HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(198-205) | Gag Epitope Map
View variants at this location |
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| Epitope |
MQMLKETI
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Epitope Alignment | |||||||
| Variants |
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| Epitope Name | Gag MI8 | ||||||||
| Species (MHC/HLA) | human(B*52:01) | ||||||||
Showing all: 2 variant(s).
| Variant ID. | 4086 |
|---|---|
| Epitope Seq. | MQMLKETI |
| Variant Seq. | MQMLKdTI |
| Mutations | E/D |
| Epitope Location | E6D |
| HXB2 Location | E203D |
| Mutation Type | NSF: non-susceptible form OV: observed variant |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other |
| Note | MQMLKdTI, MI8-6D is a variant of B*5201-restricted WT epitope MQMLKETI. It is not recognized by MI8-specific CTL, but is found in 4.3% chronically HIV-1-infected Japanese patients and 3.6% of those who were B*5201+. |
| Variant ID. | 4087 |
|---|---|
| Epitope Seq. | MQMLKETI |
| Variant Seq. | MQiLKETI |
| Mutations | M/I |
| Epitope Location | M3I |
| HXB2 Location | M200I |
| Mutation Type | OV: observed variant SF: susceptible form |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other |
| Note | MQiLKETI, MI8-3I is a variant of B*5201-restricted WT epitope MQMLKETI. It was cross-recognized by MI8-specific CTL, and is found in 0.6% chronically HIV-1-infected Japanese patients and 1.2% of those who were B*5201+. |
Murakoshi2019 Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Yu Zhang, Takayuki Chikata, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, Keiko Sakai, and Masafumi Takiguchi. Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30333175. Show all entries for this paper.