HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(76-86) | Gag Epitope Map
View variants at this location |
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| Epitope |
RSLYNTVATLY
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Epitope Alignment | ||||||||||
| Variants |
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| Epitope Name | GagRY11 | |||||||||||
| Species (MHC/HLA) | human, macaque(A*30:02) | |||||||||||
Showing all: 3 variant(s).
| Variant ID. | 3056 |
|---|---|
| Epitope Seq. | RSLYNTVATLY |
| Variant Seq. | RSLYNTVATLc |
| Mutations | Y/C |
| Epitope Location | Y11C |
| HXB2 Location | Y86C |
| Mutation Type | E: escape documented in this paper |
| Method | Cytokine production, Sequence, Tetramer binding |
| Note | 5/5 (100%) sequenced variants showed this escape, RSLYNTVATLc, in subject 0406; 13/15 (86.7%) in subject 2401; and 8/16 (50%) in subject 3902. |
| Variant ID. | 3057 |
|---|---|
| Epitope Seq. | RSLYNTVATLY |
| Variant Seq. | kSLfNTVATLc |
| Mutations | R/K Y/C Y/F |
| Epitope Location | R1K Y11C Y4F |
| HXB2 Location | R76K Y86C Y79F |
| Mutation Type | E: escape documented in this paper |
| Method | Cytokine production, Sequence, Tetramer binding |
| Note | 1/22 (4.5%) sequenced variants showed this escape, kSLfNTVATLc, in subject 2007; 1/4 (25%) in subject 5506. |
| Variant ID. | 3058 |
|---|---|
| Epitope Seq. | RSLYNTVATLY |
| Variant Seq. | RSLfNTiATLf |
| Mutations | Y/F Y/F V/I |
| Epitope Location | Y11F Y4F V7I |
| HXB2 Location | Y86F Y79F V82I |
| Mutation Type | E: escape documented in this paper |
| Method | Cytokine production, Sequence, Tetramer binding |
| Note | 12/18 (66.7%) sequenced variants showed this escape, RSLfNTiATLf, in subject 3706. |
Mahlokozera2011 Tatenda Mahlokozera, Helen H. Kang, Nilu Goonetilleke, Andrea R. Stacey, Rachel V. Lovingood, Thomas N. Denny, Linda Kalilani, James E. G. Bunn, Steve R. Meshnick, Persephone Borrow, Norman L. Letvin, Sallie R. Permar, and Center for HIV/AIDS Vaccine Immunology. The Magnitude and Kinetics of the Mucosal HIV-Specific CD8+ T Lymphocyte Response and Virus RNA Load in Breast Milk. PLoS One, 6(8):e23735, 2011. PubMed ID: 21886819. Show all entries for this paper.