1 variant(s).
Variant ID. | 309 |
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Epitope Seq. | LPPVVAKEI |
Variant Seq. | LPPiVAKEI |
Mutations | V/I |
Epitope Location | V4I |
HXB2 Location | V746I |
Mutation Type | OV: observed variant |
Note | The epitope varied over time but the mutations did not become fixed. The variant arose at intermediate timepoints. |
Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.
HXB2 Location | Env(375-383) | Env Epitope Map
View variants at this location |
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Epitope |
SFNCGGEFF
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Epitope Alignment | ||||
Variants |
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Species (MHC/HLA) | human(B15) |
Showing all: 1 variant(s).
Variant ID. | 310 |
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Epitope Seq. | SFNCGGEFF |
Variant Seq. | SFNCrGEFF |
Mutations | G/R |
Epitope Location | G5R |
HXB2 Location | G379R |
Mutation Type | E: escape documented in this paper |
Note | A dramatic decrease in CTL activity against the epitope occurred as the mutations arose. The variant became fixed in the population 20 months post-seroconversion. |
Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.
HXB2 Location | Env(701-719) | Env Epitope Map
View variants at this location |
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Epitope |
VLSIVNQVRRQGYSPLSFQT
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Epitope Alignment | ||||
Variants |
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Species (MHC/HLA) | human(B15) |
Showing all: 1 variant(s).
Variant ID. | 311 |
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Epitope Seq. | VLSIVNQVRRQGYSPLSFQT |
Variant Seq. | VLSIVNkVRRQGYSPLSFQT |
Mutations | Q/K |
Epitope Location | Q7K |
HXB2 Location | Q707K |
Mutation Type | E: escape documented in this paper |
Note | A dramatic decrease in CTL activity against the epitope occurred as the mutations arose. The variant became fixed in the population at 47 months post-seroconversion. |
Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.
HXB2 Location | Env(770-780) | Env Epitope Map
View variants at this location |
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Epitope |
RLRDLLLIVTR
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Epitope Alignment | |||||||
Variants |
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Species (MHC/HLA) | human(A3) |
Showing all: 2 variant(s).
Variant ID. | 312 |
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Epitope Seq. | RLRDLLLIVTR |
Variant Seq. | RLRDLLLIiTR |
Mutations | V/I |
Epitope Location | V9I |
HXB2 Location | V778I |
Mutation Type | OV: observed variant |
Note | The epitope varied over time but the mutations did not become fixed. The variant arose at intermediate timepoints. |
Variant ID. | 313 |
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Epitope Seq. | RLRDLLLIVTR |
Variant Seq. | RLRDLLLvVTR |
Mutations | I/V |
Epitope Location | I8V |
HXB2 Location | I777V |
Mutation Type | OV: observed variant |
Note | The epitope varied over time but the mutations did not become fixed. The variant arose at late timepoints. |
Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.
HXB2 Location | Env(835-843) | Env Epitope Map
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Epitope |
RAYRAILHI
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Epitope Alignment | |||||||
Variants |
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Species (MHC/HLA) | human(B51) |
Showing all: 2 variant(s).
Variant ID. | 314 |
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Epitope Seq. | RAYRAILHI |
Variant Seq. | RtfRAILHI |
Mutations | A/T Y/F |
Epitope Location | A2T Y3F |
HXB2 Location | A836T Y837F |
Mutation Type | OV: observed variant |
Note | The epitope varied over time but the mutations did not become fixed. The variant arose at early timepoints. |
Variant ID. | 315 |
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Epitope Seq. | RAYRAILHI |
Variant Seq. | RiYRAILHx |
Mutations | A/I I/X |
Epitope Location | A2I I9X |
HXB2 Location | A836I I843X |
Mutation Type | OV: observed variant |
Note | The epitope varied over time but the mutations did not become fixed. The variant arose at intermediate timepoints. |
Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.
HXB2 Location | Nef(120-128) | Nef Epitope Map
View variants at this location |
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Epitope |
FFPDWKNYT
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Epitope Alignment | ||||||||||||||||
Variants |
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Species (MHC/HLA) | human(B51) |
Showing all: 5 variant(s).
Variant ID. | 316 |
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Epitope Seq. | FFPDWKNYT |
Variant Seq. | yFPDWqNYT |
Mutations | F/Y K/Q |
Epitope Location | F1Y K6Q |
HXB2 Location | F120Y K125Q |
Mutation Type | E: escape documented in this paper |
Note | A dramatic decrease in CTL activity against the epitope occurred as the mutations arose. The variant was found at 2 months post-seroconversion. |
Variant ID. | 317 |
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Epitope Seq. | FFPDWKNYT |
Variant Seq. | yFPDWhNYT |
Mutations | F/Y K/H |
Epitope Location | F1Y K6H |
HXB2 Location | F120Y K125H |
Mutation Type | E: escape documented in this paper |
Note | A dramatic decrease in CTL activity against the epitope occurred as the mutations arose. The variant was found at 2 months post-seroconversion. |
Variant ID. | 318 |
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Epitope Seq. | FFPDWKNYT |
Variant Seq. | yFPDWqsYT |
Mutations | F/Y K/Q N/S |
Epitope Location | F1Y K6Q N7S |
HXB2 Location | F120Y K125Q N126S |
Mutation Type | E: escape documented in this paper |
Note | A dramatic decrease in CTL activity against the epitope occurred as the mutations arose. The variant was found at 20 and 47 months post-seroconversion. |
Variant ID. | 319 |
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Epitope Seq. | FFPDWKNYT |
Variant Seq. | ylPDWqsYT |
Mutations | F/Y F/L K/Q N/S |
Epitope Location | F1Y F2L K6Q N7S |
HXB2 Location | F120Y F121L K125Q N126S |
Mutation Type | E: escape documented in this paper |
Note | A dramatic decrease in CTL activity against the epitope occurred as the mutations arose. The variant was found at 20 months post-seroconversion. |
Variant ID. | 320 |
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Epitope Seq. | FFPDWKNYT |
Variant Seq. | yFPDWdNYT |
Mutations | F/Y K/D |
Epitope Location | F1Y K6D |
HXB2 Location | F120Y K125D |
Mutation Type | E: escape documented in this paper |
Note | A dramatic decrease in CTL activity against the epitope occurred as the mutations arose. The variant was found at 20 and 47 months post-seroconversion. |
Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.
HXB2 Location | Nef(186-194) | Nef Epitope Map
View variants at this location |
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Epitope |
DSRLAFHHV
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Epitope Alignment | |||||||
Variants |
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Species (MHC/HLA) | human(B51) |
Showing all: 2 variant(s).
Variant ID. | 321 |
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Epitope Seq. | DSRLAFHHV |
Variant Seq. | DSlLAlrHm |
Mutations | R/L F/L H/R V/M |
Epitope Location | R3L F6L H7R V9M |
HXB2 Location | R188L F191L H192R V194M |
Mutation Type | OV: observed variant |
Note | The epitope varied over time but the mutations did not become fixed. The variant arose at early timepoints. |
Variant ID. | 322 |
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Epitope Seq. | DSRLAFHHV |
Variant Seq. | DSRLAvHHV |
Mutations | F/V |
Epitope Location | F6V |
HXB2 Location | F191V |
Mutation Type | OV: observed variant |
Note | The epitope varied over time but the mutations did not become fixed. The variant arose at intermediate timepoints. |
Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.
HXB2 Location | Nef(190-198) | Nef Epitope Map
View variants at this location |
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Epitope |
AFHHVAREK
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Epitope Alignment | ||||||||||
Variants |
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Species (MHC/HLA) | human(B51) |
Showing all: 3 variant(s).
Variant ID. | 323 |
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Epitope Seq. | AFHHVAREK |
Variant Seq. | AlrHmAREK |
Mutations | F/L H/R V/M |
Epitope Location | F2L H3R V5M |
HXB2 Location | F191L H192R V194M |
Mutation Type | OV: observed variant |
Note | The epitope varied over time but the mutations did not become fixed. The variant arose at early timepoints. |
Variant ID. | 324 |
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Epitope Seq. | AFHHVAREK |
Variant Seq. | AvHHVAREK |
Mutations | F/V |
Epitope Location | F2V |
HXB2 Location | F191V |
Mutation Type | OV: observed variant |
Note | The epitope varied over time but the mutations did not become fixed. The variant arose at intermediate timepoints. |
Variant ID. | 325 |
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Epitope Seq. | AFHHVAREK |
Variant Seq. | AFHHVAxEi |
Mutations | R/X K/I |
Epitope Location | R7X K9I |
HXB2 Location | R196X K198I |
Mutation Type | OV: observed variant |
Note | The epitope varied over time but the mutations did not become fixed. The variant arose at late timepoints. |
Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.
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