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Found 1 matching record:

Displaying record number 62220

HXB2 Location  Gag(180-188)   Gag Epitope Map
View variants at this location
Epitope TPQDLNTML   Epitope Alignment
Variants
TPtDLNTML   literature escape
TPaDLNTML   observed variant
TPsDLNTML   observed variant
Epitope Name Gag-TL9
Species (MHC/HLA human(B*42:01)

Variant Details

Showing all: 3 variant(s).


Variant ID.  4252
Epitope Seq.  TPQDLNTML
Variant Seq.  TPtDLNTML
Mutations Q/T
Epitope Location Q3T
HXB2 Location Q182T
Mutation Type LE: literature escape
Epitope Subtype C
Variant Subtype C
Method Other
Note TPtDLNTML (Q182T) is documented escape variant. It was observed to arise in B*42+ (which is a restricting HLA for TL9) subject 133-M when her B*42- child, 133-C, was at age 7. Q182T was also observed in B*42+ subject 517-M when her B*42+ child, 517-C, was 0.25yrs old. However, it was not observed in 517-C. In B*42+ subject 021-M, the Q182T variant was observed starting at 0.1yr before the birth of her child, 021-C. However it was not observed 021-C, who is B*42+, until 4.9yrs.


Variant ID.  4253
Epitope Seq.  TPQDLNTML
Variant Seq.  TPaDLNTML
Mutations Q/A
Epitope Location Q3A
HXB2 Location Q182A
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Other
Note TPaDLNTML (Q182A) was observed in B*42+ (which is a restricting HLA for TL9) subject 517-M when her B*42+ child, 517-C, was 0.25yrs old. However, it was not observed in 517-C.


Variant ID.  4349
Epitope Seq.  TPQDLNTML
Variant Seq.  TPsDLNTML
Mutations Q/S
Epitope Location Q3S
HXB2 Location Q182S
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Other
Note TPsDLNTML (Q182S) was observed in B*8101+ (which is a restricting HLA for TL9) subject K-3046-C at age 7.8. K-3046-C was a subject in the Pediatric Early HAART and Strategic Treatment Interruption Study.

References

Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.


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