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Displaying record number 61203

HXB2 Location  Gag(180-188)   Gag Epitope Map
View variants at this location
Epitope TPQDLNTML   Epitope Alignment
Variants
TPtDLNTML   escape documented in this paper; replicative capacity reduced
TPeDLNTML   escape documented in this paper; replicative capacity reduced
TPgDLNTML   escape documented in this paper; replicative capacity reduced
TPsDLNTML   escape documented in this paper; replicative capacity reduced
TPQDLNsML   escape documented in this paper; replicative capacity reduced
Epitope Name TL9
Species (MHC/HLA human(B*07:02, B*39:10, B*42:01, B*81:01, C*08:02)

Variant Details

Showing all: 5 variant(s).


Variant ID.  3705
Epitope Seq.  TPQDLNTML
Variant Seq.  TPtDLNTML
Mutations Q/T
Epitope Location Q3T
HXB2 Location Q182T
Mutation Type E: escape documented in this paper
RCR: replicative capacity reduced
Epitope Subtype B
Variant Subtype B
Method Other
Note TPtDLNTML is an escape variant of TPQDLNTML that reduces VRC.


Variant ID.  3706
Epitope Seq.  TPQDLNTML
Variant Seq.  TPeDLNTML
Mutations Q/E
Epitope Location Q3E
HXB2 Location Q182E
Mutation Type E: escape documented in this paper
RCR: replicative capacity reduced
Epitope Subtype B
Variant Subtype B
Method Other
Note TPeDLNTML is an escape variant of TPQDLNTML that reduces VRC.


Variant ID.  3707
Epitope Seq.  TPQDLNTML
Variant Seq.  TPgDLNTML
Mutations Q/G
Epitope Location Q3G
HXB2 Location Q182G
Mutation Type E: escape documented in this paper
RCR: replicative capacity reduced
Epitope Subtype B
Variant Subtype B
Method Other
Note TPgDLNTML is an escape variant of TPQDLNTML that reduces VRC.


Variant ID.  3708
Epitope Seq.  TPQDLNTML
Variant Seq.  TPsDLNTML
Mutations Q/S
Epitope Location Q3S
HXB2 Location Q182S
Mutation Type E: escape documented in this paper
RCR: replicative capacity reduced
Epitope Subtype B
Variant Subtype B
Method Other
Note TPsDLNTML is an escape variant of TPQDLNTML that reduces VRC.


Variant ID.  3709
Epitope Seq.  TPQDLNTML
Variant Seq.  TPQDLNsML
Mutations T/S
Epitope Location T7S
HXB2 Location T186S
Mutation Type E: escape documented in this paper
RCR: replicative capacity reduced
Epitope Subtype B
Variant Subtype B
Method Other
Note B*8101-restricted TPsDLNTML is the most commonly selected escape variant of TPQDLNTML (25-30% of chronic patients) and substantially reduces VRC. No clear compensatory mutations have been identified.

References

Kloverpris2015a Henrik N. Kløverpris, Alasdair Leslie, and Philip Goulder. Role of HLA Adaptation in HIV Evolution. Front. Immunol., 6:665, 18 Jan 2016. PubMed ID: 26834742. Show all entries for this paper.


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