HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(147-155) | Gag Epitope Map
View variants at this location |
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| Epitope |
ISPRTLNAW
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Epitope Alignment | |||||||
| Variants |
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| Epitope Name | ISW9 | ||||||||
| Species (MHC/HLA) | human(B*57:03) | ||||||||
Showing all: 2 variant(s).
| Variant ID. | 4021 |
|---|---|
| Epitope Seq. | ISPRTLNAW |
| Variant Seq. | xSPRTLNAW |
| Mutations | I/X |
| Epitope Location | I1X |
| HXB2 Location | I147X |
| Mutation Type | A: HLA association LE: literature escape OV: observed variant SNSF: subtype-specific non-susceptible form |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Sequence |
| Note | Polymorphism at I147X, for escape xSPRTLNAW, was associated with HLA-B*5703 in B-infected subjects of the Barbados cohort. |
| Variant ID. | 4023 |
|---|---|
| Epitope Seq. | ISPRTLNAW |
| Variant Seq. | lSPRTLNAW |
| Mutations | I/L |
| Epitope Location | I1L |
| HXB2 Location | I147L |
| Mutation Type | LE: literature escape |
| Epitope Subtype | B, C |
| Variant Subtype | B, C |
| Method | Sequence |
| Note | There are no observable clade-specific differences between C-clade (Botswana) and B-clade (Barbados) 147L. |
Payne2014 R. P. Payne, S. Branch, H Kløverpris, P. C. Matthews, C. K. Koofhethile, T. Strong, E. Adland, E. Leitman, J. Frater, T. Ndung'u, E. Hunter, R. Haubrich, B. Mothe, A. Edwards, L. Riddell, F. Chen, P. R. Harrigan, Z. L. Brumme, S. Mallal, M. John, J. P. Jooste, R. Shapiro, S. G. Deeks, B. D. Walker, C. Brander, C. Landis, J. M. Carlson, J. G. Prado, and P. J. R. Goulder. Differential Escape Patterns within the Dominant HLA-B*57:03-Restricted HIV Gag Epitope Reflect Distinct Clade-Specific Functional Constraints. J. Virol., 88(9):4668-4678, May 2014. PubMed ID: 24501417. Show all entries for this paper.