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Displaying record number 62248

HXB2 Location  Gag(76-86)   Gag Epitope Map
View variants at this location
Epitope RSLYNTVATLY   Epitope Alignment
Variants
RSLfNTVATLY   observed variant
kSLYNTVATLY   literature escape
RSLYNTVAvLY   observed variant
RSLYNTiATLY   observed variant
RSLYNTVvTLY   observed variant
Epitope Name Gag-RY11
Species (MHC/HLA human(A*30)

Variant Details

Showing all: 5 variant(s).


Variant ID.  4289
Epitope Seq.  RSLYNTVATLY
Variant Seq.  RSLfNTVATLY
Mutations Y/F
Epitope Location Y4F
HXB2 Location Y79F
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note RSLfNTVATLY (Y79F) was observed in A*30+ (which is a restricting HLA for RY11) subject 517-M and her A*30+ child, 517-C. It was present at all sampling time points and was always observed as a covariant with T84V and R76K. Sometimes it was also observed with A83V or V82I.


Variant ID.  4290
Epitope Seq.  RSLYNTVATLY
Variant Seq.  kSLYNTVATLY
Mutations R/K
Epitope Location R1K
HXB2 Location R76K
Mutation Type LE: literature escape
Epitope Subtype C
Variant Subtype C
Method Sequence
Note kSLYNTVATLY (R76K) is a documented escape variant. It was observed in A*30+ (which is a restricting HLA for RY11) subject 517-M and her A*30+ child, 517-C. It was present at all sampling time points and was always observed as a covariant with T84V. Sometimes it was also observed with A83V, Y79F, or V82I.


Variant ID.  4291
Epitope Seq.  RSLYNTVATLY
Variant Seq.  RSLYNTVAvLY
Mutations T/V
Epitope Location T9V
HXB2 Location T84V
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note RSLYNTVAvLY (T84V) was observed in A*30+ (which is a restricting HLA for RY11) subject 517-M and her A*30+ child, 517-C. It was present at all sampling time points and was always observed as a covariant with Y79F and R76K. Sometimes it was also observed with A83V or V82I.


Variant ID.  4292
Epitope Seq.  RSLYNTVATLY
Variant Seq.  RSLYNTiATLY
Mutations V/I
Epitope Location V7I
HXB2 Location V82I
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note RSLYNTiATLY (V82I) was observed to arise in A*30+ (which is a restricting HLA for RY11) subject 517-C between 2.5 and 5 years. It was always observed as a covariant with Y79F, T84V, and R76K. Sometimes it was also observed with A83V.


Variant ID.  4293
Epitope Seq.  RSLYNTVATLY
Variant Seq.  RSLYNTVvTLY
Mutations A/V
Epitope Location A8V
HXB2 Location A83V
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note RSLYNTVvTLY (A83V) was observed to arise in A*30+ (which is a restricting HLA for RY11) subject 517-C between 2.5 and 5 years. It was always observed as a covariant with Y79F, T84V, and R76K. Sometimes it was also observed with V82I.

References

Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.


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