HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(22-30) | Gag Epitope Map
View variants at this location |
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| Epitope |
RPGGKKHYM
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | RM9-p17 | |||||
| Species (MHC/HLA) | human(B*07:02) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3219 |
|---|---|
| Epitope Seq. | RPGGKKHYM |
| Variant Seq. | RPGGKKkYk |
| Mutations | H/K M/K |
| Epitope Location | H7K M9K |
| HXB2 Location | H28K M30K |
| Mutation Type | SNSF: subtype-specific non-susceptible form |
| Epitope Subtype | C |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, HLA binding |
| Note | Epitope RK9, RPGGKKkYk, the B-clade consensus epitope differs at H7K and M9K, and is not recognized by HLA-B*0702. RK9 is unstable in complex with HLA-B*0702; and its binding affinity is Kd = >20,000 nM. RK9 is contained within OLP3, EKIRLRPGGKKkYkLKHI. |
Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.