HIV molecular immunology database
Found 5 matching records:
| HXB2 Location | Gag(20-28) | Gag Epitope Map
View variants at this location |
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| Epitope |
RLRPGGKKK
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | RK9 | |||||
| Species (MHC/HLA) | human(A*03:01) | |||||
Showing all: 1 variant(s).
| Variant ID. | 59 |
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| Epitope Seq. | RLRPGGKKK |
| Variant Seq. | RLRPGGKKq |
| Mutations | K/Q |
| Epitope Location | K9Q |
| HXB2 Location | K28Q |
| Mutation Type | E: escape documented in this paper |
| Method | CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining |
| Note | Drastically reduced avidity. The response to this peptide was not apparent until month 20, by month 32 the escape variant was present. |
Bansal2005a Anju Bansal, Ethan Gough, Steffanie Sabbaj, Doug Ritter, Karina Yusim, Greg Sfakianos, Grace Aldrovandi, Richard A. Kaslow, Craig M. Wilson, Mark J. Mulligan, J. Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Responses in Early HIV-1 Infection Are Skewed Towards High Entropy Peptides. AIDS, 19(3):241-250, 18 Feb 2005. PubMed ID: 15718834. Show all entries for this paper.
| HXB2 Location | Gag(77-85) | Gag Epitope Map
View variants at this location |
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| Epitope |
SLYNTIATL
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Epitope Alignment | |||||||
| Variants |
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| Epitope Name | SL9 | ||||||||
| Species (MHC/HLA) | human(A*02:01) | ||||||||
Showing all: 2 variant(s).
| Variant ID. | 60 |
|---|---|
| Epitope Seq. | SLYNTIATL |
| Variant Seq. | SLYNTIAvL |
| Mutations | T/V |
| Epitope Location | T8V |
| HXB2 Location | T84V |
| Mutation Type | SF: susceptible form |
| Method | CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining |
| Note | The response to this variant peptide, SVL9, was not apparent until month 20, by month 32 a T to V change was dominant, but the SLYNTIAvL mutant showed comparable avidity. |
| Variant ID. | 4374 |
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| Epitope Seq. | SLYNTIATL |
| Variant Seq. | SLYNTvATL |
| Mutations | I/V |
| Epitope Location | I6V |
| HXB2 Location | I82V |
| Mutation Type | SF: susceptible form |
| Method | CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining |
| Note | The response to this variant peptide, A2-SL9, was seen by PBMC from subject 8183A. |
Bansal2005a Anju Bansal, Ethan Gough, Steffanie Sabbaj, Doug Ritter, Karina Yusim, Greg Sfakianos, Grace Aldrovandi, Richard A. Kaslow, Craig M. Wilson, Mark J. Mulligan, J. Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Responses in Early HIV-1 Infection Are Skewed Towards High Entropy Peptides. AIDS, 19(3):241-250, 18 Feb 2005. PubMed ID: 15718834. Show all entries for this paper.
| HXB2 Location | Vif(61-69) | Vif Epitope Map
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| Epitope |
DAKLIITTY
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | DY9 | |||||
| Species (MHC/HLA) | human(B*35:01) | |||||
Showing all: 1 variant(s).
| Variant ID. | 61 |
|---|---|
| Epitope Seq. | DAKLIITTY |
| Variant Seq. | DAKLIIkTY |
| Mutations | T/K |
| Epitope Location | T7K |
| HXB2 Location | T67K |
| Mutation Type | E: escape documented in this paper |
| Method | CD8 T-cell Elispot - IFNy |
| Note | The peptide that carries this epitope was recognized early in infection but the response diminished over time. A point mutation of epitope position 7 (T to K, DAKLIIkTY) was detected at high frequency at a chronic infection timepoint, 34 months. The K variant was an escape form, and had low avidity by gamma IFN EliSpot. |
Bansal2005a Anju Bansal, Ethan Gough, Steffanie Sabbaj, Doug Ritter, Karina Yusim, Greg Sfakianos, Grace Aldrovandi, Richard A. Kaslow, Craig M. Wilson, Mark J. Mulligan, J. Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Responses in Early HIV-1 Infection Are Skewed Towards High Entropy Peptides. AIDS, 19(3):241-250, 18 Feb 2005. PubMed ID: 15718834. Show all entries for this paper.
| HXB2 Location | Nef(74-81) | Nef Epitope Map
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| Epitope |
VPLRPMTY
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | VY8 | |||||
| Species (MHC/HLA) | human(B*35:01) | |||||
Showing all: 1 variant(s).
| Variant ID. | 62 |
|---|---|
| Epitope Seq. | VPLRPMTY |
| Variant Seq. | VPLRPMTf |
| Mutations | Y/F |
| Epitope Location | Y8F |
| HXB2 Location | Y81F |
| Mutation Type | DR: diminished response |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Point mutation of epitope at position 8 (Y to F,VPLRPMTf) was detected at a chronic infection timepoint. The CTL response was strong in early infection, but diminished by month 13. This mutation had reduced avidity. |
Bansal2005a Anju Bansal, Ethan Gough, Steffanie Sabbaj, Doug Ritter, Karina Yusim, Greg Sfakianos, Grace Aldrovandi, Richard A. Kaslow, Craig M. Wilson, Mark J. Mulligan, J. Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Responses in Early HIV-1 Infection Are Skewed Towards High Entropy Peptides. AIDS, 19(3):241-250, 18 Feb 2005. PubMed ID: 15718834. Show all entries for this paper.
| HXB2 Location | Nef(128-137) | Nef Epitope Map
View variants at this location |
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| Epitope |
TPGPGVRYPL
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | Nef-TL10 | |||||
| Species (MHC/HLA) | human(B*35:01) | |||||
Showing all: 1 variant(s).
| Variant ID. | 4375 |
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| Epitope Seq. | TPGPGVRYPL |
| Variant Seq. | TsGPGVRYPL |
| Mutations | P/S |
| Epitope Location | P2S |
| HXB2 Location | P129S |
| Mutation Type | SF: susceptible form |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Variant TsGPGVRYPL was recognized by month 34. |
Bansal2005a Anju Bansal, Ethan Gough, Steffanie Sabbaj, Doug Ritter, Karina Yusim, Greg Sfakianos, Grace Aldrovandi, Richard A. Kaslow, Craig M. Wilson, Mark J. Mulligan, J. Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Responses in Early HIV-1 Infection Are Skewed Towards High Entropy Peptides. AIDS, 19(3):241-250, 18 Feb 2005. PubMed ID: 15718834. Show all entries for this paper.