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Found 1 matching record:

Displaying record number 61936

HXB2 Location  Gag(146-155)   Gag Epitope Map
View variants at this location
Epitope {P}LSPRTLNAW   Epitope Alignment
Variants
{s}LSPRTLNAW   observed variant
{P}iSPRTLNAW   observed variant
{P}vSPRTLNAW   observed variant
Epitope Name ISW9
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 3 variant(s).


Variant ID.  4136
Epitope Seq.  {P}LSPRTLNAW
Variant Seq.  {s}LSPRTLNAW
Mutations P/S
Epitope Location P1S
HXB2 Location P146S
Mutation Type OV: observed variant
Epitope Subtype CRF01_AE
Variant Subtype CRF01_AE
Method Sequence
Note Variant {s}LSPRTLNAW, at -1 position of the CRF01_AE ISW9 epitope was seen in donor patient N094 at 86%, 77% and 100%; 8, 20 and 42 mpd respectively. For recipient patient N107, this mutation was seen at 100% and 98% at months 42 and 52 post diagnosis.


Variant ID.  4137
Epitope Seq.  {P}LSPRTLNAW
Variant Seq.  {P}iSPRTLNAW
Mutations L/I
Epitope Location L3I
HXB2 Location L148I
Mutation Type OV: observed variant
Epitope Subtype CRF01_AE
Variant Subtype CRF01_AE
Method Sequence
Note Variant {P}iSPRTLNAW, at 1st position of the CRF01_AE ISW9 epitope was seen in donor patient N094 at 1% 8 months post diagnosis; and was never seen in the recipient patient.


Variant ID.  4138
Epitope Seq.  {P}LSPRTLNAW
Variant Seq.  {P}vSPRTLNAW
Mutations L/V
Epitope Location L3V
HXB2 Location L148V
Mutation Type OV: observed variant
Epitope Subtype CRF01_AE
Variant Subtype CRF01_AE
Method Sequence
Note Variant {P}vSPRTLNAW, at 1st position of the CRF01_AE ISW9 epitope was seen in donor patient N094 at 10% and 2% 8 and 20 months post diagnosis; this mutation was never seen in the recipient patient, N107.

References

Brener2015 Jacqui Brener, Astrid Gall, Rebecca Batorsky, Lynn Riddell, Soren Buus, Ellen Leitman, Paul Kellam, Todd Allen, Philip Goulder, and Philippa C. Matthews. Disease Progression Despite Protective HLA Expression in an HIV-Infected Transmission Pair. Retrovirology, 12:55, 2015. PubMed ID: 26123575. Show all entries for this paper.


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