Search the Epitope Variant and Escape Mutation Database

Help

Found 1 matching record:

Displaying record number 58383

HXB2 Location Gag(42-56) Gag Epitope Map
View variants at this location

ERFALNPGLLETSEG

`lERFAvNPGLLETSE`		subtype-specific non-susceptible form
`ERFALNPsLLETaEG`		subtype-specific non-susceptible form

Epitope Name Peptide 11

Species (MHC/HLA) human

Variant Details

Showing all: 2 variant(s).

Variant ID.	`2905`
Epitope Seq.	`xERFALNPGLLETSE`
Variant Seq.	`lERFAvNPGLLETSE`
Mutations	x/L L/V
Epitope Location	x1L L6V
HXB2 Location	x42L L47V
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	C
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-B peptide 11, lERFAvNPGLLETSE, did not cross react to elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2906`
Epitope Seq.	`ERFALNPGLLETSEG`
Variant Seq.	`ERFALNPsLLETaEG`
Mutations	S/A G/S
Epitope Location	S13A G8S
HXB2 Location	S54A G49S
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	C
Variant Subtype	A
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-A peptide 11, ERFALNPsLLETaEG, did not cross react to elicit a response from South African subjects carrying clade-C virus.

References

Zembe2011 Lycias Zembe, Wendy A. Burgers, Heather B. Jaspan, Linda-Gail Bekker, Helba Bredell, Gwynneth Stevens, Jill Gilmour, Josephine H. Cox, Patricia Fast, Peter Hayes, Eftyhia Vardas, Carolyn Williamson, and Clive M. Gray. Intra- and Inter-Clade Cross-Reactivity by HIV-1 Gag Specific T-Cells Reveals Exclusive and Commonly Targeted Regions: Implications for Current Vaccine Trials. PLoS One, 6(10):e26096, 2011. PubMed ID: 22022524. Show all entries for this paper.