Found 1 matching record:
HXB2 Location | Gag(77-85) | Gag Epitope Map
View variants at this location |
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Epitope |
SLYNTVATL
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Epitope Alignment | ||||||||||
Variants |
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Epitope Name | SL9 | |||||||||||
Species (MHC/HLA) |
Showing all: 3 variant(s).
Variant ID. | 178 |
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Epitope Seq. | SLYNTVATL |
Variant Seq. | SLYNTVAvL |
Mutations | T/V |
Epitope Location | T8V |
HXB2 Location | T84V |
Mutation Type | SF: susceptible form |
Note | SLYNTVATL was the only form of the epitope found initially, but three alternate forms eventually appeared: SLYNTVAVL, SLYNTIATL, and most commonly SLYNTIAVL. These distinct forms bind A2, but have distinct abilities to stimulate different T-cell clonotypes. In subject TX7, the observed mutations of SL9 failed to escape overall CTL recognition, presumably because the six T-cell clonotypes allowed a more flexible response. The BV17 T-cell clone recognized SL9 but not SLYNTIAVL, and BV17 became undetectable at week 20 when SLYNTIAVL predominated. Subsequently BV17 became the second most common clone. |
Variant ID. | 179 |
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Epitope Seq. | SLYNTVATL |
Variant Seq. | SLYNTiATL |
Mutations | V/I |
Epitope Location | V6I |
HXB2 Location | V82I |
Mutation Type | E: escape documented in this paper SF: susceptible form |
Note | SLYNTVATL was the only form of the epitope found initially, but three alternate forms eventually appeared: SLYNTVAVL, SLYNTIATL, and most commonly SLYNTIAVL. These distinct forms bind A2, but have distinct abilities to stimulate different T-cell clonotypes. In subject TX7, the observed mutations of SL9 failed to escape overall CTL recognition, presumably because the six T-cell clonotypes allowed a more flexible response. The BV17 T-cell clone recognized SL9 but not SLYNTIAVL, and BV17 became undetectable at week 20 when SLYNTIAVL predominated. Subsequently BV17 became the second most common clone. |
Variant ID. | 180 |
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Epitope Seq. | SLYNTVATL |
Variant Seq. | SLYNTiAvL |
Mutations | V/I T/V |
Epitope Location | V6I T8V |
HXB2 Location | V82I T84V |
Mutation Type | SF: susceptible form |
Note | SLYNTVATL was the only form of the epitope found initially, but three alternate forms eventually appeared: SLYNTVAVL, SLYNTIATL, and most commonly SLYNTIAVL. These distinct forms bind A2, but have distinct abilities to stimulate different T-cell clonotypes. In subject TX7, the observed mutations of SL9 failed to escape overall CTL recognition, presumably because the six T-cell clonotypes allowed a more flexible response. The BV17 T-cell clone recognized SL9 but not SLYNTIAVL, and BV17 became undetectable at week 20 when SLYNTIAVL predominated. Subsequently BV17 became the second most common clone. |
Douek2002 Daniel C. Douek, Michael R. Betts, Jason M. Brenchley, Brenna J. Hill, David R. Ambrozak, Ka-Leung Ngai, Nitin J. Karandikar, Joseph P. Casazza, and Richard A. Koup. A Novel Approach to the Analysis of Specificity, Clonality, and Frequency of HIV-Specific T Cell Responses Reveals a Potential Mechanism for Control of Viral Escape. J. Immunol., 168(6):3099-3104, 15 Mar 2002. PubMed ID: 11884484. Show all entries for this paper.
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