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Found 1 matching record:

Displaying record number 61877

HXB2 Location  Gag(124-132)   Gag Epitope Map
View variants at this location
Epitope NSSQVSQNY   Epitope Alignment
Variants
NSgQVSQNY   observed variant; replicative capacity is not abrogated
Epitope Name NY9, p17NY9
Species (MHC/HLA human(B*35:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  4124
Epitope Seq.  NSSQVSQNY
Variant Seq.  NSgQVSQNY
Mutations S/G
Epitope Location S3G
HXB2 Location S126G
Mutation Type OV: observed variant
RCOK: replicative capacity is not abrogated
Epitope Subtype B
Variant Subtype B
Method CTL suppression of replication, Intracellular cytokine staining, Tetramer binding
Note Gag S126G, an HLA-A*1101-associated polymorphism is in the GagNY9 epitope, and did not accumulate in HLA-B*3501+ Japanese individuals. This mutation is selected by A*1101-restricted CTL and did not influence control of HIV-1 by B*3501-specific CTL.

References

Murakoshi2018a Hayato Murakoshi, Madoka Koyanagi, Tomohiro Akahoshi, Takayuki Chikata, Nozomi Kuse, Hiroyuki Gatanaga, Sarah L. Rowland-Jones, Shinichi Oka, and Masafumi Takiguchi. Impact of a Single HLA-A*24:02-Associated Escape Mutation on the Detrimental Effect of HLA-B*35:01 in HIV-1 Control. EBioMedicine, 36:103-112, Oct 2018. PubMed ID: 30249546. Show all entries for this paper.


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