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Displaying record number 61214

HXB2 Location  Gag(162-172)   Gag Epitope Map
View variants at this location
Epitope KAFSPEVIPMF   Epitope Alignment
Variants
KgFSPEVIPMF   diminished HLA binding or increased off-rate; diminished response; escape documented in this paper; replicative capacity reduced
KgFnPEVIPMF   compensatory mutation; escape documented in this paper; replicative capacity reduced
KsFSPEVIPMF   diminished HLA binding or increased off-rate; diminished response; escape documented in this paper; replicative capacity reduced
KxFkPEVIPMF   compensatory mutation; escape documented in this paper
Epitope Name KF11
Species (MHC/HLA human(B*57:01, B*57:03)

Variant Details

Showing all: 4 variant(s).


Variant ID.  3734
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KgFSPEVIPMF
Mutations A/G
Epitope Location A2G
HXB2 Location A163G
Mutation Type DHB: diminished HLA binding or increased off-rate
DR: diminished response
E: escape documented in this paper
RCR: replicative capacity reduced
Epitope Subtype B
Variant Subtype B
Method Other
Note KgFSPEVIPMF, position-2 escape from KF11, results in a loss but not abrogation of HLA binding. The resulting VRC reduction is substantially reversed by compensatory S165N. Combination of A163G/S165N results in complete loss of epitope recognition by CTL.


Variant ID.  3735
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KgFnPEVIPMF
Mutations A/G S/N
Epitope Location A2G S4N
HXB2 Location A163G S165N
Mutation Type CM: compensatory mutation
E: escape documented in this paper
RCR: replicative capacity reduced
Epitope Subtype B
Variant Subtype B
Method Other
Note KgFnPEVIPMF, double/compensatory escape from KF11, results in complete loss of epitope recognition by CTL. S165N is frequently a compensatory mutation to initial A163G, fully abrogating a reduced recognition of HLA, and countering loss of VRC partially.


Variant ID.  3736
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KsFSPEVIPMF
Mutations A/S
Epitope Location A2S
HXB2 Location A163S
Mutation Type DHB: diminished HLA binding or increased off-rate
DR: diminished response
E: escape documented in this paper
RCR: replicative capacity reduced
Epitope Subtype B
Variant Subtype B
Method Other
Note KsFSPEVIPMF, position-2 escape from KF11, is at A163S.


Variant ID.  3737
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KxFkPEVIPMF
Mutations A/X S/K
Epitope Location A2X S4K
HXB2 Location A163X S165K
Mutation Type CM: compensatory mutation
E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Other
Note KAFkPEVIPMF, a compensatory mutation to A163X mutations in KF11, is at S165K.

References

Kloverpris2015a Henrik N. Kløverpris, Alasdair Leslie, and Philip Goulder. Role of HLA Adaptation in HIV Evolution. Front. Immunol., 6:665, 18 Jan 2016. PubMed ID: 26834742. Show all entries for this paper.


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