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Found 1 matching record:

Displaying record number 59229

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLFNTVATL   Epitope Alignment
Variants
SLFNTVAAL   diminished response
SLFNTVATP   diminished response
SLFSTVATL   observed variant
SLFNTIATL   susceptible form
SLYNTVATL   susceptible form
Species (MHC/HLA human(A*02:01)

Variant Details

Showing all: 5 variant(s).


Variant ID.  3368
Epitope Seq.  SLFNTVATL
Variant Seq.  SLFNTVAAL
Mutations T/A
Epitope Location T8A
HXB2 Location T84A
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note First variant to arise; seen only in early post-seroconversion period; Elispot response <100 SFC/106PBMC.


Variant ID.  3369
Epitope Seq.  SLFNTVATL
Variant Seq.  SLFNTVATP
Mutations L/P
Epitope Location L9P
HXB2 Location L85P
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Second variant to arise; seen only in early post-seroconversion period; Elispot response <50 SFC/106PBMC.


Variant ID.  3370
Epitope Seq.  SLFNTVATL
Variant Seq.  SLFSTVATL
Mutations N/S
Epitope Location N4S
HXB2 Location N80S
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Third variant to arise; seen only in early post-seroconversion period; zero Elispot response.


Variant ID.  3371
Epitope Seq.  SLFNTVATL
Variant Seq.  SLFNTIATL
Mutations V/I
Epitope Location V6I
HXB2 Location V82I
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Fourth variant to arise; seen only in late post-seroconversion period; Elispot response <100 SFC/106PBMC.


Variant ID.  3372
Epitope Seq.  SLFNTVATL
Variant Seq.  SLYNTVATL
Mutations F/Y
Epitope Location F3Y
HXB2 Location F79Y
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Fifth variant to arise; seen only in late post-seroconversion period; positive Elispot response <50 SFC/106PBMC.

References

Melhem2014 Nada M Melhem, Kellie N. Smith, Xiao-Li Huang, Bonnie A Colleton, Weimin Jiang, Robbie B. Mailliard, James I. Mullins, and Charles R. Rinaldo. The Impact of Viral Evolution and Frequency of Variant Epitopes on Primary and Memory Human Immunodeficiency Virus Type 1-Specific CD8+ T Cell Responses. Virology, 450-451:34-48, Feb 2014. PubMed ID: 24503065. Show all entries for this paper.


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