Search the Epitope Variant and Escape Mutation Database

Help

Found 6 matching records:

Displaying record number 55068

HXB2 Location Gag(156-164) Gag Epitope Map
View variants at this location

Epitope

VKVVEEKAF

Epitope Alignment

Variants

VKViEEKAF subtype-specific susceptible form

Species (MHC/HLA) human(B*15:03)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`213`
Epitope Seq.	`VKVVEEKAF`
Variant Seq.	`VKViEEKAF`
Mutations	V/I
Epitope Location	V4I
HXB2 Location	V159I
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	B
Variant Subtype	C
Note	VKVVEEKAF epitope is found in subtype B, while the variant is found in subtype C. Both are frequently targeted by B*1503 positive individuals.

References

Frahm2006 Nicole Frahm, Photini Kiepiela, Sharon Adams, Caitlyn H. Linde, Hannah S. Hewitt, Kaori Sango, Margaret E. Feeney, Marylyn M. Addo, Mathias Lichterfeld, Matthew P. Lahaie, Eunice Pae, Alysse G. Wurcel, Timothy Roach, M Anne. St. John, Marcus Altfeld, Francesco M. Marincola, Corey Moore, Simon Mallal, Mary Carrington, David Heckerman, Todd M. Allen, James I. Mullins, Bette T. Korber, Philip J. R. Goulder, Bruce D. Walker, and Christian Brander. Control of Human Immunodeficiency Virus Replication by Cytotoxic T Lymphocytes Targeting Subdominant Epitopes. Nat. Immunol., 7(2):173-178, Feb 2006. PubMed ID: 16369537. Show all entries for this paper.

Displaying record number 55070

HXB2 Location Pol(147-155) Pol Epitope Map
View variants at this location

Epitope

TQIGCTLNF

Epitope Alignment

Variants

TQlGCTLNF subtype-specific non-susceptible form

Species (MHC/HLA) human(B*15:03)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`214`
Epitope Seq.	`TQIGCTLNF`
Variant Seq.	`TQlGCTLNF`
Mutations	I/L
Epitope Location	I3L
HXB2 Location	I149L
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	B
Variant Subtype	C
Note	TQIGCTLNF epitope is found in subtype B, while the variant is found in subtype C. Only subtype B epitope is frequently recognized by B*1503 positive individuals.

References

Displaying record number 55071

HXB2 Location Pol(328-336) Pol Epitope Map
View variants at this location

Epitope

KQNPDIVIY

Epitope Alignment

Variants

KQNPeIVIY subtype-specific non-susceptible form

Species (MHC/HLA) human(B*15:03)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`215`
Epitope Seq.	`KQNPDIVIY`
Variant Seq.	`KQNPeIVIY`
Mutations	D/E
Epitope Location	D5E
HXB2 Location	D332E
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	B
Variant Subtype	C
Note	KQNPDIVIY epitope is found in subtype B, while the variant is found in subtype C. Only subtype B epitope is frequently recognized by B*1503 positive individuals.

References

Displaying record number 55073

HXB2 Location Pol(933-942) Pol Epitope Map
View variants at this location

Epitope

TKIQNFRVYY

Epitope Alignment

Variants

iKIQNFRVYY subtype-specific non-susceptible form

Species (MHC/HLA) human(B*15:03)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`216`
Epitope Seq.	`TKIQNFRVYY`
Variant Seq.	`iKIQNFRVYY`
Mutations	T/I
Epitope Location	T1I
HXB2 Location	T933I
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	B
Variant Subtype	C
Note	TKIQNFRVYY epitope is found in subtype B, while the variant is found in subtype C. Subtype B epitope is significantly more frequently recognized by B*1503 positive individuals than the variant C epitope.

References

Displaying record number 55077

HXB2 Location Pol(978-986) Pol Epitope Map
View variants at this location

Epitope

RKAKIIRDY

Epitope Alignment

Variants

RKAKIIkDY subtype-specific non-susceptible form

Species (MHC/HLA) human(B*15:03)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`217`
Epitope Seq.	`RKAKIIRDY`
Variant Seq.	`RKAKIIkDY`
Mutations	R/K
Epitope Location	R7K
HXB2 Location	R984K
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	B
Variant Subtype	C
Note	RKAKIIRDY epitope is found in subtype B, while the variant is found in subtype C. Subtype B epitope is significantly more frequently recognized by B*1503 positive individuals than the variant C epitope.

References

Displaying record number 55075

HXB2 Location Nef(183-191) Nef Epitope Map
View variants at this location

Epitope

WKFDSRLAF

Epitope Alignment

Variants

WKFDSqLAF subtype-specific non-susceptible form

Species (MHC/HLA) human(B*15:03)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`218`
Epitope Seq.	`WKFDSRLAF`
Variant Seq.	`WKFDSqLAF`
Mutations	R/Q
Epitope Location	R6Q
HXB2 Location	R188Q
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	B
Variant Subtype	C
Note	WKFDSRLAF epitope is found in subtype B, while the variant is found in subtype C, Subtype B epitope is significantly more frequently recognized by B*1503 positive individuals than the variant C epitope.