Search the Epitope Variant and Escape Mutation Database

Help

Found 1 matching record:

Displaying record number 61177

HXB2 Location Gag(28-36) Gag Epitope Map
View variants at this location

KYKLKHIVW

`KYrLKHIVW`		diminished response; escape documented in this paper; non-susceptible form
`KYqLKHIVW`		diminished response; escape documented in this paper; non-susceptible form; susceptible form

Epitope Name KW9

Species (MHC/HLA) human(A*24:02)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`3672`
Epitope Seq.	`KYKLKHIVW`
Variant Seq.	`KYrLKHIVW`
Mutations	K/R
Epitope Location	K3R
HXB2 Location	K30R
Mutation Type	DR: diminished response E: escape documented in this paper NSF: non-susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note	Gag KW9 escape variant KYrLKHIVW did not cross-react to autologous KW9 (KYKLKHIVW)-specific T cells during acute and chronic infection in A*2402 patients.

Variant ID.	`3673`
Epitope Seq.	`KYKLKHIVW`
Variant Seq.	`KYqLKHIVW`
Mutations	K/Q
Epitope Location	K3Q
HXB2 Location	K30Q
Mutation Type	DR: diminished response E: escape documented in this paper NSF: non-susceptible form SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note	Gag KW9 escape variant KYqLKHIVW did not cross-react to autologous KW9 (KYKLKHIVW)-specific T cells during acute infection but did cross-react during chronic infection in A*2402 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.