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Displaying record number 58783

HXB2 Location Gag(209-218) Gag Epitope Map
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AAEWDRLHPV

`AAEWDRmHPV`		HLA association; diminished HLA binding or increased off-rate
`AAEWDRaHPV`		HLA association
`AAEWDRqHPV`		HLA association; diminished HLA binding or increased off-rate
`AAEWDRsHPV`		HLA association
`AAEWDRtHPV`		HLA association
`AAEWDRvHPV`		HLA association
`AAEWDRiHPV`		HLA association
`-AEWDRxHPV`		HLA association; diminished HLA binding or increased off-rate
`AAEWDRxHP-`		HLA association; diminished HLA binding or increased off-rate

Epitope Name p24Gag209-218

Species (MHC/HLA) human

Variant Details

Showing all: 9 variant(s).

Variant ID.	`3146`
Epitope Seq.	`AAEWDRLHPV`
Variant Seq.	`AAEWDRmHPV`
Mutations	L/M
Epitope Location	L7M
HXB2 Location	L215M
Mutation Type	A: HLA association DHB: diminished HLA binding or increased off-rate
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding
Note	Gag209-218-M, AAEWDRmHPV, binds HLA-Cw*0102 but at a decreased level. 2.9% sequences carried this variation.

Variant ID.	`3147`
Epitope Seq.	`AAEWDRLHPV`
Variant Seq.	`AAEWDRaHPV`
Mutations	L/A
Epitope Location	L7A
HXB2 Location	L215A
Mutation Type	A: HLA association
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding
Note	Gag209-218-A, AAEWDRaHPV, showed a significant increase in binding to HLA-Cw*0102. 0.9% of sequences carried this variant.

Variant ID.	`3148`
Epitope Seq.	`AAEWDRLHPV`
Variant Seq.	`AAEWDRqHPV`
Mutations	L/Q
Epitope Location	L7Q
HXB2 Location	L215Q
Mutation Type	A: HLA association DHB: diminished HLA binding or increased off-rate
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding
Note	Gag209-218-Q, AAEWDRqHPV, showed a slight decrease in binding to HLA-Cw*0102. 0.1% of sequences carried this variant.

Variant ID.	`3149`
Epitope Seq.	`AAEWDRLHPV`
Variant Seq.	`AAEWDRsHPV`
Mutations	L/S
Epitope Location	L7S
HXB2 Location	L215S
Mutation Type	A: HLA association
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding
Note	Gag209-218-S, AAEWDRsHPV, showed an increase in binding to HLA-Cw*0102. 0.1% of sequences carried this variant.

Variant ID.	`3150`
Epitope Seq.	`AAEWDRLHPV`
Variant Seq.	`AAEWDRtHPV`
Mutations	L/T
Epitope Location	L7T
HXB2 Location	L215T
Mutation Type	A: HLA association
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding
Note	Gag209-218-T, AAEWDRtHPV, showed a significant increase in binding to HLA-Cw*0102. 5.2% of sequences carried this variant.

Variant ID.	`3151`
Epitope Seq.	`AAEWDRLHPV`
Variant Seq.	`AAEWDRvHPV`
Mutations	L/V
Epitope Location	L7V
HXB2 Location	L215V
Mutation Type	A: HLA association
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding
Note	Gag209-218-V, AAEWDRvHPV, showed a significant increase in binding to HLA-Cw*0102. 16.3% of sequences carried this variant.

Variant ID.	`3152`
Epitope Seq.	`AAEWDRLHPV`
Variant Seq.	`AAEWDRiHPV`
Mutations	L/I
Epitope Location	L7I
HXB2 Location	L215I
Mutation Type	A: HLA association
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding
Note	Gag209-218-I, AAEWDRiHPV, showed an increase in binding to HLA-Cw*0102. 3.6% of sequences carried this variant.

Variant ID.	`3153`
Epitope Seq.	`AAEWDRLHPV`
Variant Seq.	`-AEWDRxHPV`
Mutations	A/- L/X
Epitope Location	A1- L7X
HXB2 Location	A209- L215X
Mutation Type	A: HLA association DHB: diminished HLA binding or increased off-rate
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding
Note	All sequences with mutations at position 7 and without the N-terminal Alanine were able to bind Cw*0102, but at reduced levels.

Variant ID.	`3154`
Epitope Seq.	`AAEWDRLHPV`
Variant Seq.	`AAEWDRxHP-`
Mutations	V/- L/X
Epitope Location	V10- L7X
HXB2 Location	V218- L215X
Mutation Type	A: HLA association DHB: diminished HLA binding or increased off-rate
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding
Note	All sequences with mutations at position 7 and without the C-terminal Valine were unable to bind Cw*0102.

References

Fadda2012 Lena Fadda, Christian Körner, Swati Kumar, Nienke H. van Teijlingen, Alicja Piechocka-Trocha, Mary Carrington, and Marcus Altfeld. HLA-Cw*0102-Restricted HIV-1 p24 Epitope Variants Can Modulate the Binding of the Inhibitory KIR2DL2 Receptor and Primary NK Cell Function. PLoS Pathog., 8(7):e1002805, 2012. PubMed ID: 22807681. Show all entries for this paper.