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Displaying record number 58604

HXB2 Location  Gag(76-86)   Gag Epitope Map
View variants at this location
Epitope RSLYNTVATLY   Epitope Alignment
Variants
RSLYNTVATLc   escape documented in this paper
kSLfNTVATLc   escape documented in this paper
RSLfNTiATLf   escape documented in this paper
Epitope Name GagRY11
Species (MHC/HLA human, macaque(A*30:02)

Variant Details

Showing all: 3 variant(s).


Variant ID.  3056
Epitope Seq.  RSLYNTVATLY
Variant Seq.  RSLYNTVATLc
Mutations Y/C
Epitope Location Y11C
HXB2 Location Y86C
Mutation Type E: escape documented in this paper
Method Cytokine production, Sequence, Tetramer binding
Note 5/5 (100%) sequenced variants showed this escape, RSLYNTVATLc, in subject 0406; 13/15 (86.7%) in subject 2401; and 8/16 (50%) in subject 3902.


Variant ID.  3057
Epitope Seq.  RSLYNTVATLY
Variant Seq.  kSLfNTVATLc
Mutations R/K Y/C Y/F
Epitope Location R1K Y11C Y4F
HXB2 Location R76K Y86C Y79F
Mutation Type E: escape documented in this paper
Method Cytokine production, Sequence, Tetramer binding
Note 1/22 (4.5%) sequenced variants showed this escape, kSLfNTVATLc, in subject 2007; 1/4 (25%) in subject 5506.


Variant ID.  3058
Epitope Seq.  RSLYNTVATLY
Variant Seq.  RSLfNTiATLf
Mutations Y/F Y/F V/I
Epitope Location Y11F Y4F V7I
HXB2 Location Y86F Y79F V82I
Mutation Type E: escape documented in this paper
Method Cytokine production, Sequence, Tetramer binding
Note 12/18 (66.7%) sequenced variants showed this escape, RSLfNTiATLf, in subject 3706.

References

Mahlokozera2011 Tatenda Mahlokozera, Helen H. Kang, Nilu Goonetilleke, Andrea R. Stacey, Rachel V. Lovingood, Thomas N. Denny, Linda Kalilani, James E. G. Bunn, Steve R. Meshnick, Persephone Borrow, Norman L. Letvin, Sallie R. Permar, and Center for HIV/AIDS Vaccine Immunology. The Magnitude and Kinetics of the Mucosal HIV-Specific CD8+ T Lymphocyte Response and Virus RNA Load in Breast Milk. PLoS One, 6(8):e23735, 2011. PubMed ID: 21886819. Show all entries for this paper.


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