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Displaying record number 58386

HXB2 Location Gag(129-143) Gag Epitope Map
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SQNYPIVQNLQGQMV

`sqvSQNYPIVQNLQG`		subtype-specific susceptible form
`kvSQNYalkhrayel`		subtype-specific non-susceptible form

Epitope Name Peptide 32

Species (MHC/HLA) human

Variant Details

Showing all: 2 variant(s).

Variant ID.	`2915`
Epitope Seq.	`xxxSQNYPIVQNLQG`
Variant Seq.	`sqvSQNYPIVQNLQG`
Mutations	x/S x/Q x/V
Epitope Location	x1S x2Q x3V
HXB2 Location	x129S x130Q x131V
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	C
Variant Subtype	D
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-D peptide 32, sqvSQNYPIVQNLQG, cross reacted to elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2916`
Epitope Seq.	`xxSQNYPIVQNLQGM`
Variant Seq.	`kvSQNYalkhrayel`
Mutations	x/K Q/H N/R L/A Q/Y G/E M/L x/V P/A I/L V/K
Epitope Location	x1K Q10H N11R L12A Q13Y G14E M15L x2V P7A I8L V9K
HXB2 Location	x129K Q138H N139R L140A Q141Y G142E M143L x130V P135A I136L V137K
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	C
Variant Subtype	A
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-A peptide 32, kvSQNYalkhrayel, did not elicit a response from South African subjects carrying clade-C virus.

References

Zembe2011 Lycias Zembe, Wendy A. Burgers, Heather B. Jaspan, Linda-Gail Bekker, Helba Bredell, Gwynneth Stevens, Jill Gilmour, Josephine H. Cox, Patricia Fast, Peter Hayes, Eftyhia Vardas, Carolyn Williamson, and Clive M. Gray. Intra- and Inter-Clade Cross-Reactivity by HIV-1 Gag Specific T-Cells Reveals Exclusive and Commonly Targeted Regions: Implications for Current Vaccine Trials. PLoS One, 6(10):e26096, 2011. PubMed ID: 22022524. Show all entries for this paper.