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Displaying record number 61945

HXB2 Location  Gag(124-132)   Gag Epitope Map
View variants at this location
Epitope NSSKVSQNY   Epitope Alignment
Variants
sSSKVSQNY   susceptible form
NSSqVSQNY   susceptible form
NSSqVSrNY   susceptible form
hSnqVSQNY   susceptible form
hSSqVSQNY   susceptible form
sSSqVSQNY   susceptible form
Species (MHC/HLA human(A*01:01)

Variant Details

Showing all: 6 variant(s).


Variant ID.  4148
Epitope Seq.  NSSKVSQNY
Variant Seq.  sSSKVSQNY
Mutations N/S
Epitope Location N1S
HXB2 Location N124S
Mutation Type SF: susceptible form
Epitope Subtype A, D
Variant Subtype A, D
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 2/5 female A*0101+ patients responded to this novel variant of NSSKVSQNY, sSSKVSQNY, with a mean of 115 SFU/million cells.


Variant ID.  4149
Epitope Seq.  NSSKVSQNY
Variant Seq.  NSSqVSQNY
Mutations K/Q
Epitope Location K4Q
HXB2 Location K127Q
Mutation Type SF: susceptible form
Epitope Subtype A, D
Variant Subtype A, D
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 4/5 female A*0101+ patients responded to this variant of NSSKVSQNY, NSSqVSQNY, with a mean of 96 SFU/million cells.


Variant ID.  4150
Epitope Seq.  NSSKVSQNY
Variant Seq.  NSSqVSrNY
Mutations K/Q Q/R
Epitope Location K4Q Q7R
HXB2 Location K127Q Q130R
Mutation Type SF: susceptible form
Epitope Subtype A, D
Variant Subtype A, D
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 3/5 female A*0101+ patients responded to this novel variant of NSSKVSQNY, NSSqVSrNY, with a mean of 127 SFU/million cells.


Variant ID.  4151
Epitope Seq.  NSSKVSQNY
Variant Seq.  hSnqVSQNY
Mutations N/H S/N K/Q
Epitope Location N1H S3N K4Q
HXB2 Location N124H S126N K127Q
Mutation Type SF: susceptible form
Epitope Subtype A, D
Variant Subtype A, D
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 4/5 female A*0101+ patients responded to this variant of NSSKVSQNY, hSnqVSQNY, with a mean of 115 SFU/million cells.


Variant ID.  4152
Epitope Seq.  NSSKVSQNY
Variant Seq.  hSSqVSQNY
Mutations N/H K/Q
Epitope Location N1H K4Q
HXB2 Location N124H K127Q
Mutation Type SF: susceptible form
Epitope Subtype A, D
Variant Subtype A, D
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 4/5 female A*0101+ patients responded to this novel variant of NSSKVSQNY, hSSqVSQNY, with a mean of 74 SFU/million cells.


Variant ID.  4153
Epitope Seq.  NSSKVSQNY
Variant Seq.  sSSqVSQNY
Mutations N/S K/Q
Epitope Location N1S K4Q
HXB2 Location N124S K127Q
Mutation Type SF: susceptible form
Epitope Subtype A, D
Variant Subtype A, D
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 4/5 female A*0101+ patients responded to this novel variant of NSSKVSQNY, sSSqVSQNY, with a mean of 130 SFU/million cells.

References

Luo2012 Ma Luo, Christina A. Daniuk, Tamsir O. Diallo, Rupert E. Capina, Joshua Kimani, Charles Wachihi, Makubo Kimani, Thomas Bielawny, Trevor Peterson, Mark G. R. Mendoza, Sandra Kiazyk, T. Blake Ball, and Francis A. Plummer. For Protection from HIV-1 Infection, More Might Not Be Better: A Systematic Analysis of HIV Gag Epitopes of Two Alleles Associated with Different Outcomes of HIV-1 Infection. J. Virol., 86(2):1166-1180, Jan 2012. PubMed ID: 22072744. Show all entries for this paper.


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