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Displaying record number 62490

HXB2 Location Gag(156-165) Gag Epitope Map
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Epitope

VKVIEEKAF{S}

Epitope Alignment

Variants

VKVIEqKAF{N} observed variant; susceptible form

Epitope Name VF9_156-164

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`4457`
Epitope Seq.	`VKVIEEKAF{S}`
Variant Seq.	`VKVIEqKAF{N}`
Mutations	S/N E/Q
Epitope Location	S10N E6Q
HXB2 Location	S165N E161Q
Mutation Type	OV: observed variant SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Longitudinal study, Other, Sequence
Note	Mutations E161Q/S165N awere fixed to completion (100%) by 670d post-screening, indicating strong selection. No T-cell- or Ab-responses were detected against the mutant, and it was not a cryptic epitope, showing host-specific, non-adaptive immune selection pressures.

References

Liu2017a Donglai Liu, Chu Wang, Bhavna Hora, Tao Zuo, Nilu Goonetilleke, Michael K. P. Liu, Mark Berrong, Guido Ferrari, Andrew J. McMichael, Tanmoy Bhattacharya, Alan S. Perelson, and Feng Gao. A Strongly Selected Mutation in the HIV-1 Genome Is Independent of T Cell Responses and Neutralizing Antibodies. Retrovirology, 14(1):46, 10 Oct 2017. PubMed ID: 29017536. Show all entries for this paper.