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Found 1 matching record:

Displaying record number 59244

HXB2 Location  Gag(151-159)   Gag Epitope Map
View variants at this location
Epitope TLNAWVKVV   Epitope Alignment
Variants
TLDAWVKVV   susceptible form
ALNAWVKVV   susceptible form
PLNAWVKVV   susceptible form
TLSAWVKVV   susceptible form
Species (MHC/HLA human(A*02:01)

Variant Details

Showing all: 4 variant(s).


Variant ID.  3378
Epitope Seq.  TLNAWVKVV
Variant Seq.  TLDAWVKVV
Mutations N/D
Epitope Location N3D
HXB2 Location N153D
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note First variant to arise; seen in early and late post-seroconversion periods; positive Elispot <100 SFC/106PBMC in early post-SC, and <50 SFC/106PBMC in late post-SC period.


Variant ID.  3379
Epitope Seq.  TLNAWVKVV
Variant Seq.  ALNAWVKVV
Mutations T/A
Epitope Location T1A
HXB2 Location T151A
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Second variant to arise; seen in early and late post-seroconversion periods; positive Elispot response <100 SFC/106PBMC in early period, but negative in late period.


Variant ID.  3380
Epitope Seq.  TLNAWVKVV
Variant Seq.  PLNAWVKVV
Mutations T/P
Epitope Location T1P
HXB2 Location T151P
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Third variant to arise; seen in early and late ART periods; positive Elispot >600 SFC/106PBMC in early ART, and 100-200 SFC/106PBMC in late ART period.


Variant ID.  3381
Epitope Seq.  TLNAWVKVV
Variant Seq.  TLSAWVKVV
Mutations N/S
Epitope Location N3S
HXB2 Location N153S
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Fourth variant to arise; seen in early and late ART periods; positive Elispot about 300 SFC/106PBMC in early ART, and 100-200 SFC/106PBMC in late ART period.

References

Melhem2014 Nada M Melhem, Kellie N. Smith, Xiao-Li Huang, Bonnie A Colleton, Weimin Jiang, Robbie B. Mailliard, James I. Mullins, and Charles R. Rinaldo. The Impact of Viral Evolution and Frequency of Variant Epitopes on Primary and Memory Human Immunodeficiency Virus Type 1-Specific CD8+ T Cell Responses. Virology, 450-451:34-48, Feb 2014. PubMed ID: 24503065. Show all entries for this paper.


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