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Displaying record number 62101

HXB2 Location Gag(78-86) Gag Epitope Map
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LYNTVAVLY

`LYNTiAVLY`		observed variant
`LfNTiAVLY`		observed variant
`LfNTVAVLY`		observed variant

Epitope Name LY9

Species (MHC/HLA) human(A*29)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`4195`
Epitope Seq.	`LYNTVAVLY`
Variant Seq.	`LYNTiAVLY`
Mutations	V/I
Epitope Location	V5I
HXB2 Location	V82I
Mutation Type	OV: observed variant
Method	Other, Relative replication capacity assay
Note	Longitudinal deep sequencing in Subject 9213 showed that the mutant LYNTiAVL corresponding to the position with the lowest h value, was the infecting strain (100%) until day 476, but was at 5.4% of the viral population by day 1543.

Variant ID.	`4196`
Epitope Seq.	`LYNTVAVLY`
Variant Seq.	`LfNTiAVLY`
Mutations	V/I
Epitope Location	V5I
HXB2 Location	V82I
Mutation Type	OV: observed variant
Method	Other, Relative replication capacity assay
Note	Longitudinal deep sequencing in Subject 9213 showed that the double mutant LfNTiAVL corresponding to the positions with the two lowest h values, was at 6.3% of the viral population by day 1543.

Variant ID.	`4197`
Epitope Seq.	`LYNTVAVLY`
Variant Seq.	`LfNTVAVLY`
Mutations	Y/F
Epitope Location	Y2F
HXB2 Location	Y79F
Mutation Type	OV: observed variant
Method	Other, Relative replication capacity assay
Note	Longitudinal deep sequencing in Subject 9213 showed that the single mutant LfNTVAVL corresponding to the position with the second lowest h value, was at 57.1% of the viral population by day 1543.

References

Ferguson2013a Andrew L. Ferguson, Jaclyn K. Mann, Saleha Omarjee, Thumbi Ndung'u, Bruce D Walker, and Arup K. Chakraborty. Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design. Immunity, 38(3):606-617, 21 Mar 2013. PubMed ID: 23521886. Show all entries for this paper.