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Found 1 matching record:

Displaying record number 60505

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
pLYNTVATL   HLA association; TCR related mutation
SLfNTVATL   HLA association; TCR related mutation
SLYNTiATL   HLA association; TCR related mutation
SLfNTVAvL   HLA association; TCR related mutation
SLfNaVAvL   HLA association; TCR related mutation
Epitope Name A2-SL9
Species (MHC/HLA human

Variant Details

Showing all: 5 variant(s).


Variant ID.  3502
Epitope Seq.  SLYNTVATL
Variant Seq.  pLYNTVATL
Mutations S/P
Epitope Location S1P
HXB2 Location S77P
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note At t1, subject 6 (ACS 18840) carried 5.3% pLYNTVATL.


Variant ID.  3503
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVATL
Mutations Y/F
Epitope Location Y3F
HXB2 Location Y79F
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note By t2, subject 5 (ACS 19342) carried 100% SLfNTVATL, and at t1 subject 7 (ACS 19453) carried 51.7% of this variant that was lost by t2.


Variant ID.  3504
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTiATL
Mutations V/I
Epitope Location V6I
HXB2 Location V82I
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note At t2, subject 1 (ACS 19957) carried 100% SLYNTiATL while subject 7 (AC 18839) had 9.7% of this variant by t2.


Variant ID.  3505
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVAvL
Mutations Y/F T/V
Epitope Location Y3F T8V
HXB2 Location Y79F T84V
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note At t2, subject 2 (ACS 19957) carried 93.8% SLfNTVAvL.


Variant ID.  3506
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNaVAvL
Mutations Y/F T/A T/V
Epitope Location Y3F T5A T8V
HXB2 Location Y79F T81A T84V
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note At t1, subject 2 (ACS 19957) carried 100% SLfNaVAvL, which decreased to 6.3% with reversion of T81A to T at t2.

References

Costa2015 Ana I. Costa, Dan Koning, Kristin Ladell, James E. McLaren, Bart P. X. Grady, Ingrid M. M. Schellens, Petra van Ham, Monique Nijhuis, José A. M. Borghans, Can Keşmir, David A. Price, and Debbie van Baarle. Complex T-Cell Receptor Repertoire Dynamics Underlie the CD8+ T-Cell Response to HIV-1. J. Virol., 89(1):110-119, Jan 2015. PubMed ID: 25320304. Show all entries for this paper.


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