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Displaying record number 61186

HXB2 Location Gag(18-26) Gag Epitope Map
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Epitope

KIRLRPGGK

Epitope Alignment

Variants

rIRLRPGGK diminished response; escape documented in this paper; non-susceptible form

Epitope Name KK9

Species (MHC/HLA) human(A*03:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3692`
Epitope Seq.	`KIRLRPGGK`
Variant Seq.	`rIRLRPGGK`
Mutations	K/R
Epitope Location	K1R
HXB2 Location	K18R
Mutation Type	DR: diminished response E: escape documented in this paper NSF: non-susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note	Gag KK9 escape variant KRQdILDLWVY did not cross-react to autologous KK9 (KRQEILDLWVY)-specific T cells during acute and chronic infection in A*0301 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.