HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 59230

HXB2 Location  Gag(148-156)   Gag Epitope Map
View variants at this location
Epitope SPRTLNAWV   Epitope Alignment
Variants
SPRTLDAWV   susceptible form
SPRALNAWV   susceptible form
PPRTLNAWV   observed variant
SPRPLNAWV   susceptible form
SPRTLSAWV   susceptible form
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 5 variant(s).


Variant ID.  3373
Epitope Seq.  SPRTLNAWV
Variant Seq.  SPRTLDAWV
Mutations N/D
Epitope Location N6D
HXB2 Location N153D
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note First variant to arise; seen only in early post-seroconversion period; positive Elispot response <100 SFC/106PBMC.


Variant ID.  3374
Epitope Seq.  SPRTLNAWV
Variant Seq.  SPRALNAWV
Mutations T/A
Epitope Location T4A
HXB2 Location T151A
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Second variant to arise; seen in early post-seroconversion period; positive Elispot response <100 SFC/106PBMC.


Variant ID.  3375
Epitope Seq.  SPRTLNAWV
Variant Seq.  PPRTLNAWV
Mutations S/P
Epitope Location S1P
HXB2 Location S148P
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Third variant to arise; seen in late post-seroconversion period; zero Elispot response.


Variant ID.  3376
Epitope Seq.  SPRTLNAWV
Variant Seq.  SPRPLNAWV
Mutations T/P
Epitope Location T4P
HXB2 Location T151P
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Fourth variant to arise; seen in early ART period; positive Elispot response >300 SFC/106PBMC.


Variant ID.  3377
Epitope Seq.  SPRTLNAWV
Variant Seq.  SPRTLSAWV
Mutations N/S
Epitope Location N6S
HXB2 Location N153S
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Fifth variant to arise; seen in early and late ART period; positive Elispot result in early ART >200 SFC/106PBMC, but no response in late ART.

References

Melhem2014 Nada M Melhem, Kellie N. Smith, Xiao-Li Huang, Bonnie A Colleton, Weimin Jiang, Robbie B. Mailliard, James I. Mullins, and Charles R. Rinaldo. The Impact of Viral Evolution and Frequency of Variant Epitopes on Primary and Memory Human Immunodeficiency Virus Type 1-Specific CD8+ T Cell Responses. Virology, 450-451:34-48, Feb 2014. PubMed ID: 24503065. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health