HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 59207

HXB2 Location  Gag(147-155)   Gag Epitope Map
View variants at this location
Epitope ISPRTLNAW   Epitope Alignment
Variants
lSPRTLNAW   observed variant
ltPRTLNAW   observed variant
ItPRTLNAW   observed variant
IaPRTLNAW   observed variant
IlPRTLNAW   observed variant
Epitope Name ISW9
Species (MHC/HLA human(B*57:01)

Variant Details

Showing all: 5 variant(s).


Variant ID.  3339
Epitope Seq.  ISPRTLNAW
Variant Seq.  lSPRTLNAW
Mutations I/L
Epitope Location I1L
HXB2 Location I147L
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant lSPRTLNAW, was seen in 2/3 HRPs and 2/3 LRPs. lSPRTLNAW was the only analogous ISW9 in patient P1 and was found in the major viral population in patients P5 and P6 at latter time points.


Variant ID.  3340
Epitope Seq.  ISPRTLNAW
Variant Seq.  ltPRTLNAW
Mutations I/L S/T
Epitope Location I1L S2T
HXB2 Location I147L S148T
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant ltPRTLNAW, was seen in 0/3 HRPs and 1/3 LRPs (patient P4) at the last sampling point.


Variant ID.  3341
Epitope Seq.  ISPRTLNAW
Variant Seq.  ItPRTLNAW
Mutations S/T
Epitope Location S2T
HXB2 Location S148T
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant ItPRTLNAW, was seen in 0/3 HRPs and 1/3 LRPs. It was the predominant variant in subject P4.


Variant ID.  3342
Epitope Seq.  ISPRTLNAW
Variant Seq.  IaPRTLNAW
Mutations S/A
Epitope Location S2A
HXB2 Location S148A
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant ItPRTLNAW, was seen in 1/3 HRPs and 0/3 LRPs. It was the predominant variant in subject P4.


Variant ID.  3343
Epitope Seq.  ISPRTLNAW
Variant Seq.  IlPRTLNAW
Mutations S/L
Epitope Location S2L
HXB2 Location S148L
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant IlPRTLNAW, was seen in 1/3 HRPs and 0/3 LRPs. It was an early variant in Gag that was later lost in subject P3.

References

Buggert2014 Marcus Buggert, Melissa M. Norström, Marco Salemi, Frederick M. Hecht, and Annika C. Karlsson. Functional Avidity and IL-2/Perforin Production Is Linked to the Emergence of Mutations within HLA-B*5701-Restricted Epitopes and HIV-1 Disease Progression. J. Immunol., 192(10):4685-4696, 15 May 2014. PubMed ID: 24740510. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health