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Displaying record number 62099

HXB2 Location Gag(28-36) Gag Epitope Map
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KYRLKHIVW

`qYRLKHvVW`		observed variant
`qYRLKHIVW`		observed variant
`KYRLKHvVW`		observed variant

Epitope Name KW9

Species (MHC/HLA) human(A*24)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`4192`
Epitope Seq.	`KYRLKHIVW`
Variant Seq.	`qYRLKHvVW`
Mutations	K/Q I/V
Epitope Location	K1Q I7V
HXB2 Location	K28Q I34V
Mutation Type	OV: observed variant
Method	Sequence
Note	Longitudinal deep sequencing in Subject 9213 showed that the double mutant qYRLKHvVW corresponding to positions with the second and third lowest h values, was the infecting strain and stayed at 100% till day 165. On d476 it was 38.5% of the circulating viral population.

Variant ID.	`4193`
Epitope Seq.	`KYRLKHIVW`
Variant Seq.	`qYRLKHIVW`
Mutations	K/Q
Epitope Location	K1Q
HXB2 Location	K28Q
Mutation Type	OV: observed variant
Method	Sequence
Note	Longitudinal deep sequencing in Subject 9213 showed that the mutant qYRLKHIVW corresponding to the position with the lowest h value, appeared by day 476 in 61.5% of the viral population.

Variant ID.	`4194`
Epitope Seq.	`KYRLKHIVW`
Variant Seq.	`KYRLKHvVW`
Mutations	I/V
Epitope Location	I7V
HXB2 Location	I34V
Mutation Type	OV: observed variant
Method	Sequence
Note	Longitudinal deep sequencing in Subject 9213 showed that the mutant KYRLKHvVW corresponding to the position with the third lowest h value, appeared by day 1543 in 20.5% of the viral population, the rest being WT.

References

Ferguson2013a Andrew L. Ferguson, Jaclyn K. Mann, Saleha Omarjee, Thumbi Ndung'u, Bruce D Walker, and Arup K. Chakraborty. Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design. Immunity, 38(3):606-617, 21 Mar 2013. PubMed ID: 23521886. Show all entries for this paper.