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Found 2 matching records:

Displaying record number 55518

HXB2 Location Gag(77-85) Gag Epitope Map
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SLYNTVATL

`SLYNTVAvL`		subtype-specific susceptible form
`SLfNTVATL`		subtype-specific susceptible form

Epitope Name SL9

Species (MHC/HLA) human(A*02)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`69`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTVAvL`
Mutations	T/V
Epitope Location	T8V
HXB2 Location	T84V
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	B
Variant Subtype	A, F
Method	Chromium-release assay
Note	SL9 epitope variants used were SLYNTVATL for clades B/A1/C/D, SLYNTVAVL for clades A2/F1, and SLFNTVATL for clades G/K. Clade B-elicited CTLs recognized epitopes from all other clades when tested by Cr-release.

Variant ID.	`70`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTVATL`
Mutations	Y/F
Epitope Location	Y3F
HXB2 Location	Y79F
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	B
Variant Subtype	G, K
Method	Chromium-release assay
Note	SL9 epitope variants used were SLYNTVATL for clades B/A1/C/D, SLYNTVAVL for clades A2/F1, and SLFNTVATL for clades G/K. Clade B-elicited CTLs recognized epitopes from all other clades when tested by Cr-release.

References

Bennett2008 Michael S. Bennett, Hwee L. Ng, Ayub Ali, and Otto O. Yang. Cross-Clade Detection of HIV-1-Specific Cytotoxic T Lymphocytes Does Not Reflect Cross-Clade Antiviral Activity. J. Infect. Dis., 197(3):390-397, 1 Feb 2008. PubMed ID: 18184090. Show all entries for this paper.

Displaying record number 55517

HXB2 Location Rev(66-75) Rev Epitope Map
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Epitope

RPAEPVPLQL

Epitope Alignment

Variants

`RsAEPVPLQL`		subtype-specific susceptible form
`RPtEPVPLQL`		subtype-specific susceptible form
`RseEPVPLQL`		subtype-specific susceptible form
`RPeEPVPLQL`		subtype-specific susceptible form

Epitope Name RL10

Species (MHC/HLA) human(B*07)

Variant Details

Showing all: 4 variant(s).

Variant ID.	`71`
Epitope Seq.	`RPAEPVPLQL`
Variant Seq.	`RsAEPVPLQL`
Mutations	P/S
Epitope Location	P2S
HXB2 Location	P67S
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	B
Variant Subtype	A1
Method	Chromium-release assay
Note	RL10 epitope variants used were RPAEPVPLQL for clades B/C/G, RSAEPVPLQL for clade A1, RPTEPVPLQL for clades A2/F2, RSEEPVPLQL for clade D, and RPEEPVPLQL for clade F1. Clade B-elicited CTLs recognized epitopes from all other clades when tested by Cr-release.

Variant ID.	`72`
Epitope Seq.	`RPAEPVPLQL`
Variant Seq.	`RPtEPVPLQL`
Mutations	A/T
Epitope Location	A3T
HXB2 Location	A68T
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	B
Variant Subtype	A2, F2
Method	Chromium-release assay
Note	RL10 epitope variants used were RPAEPVPLQL for clades B/C/G, RSAEPVPLQL for clade A1, RPTEPVPLQL for clades A2/F2, RSEEPVPLQL for clade D, and RPEEPVPLQL for clade F1. Clade B-elicited CTLs recognized epitopes from all other clades when tested by Cr-release.

Variant ID.	`73`
Epitope Seq.	`RPAEPVPLQL`
Variant Seq.	`RseEPVPLQL`
Mutations	P/S A/E
Epitope Location	P2S A3E
HXB2 Location	P67S A68E
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	B
Variant Subtype	D
Method	Chromium-release assay
Note	RL10 epitope variants used were RPAEPVPLQL for clades B/C/G, RSAEPVPLQL for clade A1, RPTEPVPLQL for clades A2/F2, RSEEPVPLQL for clade D, and RPEEPVPLQL for clade F1. Clade B-elicited CTLs recognized epitopes from all other clades when tested by Cr-release.

Variant ID.	`74`
Epitope Seq.	`RPAEPVPLQL`
Variant Seq.	`RPeEPVPLQL`
Mutations	A/E
Epitope Location	A3E
HXB2 Location	A68E
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	B
Variant Subtype	F1
Method	Chromium-release assay
Note	RL10 epitope variants used were RPAEPVPLQL for clades B/C/G, RSAEPVPLQL for clade A1, RPTEPVPLQL for clades A2/F2, RSEEPVPLQL for clade D, and RPEEPVPLQL for clade F1. Clade B-elicited CTLs recognized epitopes from all other clades when tested by Cr-release.