HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(180-188) | Gag Epitope Map
View variants at this location |
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| Epitope |
TPQDLNTML
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Epitope Alignment | ||||||||||||||||
| Variants |
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| Epitope Name | TL9 | |||||||||||||||||
| Species (MHC/HLA) | human(B*07:02, B*39:10, B*42:01, B*81:01, C*08:02) | |||||||||||||||||
Showing all: 5 variant(s).
| Variant ID. | 3705 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TPtDLNTML |
| Mutations | Q/T |
| Epitope Location | Q3T |
| HXB2 Location | Q182T |
| Mutation Type | E: escape documented in this paper RCR: replicative capacity reduced |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Other |
| Note | TPtDLNTML is an escape variant of TPQDLNTML that reduces VRC. |
| Variant ID. | 3706 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TPeDLNTML |
| Mutations | Q/E |
| Epitope Location | Q3E |
| HXB2 Location | Q182E |
| Mutation Type | E: escape documented in this paper RCR: replicative capacity reduced |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Other |
| Note | TPeDLNTML is an escape variant of TPQDLNTML that reduces VRC. |
| Variant ID. | 3707 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TPgDLNTML |
| Mutations | Q/G |
| Epitope Location | Q3G |
| HXB2 Location | Q182G |
| Mutation Type | E: escape documented in this paper RCR: replicative capacity reduced |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Other |
| Note | TPgDLNTML is an escape variant of TPQDLNTML that reduces VRC. |
| Variant ID. | 3708 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TPsDLNTML |
| Mutations | Q/S |
| Epitope Location | Q3S |
| HXB2 Location | Q182S |
| Mutation Type | E: escape documented in this paper RCR: replicative capacity reduced |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Other |
| Note | TPsDLNTML is an escape variant of TPQDLNTML that reduces VRC. |
| Variant ID. | 3709 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TPQDLNsML |
| Mutations | T/S |
| Epitope Location | T7S |
| HXB2 Location | T186S |
| Mutation Type | E: escape documented in this paper RCR: replicative capacity reduced |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Other |
| Note | B*8101-restricted TPsDLNTML is the most commonly selected escape variant of TPQDLNTML (25-30% of chronic patients) and substantially reduces VRC. No clear compensatory mutations have been identified. |
Kloverpris2015a Henrik N. Kløverpris, Alasdair Leslie, and Philip Goulder. Role of HLA Adaptation in HIV Evolution. Front. Immunol., 6:665, 18 Jan 2016. PubMed ID: 26834742. Show all entries for this paper.