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Found 1 matching record:

Displaying record number 58675

HXB2 Location  Gag(180-188)   Gag Epitope Map
View variants at this location
Epitope TPQDLNTML   Epitope Alignment
Variants
TPxDLNTML   escape documented in this paper
Epitope Name Gag-TL9
Species (MHC/HLA human(B*42:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3113
Epitope Seq.  TPQDLNTML
Variant Seq.  TPxDLNTML
Mutations Q/X
Epitope Location Q3X
HXB2 Location Q182X
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note p24-TL9 mutation, TPxDLNTML, is selected in 21% HLA-B*4201 (75% have wt TL9), 15% HLA-B*4202 (82% have wt TL9) and 5% HLA-B*42-negative (89% have wt TL9) subjects. Mutant TPlDLNTML is designated as an escape by the authors when presented by HLA-B*4201.

References

Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.


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