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Displaying record number 58386

HXB2 Location  Gag(129-143)   Gag Epitope Map
View variants at this location
Epitope SQNYPIVQNLQGQMV   Epitope Alignment
Variants
sqvSQNYPIVQNLQG   subtype-specific susceptible form
kvSQNYalkhrayel   subtype-specific non-susceptible form
Epitope Name Peptide 32
Species (MHC/HLA human

Variant Details

Showing all: 2 variant(s).


Variant ID.  2915
Epitope Seq.  xxxSQNYPIVQNLQG
Variant Seq.  sqvSQNYPIVQNLQG
Mutations x/S x/Q x/V
Epitope Location x1S x2Q x3V
HXB2 Location x129S x130Q x131V
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype C
Variant Subtype D
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-D peptide 32, sqvSQNYPIVQNLQG, cross reacted to elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2916
Epitope Seq.  xxSQNYPIVQNLQGM
Variant Seq.  kvSQNYalkhrayel
Mutations x/K Q/H N/R L/A Q/Y G/E M/L x/V P/A I/L V/K
Epitope Location x1K Q10H N11R L12A Q13Y G14E M15L x2V P7A I8L V9K
HXB2 Location x129K Q138H N139R L140A Q141Y G142E M143L x130V P135A I136L V137K
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype A
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-A peptide 32, kvSQNYalkhrayel, did not elicit a response from South African subjects carrying clade-C virus.

References

Zembe2011 Lycias Zembe, Wendy A. Burgers, Heather B. Jaspan, Linda-Gail Bekker, Helba Bredell, Gwynneth Stevens, Jill Gilmour, Josephine H. Cox, Patricia Fast, Peter Hayes, Eftyhia Vardas, Carolyn Williamson, and Clive M. Gray. Intra- and Inter-Clade Cross-Reactivity by HIV-1 Gag Specific T-Cells Reveals Exclusive and Commonly Targeted Regions: Implications for Current Vaccine Trials. PLoS One, 6(10):e26096, 2011. PubMed ID: 22022524. Show all entries for this paper.


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