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Displaying record number 59244

HXB2 Location Gag(151-159) Gag Epitope Map
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TLNAWVKVV

`TLDAWVKVV`		susceptible form
`ALNAWVKVV`		susceptible form
`PLNAWVKVV`		susceptible form
`TLSAWVKVV`		susceptible form

Species (MHC/HLA) human(A*02:01)

Variant Details

Showing all: 4 variant(s).

Variant ID.	`3378`
Epitope Seq.	`TLNAWVKVV`
Variant Seq.	`TLDAWVKVV`
Mutations	N/D
Epitope Location	N3D
HXB2 Location	N153D
Mutation Type	SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	First variant to arise; seen in early and late post-seroconversion periods; positive Elispot <100 SFC/10⁶PBMC in early post-SC, and <50 SFC/10⁶PBMC in late post-SC period.

Variant ID.	`3379`
Epitope Seq.	`TLNAWVKVV`
Variant Seq.	`ALNAWVKVV`
Mutations	T/A
Epitope Location	T1A
HXB2 Location	T151A
Mutation Type	SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Second variant to arise; seen in early and late post-seroconversion periods; positive Elispot response <100 SFC/10⁶PBMC in early period, but negative in late period.

Variant ID.	`3380`
Epitope Seq.	`TLNAWVKVV`
Variant Seq.	`PLNAWVKVV`
Mutations	T/P
Epitope Location	T1P
HXB2 Location	T151P
Mutation Type	SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Third variant to arise; seen in early and late ART periods; positive Elispot >600 SFC/10⁶PBMC in early ART, and 100-200 SFC/10⁶PBMC in late ART period.

Variant ID.	`3381`
Epitope Seq.	`TLNAWVKVV`
Variant Seq.	`TLSAWVKVV`
Mutations	N/S
Epitope Location	N3S
HXB2 Location	N153S
Mutation Type	SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Fourth variant to arise; seen in early and late ART periods; positive Elispot about 300 SFC/10⁶PBMC in early ART, and 100-200 SFC/10⁶PBMC in late ART period.

References

Melhem2014 Nada M Melhem, Kellie N. Smith, Xiao-Li Huang, Bonnie A Colleton, Weimin Jiang, Robbie B. Mailliard, James I. Mullins, and Charles R. Rinaldo. The Impact of Viral Evolution and Frequency of Variant Epitopes on Primary and Memory Human Immunodeficiency Virus Type 1-Specific CD8+ T Cell Responses. Virology, 450-451:34-48, Feb 2014. PubMed ID: 24503065. Show all entries for this paper.