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Found 7 matching records:

Displaying record number 59207

HXB2 Location Gag(147-155) Gag Epitope Map
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ISPRTLNAW

`lSPRTLNAW`		observed variant
`ltPRTLNAW`		observed variant
`ItPRTLNAW`		observed variant
`IaPRTLNAW`		observed variant
`IlPRTLNAW`		observed variant

Epitope Name ISW9

Species (MHC/HLA) human(B*57:01)

Variant Details

Showing all: 5 variant(s).

Variant ID.	`3339`
Epitope Seq.	`ISPRTLNAW`
Variant Seq.	`lSPRTLNAW`
Mutations	I/L
Epitope Location	I1L
HXB2 Location	I147L
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant lSPRTLNAW, was seen in 2/3 HRPs and 2/3 LRPs. lSPRTLNAW was the only analogous ISW9 in patient P1 and was found in the major viral population in patients P5 and P6 at latter time points.

Variant ID.	`3340`
Epitope Seq.	`ISPRTLNAW`
Variant Seq.	`ltPRTLNAW`
Mutations	I/L S/T
Epitope Location	I1L S2T
HXB2 Location	I147L S148T
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant ltPRTLNAW, was seen in 0/3 HRPs and 1/3 LRPs (patient P4) at the last sampling point.

Variant ID.	`3341`
Epitope Seq.	`ISPRTLNAW`
Variant Seq.	`ItPRTLNAW`
Mutations	S/T
Epitope Location	S2T
HXB2 Location	S148T
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant ItPRTLNAW, was seen in 0/3 HRPs and 1/3 LRPs. It was the predominant variant in subject P4.

Variant ID.	`3342`
Epitope Seq.	`ISPRTLNAW`
Variant Seq.	`IaPRTLNAW`
Mutations	S/A
Epitope Location	S2A
HXB2 Location	S148A
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant ItPRTLNAW, was seen in 1/3 HRPs and 0/3 LRPs. It was the predominant variant in subject P4.

Variant ID.	`3343`
Epitope Seq.	`ISPRTLNAW`
Variant Seq.	`IlPRTLNAW`
Mutations	S/L
Epitope Location	S2L
HXB2 Location	S148L
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant IlPRTLNAW, was seen in 1/3 HRPs and 0/3 LRPs. It was an early variant in Gag that was later lost in subject P3.

References

Buggert2014 Marcus Buggert, Melissa M. Norström, Marco Salemi, Frederick M. Hecht, and Annika C. Karlsson. Functional Avidity and IL-2/Perforin Production Is Linked to the Emergence of Mutations within HLA-B*5701-Restricted Epitopes and HIV-1 Disease Progression. J. Immunol., 192(10):4685-4696, 15 May 2014. PubMed ID: 24740510. Show all entries for this paper.

Displaying record number 59208

HXB2 Location Gag(162-172) Gag Epitope Map
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Epitope

KAFSPEVIPMF

Epitope Alignment

Variants

`KAFSPEVIPMs`		observed variant
`KAFSPEVIPMt`		observed variant
`KAFSPEiIPMF`		observed variant
`KAsSPEVIPMF`		observed variant

Epitope Name KF11

Species (MHC/HLA) human(B*57:01)

Variant Details

Showing all: 4 variant(s).

Variant ID.	`3344`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KAFSPEVIPMs`
Mutations	F/S
Epitope Location	F11S
HXB2 Location	F172S
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant KAFSPEVIPMs was seen in 1/3 HRP subjects (patient P1).

Variant ID.	`3345`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KAFSPEVIPMt`
Mutations	F/T
Epitope Location	F11T
HXB2 Location	F172T
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant KAFSPEVIPMt was seen in 1/3 HRP (patient P1) and 1/3 LRP (patient P6) subjects.

Variant ID.	`3346`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KAFSPEiIPMF`
Mutations	V/I
Epitope Location	V7I
HXB2 Location	V168I
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant KAFSPEiIPMF was seen in 1/3 HRP (patient P1) and 1/3 LRP (patient P6) subjects.

Variant ID.	`3347`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KAsSPEVIPMF`
Mutations	F/S
Epitope Location	F3S
HXB2 Location	F164S
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant KAsSPEVIPMF was seen in 1/3 LRP (patient P6) subjects.

References

Displaying record number 59210

HXB2 Location Gag(240-249) Gag Epitope Map
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Epitope

TSTLQEQIGW

Epitope Alignment

Variants

`TSTLrEQIGW`		observed variant
`TSTLQEQIeW`		observed variant
`TSsLQEQIGW`		observed variant
`TSnLQEQIGW`		escape documented in this paper; observed variant
`TSnLQEQIrW`		observed variant
`TSnLQEQItW`		observed variant
`TSnLQEQIaW`		escape documented in this paper; observed variant
`TSTLQEQIaW`		observed variant

Epitope Name TW10

Species (MHC/HLA) human(B*57:01)

Variant Details

Showing all: 8 variant(s).

Variant ID.	`3348`
Epitope Seq.	`TSTLQEQIGW`
Variant Seq.	`TSTLrEQIGW`
Mutations	Q/R
Epitope Location	Q5R
HXB2 Location	Q244R
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant TSTLrEQIGW was seen in 1/3 HRP (patient P1) subjects.

Variant ID.	`3349`
Epitope Seq.	`TSTLQEQIGW`
Variant Seq.	`TSTLQEQIeW`
Mutations	Q/R G/E
Epitope Location	Q5R G9E
HXB2 Location	Q244R G248E
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant TSTLQEQIeW was seen in 1/3 HRP (patient P1) and 1/3 LRP (patient 5) subjects.

Variant ID.	`3350`
Epitope Seq.	`TSTLQEQIGW`
Variant Seq.	`TSsLQEQIGW`
Mutations	T/S
Epitope Location	T3S
HXB2 Location	T242S
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant TSTLrEQIeW was seen in 1/3 HRP (patient P2) subjects.

Variant ID.	`3351`
Epitope Seq.	`TSTLQEQIGW`
Variant Seq.	`TSnLQEQIGW`
Mutations	T/N
Epitope Location	T3N
HXB2 Location	T242N
Mutation Type	E: escape documented in this paper OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant TSnLQEQIGW, TW10-3N was seen in all 6 HRP and LRP subjects.

Variant ID.	`3352`
Epitope Seq.	`TSTLQEQIGW`
Variant Seq.	`TSnLQEQIrW`
Mutations	T/N G/R
Epitope Location	T3N G9R
HXB2 Location	T242N G248R
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant TSnLQEQIrW was seen in all 1/3 HRP (patient P2) subjects.

Variant ID.	`3353`
Epitope Seq.	`TSTLQEQIGW`
Variant Seq.	`TSnLQEQItW`
Mutations	T/N G/T
Epitope Location	T3N G9T
HXB2 Location	T242N G248T
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant TSnLQEQItW was seen in all 1/3 HRP (patient P2) subjects.

Variant ID.	`3354`
Epitope Seq.	`TSTLQEQIGW`
Variant Seq.	`TSnLQEQIaW`
Mutations	T/N G/A
Epitope Location	T3N G9A
HXB2 Location	T242N G248A
Mutation Type	E: escape documented in this paper OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant TSnLQEQIaW, TW10-3N-9A, was seen in 1/3 HRP (patient P3) and 1/3 LRP (patient 5) subjects. It was the analogous epitope of the major viral population at the last time point in patient P1, the earliest time point in patients P2 and P3, and the only variant in LRP patients P4 and P6.

Variant ID.	`3355`
Epitope Seq.	`TSTLQEQIGW`
Variant Seq.	`TSTLQEQIaW`
Mutations	G/A
Epitope Location	G9A
HXB2 Location	G248A
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant TSTLQEQIaW was seen in 1/3 LRP (patient 5) subjects.

References

Displaying record number 59209

HXB2 Location Gag(308-316) Gag Epitope Map
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Epitope

QASQEVKNW

Epitope Alignment

Variants

`QASQdVKNW`		observed variant
`QASQtVKNW`		observed variant

Epitope Name QW9

Species (MHC/HLA) human(B*57:01)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`3356`
Epitope Seq.	`QASQEVKNW`
Variant Seq.	`QASQdVKNW`
Mutations	E/D
Epitope Location	E5D
HXB2 Location	E312D
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant QASQdVKNW was seen in 2/3 HRP and no LRP subjects. It was the analogous epitope of the major viral population at the last time points in patient P3, the earliest time point in patient P1.

Variant ID.	`3357`
Epitope Seq.	`QASQEVKNW`
Variant Seq.	`QASQtVKNW`
Mutations	E/T
Epitope Location	E5T
HXB2 Location	E312T
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant QASQtVKNW was seen in 1/3 HRP and no LRP subjects. It was the only analogous epitope of the major viral population patient P2.

References

Displaying record number 59211

HXB2 Location Nef(82-91) Nef Epitope Map
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Epitope

KAALDLSHFL

Epitope Alignment

Variants

`KAALDLSHlL`		observed variant
`rAALDLSHFL`		observed variant
`rAALDLSHlL`		observed variant
`rAAvDLSHFL`		observed variant
`KgALDLSHFL`		observed variant
`KAAvDLSHFL`		observed variant

Epitope Name KL10

Species (MHC/HLA) human(B*57:01)

Variant Details

Showing all: 6 variant(s).

Variant ID.	`3358`
Epitope Seq.	`KAALDLSHFL`
Variant Seq.	`KAALDLSHlL`
Mutations	F/L
Epitope Location	F9L
HXB2 Location	F90L
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant KAALDLSHlL was seen in 1/3 HRP (patient P2) and 2/3 LRP (patients P4, P6) subjects.

Variant ID.	`3359`
Epitope Seq.	`KAALDLSHFL`
Variant Seq.	`rAALDLSHFL`
Mutations	K/R
Epitope Location	K1R
HXB2 Location	K82R
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant rAALDLSHlL was seen in 1/3 LRP (patient P6) and no HRP subjects.

Variant ID.	`3360`
Epitope Seq.	`KAALDLSHFL`
Variant Seq.	`rAALDLSHlL`
Mutations	K/R F/L
Epitope Location	K1R F9L
HXB2 Location	K82R F90L
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant rAALDLSHlL was seen in no HRP and 1/3 LRP (patient P6) subjects.

Variant ID.	`3361`
Epitope Seq.	`KAALDLSHFL`
Variant Seq.	`rAAvDLSHFL`
Mutations	K/R L/V
Epitope Location	K1R L4V
HXB2 Location	K82R L85V
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant rAAvDLSHFL was seen in no HRP and 1/3 LRP (patient P6) subjects and was the major analogous epitope at later time points.

Variant ID.	`3362`
Epitope Seq.	`KAALDLSHFL`
Variant Seq.	`KgALDLSHFL`
Mutations	A/G
Epitope Location	A2G
HXB2 Location	A83G
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant KgALDLSHFL was seen in 1/3 HRP (patient P3) and 1/3 (patient P4) LRP subjects. It was the autologous epitope of the major viral population in the later time points for the LRP but the only epitope in the HRP.

Variant ID.	`3363`
Epitope Seq.	`KAALDLSHFL`
Variant Seq.	`KAAvDLSHFL`
Mutations	L/V
Epitope Location	L4V
HXB2 Location	L85V
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant KAAvDLSHFL was seen in no HRP and 2/3 LRP subjects. It was the autologous epitope of the major viral population at the first time point for the patient P6 but was then lost.

References

Displaying record number 59212

HXB2 Location Nef(116-125) Nef Epitope Map
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Epitope

HTQGYFPDWQ

Epitope Alignment

Variants

nTQGYFPDWQ observed variant

Epitope Name HQ10

Species (MHC/HLA) human(B*57:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3364`
Epitope Seq.	`HTQGYFPDWQ`
Variant Seq.	`nTQGYFPDWQ`
Mutations	H/N
Epitope Location	H1N
HXB2 Location	H116N
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant nTQGYFPDWQ was seen in 2/3 HRP and all 3 LRP subjects. It was the autologous epitope of the major viral population in patients P2, P3 and P6; and it was the only form in patients P4 and P5.

References

Displaying record number 59213

HXB2 Location Nef(120-128) Nef Epitope Map
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Epitope

YFPDWQNYT

Epitope Alignment

Variants

`YFPDWQcYT`		observed variant
`YFPDWQchT`		observed variant

Epitope Name YT9

Species (MHC/HLA) human(B*57:01)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`3365`
Epitope Seq.	`YFPDWQNYT`
Variant Seq.	`YFPDWQcYT`
Mutations	N/C
Epitope Location	N7C
HXB2 Location	N126C
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant YFPDWQcYT was an autologous epitope found in 1/3 HRP (patient P2) and 1/3 LRP (patient P4).

Variant ID.	`3366`
Epitope Seq.	`YFPDWQNYT`
Variant Seq.	`YFPDWQchT`
Mutations	N/C Y/H
Epitope Location	N7C Y8H
HXB2 Location	N126C Y127H
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	Variant YFPDWQchT was an autologous epitope found in no HRP and 1/3 LRP (patient P4).