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Found 1 matching record:

Displaying record number 61684

HXB2 Location  Gag(11-31)   Gag Epitope Map
View variants at this location
Epitope GKLDAWEKIRLRPGGKKKYRL   Epitope Alignment
Variants
-----WEKIRLRPGG------   non-susceptible form; susceptible form
GKLDAWEKIyLRPGGKKKYRL   non-susceptible form; susceptible form
GKLDkWEKIRLRPGGKKKYRL   non-susceptible form; susceptible form
---DrWEKIRLRPGGKKKYRL   non-susceptible form; susceptible form
GKLDeWEKIRLRPGGKKKYRL   non-susceptible form; susceptible form; subtype-specific susceptible form
GKLDeWEKIRLRPGGKKKYRL   non-susceptible form; susceptible form; subtype-specific susceptible form
Species (MHC/HLA human

Variant Details

Showing all: 6 variant(s).


Variant ID.  4078
Epitope Seq.  GKLDAWEKIRLRPGGKKKYRL
Variant Seq.  -----WEKIRLRPGG------
Mutations G/- K/- K/- K/- Y/- K/- R/- L/- L/- D/- A/-
Epitope Location G1- K16- K17- K18- Y19- K2- R20- L21- L3- D4- A5-
HXB2 Location G11- K26- K27- K28- Y29- K12- R30- L31- L13- D14- A15-
Mutation Type NSF: non-susceptible form
SF: susceptible form
Epitope Subtype A1, D, M group
Variant Subtype A
Method CD8 T-cell Elispot - IFNy
Note HIV clone UG003 ConA- or ConD-specific truncated OLP variant -----WEKIRLRPGG------ was reactive in 9/10 subjects tested each, 1540 or 2225 sfu/106 pbmc.


Variant ID.  4079
Epitope Seq.  GKLDAWEKIRLRPGGKKKYRL
Variant Seq.  GKLDAWEKIyLRPGGKKKYRL
Mutations R/Y
Epitope Location R10Y
HXB2 Location R20Y
Mutation Type NSF: non-susceptible form
SF: susceptible form
Epitope Subtype A1, D, M group
Variant Subtype A
Method CD8 T-cell Elispot - IFNy
Note HIV clone UG012 ConA-specific OLP variant GKLDAWEKIyLRPGGKKKYRL was reactive in 19/20 subjects tested, 132 sfu/106 pbmc.


Variant ID.  4080
Epitope Seq.  GKLDAWEKIRLRPGGKKKYRL
Variant Seq.  GKLDkWEKIRLRPGGKKKYRL
Mutations A/K
Epitope Location A5K
HXB2 Location A15K
Mutation Type NSF: non-susceptible form
SF: susceptible form
Epitope Subtype A1, D, M group
Variant Subtype A
Method CD8 T-cell Elispot - IFNy
Note HIV clone UG060 ConA-specific OLP variant GKLDkWEKIRLRPGGKKKYRL was reactive in 19/20 subjects tested, 388 sfu/106 pbmc.


Variant ID.  4081
Epitope Seq.  GKLDAWEKIRLRPGGKKKYRL
Variant Seq.  ---DrWEKIRLRPGGKKKYRL
Mutations G/- K/- L/- A/R
Epitope Location G1- K2- L3- A5R
HXB2 Location G11- K12- L13- A15R
Mutation Type NSF: non-susceptible form
SF: susceptible form
Epitope Subtype A1, D, M group
Variant Subtype A
Method CD8 T-cell Elispot - IFNy
Note HIV clone UG026 ConA-specific truncated OLP variant ---DrWEKIRLRPGGKKKYRL was reactive in 16/17 subjects tested, 190 sfu/106 pbmc.


Variant ID.  4082
Epitope Seq.  GKLDAWEKIRLRPGGKKKYRL
Variant Seq.  GKLDeWEKIRLRPGGKKKYRL
Mutations A/E
Epitope Location A5E
HXB2 Location A15E
Mutation Type NSF: non-susceptible form
SF: susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A1, D, M group
Variant Subtype D
Method CD8 T-cell Elispot - IFNy
Note HIV ConD-specific OLP GKLDeWEKIRLRPGGKKKYRL was reactive in 19/20 subjects tested, 2377 sfu/106 pbmc.


Variant ID.  4083
Epitope Seq.  GKLDAWEKIRLRPGGKKKYRL
Variant Seq.  GKLDeWEKIRLRPGGKKKYRL
Mutations A/E
Epitope Location A5E
HXB2 Location A15E
Mutation Type NSF: non-susceptible form
SF: susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A1, D, M group
Variant Subtype D
Method CD8 T-cell Elispot - IFNy
Note HIV ConD-specific OLP GKLDeWEKIRLRPGGKKKYRL was reactive in 19/20 subjects tested, 2377 sfu/106 pbmc.

References

Mugaba2014 S. Mugaba, R. Nakiboneka, M. Nanyonjo, D. Bugembe-Lule, I. Kaddu, B. Nanteza, R. Tweyongyere, P. Kaleebu, and J. Serwanga. Group M Consensus Gag and Nef Peptides Are as Efficient at Detecting Clade A1 and D Cross-Subtype T-Cell Functions as Subtype-Specific Consensus Peptides. Vaccine, 32(30):3787-3795, 24 Jun 2014. PubMed ID: 24837770. Show all entries for this paper.


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