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Found 12 matching records:

Displaying record number 52994

HXB2 Location  Gag(20-28)   Gag Epitope Map
View variants at this location
Epitope RLRPGGKKK   Epitope Alignment
Variants
RLRPGGKKr   susceptible form
Species (MHC/HLA human(A3)

Variant Details

Showing all: 1 variant(s).


Variant ID.  305
Epitope Seq.  RLRPGGKKK
Variant Seq.  RLRPGGKKr
Mutations K/R
Epitope Location K9R
HXB2 Location K28R
Mutation Type SF: susceptible form
Note The variant became fixed in the viral population at 20 months post-seroconversion. CTL responses to both wild type and variant peptides were detectable and decreased over time, then increased after mutation fixation.

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.


Displaying record number 52995

HXB2 Location  Pol(283-290)   Pol Epitope Map
View variants at this location
Epitope TAFTIPSI   Epitope Alignment
Variants
TAFTIPSt   escape documented in this paper
Species (MHC/HLA human(B51)

Variant Details

Showing all: 1 variant(s).


Variant ID.  306
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSt
Mutations I/T
Epitope Location I8T
HXB2 Location I290T
Mutation Type E: escape documented in this paper
Note A dramatic decrease in CTL activity against the epitope occurred as the mutation became fixed. The variant was found at 47 months post-seroconversion.

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.


Displaying record number 52987

HXB2 Location  Pol(347-356)   Pol Epitope Map
View variants at this location
Epitope DLEIGQHRTK   Epitope Alignment
Variants
DLEmGQHRTK   observed variant
Species (MHC/HLA human(A3)

Variant Details

Showing all: 1 variant(s).


Variant ID.  307
Epitope Seq.  DLEIGQHRTK
Variant Seq.  DLEmGQHRTK
Mutations I/M
Epitope Location I4M
HXB2 Location I350M
Mutation Type OV: observed variant
Note The epitope varied over time but the mutations did not become fixed. The variant arose at late timepoints.

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.


Displaying record number 52988

HXB2 Location  Pol(415-426)   Pol Epitope Map
View variants at this location
Epitope LVGKLNWASQIY   Epitope Alignment
Variants
LVGKxNWASQIY   observed variant
Species (MHC/HLA human(B15)

Variant Details

Showing all: 1 variant(s).


Variant ID.  308
Epitope Seq.  LVGKLNWASQIY
Variant Seq.  LVGKxNWASQIY
Mutations L/X
Epitope Location L5X
HXB2 Location L419X
Mutation Type OV: observed variant
Note The epitope varied over time but the mutations did not become fixed. The variant arose at late timepoints.

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.


Displaying record number 52989

HXB2 Location  Pol(743-751)   Pol Epitope Map
View variants at this location
Epitope LPPVVAKEI   Epitope Alignment
Variants
LPPiVAKEI   observed variant
Species (MHC/HLA human(B51)

Variant Details

Showing all: 1 variant(s).


Variant ID.  309
Epitope Seq.  LPPVVAKEI
Variant Seq.  LPPiVAKEI
Mutations V/I
Epitope Location V4I
HXB2 Location V746I
Mutation Type OV: observed variant
Note The epitope varied over time but the mutations did not become fixed. The variant arose at intermediate timepoints.

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.


Displaying record number 52996

HXB2 Location  Env(375-383)   Env Epitope Map
View variants at this location
Epitope SFNCGGEFF   Epitope Alignment
Variants
SFNCrGEFF   escape documented in this paper
Species (MHC/HLA human(B15)

Variant Details

Showing all: 1 variant(s).


Variant ID.  310
Epitope Seq.  SFNCGGEFF
Variant Seq.  SFNCrGEFF
Mutations G/R
Epitope Location G5R
HXB2 Location G379R
Mutation Type E: escape documented in this paper
Note A dramatic decrease in CTL activity against the epitope occurred as the mutations arose. The variant became fixed in the population 20 months post-seroconversion.

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.


Displaying record number 52998

HXB2 Location  Env(701-719)   Env Epitope Map
View variants at this location
Epitope VLSIVNQVRRQGYSPLSFQT   Epitope Alignment
Variants
VLSIVNkVRRQGYSPLSFQT   escape documented in this paper
Species (MHC/HLA human(B15)

Variant Details

Showing all: 1 variant(s).


Variant ID.  311
Epitope Seq.  VLSIVNQVRRQGYSPLSFQT
Variant Seq.  VLSIVNkVRRQGYSPLSFQT
Mutations Q/K
Epitope Location Q7K
HXB2 Location Q707K
Mutation Type E: escape documented in this paper
Note A dramatic decrease in CTL activity against the epitope occurred as the mutations arose. The variant became fixed in the population at 47 months post-seroconversion.

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.


Displaying record number 52990

HXB2 Location  Env(770-780)   Env Epitope Map
View variants at this location
Epitope RLRDLLLIVTR   Epitope Alignment
Variants
RLRDLLLIiTR   observed variant
RLRDLLLvVTR   observed variant
Species (MHC/HLA human(A3)

Variant Details

Showing all: 2 variant(s).


Variant ID.  312
Epitope Seq.  RLRDLLLIVTR
Variant Seq.  RLRDLLLIiTR
Mutations V/I
Epitope Location V9I
HXB2 Location V778I
Mutation Type OV: observed variant
Note The epitope varied over time but the mutations did not become fixed. The variant arose at intermediate timepoints.


Variant ID.  313
Epitope Seq.  RLRDLLLIVTR
Variant Seq.  RLRDLLLvVTR
Mutations I/V
Epitope Location I8V
HXB2 Location I777V
Mutation Type OV: observed variant
Note The epitope varied over time but the mutations did not become fixed. The variant arose at late timepoints.

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.


Displaying record number 52991

HXB2 Location  Env(835-843)   Env Epitope Map
View variants at this location
Epitope RAYRAILHI   Epitope Alignment
Variants
RtfRAILHI   observed variant
RiYRAILHx   observed variant
Species (MHC/HLA human(B51)

Variant Details

Showing all: 2 variant(s).


Variant ID.  314
Epitope Seq.  RAYRAILHI
Variant Seq.  RtfRAILHI
Mutations A/T Y/F
Epitope Location A2T Y3F
HXB2 Location A836T Y837F
Mutation Type OV: observed variant
Note The epitope varied over time but the mutations did not become fixed. The variant arose at early timepoints.


Variant ID.  315
Epitope Seq.  RAYRAILHI
Variant Seq.  RiYRAILHx
Mutations A/I I/X
Epitope Location A2I I9X
HXB2 Location A836I I843X
Mutation Type OV: observed variant
Note The epitope varied over time but the mutations did not become fixed. The variant arose at intermediate timepoints.

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.


Displaying record number 52997

HXB2 Location  Nef(120-128)   Nef Epitope Map
View variants at this location
Epitope FFPDWKNYT   Epitope Alignment
Variants
yFPDWqNYT   escape documented in this paper
yFPDWhNYT   escape documented in this paper
yFPDWqsYT   escape documented in this paper
ylPDWqsYT   escape documented in this paper
yFPDWdNYT   escape documented in this paper
Species (MHC/HLA human(B51)

Variant Details

Showing all: 5 variant(s).


Variant ID.  316
Epitope Seq.  FFPDWKNYT
Variant Seq.  yFPDWqNYT
Mutations F/Y K/Q
Epitope Location F1Y K6Q
HXB2 Location F120Y K125Q
Mutation Type E: escape documented in this paper
Note A dramatic decrease in CTL activity against the epitope occurred as the mutations arose. The variant was found at 2 months post-seroconversion.


Variant ID.  317
Epitope Seq.  FFPDWKNYT
Variant Seq.  yFPDWhNYT
Mutations F/Y K/H
Epitope Location F1Y K6H
HXB2 Location F120Y K125H
Mutation Type E: escape documented in this paper
Note A dramatic decrease in CTL activity against the epitope occurred as the mutations arose. The variant was found at 2 months post-seroconversion.


Variant ID.  318
Epitope Seq.  FFPDWKNYT
Variant Seq.  yFPDWqsYT
Mutations F/Y K/Q N/S
Epitope Location F1Y K6Q N7S
HXB2 Location F120Y K125Q N126S
Mutation Type E: escape documented in this paper
Note A dramatic decrease in CTL activity against the epitope occurred as the mutations arose. The variant was found at 20 and 47 months post-seroconversion.


Variant ID.  319
Epitope Seq.  FFPDWKNYT
Variant Seq.  ylPDWqsYT
Mutations F/Y F/L K/Q N/S
Epitope Location F1Y F2L K6Q N7S
HXB2 Location F120Y F121L K125Q N126S
Mutation Type E: escape documented in this paper
Note A dramatic decrease in CTL activity against the epitope occurred as the mutations arose. The variant was found at 20 months post-seroconversion.


Variant ID.  320
Epitope Seq.  FFPDWKNYT
Variant Seq.  yFPDWdNYT
Mutations F/Y K/D
Epitope Location F1Y K6D
HXB2 Location F120Y K125D
Mutation Type E: escape documented in this paper
Note A dramatic decrease in CTL activity against the epitope occurred as the mutations arose. The variant was found at 20 and 47 months post-seroconversion.

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.


Displaying record number 52992

HXB2 Location  Nef(186-194)   Nef Epitope Map
View variants at this location
Epitope DSRLAFHHV   Epitope Alignment
Variants
DSlLAlrHm   observed variant
DSRLAvHHV   observed variant
Species (MHC/HLA human(B51)

Variant Details

Showing all: 2 variant(s).


Variant ID.  321
Epitope Seq.  DSRLAFHHV
Variant Seq.  DSlLAlrHm
Mutations R/L F/L H/R V/M
Epitope Location R3L F6L H7R V9M
HXB2 Location R188L F191L H192R V194M
Mutation Type OV: observed variant
Note The epitope varied over time but the mutations did not become fixed. The variant arose at early timepoints.


Variant ID.  322
Epitope Seq.  DSRLAFHHV
Variant Seq.  DSRLAvHHV
Mutations F/V
Epitope Location F6V
HXB2 Location F191V
Mutation Type OV: observed variant
Note The epitope varied over time but the mutations did not become fixed. The variant arose at intermediate timepoints.

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.


Displaying record number 52993

HXB2 Location  Nef(190-198)   Nef Epitope Map
View variants at this location
Epitope AFHHVAREK   Epitope Alignment
Variants
AlrHmAREK   observed variant
AvHHVAREK   observed variant
AFHHVAxEi   observed variant
Species (MHC/HLA human(B51)

Variant Details

Showing all: 3 variant(s).


Variant ID.  323
Epitope Seq.  AFHHVAREK
Variant Seq.  AlrHmAREK
Mutations F/L H/R V/M
Epitope Location F2L H3R V5M
HXB2 Location F191L H192R V194M
Mutation Type OV: observed variant
Note The epitope varied over time but the mutations did not become fixed. The variant arose at early timepoints.


Variant ID.  324
Epitope Seq.  AFHHVAREK
Variant Seq.  AvHHVAREK
Mutations F/V
Epitope Location F2V
HXB2 Location F191V
Mutation Type OV: observed variant
Note The epitope varied over time but the mutations did not become fixed. The variant arose at intermediate timepoints.


Variant ID.  325
Epitope Seq.  AFHHVAREK
Variant Seq.  AFHHVAxEi
Mutations R/X K/I
Epitope Location R7X K9I
HXB2 Location R196X K198I
Mutation Type OV: observed variant
Note The epitope varied over time but the mutations did not become fixed. The variant arose at late timepoints.

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.


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