HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(77-85) | Gag Epitope Map
View variants at this location |
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| Epitope |
SLYNTVATL
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | SL9 | |||||
| Species (MHC/HLA) | human(A2) | |||||
Showing all: 1 variant(s).
| Variant ID. | 1555 |
|---|---|
| Epitope Seq. | SLYNTVATL |
| Variant Seq. | SLfNTVATL |
| Mutations | Y/F |
| Epitope Location | Y3F |
| HXB2 Location | Y79F |
| Mutation Type | OV: observed variant |
| Epitope Subtype | B, D |
| Variant Subtype | A |
| Method | Chromium-release assay |
| Note | 5/6 Kenyan HEPS subjects recognized this clade B epitope which differed from the clade A variant, SLfNTVATL. |
RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.