HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(180-188) | Gag Epitope Map
View variants at this location |
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| Epitope |
TPQDLNTML
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Epitope Alignment | |||||||
| Variants |
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| Epitope Name | Gag TL9 | ||||||||
| Species (MHC/HLA) | human(B*67:01) | ||||||||
Showing all: 2 variant(s).
| Variant ID. | 4091 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TPsDLNlML |
| Mutations | Q/S T/L |
| Epitope Location | Q3S T7L |
| HXB2 Location | Q182S T186L |
| Mutation Type | NSF: non-susceptible form OV: observed variant |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Intracellular cytokine staining, Other |
| Note | TPsDLNlML, TL9-3S7L is a variant of B*6701-restricted WT epitope TPQDLNTML. It is not recognized by TL9-specific CTL, but is found in 2.3% chronically HIV-1-infected Japanese patients and in none who are B*6701+. |
| Variant ID. | 4092 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TPaDLNlML |
| Mutations | Q/A T/L |
| Epitope Location | Q3A T7L |
| HXB2 Location | Q182A T186L |
| Mutation Type | NSF: non-susceptible form OV: observed variant |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Intracellular cytokine staining, Other |
| Note | TPaDLNlML, TL9-3A7L is a variant of B*6701-restricted WT epitope TPQDLNTML. It is not recognized by TL9-specific CTL, but is found in 0.6% chronically HIV-1-infected Japanese patients and in none who are B*6701+. |
Murakoshi2019 Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Yu Zhang, Takayuki Chikata, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, Keiko Sakai, and Masafumi Takiguchi. Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30333175. Show all entries for this paper.