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Displaying record number 59314

HXB2 Location  Gag(22-30)   Gag Epitope Map
View variants at this location
Epitope RPGGKKHYM   Epitope Alignment
Variants
{IsL}RPGGKKHYM   escape documented in this paper; observed variant
RPGGKKqYM   diminished response; escape documented in this paper; observed variant
RPGGKKsYM   diminished response; escape documented in this paper; observed variant
RPGGKKrYM   diminished response; escape documented in this paper; observed variant
RPGGKKHYk   diminished response; escape documented in this paper; observed variant
Epitope Name Gag-RM9
Species (MHC/HLA human(B*42:01)

Variant Details

Showing all: 5 variant(s).


Variant ID.  3477
Epitope Seq.  {IRL}RPGGKKHYM
Variant Seq.  {IsL}RPGGKKHYM
Mutations R/S
Epitope Location R-2S
HXB2 Location R20S
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Other, Tetramer binding
Note 5% of B*4201+ and 2% of B*4201- subjects (n=1767) carried this upstream escape variant, {IsL}RPGGKKHYM.


Variant ID.  3478
Epitope Seq.  RPGGKKHYM
Variant Seq.  RPGGKKqYM
Mutations H/Q
Epitope Location H7Q
HXB2 Location H28Q
Mutation Type DR: diminished response
E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Other, Tetramer binding
Note 29% of B*4201+ and 13% of B*4201- subjects (n=1765) carried this escape variant, RPGGKKqYM.


Variant ID.  3479
Epitope Seq.  RPGGKKHYM
Variant Seq.  RPGGKKsYM
Mutations H/S
Epitope Location H7S
HXB2 Location H28S
Mutation Type DR: diminished response
E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Other, Tetramer binding
Note 6% of B*4201+ and 2% of B*4201- subjects (n=1765) carried this escape variant, RPGGKKsYM.


Variant ID.  3480
Epitope Seq.  RPGGKKHYM
Variant Seq.  RPGGKKrYM
Mutations H/R
Epitope Location H7R
HXB2 Location H28R
Mutation Type DR: diminished response
E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Other, Tetramer binding
Note 22% of B*4201+ and 13% of B*4201- subjects (n=1765) carried this escape variant, RPGGKKrYM.


Variant ID.  3481
Epitope Seq.  RPGGKKHYM
Variant Seq.  RPGGKKHYk
Mutations M/K
Epitope Location M9K
HXB2 Location M30K
Mutation Type DR: diminished response
E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Other, Tetramer binding
Note 14% of B*4201+ and 7% of B*4201- subjects (n=1765) carried this escape variant, RPGGKKHYk.

References

Kloverpris2015 Henrik N Kløverpris, Reuben McGregor, James E. McLaren, Kristin Ladell, Mikkel Harndahl, Anette Stryhn, Jonathan M. Carlson, Catherine Koofhethile, Bram Gerritsen, Can Keşmir, Fabian Chen, Lynn Riddell, Graz Luzzi, Alasdair Leslie, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, David A. Price, and Philip J. Goulder. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J. Immunol., 194(11):5329-5345, 1 Jun 2015. PubMed ID: 25911754. Show all entries for this paper.


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