HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(147-155) | Gag Epitope Map
View variants at this location |
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| Epitope |
ISPRTLNAW
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Epitope Alignment | ||||||||||||||||
| Variants |
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| Epitope Name | ISW9 | |||||||||||||||||
| Species (MHC/HLA) | human(B*57:01) | |||||||||||||||||
Showing all: 5 variant(s).
| Variant ID. | 3339 |
|---|---|
| Epitope Seq. | ISPRTLNAW |
| Variant Seq. | lSPRTLNAW |
| Mutations | I/L |
| Epitope Location | I1L |
| HXB2 Location | I147L |
| Mutation Type | OV: observed variant |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | HLA binding, Intracellular cytokine staining, Sequence |
| Note | Variant lSPRTLNAW, was seen in 2/3 HRPs and 2/3 LRPs. lSPRTLNAW was the only analogous ISW9 in patient P1 and was found in the major viral population in patients P5 and P6 at latter time points. |
| Variant ID. | 3340 |
|---|---|
| Epitope Seq. | ISPRTLNAW |
| Variant Seq. | ltPRTLNAW |
| Mutations | I/L S/T |
| Epitope Location | I1L S2T |
| HXB2 Location | I147L S148T |
| Mutation Type | OV: observed variant |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | HLA binding, Intracellular cytokine staining, Sequence |
| Note | Variant ltPRTLNAW, was seen in 0/3 HRPs and 1/3 LRPs (patient P4) at the last sampling point. |
| Variant ID. | 3341 |
|---|---|
| Epitope Seq. | ISPRTLNAW |
| Variant Seq. | ItPRTLNAW |
| Mutations | S/T |
| Epitope Location | S2T |
| HXB2 Location | S148T |
| Mutation Type | OV: observed variant |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | HLA binding, Intracellular cytokine staining, Sequence |
| Note | Variant ItPRTLNAW, was seen in 0/3 HRPs and 1/3 LRPs. It was the predominant variant in subject P4. |
| Variant ID. | 3342 |
|---|---|
| Epitope Seq. | ISPRTLNAW |
| Variant Seq. | IaPRTLNAW |
| Mutations | S/A |
| Epitope Location | S2A |
| HXB2 Location | S148A |
| Mutation Type | OV: observed variant |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | HLA binding, Intracellular cytokine staining, Sequence |
| Note | Variant ItPRTLNAW, was seen in 1/3 HRPs and 0/3 LRPs. It was the predominant variant in subject P4. |
| Variant ID. | 3343 |
|---|---|
| Epitope Seq. | ISPRTLNAW |
| Variant Seq. | IlPRTLNAW |
| Mutations | S/L |
| Epitope Location | S2L |
| HXB2 Location | S148L |
| Mutation Type | OV: observed variant |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | HLA binding, Intracellular cytokine staining, Sequence |
| Note | Variant IlPRTLNAW, was seen in 1/3 HRPs and 0/3 LRPs. It was an early variant in Gag that was later lost in subject P3. |
Buggert2014 Marcus Buggert, Melissa M. Norström, Marco Salemi, Frederick M. Hecht, and Annika C. Karlsson. Functional Avidity and IL-2/Perforin Production Is Linked to the Emergence of Mutations within HLA-B*5701-Restricted Epitopes and HIV-1 Disease Progression. J. Immunol., 192(10):4685-4696, 15 May 2014. PubMed ID: 24740510. Show all entries for this paper.