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Found 5 matching records:

Displaying record number 53602

HXB2 Location  Gag(20-28)   Gag Epitope Map
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Epitope RLRPGGKKK   Epitope Alignment
Variants
RLRPGGKKq   escape documented in this paper
Epitope Name RK9
Species (MHC/HLA human(A*03:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  59
Epitope Seq.  RLRPGGKKK
Variant Seq.  RLRPGGKKq
Mutations K/Q
Epitope Location K9Q
HXB2 Location K28Q
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining
Note Drastically reduced avidity. The response to this peptide was not apparent until month 20, by month 32 the escape variant was present.

References

Bansal2005a Anju Bansal, Ethan Gough, Steffanie Sabbaj, Doug Ritter, Karina Yusim, Greg Sfakianos, Grace Aldrovandi, Richard A. Kaslow, Craig M. Wilson, Mark J. Mulligan, J. Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Responses in Early HIV-1 Infection Are Skewed Towards High Entropy Peptides. AIDS, 19(3):241-250, 18 Feb 2005. PubMed ID: 15718834. Show all entries for this paper.


Displaying record number 53603

HXB2 Location  Gag(77-85)   Gag Epitope Map
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Epitope SLYNTIATL   Epitope Alignment
Variants
SLYNTIAvL   susceptible form
SLYNTvATL   susceptible form
Epitope Name SL9
Species (MHC/HLA human(A*02:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  60
Epitope Seq.  SLYNTIATL
Variant Seq.  SLYNTIAvL
Mutations T/V
Epitope Location T8V
HXB2 Location T84V
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining
Note The response to this variant peptide, SVL9, was not apparent until month 20, by month 32 a T to V change was dominant, but the SLYNTIAvL mutant showed comparable avidity.


Variant ID.  4374
Epitope Seq.  SLYNTIATL
Variant Seq.  SLYNTvATL
Mutations I/V
Epitope Location I6V
HXB2 Location I82V
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining
Note The response to this variant peptide, A2-SL9, was seen by PBMC from subject 8183A.

References

Bansal2005a Anju Bansal, Ethan Gough, Steffanie Sabbaj, Doug Ritter, Karina Yusim, Greg Sfakianos, Grace Aldrovandi, Richard A. Kaslow, Craig M. Wilson, Mark J. Mulligan, J. Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Responses in Early HIV-1 Infection Are Skewed Towards High Entropy Peptides. AIDS, 19(3):241-250, 18 Feb 2005. PubMed ID: 15718834. Show all entries for this paper.


Displaying record number 53597

HXB2 Location  Vif(61-69)   Vif Epitope Map
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Epitope DAKLIITTY   Epitope Alignment
Variants
DAKLIIkTY   escape documented in this paper
Epitope Name DY9
Species (MHC/HLA human(B*35:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  61
Epitope Seq.  DAKLIITTY
Variant Seq.  DAKLIIkTY
Mutations T/K
Epitope Location T7K
HXB2 Location T67K
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy
Note The peptide that carries this epitope was recognized early in infection but the response diminished over time. A point mutation of epitope position 7 (T to K, DAKLIIkTY) was detected at high frequency at a chronic infection timepoint, 34 months. The K variant was an escape form, and had low avidity by gamma IFN EliSpot.

References

Bansal2005a Anju Bansal, Ethan Gough, Steffanie Sabbaj, Doug Ritter, Karina Yusim, Greg Sfakianos, Grace Aldrovandi, Richard A. Kaslow, Craig M. Wilson, Mark J. Mulligan, J. Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Responses in Early HIV-1 Infection Are Skewed Towards High Entropy Peptides. AIDS, 19(3):241-250, 18 Feb 2005. PubMed ID: 15718834. Show all entries for this paper.


Displaying record number 53599

HXB2 Location  Nef(74-81)   Nef Epitope Map
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Epitope VPLRPMTY   Epitope Alignment
Variants
VPLRPMTf   diminished response
Epitope Name VY8
Species (MHC/HLA human(B*35:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  62
Epitope Seq.  VPLRPMTY
Variant Seq.  VPLRPMTf
Mutations Y/F
Epitope Location Y8F
HXB2 Location Y81F
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy
Note Point mutation of epitope at position 8 (Y to F,VPLRPMTf) was detected at a chronic infection timepoint. The CTL response was strong in early infection, but diminished by month 13. This mutation had reduced avidity.

References

Bansal2005a Anju Bansal, Ethan Gough, Steffanie Sabbaj, Doug Ritter, Karina Yusim, Greg Sfakianos, Grace Aldrovandi, Richard A. Kaslow, Craig M. Wilson, Mark J. Mulligan, J. Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Responses in Early HIV-1 Infection Are Skewed Towards High Entropy Peptides. AIDS, 19(3):241-250, 18 Feb 2005. PubMed ID: 15718834. Show all entries for this paper.


Displaying record number 53610

HXB2 Location  Nef(128-137)   Nef Epitope Map
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Epitope TPGPGVRYPL   Epitope Alignment
Variants
TsGPGVRYPL   susceptible form
Epitope Name Nef-TL10
Species (MHC/HLA human(B*35:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  4375
Epitope Seq.  TPGPGVRYPL
Variant Seq.  TsGPGVRYPL
Mutations P/S
Epitope Location P2S
HXB2 Location P129S
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note Variant TsGPGVRYPL was recognized by month 34.

References

Bansal2005a Anju Bansal, Ethan Gough, Steffanie Sabbaj, Doug Ritter, Karina Yusim, Greg Sfakianos, Grace Aldrovandi, Richard A. Kaslow, Craig M. Wilson, Mark J. Mulligan, J. Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Responses in Early HIV-1 Infection Are Skewed Towards High Entropy Peptides. AIDS, 19(3):241-250, 18 Feb 2005. PubMed ID: 15718834. Show all entries for this paper.


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