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Found 1 matching record:

Displaying record number 58383

HXB2 Location  Gag(42-56)   Gag Epitope Map
View variants at this location
Epitope ERFALNPGLLETSEG   Epitope Alignment
Variants
lERFAvNPGLLETSE   subtype-specific non-susceptible form
ERFALNPsLLETaEG   subtype-specific non-susceptible form
Epitope Name Peptide 11
Species (MHC/HLA human

Variant Details

Showing all: 2 variant(s).


Variant ID.  2905
Epitope Seq.  xERFALNPGLLETSE
Variant Seq.  lERFAvNPGLLETSE
Mutations x/L L/V
Epitope Location x1L L6V
HXB2 Location x42L L47V
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-B peptide 11, lERFAvNPGLLETSE, did not cross react to elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2906
Epitope Seq.  ERFALNPGLLETSEG
Variant Seq.  ERFALNPsLLETaEG
Mutations S/A G/S
Epitope Location S13A G8S
HXB2 Location S54A G49S
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype A
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-A peptide 11, ERFALNPsLLETaEG, did not cross react to elicit a response from South African subjects carrying clade-C virus.

References

Zembe2011 Lycias Zembe, Wendy A. Burgers, Heather B. Jaspan, Linda-Gail Bekker, Helba Bredell, Gwynneth Stevens, Jill Gilmour, Josephine H. Cox, Patricia Fast, Peter Hayes, Eftyhia Vardas, Carolyn Williamson, and Clive M. Gray. Intra- and Inter-Clade Cross-Reactivity by HIV-1 Gag Specific T-Cells Reveals Exclusive and Commonly Targeted Regions: Implications for Current Vaccine Trials. PLoS One, 6(10):e26096, 2011. PubMed ID: 22022524. Show all entries for this paper.


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